- Overview
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My research interests are focused on improving outcomes and quality of care for children with rheumatic disease. I am currently involved in a study evaluating disparities in care in juvenile arthritis based on place of residence through collaboration with the Canadian Alliance for Pediatric Rheumatology Investigators. I am also leading a clinical trial at BC Children’s Hospital evaluating a new treatment for children with systemic lupus erythematosus, enabling access to medication that would otherwise not be available for our patients.
- Publications
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Effect of Time to Start of Biologic Therapy on Treatment Response in Childhood Arthritis: Results From the UCAN CAN-DU Cohort
Arthritis and Rheumatology
de Jonge, J.B. and de Roock, S. and Schonenberg-Meinema, D. and van den Berg, J.M. and Marshall, D.A. and Vastert, S.J. and Yeung, R.S.M. and Swart, J.F. and Benseler, S.M. and Huber, A. and Lang, B. and DeCoste, C. and Stringer, E. and Ramsey, S. and Rosenberg, A. and Neufeld, K. and Jariwala, M. and Kerr, T. and Mosoiu, A. and Rachlis, A. and Xu, A. and Cheng, A. and Jebb, B. and Feldman, B. and Pereira, B. and Levy, D. and Dissanayake, D. and Limenis, E. and Rozenblyum, E. and Cheng, H. and Lee, J.J.Y. and Spiegel, L. and Schneider, R. and Laxer, R. and Verstegen, R. and Tse, S. and Duong, T. and Human, A. and Cabral, D. and Tam, H. and Guzman, J. and Morishita, K. and Houghton, K. and Tucker, L. and Chan, M. and Petty, R. and Gerschman, T. and van Royen-Kerkhof, A. and Prakken, B. and Van Nieuwenhove, E. and Jansen, M. and Wulffraat, N. and Duffy, C. and Luca, N. and Jurencak, R. and El Tal, T. and LeBlanc, C. and Ch{\'e}deville, G. and Lahiry, P. and Scuccimarri, R. and Campillo, S. and Hutchinson, C. and Basodan, D. and Rumsey, D.G. and Ng, H.Y. and McColl, J. and Lim, L. and McGrath, T. and Brinkman, D. and Hissink Muller, P. and Legger, E. and Armbrust, W. and Schatorje, E. and Hoppenreijs, E. and Boudes, E. and Currie, G. and Schmeling, H. and Dhalla, M. and Johnson, N. and Miettunen, P. and Sran, R. and Stevenson, R. and Demirkaya, E. and Park, J. and Berard, R. and Biesbroek, G. and Gruppen, M. and Soon, G. and Cafazzo, J. and Heale, L. and Batthish, M. and Cellucci, T. and Lim, L. and IJzerman, M. and Twilt, M. and Verkaaik, M. and van Pelt, P. and Kamphuis, S. and Kip, M. and Blanchette, N. and Dancey, P. and de Geus, R.
DOI: 10.1002/art.43401
2026A Tale of Many Canadas: Associations of Ancestry With Juvenile Idiopathic Arthritis Categories and Disease Severity at Presentation to Care
Acr Open Rheumatology
Wong, S.K.A. and Tucker, L.B. and Houghton, K. and Cabral, D.A. and Chan, M. and Morishita, K.A. and Yeung, R.S.M. and Oen, K. and Duffy, C.M. and Berard, R.A. and Ch{\'e}deville, G. and Loughin, T. and Guzman, J. and Petty, R.E. and Human, A. and Bolaria, R. and Gross, K. and Turvey, S.E. and Ellsworth, J. and Benseler, S. and Johnson, N. and Miettunen, P. and Schmeling, H. and Larch{\'e}, M. and Cameron, B. and Laxer, R.M. and Spiegel, L. and Schneider, R. and Silverman, E. and Gibbon, M. and Roth, J. and Duffy, K.W. and Chetaille, A.-L. and Dorval, J. and Boire, G. and Bruns, A. and Campillo, S. and LeBlanc, C. and Scuccimarri, R. and Haddad, E. and St. Cyr, C. and Feldman, D. and Lang, B. and Ramsey, S.E. and Stringer, E. and Dancey, P.
DOI: 10.1002/acr2.70092
2025A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: Results from ReACCh-Out and the CAPRI registry
Rheumatology United Kingdom
Nguyen, K. and Barsalou, J. and Basodan, D. and Batthish, M. and Benseler, S.M. and Berard, R.A. and Blanchette, N. and Boire, G. and Bolaria, R. and Bruns, A. and Cabral, D.A. and Cameron, B. and Campillo, S. and Cellucci, T. and Chan, M. and Chedeville, G. and Chetaille, A.-L. and Chhabra, A. and Couture, J. and Dancey, P. and De Bruycker, J.-J. and Demirkaya, E. and Dhalla, M. and Duffy, C.M. and Feldman, B.M. and Feldman, D.E. and Gerschman, T. and Haddad, E. and Heale, L. and Herrington, J. and Houghton, K. and Huber, A.M. and Human, A. and Johnson, N. and Jurencak, R. and Lang, B. and Larche, M. and Laxer, R.M. and Leblanc, C.M. and Lee, J.J.Y. and Levy, D.M. and Lim, L. and Lim, L.S.H. and Luca, N. and McGrath, T. and McMillan, T. and Miettunen, P.M. and Morishita, K.A. and Ng, H.Y. and Oen, K. and Park, J. and Petty, R.E. and Proulx-Gauthier, J.-P. and Ramsey, S. and Roth, J. and Rosenberg, A.M. and Rozenblyum, E. and Rumsey, D.G. and Schmeling, H. and Schneider, R. and Scuccimarri, R. and Shiff, N.J. and Silverman, E. and Soon, G. and Spiegel, L. and Stringer, E. and Tam, H. and Tse, S.M. and Tucker, L.B. and Turvey, S. and Twilt, M. and Duffy, K.W. and Yeung, R.S.M. and Guzman, J.
DOI: 10.1093/rheumatology/kead560
2024Relationship of Fatigue, Pain Interference, and Physical Disability in Children Newly Diagnosed With Juvenile Idiopathic Arthritis
Arthritis Care and Research
Choong, N. and Batthish, M. and Berard, R.A. and Ch{\'e}deville, G. and Feldman, B.M. and Houghton, K.M. and Huber, A.M. and James, S. and Proulx-Gauthier, J.-P. and Rumsey, D.G. and Schmeling, H. and Toupin-April, K. and Guzman, J. and Cabral, D.A. and Ch{\'e}deville, G. and Duffy, C.M. and Gerhold, K. and Hiraki, L. and Shiff, N.J. and Tucker, L.B. and Barsalou, J. and Basodan, D. and Blanchette, N. and Boire, G. and Bolaria, R. and Bruns, A. and Campillo, S. and Cellucci, T. and Chan, M. and Chhabra, A. and Couture, J. and Dancey, P. and De Bruycker, J.-J. and Demirkaya, E. and Dhalla, M. and El Tal, T. and Gerschman, T. and Heale, L. and Herrington, J. and Huber, A.M. and Human, A. and Johnson, N. and Jurencak, R. and Lang, B. and LeBlanc, C. and Lim, L. and Lim, L.S.H. and Luca, N. and McColl, J. and McGrath, T. and McMillan, T. and McPherson, M. and Miettunen, P. and Morishita, K. and Ng, H. and Park, J. and Roth, J. and Rozenblyum, E. and Scuccimarri, R. and Soon, G. and Stevenson, R. and Stringer, E. and Tam, H. and Twilt, M. and Verstegen, R.H.J. and Duffy, K.W.
DOI: 10.1002/acr.25377
2024Choosing Wisely: The Canadian Rheumatology Association Pediatric Committee’s List of Items Physicians and Patients Should Question
Journal of Rheumatology
Lim, L. and McMillan, T. and Ch{\'e}deville, G. and Lahiry, P. and Lee, J.J.Y. and Heale, L.D. and Human, A.L. and McGrath, T.R. and MacQueen, S.E. and Stringer, E. and Jariwala, M.P. and Neufeld, K.M. and Soon, G.S. and Spiegel, L.R. and Luca, N.J.C.
DOI: 10.3899/jrheum.2023-0043
2023Comparing Canadian paediatric rheumatology practice to the 2019 ACR Juvenile Idiopathic Arthritis guidelines: Results from the CAPRI Registry
Rheumatology United Kingdom
Park, J. and Batthish, M. and Berard, R.A. and Ch{\'e}deville, G. and Proulx-Gauthier, J.-P. and Rumsey, D.G. and Tucker, L.B. and Wong, S. and Guzman, J. and Cabral, D. and Duffy, C. and Gerhold, K. and Hiraki, L. and Huber, A. and Schmeling, H. and Shiff, N. and Basodan, D. and Bolaria, R. and Bruns, A. and Campillo, S. and Cellucci, T. and Chan, M. and Chhabra, A. and Dancey, P. and Demirkaya, E. and Dhalla, M. and Duffy, K.W. and Gerschman, T. and Heale, L. and Houghton, K. and Human, A. and Jurencak, R. and LeBlanc, C. and Lim, L. and Miettunen, P. and Morishita, K. and Ng, H. and Roth, J. and Rozenblyum, E. and Scuccimarri, R. and Soon, G.
DOI: 10.1093/rheumatology/keac468
2023Canadian Rheumatology Association Recommendations for the Screening, Monitoring, and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis
Journal of Rheumatology
Berard, R. and Ng, H.Y. and Human, A. and Piskin, D. and Dhalla, M. and Gottlieb, C. and Batthish, M. and Ch{\'e}deville, G. and Forest, C. and Fortin, E. and Gardiner, J. and Gerhold, K. and Jastrzebski, A. and Lang, B. and Miettunen, P.M.H. and Morgenstern, S. and Morin, M.-P. and Rosenberg, A. and Rumsey, D.G. and Solarte, C.E. and Tehrani, N. and Duffy, K.W. and Pardo, J.P. and Hazlewood, G.S. and Levy, D.M.
DOI: 10.3899/jrheum.220261
2023Children with systemic autoinflammatory diseases have multiple, mixed ethnicities that reflect regional ethnic diversity
Clinical and Experimental Rheumatology
Tucker, L.B. and Niemietz, I. and Mangat, P. and Belen, M. and Tekano, J. and Cabral, D.A. and Guzman, J. and Houghton, K.M. and Morishita, K.A. and Chan, M.O. and Human, A. and Sundqvist, M. and Brown, K.L.
2021Hydroxychloroquine-induced hyperpigmentation in a 14-year-old female with systemic lupus erythematosus
Drugs in Context
Leung, A.K.C. and McMillan, T. and Human, A. and Lam, J.M.
DOI: 10.7573/DIC.2020-5-8
2020A great masquerader: Chronic active Epstein-Barr virus for the rheumatologist
Journal of Rheumatology
Chhabra, A. and Alyazidi, R. and Human, A.
DOI: 10.3899/jrheum.180618
2019Diagnosis and management of ADA2 deficient polyarteritis nodosa
International Journal of Rheumatic Diseases
Human, A. and Pagnoux, C.
DOI: 10.1111/1756-185X.13283
2019 - Research
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Assessment of juvenile idiopathic arthritis outcomes and place of residence in Canada: identifying disparities in care
This is multicentre project aimed at identifying disparities in care for JIA based on geographic location. This is collaborative project utilizing the CAPRI JIA Registry. The second half of this project is focused on identifying one modifiable factor at each treatment site that could improve outcomes for children living with JIA.Phase III, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Efficacy, and Safety of IV Anifrolumab in Pediatric Participants with Moderate to Severe Active SLE
Anifrolumab is a Type I interferon receptor antagonist that has been shown to be effective adjuvant therapy for adult patients with moderate to severe Systemic Lupus Erythematosus (SLE) in previous trials. This purpose of this clinical trial is to determine to safety and efficacy of this novel treatment in children with SLE who have ongoing moderate to severe disease activity despite receiving standard of care therapy. Anifrolumab has significant potential to improve the quality of life in children with SLE and this trial provides access to this medication that would otherwise not be available for several years.GrantsCo-Principle Investigator. Assessment of juvenile idiopathic arthritis outcomes and place of residence in Canada: identifying disparities in care. Funding Source: Childhood Arthritis and Rheumatology Research Alliance (CARRA)
Honours & Awards2020–2021 - Physician Leadership Scholarship Program, Doctors of BC
2024 - Professional Development Grant, PHSA
Improving care for kids with the most common childhood cancers: Q&A with new investigator Dr. Sarah Alexander
For International Childhood Cancer Day we spoke with Dr. Sarah Alexander, a new BCCHR investigator and pediatric oncologist at BC Children’s Hospital who specializes in some of the most common childhood cancers, including non-Hodgkin lymphoma and acute lymphoblastic leukemia (ALL).
