Overview

Dr Cabral is the co-founder and current director of the young adult rheumatic disease (YARD) clinic with Mary Pack Arthritis Program of the Vancouver Coastal Health Authority. He has an interest in characterising the processes and difficulties that young adults have in transitioning from the child health care delivery system to the adult system. He is actively involved in clinical and translation research focused on the paediatric rheumatic diseases including chronic arthritis, systemic lupus erythematosus and vasculitis. He is participating in, and involved in the development of, national and international networks and patient registries to facilitate this research.

Publications

Real-World Effectiveness of Common Treatment Strategies for Juvenile Idiopathic Arthritis: Results From a Canadian Cohort.
Arthritis care & research
Chhabra A and Oen K and Huber AM and Shiff NJ and Boire G and Benseler SM and Berard RA and Scuccimarri R and Feldman BM and Lim LSH and Barsalou J and Bruns A and Cabral DA and ReACCh-Out Investigators
DOI: 10.1002/acr.23922
PubMed: 31074591
06/2020

Associations of clinical and inflammatory biomarker clusters with juvenile idiopathic arthritis categories.
Rheumatology (Oxford, England)
Rezaei E and Hogan D and Trost B and Kusalik AJ and Boire G and Cabral DA and Campillo S and Chédeville G and Chetaille AL and Dancey P and Duffy C and Duffy KW and Eng SWM and Gordon J and BBOP Study Group
DOI: 10.1093/rheumatology/kez382
PubMed: 32321162
05/2020

Worse Quality of Life, Function, and Pain in Children With Enthesitis, Irrespective of Their Juvenile Arthritis Category.
Arthritis care & research
Rumsey DG and Guzman J and Rosenberg AM and Huber AM and Scuccimarri R and Shiff NJ and Bruns A and Feldman BM and Eurich DT and Research in Arthritis in Canadian Children Emphasizing Outcomes Investigators
DOI: 10.1002/acr.23844
PubMed: 30740939
03/2020

Adenosine deaminase 2 activity negatively correlates with age during childhood
Pediatric rheumatology online journal
Bowers, S.M. and Gibson, K.M. and Cabral, D.A. and Brown, K.L.
DOI: 10.1186/s12969-020-00446-5
2020

Prospective Determination of the Incidence and Risk Factors of New-Onset Uveitis in Juvenile Idiopathic Arthritis: The Research in Arthritis in Canadian Children Emphasizing Outcomes Cohort.
Arthritis care & research
Lee JJY and Duffy CM and Guzman J and Oen K and Barrowman N and Rosenberg AM and Shiff NJ and Boire G and Stringer E and Spiegel L and Morishita KA and Lang B and Reddy D and Huber AM and ReACCh-Out Investigators
DOI: 10.1002/acr.23783
PubMed: 30320957
11/2019

Identification of Novel Adenosine Deaminase 2 Gene Variants and Varied Clinical Phenotype in Pediatric Vasculitis.
Arthritis & rheumatology (Hoboken, N.J.)
Gibson KM and Morishita KA and Dancey P and Moorehead P and Drögemöller B and Han X and Graham J and Hancock REW and Foell D and Benseler S and Luqmani R and Yeung RSM and Shenoi S and PedVas Investigators Network
DOI: 10.1002/art.40913
PubMed: 31008556
08/2019

American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus.
Arthritis care & research
Brunner HI and Holland MJ and Beresford MW and Ardoin SP and Appenzeller S and Silva CA and Flores F and Goilav B and Avar Aydin PO and Wenderfer SE and Levy DM and Ravelli A and Paediatric Rheumatology International Trial Organisation and Pediatric Rheumatology Collaborative Study Group
DOI: 10.1002/acr.23834
PubMed: 30680946
05/2019

Predicting Which Children with Juvenile Idiopathic Arthritis Will Not Attain Early Remission with Conventional Treatment: Results from the ReACCh-Out Cohort.
The Journal of rheumatology
Guzman J and Henrey A and Loughin T and Berard RA and Shiff NJ and Jurencak R and Huber AM and Oen K and Gerhold K and Feldman BM and Scuccimarri R and Houghton K and Chédeville G and ReACCh-Out Investigators
DOI: 10.3899/jrheum.180456
PubMed: 30647178
01/2019

Monocyte-Derived Interleukin-1ß As the Driver of S100A12-Induced Sterile Inflammatory Activation of Human Coronary Artery Endothelial Cells: Implications for the Pathogenesis of Kawasaki Disease
Arthritis and Rheumatology
Armaroli, G. and Verweyen, E. and Pretzer, C. and Kessel, K. and Hirono, K. and Ichida, F. and Okabe, M. and Cabral, D.A. and Foell, D. and Brown, K.L. and Kessel, C.
DOI: 10.1002/art.40784
2019

Complexity in unclassified auto-inflammatory disease: A case report illustrating the potential for disease arising from the allelic burden of multiple variants
Pediatric Rheumatology
Tucker, L.B. and Lamot, L. and Niemietz, I. and Chung, B.K. and Cabral, D.A. and Houghton, K. and Petty, R.E. and Morishita, K.A. and Rice, G.I. and Turvey, S.E. and Gibson, W.T. and Brown, K.L.
DOI: 10.1186/s12969-019-0374-x
2019

Health-related quality of life in children with inflammatory brain disease
Pediatric Rheumatology
DOI: 10.1186/s12969-018-0291-4
12/2018

Trajectories of pain severity in juvenile idiopathic arthritis: results from the Research in Arthritis in Canadian Children Emphasizing Outcomes cohort.
Pain
Shiff NJ and Tupper S and Oen K and Guzman J and Lim H and Lee CH and Bryce R and Huber AM and Boire G and Dancey P and Feldman B and Laxer R and Miettunen P and Schmeling H and Tucker LB
DOI: 10.1097/j.pain.0000000000001064
PubMed: 28937578
01/2018

S100A12 Serum Levels and PMN counts are elevated in childhood systemic vasculitides especially involving proteinase 3 specific anti-neutrophil cytoplasmic antibodies
Frontiers in Pediatrics
Brown, K.L. and Lubieniecka, J.M. and Armaroli, G. and Kessel, K. and Gibson, K.M. and Graham, J. and Liu, D. and W. Hancock, R.E. and Ross, C.J. and Benseler, S.M. and Luqmani, R.A. and Cabral, D.A. and Foell, D. and Kessel, C.
DOI: 10.3389/fped.2018.00341
2018

Health-Related Quality of Life in an Inception Cohort of Children With Juvenile Idiopathic Arthritis: A Longitudinal Analysis.
Arthritis care & research
Oen K and Guzman J and Dufault B and Tucker LB and Shiff NJ and Duffy KW and Lee JJY and Feldman BM and Berard RA and Dancey P and Huber AM and Scuccimarri R and Cabral DA and the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) investigators
DOI: 10.1002/acr.23236
PubMed: 28320056
12/2017

Assessment of Disease Activity in Large-vessel Vasculitis: Results of an International Delphi Exercise.
The Journal of rheumatology
Aydin SZ and Direskeneli H and Merkel PA and International Delphi on Disease Activity Assessment in Large-vessel Vasculitis
DOI: 10.3899/jrheum.161269
PubMed: 28864648
09/2017

Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort.
Pediatric rheumatology online journal
Guzman J and Kerr T and Ward LM and Ma J and Oen K and Rosenberg AM and Feldman BM and Boire G and Houghton K and Dancey P and Scuccimarri R and Bruns A and Huber AM and Watanabe Duffy K and Tucker LB
DOI: 10.1186/s12969-017-0196-7
PubMed: 28830457
08/2017

Early Outcomes in Children With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
Arthritis & Rheumatology
DOI: 10.1002/art.40112
07/2017

Variations in the clinical practice of physicians managing Takayasu arteritis: A nationwide survey
Open Access Rheumatology: Research and Reviews
Barra, L. and Liang, P. and Benseler, S.M. and Cabral, D.A. and Fifi-Mah, A. and Li, Y. and Milman, N. and Twilt, M. and Yacyshyn, E. and Pagnoux, C.
DOI: 10.2147/OARRR.S132080
2017

Clinical practice variation and need for pediatric-specific treatment guidelines among rheumatologists caring for children with ANCA-associated vasculitis: An international clinician survey
Pediatric Rheumatology
Westwell-Roper, C. and Lubieniecka, J.M. and Brown, K.L. and Morishita, K.A. and Mammen, C. and Wagner-Weiner, L. and Yen, E. and Li, S.C. and O{'}Neil, K.M. and Lapidus, S.K. and Brogan, P. and Cimaz, R. and Cabral, D.A.
DOI: 10.1186/s12969-017-0191-z
2017

The importance of considering monogenic causes of autoimmunity: A somatic mutation in KRAS causing pediatric Rosai-Dorfman syndrome and systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.)
Ragotte RJ and Dhanrajani A and Pleydell-Pearce J and Del Bel KL and Tarailo-Graovac M and van Karnebeek C and Terry J and Senger C and McKinnon ML and Seear M and Prendiville JS and Turvey SE
DOI: 10.1016/j.clim.2016.12.006
PubMed: 28043923
12/2016

Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's): An ARChiVe Cohort Study.
Arthritis & rheumatology (Hoboken, N.J.)
Cabral DA and Canter DL and Muscal E and Nanda K and Wahezi DM and Spalding SJ and Twilt M and Benseler SM and Campillo S and Charuvanij S and Dancey P and Eberhard BA and Elder ME and ARChiVe Investigators Network within the PedVas Initiative
DOI: 10.1002/art.39729
PubMed: 27111558
10/2016

Gene Expression Deconvolution for Uncovering Molecular Signatures in Response to Therapy in Juvenile Idiopathic Arthritis.
PloS one
Cui A and Quon G and Rosenberg AM and Yeung RS and Morris Q and BBOP Study Consortium
DOI: 10.1371/journal.pone.0156055
PubMed: 27244050
05/2016

Granulomatosis with polyangiitis in children
Pediatric Rheumatology: A Clinical Viewpoint
Cabral, D.A. and Morishita, K.
DOI: 10.1007/978-981-10-1750-6_36
2016

CanVasc recommendations for the management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides - Executive summary.
Canadian journal of kidney health and disease
McGeoch L and Twilt M and Famorca L and Bakowsky V and Barra L and Benseler S and Cabral DA and Carette S and Cox GP and Dhindsa N and Dipchand C and Fifi-Mah A and Goulet M and Khalidi N and Canadian Vasculitis research network (CanVasc)
DOI: 10.1186/s40697-015-0078-1
PubMed: 26557369
11/2015

CanVasc Recommendations for the Management of Antineutrophil Cytoplasm Antibody-associated Vasculitides.
The Journal of rheumatology
McGeoch L and Twilt M and Famorca L and Bakowsky V and Barra L and Benseler SM and Cabral DA and Carette S and Cox GP and Dhindsa N and Dipchand CS and Fifi-Mah A and Goulet M and Canadian Vasculitis Research Network
DOI: 10.3899/jrheum.150376
PubMed: 26523024
11/2015

The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort.
Annals of the rheumatic diseases
Guzman J and Oen K and Huber AM and Watanabe Duffy K and Boire G and Shiff N and Berard RA and Levy DM and Stringer E and Scuccimarri R and Morishita K and Johnson N and Cabral DA and ReACCh-Out investigators
DOI: 10.1136/annrheumdis-2014-207164
PubMed: 25985972
05/2015

Incident Vertebral Fractures and Risk Factors in the First Three Years Following Glucocorticoid Initiation Among Pediatric Patients With Rheumatic Disorders.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
LeBlanc CM and Ma J and Taljaard M and Roth J and Scuccimarri R and Miettunen P and Lang B and Huber AM and Houghton K and Jaremko JL and Ho J and Shenouda N and Matzinger MA and Lentle B and Canadian STeroid-Associated Osteoporosis in Pediatric Population (STOPP) Consortium
DOI: 10.1002/jbmr.2511
PubMed: 25801315
05/2015

Development of Canadian Recommendations for the Management of ANCA-Associated Vasculitides: Results of the National Needs Assessment Questionnaire.
The open rheumatology journal
Famorca L and Twilt M and Barra L and Bakowsky V and Benseler S and Cabral D and Carette S and Dhindsa N and Fifi-Mah A and Goulet M and Khalidi N and Khraishi M and McGeoch L and Canadian Vasculitis network (CanVasc)
DOI: 10.2174/18743129014090100016
PubMed: 25893028
04/2015

Pediatric vasculitis: Advances in treatment
Current Opinion in Rheumatology
Morishita, K. and Brown, K. and Cabral, D.
DOI: 10.1097/BOR.0000000000000203
2015

Association of health-related quality of life in childhood-onset systemic lupus erythematosus with ethnicity: results from a multiethnic multicenter Canadian cohort.
Arthritis care & research
Levy DM and Peschken CA and Tucker LB and Chédeville G and Huber AM and Pope JE and Canadian Network for Improved Outcomes in SLE (CaNIOS) 1000 Faces Investigators and Silverman ED
DOI: 10.1002/acr.22363
PubMed: 24821613
12/2014

The choice of normative pediatric reference database changes spine bone mineral density Z-scores but not the relationship between bone mineral density and prevalent vertebral fractures.
The Journal of clinical endocrinology and metabolism
Ma J and Siminoski K and Alos N and Halton J and Ho J and Lentle B and Matzinger M and Shenouda N and Atkinson S and Barr R and Cabral DA and Couch R and Cummings EA and Fernandez CV and Canadian STOPP Consortium
DOI: 10.1210/jc.2014-3096
PubMed: 25494661
12/2014

Efficacy and safety of tocilizumab in patients with polyarticular-course juvenile idiopathic arthritis: results from a phase 3, randomised, double-blind withdrawal trial.
Annals of the rheumatic diseases
Brunner HI and Ruperto N and Zuber Z and Keane C and Harari O and Kenwright A and Lu P and Cuttica R and Keltsev V and Xavier RM and Calvo I and Nikishina I and Rubio-Pérez N and Pediatric Rheumatology Collaborative Study Group (PRCSG)
DOI: 10.1136/annrheumdis-2014-205351
PubMed: 24834925
05/2014

The outcomes of juvenile idiopathic arthritis in children managed with contemporary treatments: results from the ReACCh-Out cohort.
Annals of the rheumatic diseases
Guzman J and Oen K and Tucker LB and Huber AM and Shiff N and Boire G and Scuccimarri R and Berard R and Tse SM and Morishita K and Stringer E and Johnson N and Levy DM and Duffy KW and ReACCh-Out investigators
DOI: 10.1136/annrheumdis-2014-205372
PubMed: 24842571
05/2014

Methotrexate: New uses for an old drug
Journal of Pediatrics
Hashkes, P.J. and Becker, M.L. and Cabral, D.A. and Laxer, R.M. and Paller, A.S. and Rabinovich, C.E. and Turner, D. and Zulian, F.
DOI: 10.1016/j.jpeds.2013.10.029
2014

Early atlantoaxial subluxation in enthesitis-related arthritis
Journal of Rheumatology
Enazi, A.A. and Morishita, K. and Cairns, R.A. and Tucker, L. and Cabral, D. and Petty, R. and Guzman, J.
DOI: 10.3899/jrheum.131206
2014

Skeletal findings in the first 12 months following initiation of glucocorticoid therapy for pediatric nephrotic syndrome.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Phan V and Blydt-Hansen T and Feber J and Alos N and Arora S and Atkinson S and Bell L and Clarson C and Couch R and Cummings EA and Filler G and Grant RM and Grimmer J and Hebert D and Canadian STOPP Consortium
DOI: 10.1007/s00198-013-2466-7
PubMed: 23948876
08/2013

Glucocorticoid-related changes in body mass index among children and adolescents with rheumatic diseases
Arthritis Care & Research
DOI: 10.1002/acr.21785
01/2013

Increased intracellular oxygen radical production in neutrophils during febrile episodes of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome
Arthritis and Rheumatism
Sundqvist, M. and Wekell, P. and Osla, V. and Bylund, J. and Christenson, K. and S{\"a}vman, K. and Foell, D. and Cabral, D.A. and Fasth, A. and Berg, S. and Brown, K.L. and Karlsson, A.
DOI: 10.1002/art.38134
2013

Disease activity assessment in childhood vasculitis: development and preliminary validation of the Paediatric Vasculitis Activity Score (PVAS).
Annals of the rheumatic diseases
Dolezalova P and Price-Kuehne FE and Özen S and Benseler SM and Cabral DA and Anton J and Brunner J and Cimaz R and O'Neil KM and Wallace CA and Wilkinson N and Eleftheriou D and Brogan PA
DOI: 10.1136/annrheumdis-2012-202111
PubMed: 23100606
10/2012

Access to Biologic Therapies in Canada for Children with Juvenile Idiopathic Arthritis
The Journal of Rheumatology
DOI: 10.3899/jrheum.120089
09/2012

Do adult disease severity subclassifications predict use of cyclophosphamide in children with ANCA-associated vasculitis? An analysis of ARChiVe study treatment decisions.
The Journal of rheumatology
Morishita K and Guzman J and Chira P and Muscal E and Zeft A and Klein-Gitelman M and Uribe AG and Abramson L and Benseler SM and Eberhard A and Ede K and Hashkes PJ and Hersh AO and ARChiVe Investigators Network
DOI: 10.3899/jrheum.120299
PubMed: 22859342
08/2012

Incident vertebral fractures 12 months following glucocorticoid initiation in children with rheumatic disorders.
Pediatric rheumatology online journal
Lang BA and Rodd C and Ramsay T and Cabral DA and Dent PB and Ellsworth JE and Houghton KM and Huber A and Jurencak R and Larché M and LeBlanc CM and Lentle B and Matzinger M and Ward LM
DOI: 10.1186/1546-0096-10-s1-a75
07/2012

High incidence of vertebral fractures in children with acute lymphoblastic leukemia 12 months after the initiation of therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Alos N and Grant RM and Ramsay T and Halton J and Cummings EA and Miettunen PM and Abish S and Atkinson S and Barr R and Cabral DA and Cairney E and Couch R and Dix DB and Fernandez CV and Ward LM
DOI: 10.1200/jco.2011.40.4830
PubMed: 22734031
06/2012

Increased sensitivity of the European medicines agency algorithm for classification of childhood granulomatosis with polyangiitis.
The Journal of rheumatology
Uribe AG and Huber AM and Kim S and O'Neil KM and Wahezi DM and Abramson L and Baszis K and Benseler SM and Bowyer SL and Campillo S and Chira P and Hersh AO and Higgins GC and Eberhard A and ARegistry for Children with Vasculitis e-entry (ARChiVe) Network
DOI: 10.3899/jrheum.111352
PubMed: 22589257
05/2012

Assessing the performance of the Birmingham Vasculitis Activity Score at diagnosis for children with antineutrophil cytoplasmic antibody-associated vasculitis in A Registry for Childhood Vasculitis (ARChiVe).
The Journal of rheumatology
Morishita K and Li SC and Muscal E and Spalding S and Guzman J and Uribe A and Abramson L and Baszis K and Benseler S and Bowyer S and Campillo S and Chira P and Hersh AO and Higgins G and ARChiVe Investigators Network
DOI: 10.3899/jrheum.111030
PubMed: 22337238
02/2012

Incident vertebral fractures among children with rheumatic disorders 12 months after glucocorticoid initiation: a national observational study.
Arthritis care & research
Rodd C and Lang B and Ramsay T and Alos N and Huber AM and Cabral DA and Scuccimarri R and Miettunen PM and Roth J and Atkinson SA and Couch R and Cummings EA and Dent PB and Ellsworth J and Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) Consortium
DOI: 10.1002/acr.20589
PubMed: 22213727
01/2012

Granulomatosis with polyangiitis in childhood
Current Rheumatology Reports
Twilt, M. and Benseler, S. and Cabral, D.
DOI: 10.1007/s11926-012-0238-6
2012

Granulomatous vasculitis, microscopic polyangiitis and primary angiitis of the central nervous system
Textbook of Pediatric Rheumatology
Cabral, D. and Benseler, S.
DOI: 10.1016/B978-1-4160-6581-4.10034-2
2011

Infrapatellar bursitis in children with juvenile idiopathic arthritis: A case series
Clinical Rheumatology
Alqanatish, J.T. and Petty, R.E. and Houghton, K.M. and Guzman, J. and Tucker, L.B. and Cabral, D.A. and Cairns, R.A.
DOI: 10.1007/s10067-010-1620-2
2011

Prevalent vertebral fractures among children initiating glucocorticoid therapy for the treatment of rheumatic disorders.
Arthritis care & research
Huber AM and Gaboury I and Cabral DA and Lang B and Ni A and Stephure D and Taback S and Dent P and Ellsworth J and LeBlanc C and Saint-Cyr C and Scuccimarri R and Hay J and Lentle B and Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) Consortium
DOI: 10.1002/acr.20171
PubMed: 20391507
04/2010

EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation.
Annals of the rheumatic diseases
Ruperto N and Ozen S and Pistorio A and Dolezalova P and Brogan P and Cabral DA and Cuttica R and Khubchandani R and Lovell DJ and O'Neil KM and Quartier P and Ravelli A and Iusan SM and Paediatric Rheumatology International Trials Organisation (PRINTO)
DOI: 10.1136/ard.2009.116624
PubMed: 20388738
04/2010

Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort.
Arthritis care & research
Oen K and Duffy CM and Tse SM and Ramsey S and Ellsworth J and Chédeville G and Chetaille AL and Saint-Cyr C and Cabral DA and Spiegel LR and Schneider R and Lang B and Huber AM and Tucker L
DOI: 10.1002/acr.20044
PubMed: 20391508
04/2010

Serious musculoskeletal infections in children receiving anti-tumor necrosis factor-a therapy: A case series
Clinical Rheumatology
Morishita, K. and Petty, R. and Cairns, R. and Bolaria, R. and Cabral, D. and Turvey, S.
DOI: 10.1007/s10067-010-1410-x
2010

Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: results of a Canadian multicenter, prospective inception cohort study.
Arthritis and rheumatism
Oen K and Tucker L and Huber AM and Miettunen P and Scuccimarri R and Campillo S and Cabral DA and Feldman BM and Tse S and Chédeville G and Spiegel L and Schneider R and Lang B and Duffy CM
DOI: 10.1002/art.24539
PubMed: 19644903
08/2009

Advanced vertebral fracture among newly diagnosed children with acute lymphoblastic leukemia: results of the Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) research program.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Halton J and Gaboury I and Grant R and Alos N and Cummings EA and Matzinger M and Shenouda N and Lentle B and Abish S and Atkinson S and Cairney E and Dix D and Israels S and Stephure D and Canadian STOPP Consortium
DOI: 10.1359/jbmr.090202
PubMed: 19210218
07/2009

Juvenile spondyloarthropathy
A Clinician's Pearls and Myths in Rheumatology
Cabral, D.A. and Tse, S.M.L.
DOI: 10.1007/978-1-84800-934-9_6
2009

Access to pediatric rheumatology subspecialty care in British Columbia, Canada
Journal of Rheumatology
Shiff, N.J. and Abdwani, R. and Cabral, D.A. and Houghton, K.M. and Malleson, P.N. and Petty, R.E. and Espinosa, V.M. and Tucker, L.B.
DOI: 10.3899/jrheum.080514
2009

Establishment of a pilot pediatric registry for chronic vasculitis is both essential and feasible: A Childhood Arthritis and Rheumatology Alliance (CARRA) survey
Journal of Rheumatology
Wilkinson, N.M.R. and Page, J. and Uribe, A.G. and Espinosa, V. and Cabral, D.A.
2007

Transition of the Adolescent Patient with Rheumatic Disease: Issues to Consider
Rheumatic Disease Clinics of North America
Tucker, L.B. and Cabral, D.A.
DOI: 10.1016/j.rdc.2007.07.005
2007

Old challenges and new directions in pediatric rheumatology
Journal of Rheumatology
Cabral, D.A. and Laxer, R.M. and Schrader, J. and Turvey, S. and Stevens, A. and Yeung, R.S.M. and Foster, H.E. and Emery, H. and Prendiville, J. and Tucker, L.B. and Foeldvari, I. and Sherry, D.D. and Klinkhoff, A.B. and Wallace, C.A. and Houghton, K.
2006

Is musculoskeletal history and examination so different in paediatrics?
Best Practice and Research: Clinical Rheumatology
Foster, H.E. and Cabral, D.A.
DOI: 10.1016/j.berh.2005.11.001
2006

Infliximab as rescue therapy in three cases of paediatric Wegener's granulomatosis [6]
Rheumatology
Wilkinson, N.M.R. and Erendzhinova, E. and Zeft, A. and Cabral, D.A.
DOI: 10.1093/rheumatology/kel172
2006

Systemic lupus erythematosus in the pediatric North American native population of British Columbia
Journal of Rheumatology
Houghton, K.M. and Page, J. and Cabral, D.A. and Petty, R.E. and Tucker, L.B.
2006

Primary Sjögren's syndrome in children and adolescents: Are proposed diagnostic criteria applicable?
Journal of Rheumatology
Houghton, K. and Malleson, P. and Cabral, D. and Petty, R. and Tucker, L.
2005

Transition of the adolescent patient with rheumatic disease: Issues to consider
Pediatric Clinics of North America
Tucker, L.B. and Cabral, D.A.
DOI: 10.1016/j.pcl.2005.01.008
2005

Cytokine genotypes correlate with pain and radiologically defined joint damage in patients with juvenile rheumatoid arthritis
Rheumatology
Oen, K. and Malleson, P.N. and Cabral, D.A. and Rosenberg, A.M. and Petty, R.E. and Nickerson, P. and Reed, M.
DOI: 10.1093/rheumatology/keh689
2005

Bone mineral density in children and adolescents with systemic lupus erythematosus, juvenile dermatomyositis, and systemic vasculitis: Relationship to disease duration, cumulative corticosteroid dose, calcium intake, and exercise
Journal of Rheumatology
Alsufyani, K.A. and Ortiz-Alvarez, O. and Cabral, D.A. and Tucker, L.B. and Petty, R.E. and Nadel, H. and Malleson, P.N.
2005

Primary Sjögren's syndrome in dizygotic adolescent twins: One case with lymphocytic interstitial pneumonia
Journal of Rheumatology
Houghton, K.M. and Cabral, D.A. and Petty, R.E. and Tucker, L.B.
2005

Gender and ethnic origin have no effect on longterm outcome of childhood-onset systemic lupus erythematosus
Journal of Rheumatology
Miettunen, P.M. and Ortiz-Alvarez, O. and Petty, R.E. and Cimaz, R. and Malleson, P.N. and Cabral, D.A. and Ensworth, S. and Tucker, L.B.
2004

A pruritic linear urticarial rash, fever, and systemic inflammatory disease in five adolescents: Adult-onset still disease or systemic juvenile idiopathic arthritis sine arthritis?
Pediatric Dermatology
Prendiville, J.S. and Tucker, L.B. and Cabral, D.A. and Crawford, R.I.
DOI: 10.1111/j.0736-8046.2004.21513.x
2004

Predictors of Pain in Children with Established Juvenile Rheumatoid Arthritis
Arthritis Care and Research
Malleson, P.N. and Oen, K. and Cabral, D.A. and Petty, R.E. and Rosenberg, A.M. and Cheang, M.
DOI: 10.1002/art.20238
2004

Relative ineffectiveness of triamcinolone acetonide in the treatment of juvenile idiopathic arthritis [6]
Arthritis and Rheumatism
Alsufyani, K. and Ortiz-Alvarez, O. and Cabral, D.A. and Tucker, L.B. and Petty, R.E. and Malleson, P.N.
DOI: 10.1002/art.20629
2004

The Role of Subcutaneous Administration of Methotrexate in Children with Juvenile Idiopathic Arthritis Who Have Failed Oral Methotrexate
Journal of Rheumatology
Alsufyani, K. and Ortiz-Alvarez, O. and Cabral, D.A. and Tucker, L.B. and Petty, R.E. and Malleson, P.N.
2004

Guidelines for blood test monitoring of methotrexate toxicity in juvenile idiopathic arthritis
Journal of Rheumatology
Ortiz-Alvarez, O. and Morishita, K. and Avery, G. and Green, J. and Petty, R.E. and Tucker, L.B. and Malleson, P.N. and Cabral, D.A.
2004

Early predictors of longterm outcome in patients with juvenile rheumatoid arthritis: Subset-specific correlations
Journal of Rheumatology
Oen, K. and Malleson, P.N. and Cabral, D.A. and Rosenberg, A.M. and Petty, R.E. and Reed, M. and Schroeder, M.L. and Cheang, M.
2003

Central nervous system involvement in neonatal lupus erythematosus
Pediatric Dermatology
Prendiville, J.S. and Cabral, D.A. and Poskitt, K.J. and Au, S. and Sargent, M.A.
DOI: 10.1046/j.1525-1470.2003.03014.x
2003

Radiologic outcome and its relationship to functional disability in juvenile rheumatoid arthritis
Journal of Rheumatology
Oen, K. and Reed, M. and Malleson, P.N. and Cabral, D.A. and Petty, R.E. and Rosenberg, A.M. and Cheang, M.
2003

Disease course and outcome of juvenile rheumatoid arthritis in a multicenter cohort
Journal of Rheumatology
Oen, K. and Malleson, P.N. and Cabral, D.A. and Rosenberg, A.M. and Petty, R.E. and Cheang, M.
2002

Preface
Best Practice and Research: Clinical Rheumatology
Petty, R. and Cabral, D.
DOI: 10.1016/S1521-6942(02)90231-7
2002

The early pattern of joint involvement predicts disease progression in children with oligoarticular (pauciarticular) juvenile rheumatoid arthritis
Arthritis and Rheumatism
Al-Matar, M.J. and Petty, R.E. and Tucker, L.B. and Malleson, P.N. and Schroeder, M.-L. and Cabral, D.A.
DOI: 10.1002/art.10544
2002

Isolated tuberculosis monoarthritis mimicking juvenile rheumatoid arthritis [3] (multiple letters)
Journal of Rheumatology
Sawhney, S. and Murray, K.J. and Al-Matar, M. and Cabral, D.A. and Petty, R.E.
2002

Rheumatic manifestations of Bartonella infection in 2 children
Journal of Rheumatology
Al-Matar, M.J. and Petty, R.E. and Cabral, D.A. and Tucker, L.B. and Peyvandi, B. and Prendiville, J. and Forbes, J. and Cairns, R. and Rothstein, R.
2002

Patterns of joint involvement at onset differentiate oligoarticular juvenile psoriatic arthritis from pauciarticular juvenile rheumatoid arthritis
Journal of Rheumatology
Huemer, C. and Malleson, P.N. and Cabral, D.A. and Huemer, M. and Falger, J. and Zidek, T. and Petty, R.E.
2002

Isolated tuberculous monoarthritis mimicking oligoarticular juvenile rheumatoid arthritis
Journal of Rheumatology
Al-Matar, M.J. and Cabral, D.A. and Petty, R.E.
2001

Echocardiography and pulmonary function testing in childhood onset systemic lupus erythematosus
Lupus
Al-Abbad, A.-J.A. and Cabral, D.A. and Sanatani, S. and Sandor, G.G.S. and Seear, M. and Petty, R.E. and Malleson, P.N.
DOI: 10.1191/096120301669980721
2001

Lipodystrophy in patients with juvenile dermatomyositis - Evaluation of clinical and metabolic abnormalities
Journal of Rheumatology
Huemer, C. and Kitson, H. and Malleson, P.N. and Sanderson, S. and Huemer, M. and Cabral, D.A. and Chanoine, J.-P. and Petty, R.E.
2001

Comparison of criteria for the classification of childhood arthritis
Journal of Rheumatology
Ramsey, S.E. and Bolaria, R.K. and Cabral, D.A. and Malleson, P.N. and Petty, R.E.
2000

Febrile illness in a toddler: The diagnostic clue lays skin deep
Canadian Journal of Infectious Diseases
Husain, E. and Cabral, D.
DOI: 10.1155/2000/157986
2000

Apparent medium vessel vasculitis associated with a spinal meningioma [3]
Journal of Rheumatology
Al-Abbad, A.-J.A. and Malleson, P.N. and Petty, R.E. and Cabral, D.A.
1999

Malignancies in children who initially present with rheumatic complaints
Journal of Pediatrics
Cabral, D.A. and Tucker, L.B.
DOI: 10.1016/S0022-3476(99)70372-0
1999

Knee magnetic resonance imaging in childhood chronic monarthritis
Journal of Rheumatology
Ramsey, S.E. and Cairns, R.A. and Cabral, D.A. and Malleson, P.N. and Bray, H.J. and Petty, R.E.
1999

Clinically important change in treatment trials for juvenile rheumatoid arthritis [1]
Journal of Rheumatology
Cabral, D.A. and Geenen, R. and Jacobs, J.W.G. and Giannini, E.H. and Ruperto, N.
1997

Anti-RNP antibody in a child with undifferentiated carcinoma and no evidence of mixed connective tissue disease
British Journal of Rheumatology
Foster, H.E. and Malleson, P.N. and Petty, R.E. and Cabral, D.A.
DOI: 10.1093/rheumatology/36.2.289
1997

Intestinal pseudo-obstruction as an initial presentation of systemic sclerosis in two children
British Journal of Rheumatology
Ortiz-Alvarez, O. and Cabral, D. and Prendiville, J.S. and Stringer, D. and Petty, R.E. and Malleson, P.N.
DOI: 10.1093/rheumatology/36.2.280
1997

Rheumatoid factor positive, oligoarticular onset juvenile rheumatoid arthritis
Journal of Rheumatology
Sailer, M. and Cabral, D. and Petty, R.E. and Malleson, P.N.
1997

Juvenile psoriatic arthritis: Followup and evaluation of diagnostic criteria
Journal of Rheumatology
Roberton, D.M. and Cabral, D.A. and Malleson, P.N. and Petty, R.E.
1996

Pneumocystis carinii pneumonia in childhood systemic lupus erythematosus
Journal of Rheumatology
Foster, H.E. and Malleson, P.N. and Petty, R.E. and Roberton, D.M. and Cabral, D.A.
1996

An unusual case of mixed sclerosing bone dystrophy presenting with morning stiffness and joint swelling in childhood: A case report
Clinical and Experimental Rheumatology
Foeldvari, I. and Cairns, R.A. and Petty, R.E. and Cabral, D.A.
1995

Spondyloarthropathies of childhood
Pediatric Clinics of North America
Cabral, D.A. and Malleson, P.N. and Petty, R.E.
DOI: 10.1016/S0031-3955(16)40053-2
1995

Atlantoaxial subluxation in children with seronegative enthesopathy and arthropathy syndrome: 2 case reports and a review of the literature
Journal of Rheumatology
Foster, H.E. and Cairns, R.A. and Burnell, R.H. and Malleson, P.N. and Robertson, D.M. and Tredwell, S.J. and Petty, R.E. and Cabral, D.A.
1995

Visual prognosis in children with chronic anterior uveitis and arthritis
Journal of Rheumatology
Cabral, D.A. and Petty, R.E. and Malleson, P.N. and Ensworth, S. and McCormick, A.Q. and Shroeder, M.-L.
1994

SEA syndrome revisited: A longterm followup of children with a syndrome of seronegative enthesopathy and arthropathy
Journal of Rheumatology
Cabral, D.A. and Oen, K.G. and Petty, R.E.
1992

Persistent antinuclear antibodies in children without identifiable inflammatory rheumatic or autoimmune disease
Pediatrics
Cabral, D.A. and Petty, R.E. and Fung, M. and Malleson, P.N.
1992

Sexually abused adolescents: A distinct group among sexually abused children presenting to a children's hospital
Journal of Paediatrics and Child Health
GARDNER, J.J. and CABRAL, D.A.
DOI: 10.1111/j.1440-1754.1990.tb02373.x
1990

Electrophysiologic studies, computed tomography, and neurologic outcome in acute bacterial meningitis
The Journal of Pediatrics
Pike, M.G. and Wong, P.K.H. and Bencivenga, R. and Flodmark, O. and Cabral, D.A. and Speert, D.P. and Farrell, K.
DOI: 10.1016/S0022-3476(05)82651-4
1990

Prospective study of computed tomography in acute bacterial meningitis
The Journal of Pediatrics
Cabral, D.A. and Flodmark, O. and Farrell, K. and Speert, D.P.
DOI: 10.1016/S0022-3476(87)80067-7
1987

Mucoid pseudomonas aeruginosa resists nonopsonic phagocytosis by human neutrophils and macrophages
Pediatric Research
Cabral, D.A. and Loh, B.A. and Speert, D.P.
DOI: 10.1203/00006450-198710000-00013
1987

Nonopsonic phagocytosis of nonmucoid Pseudomonas aeruginosa by human neutrophils and monocyte-derived macrophages is correlated with bacterial piliation and hydrophobicity
Infection and Immunity
Speert, D.P. and Loh, B.A. and Cabral, D.A. and Salit, I.E.
DOI: 10.1128/iai.53.1.207-212.1986
1986

Opsonin-independent phagocytosis of Pseudomonas aeruginosa.
Antibiotics and chemotherapy
Speert, D.P. and Loh, B.A. and Cabral, D.A. and Eftekhar, F.
1985

Tuberculous epididymitis as a cause of testicular pseudomalignancy in two young children
Pediatric Infectious Disease
Cabral, D.A. and Johnson, H.W. and Coleman, G.U. and Nigro, M. and Speert, D.P.
DOI: 10.1097/00006454-198501000-00015
1985

Intracranial complications of sphenoidal sinus inflammation
Medical Journal of Australia
Cook, I.F. and Cabral, D.A. and Reed, W.D. and Bond, R.J. and Henderson, A.
DOI: 10.5694/j.1326-5377.1981.tb135637.x
1981

Effects of maternal blood loss on embryonic and placental development in the rat
Journal of Reproduction and Fertility
Bruce, N.W. and Cabral, D.A.
DOI: 10.1530/jrf.0.0450349
1975

Research

Pediatric Osteoporosis
I am currently site principal investigator and on the steering committee of a CIHR funded national, multicentre observational study of steroid-induced osteoporosis in the paediatric population. This cohort of patients with acute lymphatic leukemia, nephrotic syndrome and rheumatic diseases is already the largest of its kind. The study will provide previously uncharacterised baseline characteristics and natural history of bone health in these populations. This will also establish a basis for collaborative intervention studies.

Systemic lupus erythematosus
As part of a recently funded "CIHR team in childhood autoimmunity" investigating the common underlying mechanisms and pathways in childhood onset systemic lupus erythematosus (SLE) and diabetes, I am clinical co-investigator for the SLE arm of this study.

Pediatric vasculitis
I have lead an initiative since 2004 in the Childhood Arthritis and Rheumatology Research Alliance (CARRA), and established a network of Canadian and American CARRA-associated pediatric Rheumatology centers (more than 50 centers) to study a cohort of patients with the rare Pediatric chronic vasculitides using ‘Web-based’ data entry systems. The initial focus is on Wegener’s granulomatosis and other related small-medium vessel or ANCA-related vasculitidies and is described as A Registry of Childhood Vasculitis: e-entry. ARChiVe. Because of the rarity of these diseases there is limited opportunity to study the unique pediatric clinical features and outcomes with and without various treatments. The current cohort of nearly 50 patients is already double that of any previous study.

Chronic Arthritides of Childhood
A productive ad hoc research alliance of Western Canadian paediatric rheumatology centres (in which I was a coinvestigator) provided the model for a successful national endeavor of the Canadian Pediatric Rheumatology Association in obtaining a CIHR New Emerging Team (NET) Grant: New onset juvenile idiopathic arthritis: A Canadian multi-centre collaborative outcomes study (2004). Vancouver is a core site for this endeavour and Dr Lori Tucker is one of the co-investigators. The early success of this collaboration has also lead to the successful funding of a second grant: Biological based predictors of outcome in JIA: the BBOP study. Again, Vancouver is also a core center for basic research. Dr Stuart Turvey is a co-investigator. This five year program, unique in North America, has already enrolled nearly 500 children with new onset JIA as a cohort of for current and future studies of international significance. Currently, I am a member of the interim steering committee of this research network that has evolved and become known since 2006 as the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI).

Research Group Members

Claire Grall-Johnson
Felice Mizan, Research Coordinator
Angelyne Rivera, Research Manager , Research Manager
Khaye Rufin, Research Coordinator