Matthew Wiens
BSc, PharmD, PhD
Investigator, BC Children's Hospital
Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026
INTENSIVE CARE MEDICINE
DOI: 10.1007/S00134-026-08360-2The Effect of Anemia on Mortality in Children Hospitalized with Severe Pneumonia in Uganda
JOURNAL OF PEDIATRICS
DOI: 10.1016/J.JPEDS.2026.115090Post-discharge mortality, readmission and care seeking among postpartum women and their newborns following facility-based delivery in Uganda: a prospective observational study
BMJ OPEN
DOI: 10.1136/BMJOPEN-2025-108734EPIDEMIOLOGY OF CHILDREN WITH ACUTE NEUROLOGIC DYSFUNCTION IN RESOURCE-CONSTRAINED SETTINGS
CRITICAL CARE MEDICINE
DOI: 10.1097/01.CCM.0001186348.31077.D1Epidemiology of stillbirths and maternal post-discharge outcomes following stillbirths in Uganda: a prospective cohort study
medRxiv
DOI: 10.64898/2026.01.23.26344736Effect of Household Air Pollution on the Gut Microbiome and Virome of Adult Women Living in Uganda
ENVIRONMENTAL HEALTH PERSPECTIVES
DOI: 10.1021/EHP.6C00064Risk factors for mortality in children with hypoxemia in resource-constrained settings: a secondary analysis of Global Paediatric Acute Critical Illness Point Prevalence Study (PARITY)
BMC GLOBAL AND PUBLIC HEALTH
DOI: 10.1186/S44263-025-00238-7HEMATOLOGICAL PARAMETERS AS PROGNOSTIC BIOMARKERS FOR SEPSIS AND MALARIA IN RESOURCE-LIMITED SETTING
CRITICAL CARE MEDICINE
DOI: 10.1097/01.CCM.0001187564.90493.03Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026
PEDIATRIC CRITICAL CARE MEDICINE
DOI: 10.1097/PCC.0000000000003928PHOENIX SEPSIS SCORE IN LOW-RESOURCE SETTINGS: PROPOSED MODIFIED CRITERIA FROM GLOBAL PARITY COHORT
CRITICAL CARE MEDICINE
DOI: 10.1097/01.CCM.0001187500.71449.E2Smart Discharges improves post-discharge mortality among children with suspected sepsis in Uganda: A prospective before-after study
Matthew O Wiens and Cherri Zhang and Vuong Nguyen and Jeffrey N Bone and Elias Kumbakumba and Stephen Businge and Abner Tagoola and Emmanuel Tenywa and Sheila Oyella Sherine and Emmanuel Byaruhanga and Edward Ssemwanga and Jesca Nsungwa and Charles Olaro and J Mark Ansermino and Niranjan Kissoon and Joel Singer and Charles P Larson and Pascal M Lavoie and Dustin Dunsmuir and Peter P Moschovis and Stefanie Novakowski and Jessica Trawin and Clare Komugisha and Bernard T Opar and Mellon Tayebwa and Douglas Mwesigwa and Nicholas West and Nathan Kenya Mugisha and Jerome Kabakyenga
DOI: 10.1101/2025.08.25.2533433608 / 2025
Diverging pathways: exploring the interplay between hospital readmission and postdischarge mortality in paediatric sepsis in low-income settings
BMJ GLOBAL HEALTH
DOI: 10.1136/BMJGH-2025-020128Validation of a risk-prediction model for pediatric post-discharge mortality after hospital admission for infection in Rwanda: A prospective cohort study
PLOS GLOBAL PUBLIC HEALTH
DOI: 10.1371/JOURNAL.PGPH.0004606Using Hourly Aggregated Respiratory Rate and Expiratory Time with Machine Learning to Identify Remote COPD Exacerbations
medRxiv
DOI: 10.1101/2025.10.24.25338693RSV Hospital Admissions During the First 2 Seasons Among Children With Chronic Medical Conditions
JAMA NETWORK OPEN
DOI: 10.1001/JAMANETWORKOPEN.2025.19410REPEATABILITY OF RESPIRATORY RATE MEASUREMENTS IN CHILDREN DURING TRIAIGE IN TWO UGANDAN HOSPITALS
ANESTHESIA AND ANALGESIA
The 2024 Phoenix Sepsis Score Criteria: Part 4, What About Using World-Oriented Criteria?
PEDIATRIC CRITICAL CARE MEDICINE
DOI: 10.1097/PCC.0000000000003663Post-discharge mortality in suspected pediatric sepsis: Insights from rural and urban healthcare settings in Rwanda
PLOS GLOBAL PUBLIC HEALTH
DOI: 10.1371/JOURNAL.PGPH.0005622Implementation of Smart Triage combined with a quality improvement program for children presenting to facilities in Kenya and Uganda: An interrupted time series analysis
PLOS DIGITAL HEALTH
DOI: 10.1371/JOURNAL.PDIG.0000466Discharge policies and care practices for children with suspected sepsis: A health facility scan at a nationally representative sample of hospitals and health centres in Uganda
PLOS GLOBAL PUBLIC HEALTH
DOI: 10.1371/JOURNAL.PGPH.0003559Assessing the validity of post-discharge readmission and mortality as a composite outcome among newborns in Uganda
medRxiv
DOI: 10.1101/2025.09.07.25335285Air Pollution Intervention Changes the Gut Microbiome and Virome of Adult Women in Uganda
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
DOI: 10.1164/AJRCCM.2025.211.ABSTRACTS.A7399Admission photoplethysmography-based mortality prediction in hospitalized Ugandan children with suspected or confirmed infection: a feasibility study
medRxiv
DOI: 10.1101/2025.10.05.25337385Studying the Effectiveness of Video-Assisted Education in Teaching Ugandan Mothers to Monitor Their Hospitalised Infant
ACTA PAEDIATRICA
DOI: 10.1111/APA.70136Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study
LANCET GLOBAL HEALTH
DOI: 10.1016/S2214-109X(24)00450-9Assessment of Facility Readiness for Pediatric Emergency and Critical Care Utilizing a 2-Phase Survey Conducted in Six Hospitals in Uganda and Cameroon: A Quality Improvement Study
PEDIATRIC EMERGENCY CARE
DOI: 10.1097/PEC.0000000000003276Infant-level and child-level predictors of mortality in low-resource settings: the WHO Child Mortality Risk Stratification Multi-Country Pooled Cohort (vol 13, e843, 2025)
LANCET GLOBAL HEALTH
DOI: 10.1016/S2214-109X(25)00045-2Exploring two-way text messages for post-discharge follow-up and quality improvement in rural Uganda
PLOS ONE
DOI: 10.1371/JOURNAL.PONE.0322969Contextual Phenotyping of Pediatric Sepsis Cohort Using Large Language Models
Arxiv
Transition from Hospital to Home-Based Care for Older Adults in Southwestern Uganda: Informal Caregiver's Experiences
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
DOI: 10.2147/JMDH.S495851Exposure to pollutants for household cooking and lighting and pediatric post-discharge mortality following a severe infection in Uganda
PLOS ONE
DOI: 10.1371/JOURNAL.PONE.0326105Repeatability of RRate measurements in children during triage in two Ugandan hospitals
PLOS GLOBAL PUBLIC HEALTH
DOI: 10.1371/JOURNAL.PGPH.0003097Benchmarking bulk and single-cell variant-calling approaches on Chromium scRNA-seq and scATAC-seq libraries
GENOME RESEARCH
DOI: 10.1101/GR.277066.122THE ETIOLOGY OF HOSPITAL MORTALITY IN CHILDREN IN LMICS: A SYSTEMATIC REVIEW AND META-ANALYSIS
CRITICAL CARE MEDICINE
The epidemiology and risk factors for postnatal complications among postpartum women and newborns in southwestern Uganda: A prospective cohort study
PLOS GLOBAL PUBLIC HEALTH
DOI: 10.1371/JOURNAL.PGPH.0003458Validation of a risk-prediction model for pediatric post-discharge mortality after hospital admission in Rwanda
medRxiv
DOI: 10.1101/2024.10.25.24316146Pediatric post-discharge mortality in resource-poor countries: a systematic review and meta-analysis
ECLINICALMEDICINE
DOI: 10.1016/J.ECLINM.2023.102380Digital solutions in paediatric sepsis: current state, challenges, and opportunities to improve care around the world
LANCET DIGITAL HEALTH
DOI: 10.1016/S2589-7500(24)00141-9Implementation of Smart Triage combined with a quality improvement program for children presenting to facilities in Kenya and Uganda: An interrupted time series analysis.
medRxiv
DOI: 10.1101/2024.02.09.24302601Caregivers' and nurses' perceptions of the Smart Discharges Program for children with sepsis in Uganda: A qualitative study
PLOS ONE
DOI: 10.1371/JOURNAL.PONE.0307089REPEATABILITY OF RESPIRATORY RATE MEASUREMENTS IN CHILDREN DURING TRIAIGE IN TWO UGANDAN HOSPITALS.
ANESTHESIA AND ANALGESIA
IMPLEMENTATION OF ACCEPTABILITY AND REPRODUCIBILITY CRITERIA IN INFANT OSCILLOMETRY
CHEST
DOI: 10.1016/J.CHEST.2024.06.3032Efficacy of Palivizumab Immunoprophylaxis for Reducing Severe RSV Outcomes in Children with Immunodeficiencies: A Systematic Review
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
DOI: 10.1093/JPIDS/PIAE004The 2024 Pediatric Sepsis Challenge: Predicting In-Hospital Mortality in Children With Suspected Sepsis in Uganda
PEDIATRIC CRITICAL CARE MEDICINE
DOI: 10.1097/PCC.0000000000003556International Consensus Criteria for Pediatric Sepsis and Septic Shock
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
DOI: 10.1001/JAMA.2024.0179Etiology of hospital mortality in children living in low- and middle-income countries: a systematic review and meta-analysis
FRONTIERS IN PEDIATRICS
DOI: 10.3389/FPED.2024.1397232AI-based histopathology image analysis reveals a distinct subset of endometrial cancers
NATURE COMMUNICATIONS
DOI: 10.1038/S41467-024-49017-2Facilitators and constraints to family integrated care in low-resource settings informed the adaptation in Uganda
ACTA PAEDIATRICA
DOI: 10.1111/APA.17182Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
DOI: 10.1001/JAMA.2024.0196ESTIMATING THE GLOBAL PREVALENCE OF PEDIATRIC ACUTE CRITICAL ILLNESS IN RESOURCE-LIMITED SETTINGS
CRITICAL CARE MEDICINE
Family Integrated Care in Uganda: a feasibility study
ARCHIVES OF DISEASE IN CHILDHOOD
DOI: 10.1136/ARCHDISCHILD-2022-324638Caregivers and nurses perceptions of the Smart Discharges Program for children with sepsis in Uganda: A descriptive qualitative study
medRxiv
DOI: 10.1101/2023.07.18.23292842World Health Organization Danger Signs to predict bacterial sepsis in newborns: A pragmatic prospective cohort study
medRxiv
DOI: 10.1101/2023.05.09.23289739Risk factors for postpartum maternal mortality and hospital readmission in low- and middle-income countries: a systematic review
BMC PREGNANCY AND CHILDBIRTH
DOI: 10.1186/S12884-023-05459-YClinical decision support tools for paediatric sepsis in resource-poor settings: an international qualitative study
BMJ OPEN
DOI: 10.1136/BMJOPEN-2023-074458"If you have light, your heart will be at peace": A qualitative study of household lighting and social integration in southwestern Uganda
JOURNAL OF GLOBAL HEALTH
DOI: 10.7189/JOGH.13.04026Tackling post-discharge mortality in children living in LMICs to reduce child deaths
LANCET CHILD & ADOLESCENT HEALTH
DOI: 10.1016/S2352-4642(22)00375-3Mortality after hospital discharge among children younger than 5 years admitted with suspected sepsis in Uganda: a prospective, multisite, observational cohort study
LANCET CHILD & ADOLESCENT HEALTH
DOI: 10.1016/S2352-4642(23)00052-4Transitions from hospital to home: A mixed methods study to evaluate pediatric discharges in Uganda
PLOS GLOBAL PUBLIC HEALTH
DOI: 10.1371/JOURNAL.PGPH.0002173Prediction models for post-discharge mortality among under-five children with suspected sepsis in Uganda: A multicohort analysis
medRxiv
DOI: 10.1101/2023.06.14.23291343Planning for Hospital Discharge for Older Adults in Uganda: A Qualitative Study Among Healthcare Providers Using the COM-B Framework
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
DOI: 10.2147/JMDH.S430489Pediatric post-discharge mortality in resource-poor countries: A protocol for an updated systematic review and meta-analysis
PLOS ONE
DOI: 10.1371/JOURNAL.PONE.0281732Data for assessing red blood cell deformability from microscopy images using deep learning
DATA IN BRIEF
DOI: 10.1016/J.DIB.2023.108928Artificial intelligence-based histopathology image analysis identifies a novel subset of endometrial cancers with distinct genomic features and unfavourable outcome
medRxiv
DOI: 10.1101/2023.05.23.23290415World Health Organization Danger Signs to predict bacterial sepsis in young infants: A pragmatic cohort study
PLOS GLOBAL PUBLIC HEALTH
DOI: 10.1371/JOURNAL.PGPH.0001990Prognostic algorithms for post-discharge readmission and mortality among mother-infant dyads: an observational study protocol
FRONTIERS IN EPIDEMIOLOGY
DOI: 10.3389/FEPID.2023.1233323CHALLENGES IN INSTITUTIONAL APPROVAL PROCESS FOR A MULTINATIONAL STUDY: THE GLOBAL PARITY
CRITICAL CARE MEDICINE
Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda
PEDIATRICS
DOI: 10.1542/PEDS.2023-062011Geographical validation of the Smart Triage Model by age group
medRxiv
DOI: 10.1101/2023.06.29.23292059Criteria for Pediatric Sepsis-A Systematic Review and Meta-Analysis by the Pediatric Sepsis Definition Taskforce*
CRITICAL CARE MEDICINE
DOI: 10.1097/CCM.0000000000005294PEDIATRIC DISCHARGES IN UGANDA: HEALTH WORKER AND CAREGIVER PERSPECTIVES
PEDIATRIC CRITICAL CARE MEDICINE
The Burden of Critical Illness in Hospitalized Children in Low- and Middle-Income Countries: Protocol for a Systematic Review and Meta-Analysis
FRONTIERS IN PEDIATRICS
DOI: 10.3389/FPED.2022.756643IMPLEMENTATION OF SMART SPOT: PATIENT AND TREATMENT TRACKING SYSTEM TO SUPPORT TIMELY RECOGNITION AND TREATMENT OF CRITICALLY ILL CHILDREN
PEDIATRIC CRITICAL CARE MEDICINE
SMART DISCHARGES FOR MOM plus BABY: IDENTIFYING VULNERABLE DYADS TO GUIDE DELIVERY OF POST-DISCHARGE CARE
PEDIATRIC CRITICAL CARE MEDICINE
PEDIATRIC DISCHARGES IN UGANDA: FACILITY PROCEDURES AND PRACTICES
PEDIATRIC CRITICAL CARE MEDICINE
FACTORS ASSOCIATED WITH DISCHARGE AGAINST MEDICAL ADVICE AMONG CHILDREN TREATED FOR SUSPECTED OR PROVEN INFECTIONS AT UGANDAN HOSPITALS
PEDIATRIC CRITICAL CARE MEDICINE
CHALLENGES IN INSTITUTIONAL ETHICS REVIEW AND APPROVAL PROCESS FOR A MULTI-NATIONAL, MULTI-CENTER STUDY IN RESOURCE-LIMITED SETTINGS: THE GLOBAL PARITY STUDY
PEDIATRIC CRITICAL CARE MEDICINE
PEDIATRIC DISCHARGES IN UGANDA: DEVELOPMENT OF A DISCHARGE MODEL OF CARE
PEDIATRIC CRITICAL CARE MEDICINE
SAVING YOUNG LIVES: TRIAGE AND MANAGEMENT OF SEPSIS IN CHILDREN USING SMART TRIAGE
PEDIATRIC CRITICAL CARE MEDICINE
REPEATABILITY OF PULSE OXIMETRY MEASUREMENTS IN CHILDREN DURING TRIAGE IN TWO UGANDAN HOSPITALS
medRxiv
DOI: 10.1101/2022.12.21.22283800ADMISSION LACTATE DOES NOT IMPROVE THE PREDICTION OF IN-HOSPITAL MORTALITY IN CHILDREN IN UGANDA
PEDIATRIC CRITICAL CARE MEDICINE
A proposed de-identification framework for a cohort of children presenting at a health facility in Uganda
PLOS DIGITAL HEALTH
DOI: 10.1371/JOURNAL.PDIG.0000027Parental participation in the care of hospitalized neonates in low- and middle-income countries: A systematic review and meta-analysis
FRONTIERS IN PEDIATRICS
DOI: 10.3389/FPED.2022.987228Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings
FRONTIERS IN PEDIATRICS
DOI: 10.3389/FPED.2021.793326Use, cost-effectiveness, and end user perspectives of a home solar lighting intervention in rural Uganda: a mixed methods, randomized controlled trial
ENVIRONMENTAL RESEARCH LETTERS
DOI: 10.1088/1748-9326/AC3F05Smart triage: Development of a rapid pediatric triage algorithm for use in low-and-middle income countries
FRONTIERS IN PEDIATRICS
DOI: 10.3389/FPED.2022.976870GLOBAL PARITY: A GLOBAL POINT PREVALENCE STUDY OF PEDIATRIC ACUTE CRITICAL ILLNESS IN RESOURCE-LIMITED SETTINGS
PEDIATRIC CRITICAL CARE MEDICINE
Derivation and internal validation of a data-driven prediction model to guide frontline health workers in triaging children under-five in Nairobi, Kenya
Wellcome Open Research
Alishah Mawji and Samuel Akech and Paul Mwaniki and Dustin Dunsmuir and Jeffrey Bone and Matthew O. Wiens and Matthias Grges and David Kimutai and Niranjan Kissoon and Mike English and Mark J. Ansermino
DOI: 10.12688/wellcomeopenres.15387.304 / 2021
Anticipating the future: prognostic tools as a complementary strategy to improve care for patients with febrile illnesses in resource-limited settings
BMJ GLOBAL HEALTH
DOI: 10.1136/BMJGH-2021-006057Out of pocket costs and time/productivity losses for pediatric sepsis in Uganda: a mixed-methods study
BMC HEALTH SERVICES RESEARCH
DOI: 10.1186/S12913-021-07272-9Common data elements for predictors of pediatric sepsis: A framework to standardize data collection
PLOS ONE
DOI: 10.1371/JOURNAL.PONE.0253051Assessing red blood cell deformability from microscopy images using deep learning
LAB ON A CHIP
DOI: 10.1039/D1LC01006AImpact of a Solar Lighting Intervention on Social Determinants of Health in Rural Uganda: A Mixed Methods, Randomized Controlled Trial
SSRN
Sundararajan, R. and D?Couto, H. and Mugerwa, J. and Tayebwa, M. and Lam, N. and Wallach, E. and Wiens, M. and Stanistreet, D. and Tsai, A.C. and Vallarino, J. and Allen, J.G. and Muyanja, D. and Nuwagira, E. and Lai, P.S.
DOI: 10.2139/ssrn.3756809Challenges in pediatric post-sepsis care in resource limited settings: a narrative review
TRANSLATIONAL PEDIATRICS
DOI: 10.21037/TP-20-390Impact of a Solar Lighting Interventional Trial on Non-Health Outcomes in Rural Uganda: A Mixed Methods Study
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Smart triage: triage and management of sepsis in children using the point-of-care Pediatric Rapid Sepsis Trigger (PRST) tool
BMC HEALTH SERVICES RESEARCH
DOI: 10.1186/S12913-020-05344-WEvaluation of a digital triage platform in Uganda: A quality improvement initiative to reduce the time to antibiotic administration
PLOS ONE
DOI: 10.1371/JOURNAL.PONE.0240092Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in a low-and middle-income country: A study protocol
Gates Open Research
Lavoie, P.M. and Popescu, C.R. and Tembo, B. and Chifisi, R. and Cavanagh, M.M.M. and Lee, A.-Y. and Chiluzi, B. and Ciccone, E.J. and Tegha, G. and Alonso-Prieto, E. and Claydon, J. and Dunsmuir, D. and Irvine, M. and Dumont, G. and Ansermino, J.M. and Wiens, M.O. and Juliano, J.J. and Kissoon, N. and Mvalo, T. and Lufesi, N. and Chiume-Kayuni, M.
DOI: 10.12688/gatesopenres.13172.2Evidence and Transparency are Needed to Develop a Frontline Health Worker mHealth Assessment Platform
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
DOI: 10.4269/AJTMH.19-0411ARe: "Investment Long Overdue in Primary Studies of HIV-exposed Uninfected Infant Infectious Morbidity"
PEDIATRIC INFECTIOUS DISEASE JOURNAL
DOI: 10.1097/INF.0000000000002250Exploring healthcare providers' perspectives of the paediatric discharge process in Uganda: a qualitative exploratory study
BMJ OPEN
DOI: 10.1136/BMJOPEN-2019-029526Community health workers trained to conduct verbal autopsies provide better mortality measures than existing surveillance: Results from a cross-sectional study in rural western Uganda
PLOS ONE
DOI: 10.1371/JOURNAL.PONE.0211482Determining predictors of sepsis at triage among children under 5 years of age in resource-limited settings: A modified Delphi process
PLOS ONE
DOI: 10.1371/JOURNAL.PONE.0211274Active management of atrial fibrillation or flutter in emergency department patients with renal impairment is associated with a higher risk of adverse events and treatment failure
CANADIAN JOURNAL OF EMERGENCY MEDICINE
DOI: 10.1017/CEM.2018.475Very severe anemia and one year mortality outcome after hospitalization in Tanzanian children: A prospective cohort study
bioRxiv
DOI: 10.1101/581462A low cost mobile controlled CW-NIRS absolute oximeter to prevent child mortality in low-income countries
OPTICS AND BIOPHOTONICS IN LOW-RESOURCE SETTINGS V
DOI: 10.1117/12.2510769Paediatric postdischarge mortality in developing countries: a systematic review
BMJ Open
Brooklyn Nemetchek and Lacey English and Niranjan Kissoon and John Mark Ansermino and Peter P Moschovis and Jerome Kabakyenga and Susan Fowler-Kerry and Elias Kumbakumba and Matthew O Wiens
DOI: 10.1136/bmjopen-2018-02344512 / 2018
A Locally Developed Electronic Health Platform in Uganda: Development and Implementation of Stre@mline
JMIR Formative Research
Li Liang and Matthew O Wiens and Phaisal Lubega and Ian Spillman and Samuel Mugisha
DOI: 10.2196/formative.965809 / 2018
A transformation of oxygen saturation (the saturation virtual shunt) to improve clinical prediction model calibration and interpretation
Guohai Zhou and Walter Karlen and Rollin Brant and Matthew Wiens and Niranjan Kissoon and J Mark Ansermino
DOI: 10.1101/39129208 / 2018
Individual, maternal and household risk factors for anaemia among young children in sub-Saharan Africa: a cross-sectional study
BMJ Open
Peter P Moschovis and Matthew O Wiens and Lauren Arlington and Olga Antsygina and Douglas Hayden and Walter Dzik and Julius P Kiwanuka and David C Christiani and Patricia L Hibberd
DOI: 10.1136/bmjopen-2017-01965405 / 2018
Pneumonia in HIV-exposed and Infected Children and Association With Malnutrition
PEDIATRIC INFECTIOUS DISEASE JOURNAL
DOI: 10.1097/INF.0000000000001971We need smarter trigger tools for diagnosing sepsis in children in Canada
CANADIAN MEDICAL ASSOCIATION JOURNAL
DOI: 10.1503/CMAJ.180434An Observational Study of Peripheral Muscle Oxygenation Using NIRS in a Cohort of Nourished and Malnourished Children with Pneumonia
ANESTHESIA AND ANALGESIA
WHO STAYS AND WHO GOES: PREDICTORS OF HOSPITAL ADMISSION AMONG PATIENTS PRESENTING WITH FEBRILE ILLNESS IN A RURAL UGANDAN HEALTH CENTER
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Predictor variables for post-discharge mortality modelling in infants: a protocol development project
AFRICAN HEALTH SCIENCES
DOI: 10.4314/AHS.V18I4.43Who Stays and Who Goes: Predictors of Admission among Patients Presenting with Febrile Illness and a Positive Malaria Rapid Diagnostic Test in a Rural Ugandan Health Center
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
DOI: 10.4269/AJTMH.18-0338Smart Hospital Discharges to Address a Neglected Epidemic in Sepsis in Low- and Middle-Income Countries
JAMA PEDIATRICS
DOI: 10.1001/JAMAPEDIATRICS.2017.4519Predictors of Post-Discharge Outcomes and Care-Seeking Behaviors among Children with Acute Infectious Illness in Southwestern Uganda
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Predictors of Mortality in Neonates and Infants Hospitalized With Sepsis or Serious Infections in Developing Countries: A Systematic Review
FRONTIERS IN PEDIATRICS
DOI: 10.3389/FPED.2018.00277Development and Implementation of Stre@mline, a Locally Developed Electronic Health Platform in Uganda (Preprint)
Li Liang and Matthew O Wiens and Phisal Lubega and Ian Spillman and Samuel Mugisha
DOI: 10.2196/preprints.965812 / 2017
Effect of frequency of clinic visits and medication pick-up on antiretroviral treatment outcomes: a systematic literature review and meta-analysis
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
DOI: 10.7448/IAS.20.5.21647Comparative efficacy and safety of second-line antiretroviral therapy for treatment of HIV/AIDS: a systematic review and network meta-analysis
LANCET HIV
DOI: 10.1016/S2352-3018(17)30109-1Proposal of a New Pediatric Sequential Organ Failure Assessment Score for Possible Validation Reply
PEDIATRIC CRITICAL CARE MEDICINE
DOI: 10.1097/PCC.0000000000001022Systematic Review and Meta-analysis of the Pharmacokinetics of Benznidazole in the Treatment of Chagas Disease
Antimicrobial Agents and Chemotherapy
Matthew O. Wiens and Steve Kanters and Edward Mills and Alejandro A. Peregrina Lucano and Silvia Gold and Dieter Ayers and Luis Ferrero and Alejandro Krolewiecki
DOI: 10.1128/AAC.01567-1612 / 2016
The PAediatric Risk Assessment (PARA) Mobile App to Reduce Postdischarge Child Mortality: Design, Usability, and Feasibility for Health Care Workers in Uganda
JMIR mHealth and uHealth
Lauren Lacey English and Dustin Dunsmuir and Elias Kumbakumba and John Mark Ansermino and Charles P Larson and Richard Lester and Celestine Barigye and Andrew Ndamira and Jerome Kabakyenga and Matthew O Wiens
DOI: 10.2196/mhealth.516702 / 2016
Selecting candidate predictor variables for the modelling of post-discharge mortality from sepsis: a protocol development project
AFRICAN HEALTH SCIENCES
DOI: 10.4314/AHS.V16I1.22Scheduled Follow-Up Referrals and Simple Prevention Kits Including Counseling to Improve Post-Discharge Outcomes Among Children in Uganda: A Proof-of-Concept Study
GLOBAL HEALTH-SCIENCE AND PRACTICE
DOI: 10.9745/GHSP-D-16-00069Predictors Of Unreliable Pulse Oximetry Among Young Children With Sepsis In Uganda
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Pediatric out-of-hospital deaths following hospital discharge: a mixed-methods study
AFRICAN HEALTH SCIENCES
DOI: 10.4314/AHS.V16I4.2Pediatric in-Hospital Death from Infectious Disease in Uganda: Derivation of Clinical Prediction Models
PLOS ONE
DOI: 10.1371/JOURNAL.PONE.0150683Application of Sepsis Definitions to Pediatric Patients Admitted With Suspected Infections in Uganda
PEDIATRIC CRITICAL CARE MEDICINE
DOI: 10.1097/PCC.0000000000000708Critical appraisal of clinical practice guidelines in pediatric infectious diseases
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
DOI: 10.1007/S11096-015-0123-2Postdischarge mortality in children with acute infectious diseases: derivation of postdischarge mortality prediction models
BMJ OPEN
DOI: 10.1136/BMJOPEN-2015-009449Prevalence of Ethanol Use Among Pregnant Women in Southwestern Uganda
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
DOI: 10.1016/S1701-2163(16)30027-5Post-discharge mortality prediction in under 5s with acute infectious diseases: a prospective cohort study
LANCET GLOBAL HEALTH
DOI: 10.1016/S2214-109X(15)70150-6Emergency Department Corticosteroid Use for Allergy or Anaphylaxis Is Not Associated With Decreased Relapses
ANNALS OF EMERGENCY MEDICINE
DOI: 10.1016/J.ANNEMERGMED.2015.03.003A Cohort Study of Morbidity, Mortality and Health Seeking Behavior following Rural Health Center Visits by Children under 12 in Southwestern Uganda
PLOS ONE
DOI: 10.1371/JOURNAL.PONE.0118055Mobile health applications for HIV prevention and care in Africa
CURRENT OPINION IN HIV AND AIDS
DOI: 10.1097/COH.0000000000000198Canadian demand for highly qualified personnel for therapeutic evaluation: An oppourtunity for academic institutions
Journal of Population Therapeutics and Clinical Pharmacology
MacLeod, S.M. and Soon, J.A. and Sharma, S. and Wiens, M.O.
Assessing the quality of manual respiratory rate measurements using mobile devices
IET Conference Publications
Karlen, W. and Wiens, M.O. and Gan, H. and Dunsmuir, D. and Chiu, M. and Dumont, G.A. and Ansermino, J.M.
POST-MARKET DRUG EVALUATION RESEARCH TRAINING CAPACITY IN CANADA: AN ENVIRONMENTAL SCAN OF CANADIAN EDUCATIONAL INSTITUTIONS
JOURNAL OF POPULATION THERAPEUTICS AND CLINICAL PHARMACOLOGY
CANADIAN DEMAND FOR HIGHLY QUALIFIED PERSONNEL FOR THERAPEUTIC EVALUATION: AN OPPORTUNITY FOR ACADEMIC INSTITUTIONS
JOURNAL OF POPULATION THERAPEUTICS AND CLINICAL PHARMACOLOGY
Incidence of Clinically Important Biphasic Reactions in Emergency Department Patients With Allergic Reactions or Anaphylaxis
ANNALS OF EMERGENCY MEDICINE
DOI: 10.1016/J.ANNEMERGMED.2013.10.017Characteristics and Thirty-day Outcomes of Emergency Department Patients With Elevated Creatine Kinase
ACADEMIC EMERGENCY MEDICINE
DOI: 10.1111/ACEM.12385ALCOHOL EXPOSURE AMONG PREGNANT WOMEN IN SUB-SAHARAN AFRICA: A SYSTEMATIC REVIEW
JOURNAL OF POPULATION THERAPEUTICS AND CLINICAL PHARMACOLOGY
Pediatric Post-Discharge Mortality in Resource Poor Countries: A Systematic Review
PLOS ONE
DOI: 10.1371/JOURNAL.PONE.0066698Pediatric sepsis in the developing world: Challenges in defining sepsis and issues in post-discharge mortality
Clinical Epidemiology
Wiens, M.O. and Kumbakumba, E. and Kissoon, N. and Ansermino, J.M. and Ndamira, A. and Larson, C.P.
DOI: 10.2147/CLEP.S35693Adherence to antiretroviral therapy in HIV-positive adolescents in uganda assessed by multiple methods: A prospective cohort study
Pediatric Drugs
Wiens, M.O. and MacLeod, S. and Musiime, V. and Ssenyonga, M. and Kizza, R. and Bakeera-Kitaka, S. and Odoi-Adome, R. and Ssali, F.
DOI: 10.2165/11599280-000000000-00000Adherence to Antiretroviral Therapy in HIV-Positive Adolescents in Uganda Assessed by Multiple Methods A Prospective Cohort Study
PEDIATRIC DRUGS
Clinical Decision Rules to Improve the Detection of Adverse Drug Events In Emergency Department Patients
ANNALS OF EMERGENCY MEDICINE
DOI: 10.1016/J.ANNEMERGMED.2011.06.035Patient self-management of warfarin therapy Pragmatic feasibility study in Canadian primary care
CANADIAN FAMILY PHYSICIAN
Patient self-management of warfarin therapy: Pragmatic feasibility study in Canadian primary care
Canadian Family Physician
Grunau, B.E. and Wiens, M.O. and Harder, K.K.
Exposure to Alternative Healthcare Providers and Adherence to Guidelines among Patients with Diabetes
CANADIAN JOURNAL OF DIABETES
DOI: 10.1016/S1499-2671(11)80007-9Dantrolene for the treatment of MDMA toxicity
CANADIAN JOURNAL OF EMERGENCY MEDICINE
Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review
CANADIAN JOURNAL OF EMERGENCY MEDICINE
Cocaine adulterant linked to neutropenia
CANADIAN MEDICAL ASSOCIATION JOURNAL
DOI: 10.1503/CMAJ.090286Meta-analysis of the Impact of 9 Medication Classes on Falls in Elderly Persons (vol 169, pg 1952, 2009)
ARCHIVES OF INTERNAL MEDICINE
Cesium chloride-induced torsades de pointes
CANADIAN JOURNAL OF CARDIOLOGY
Cesium-chloride-induced torsades de pointes
Canadian Journal of Cardiology
Wiens, M. and Gordon, W. and Baulcomb, D. and Mattman, A. and Mock, T. and Brown, R.
DOI: 10.1016/s0828-282x(09)70147-3Meta-analysis of the Impact of 9 Medication Classes on Falls in Elderly Persons
ARCHIVES OF INTERNAL MEDICINE
DOI: 10.1001/ARCHINTERNMED.2009.357FULL VS. RENAL DOSING OF ANTIBIOTICS IN SEPTIC SHOCK PATIENTS WITH ACUTE RENAL FAILURE: THE FRASER FEASIBILITY TRIAL
CRITICAL CARE MEDICINE
NSAID Use and the Risk of Parkinson's Disease Systematic Review and Meta-Analysis of Observational Studies
DRUGS & AGING
DOI: 10.2165/11316780-000000000-00000Incidence, severity and preventability of medication-related visits to the emergency department: a prospective study
CANADIAN MEDICAL ASSOCIATION JOURNAL
DOI: 10.1503/CMAJ.071594Use of lipid-lowering agents for the prevention of age-related macular degeneration: A meta-analysis of observational studies
OPHTHALMIC EPIDEMIOLOGY
DOI: 10.1080/09286580701421684Effects of antihypertensive drug treatments on fracture outcomes: A meta-analysis of observational studies
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
Adequacy of antidote stocking in British Columbia hospitals: The 2005 Antidote Stocking Study
Canadian Journal of Emergency Medicine
Wiens, M.O. and Zed, P.J. and Lepik, K.J. and Abu-Laban, R.B. and Brubacher, J.R. and Gorman, S.K. and Kent, D.A. and Purssell, R.A.
DOI: 10.1017/S1481803500014214Lipid lowering therapy in the prevention of age related macular degeneration: A meta-analysis of observational studies
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
Evaluation of a counselling and referral-based intervention to improve post-discharge mortality for infants and children in Uganda
We are conducting two independent multisite, prospective before-and-after studies at 6 hospitals in Uganda to evaluate a counseling and referral-based intervention to improve post-discharge survival for (1) infants under 6 months of age and (2) children 6 months to 60 months of age. Briefly, these studies consist of two phases. The first phase is a model validation phase where previously derived prediction algorithms are validated and calibrated. This phase is enrolling approximately 3000 children under 6 months and 3800 children who are 6 – 60 months of age. These studies began in 2017 (6m-60m age group) and 2018 (0-6m age group) and the first phase of both of these studies has been completed. The second phase of these studies is an interventional phase, enrolling a similar number of children. This interventional phase uses the validated prediction algorithm and implements the Smart Discharges intervention, with intervention intensity based on risk. Those with lower vulnerability receive discharge counselling focused on understanding vulnerability, education on preventative practices (hygiene, mosquito net use, etc.), danger signs, and appropriate health seeking. Children at high risk receive referrals for post-discharge follow-up with community health workers or at a health facility near their residence.
Development of models to predict post-discharge outcomes among mother-baby dyads discharged after routine hospital delivery
It is a global priority to improve health of mothers and infants and to lower their mortality rates. Countries in sub-Saharan Africa bear the largest burden of maternal and newborn death, and the majority of these deaths are preventable. One third of maternal (30%) and more than half of newborn (55%) deaths occur during the first 6 weeks after birth, after a mother-newborn dyad has returned home from the hospital. To address this issue we are conducting a prospective cohort study among mothers and their newborn babies who have been discharged following a routine hospital birth. We are enrolling 3200 dyads and completing 6-week follow-up to assess post-discharge readmission and mortality. The use of dyads in this context is unique since the health of the mother and child are so intricately linked. Using candidate predictors selected through a systematic review and expert opinion we will derive a parsimonious model to identify vulnerable infant/mother pairs. This work will lead to future studies to (1) externally validate our model and (2) develop and test a Smart Discharge approach to improving outcomes in this vulnerable
group.
Grants
Thrasher Research Fund, $525,094 USD. Role: Principal Investigator. Project: Smart Discharges to improve post-discharge survival following admission for infection in young infants. Dec 1, 2020 – Nov 30, 2022.
Grand Challenges Canada, Transition to Scale, $1,000,000 CAD. Role: Principal Investigator. Project: Smart Discharges to improve post-discharge health outcomes in Uganda. Dec 1, 2017 – Jun 30, 2021.
Thrasher Research Fund, $400,000 USD. Role: Co-Principal Investigator. Project: Smart Discharges to improve post-discharge survival following admission for infection in newborns and young infants. May 2018 – Aug 2020.
Related News
Every day, our researchers work towards breakthroughs to transform the lives of kids in BC and around the world. Learn about our latest innovations and advancements in child health.
Collaboration led by BCCHR researchers awarded European funding to improve community-based care in Uganda and Kenya
Read moreDr. Matthew Wiens and colleagues at the Institute for Global Health at BC Children’s & Women’s Hospital, BC Children’s Research Institute, and the University of British Columbia, are the first Canadian Team to lead a Horizon Europe Pillar 2 project. The consortium was recently awarded €5 million under the Global Health EDCTP3 Joint Undertaking for a project that…
Pediatric Sepsis Data Challenge invites researchers to help develop a model to save lives
Read moreWhen the body’s immune system has an extreme response to an infection, it can cause organ dysfunction that leads to shock, multiple organ failure, and death. This life-threatening condition is known as sepsis, and is the leading cause of death among kids in low- and middle-income countries (LMICs), such as Uganda. To help prevent more…
Congratulations CIHR Fall 2022 Project Grant recipients
Read moreCongratulations to the BC Children’s Hospital Research Institute (BCCHR) and Women’s Health Research Institute (WHRI) investigators and their teams who were awarded $8 million in funding through the Canadian Institutes of Health Research (CIHR) Fall 2022 Project Grant competition.
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