Research is primarily focused on epilepsy in the pediatric population.


A video case vignette: Hypermotor activity, ictal aggression, and bolting in an adolescent with an anteromedial temporal lesion
Epileptic Disorders
Anita N. Datta
DOI: 10.1002/epd2.20176

Original Research: Clinical Significance of a Unique Pediatric EEG Configuration: Bi-Frontal Spikes With Simultaneous Bi-Occipital Positivity
Clinical EEG and Neuroscience
Jacqueline Crawford and Cassie McFarlane and Anita N Datta
DOI: 10.1177/15500594241246505

Effectiveness, safety and tolerability of perampanel by age group when used to treat people with focal and generalized epilepsy in clinical practice: The PERMIT Extension study
Epilepsy & Behavior
James Wheless and Robert T. Wechsler and Patricia Penovich and Eric Segal and Michael Chez and Antonietta Coppola and Anita Datta and Wendyl D'Souza and Imad Najm and Sheri Cappucci and Ricardo Sainz-Fuertes and Vicente Villanueva
DOI: 10.1016/j.yebeh.2023.109369

Outcome of Absence Epilepsy With Onset at 8-11 Years of Age: Watershed Ages When Syndromes Overlap
Journal of Child Neurology
Anita N. Datta and Jacqueline Crawford and Laura Wallbank and Peter K. H. Wong
DOI: 10.1177/08830738231188397

Three consecutive epilepsy syndromes in one child
Epileptic Disorders
Min Jung Kim and Linda Huh and Anita N. Datta
DOI: 10.1002/epd2.20051

School performance in children at the time of new-onset seizures and at long-term follow-up: A retrospective cohort study
Journal of International Medical Research
Anita N. Datta and Peter K.H. Wong
DOI: 10.1177/03000605221081032

Children With Trisomy 21 and Lennox-Gastaut Syndrome With Predominant Myoclonic Seizures
Journal of Child Neurology
Matthew Macdonald and Jacqueline Crawford and Anita N. Datta
DOI: 10.1177/08830738211026072

Pediatric Occipital Spikes at a Single Center Over 26 Years and the Significance of Tangential Dipole
Journal of Child Neurology
Anita N. Datta and Laura Wallbank and Johann Micallef and Peter K. H. Wong
DOI: 10.1177/0883073820984042

At What Point Should We Discontinue Treatment in Super-Refractory Status Epilepticus?
Journal of Pediatric Epilepsy
Anita N. Datta
DOI: 10.1055/s-0040-1714389

Childhood Small Vessel Primary Angiitis of the Central Nervous System: A Treatable Cause of Super-refractory Status Epilepticus
Journal of Child Neurology
Michelle Chiu and Anita Datta
DOI: 10.1177/0883073819872579

Clinical Significance of Incidental Rolandic Spikes in Children With Absence Epilepsy
Journal of Child Neurology
Anita N. Datta and Laura Wallbank and Jeremy C. H. Mak and Peter K. H. Wong
DOI: 10.1177/0883073819848639

Two Patients With KCNT1-Related Epilepsy Responding to Phenobarbital and Potassium Bromide
Journal of Child Neurology
Anita N. Datta and Aspasia Michoulas and Ilaria Guella and Michelle Demos
DOI: 10.1177/0883073819854853

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy
Journal of Human Genetics
DOI: 10.1016/j.ajhg.2017.05.016

An Infant With Epilepsy and Recurrent Hemiplegia due to Compound Heterozygous Variants in ATP1A2
Pediatric Neurology
DOI: 10.1016/j.pediatrneurol.2017.06.003

Clinical Experience With Perampanel For Refractory Pediatric Epilepsy In One Canadian Center
Journal of Child Neurology
DOI: 10.1177/0883073817709195

Predictors of IQ After Pediatric Epilepsy Surgery
Scientific Times Journal of Paediatrics

Case Report: QARS Deficiency and Favorable Outcomes Following Treatment of Seizures With Ketogenic Diet
Journal of Child Neurology
DOI: 10.1177/0883073816685508

Manifestations of Tuberous Sclerosis Complex: The Experience of a Provincial Clinic
Canadian Journal Neurological Sciences
DOI: 10.1017/cjn.2016.311

DRESS and PRES in a Patient With Epilepsy: Unexpected Consequences of Adding Lamotrigine
Scientific Times Journal of Paediatrics

Care of Children with Epilepsy at BC Children's Hospital
The Official Journal of the Hong Kong Society of Child Neurology and Developmental Paediatrics


Clinical Experience with Perampanel in the Pediatric Population in two Canadian Centers
The purpose of this study is to describe the efficacy, tolerability and side effects of Perampanel in pediatric patients with refractory epilepsy. To do so, a retrospective detailed chart review of eligible patients at BCCH will be completed.

Impact of Pediatric Epilepsy Surgery on Health-Related Quality Of Life
The objective of this study is to evaluate the effectiveness of two treatments, epilepsy surgery relative to medical therapy, on improving health related quality of life (HRQL) longitudinally. The surgical group will be compared to a medical treatment group which has undergone work-up for surgery but deemed unsuitable for surgery. These two groups have been shown to have similar baseline characteristics. Outcome will be addressed using a novel comprehensive model that acknowledges a number of variables such as clinical status (seizure control), patient factors (mood and self-concept) and family factors (caregivers’ mood, family adaptation, resources and demands) can affect changes in HRQL.

A three-arm, randomized, double-blind, placebo-controlled study of the efficacy and safety of two trough-ranges of everolimus as adjunctive therapy in patients with tuberous sclerosis complex (TSC) who have refractory partial-onset seizures
The main purpose of this study is to find out if the drug everolimus (Afinitor®) is safe and has helpful effects in patients with tuberous sclerosis complex (TSC) who have refractory partial-onset seizures. These are seizures that involve some type of body movement and are not adequately responding to ongoing treatment with epilepsy drugs. Many patients with TSC develop seizures. We are not sure if the seizures are caused by growth of certain cells in the brain or by changes in the way cells in the brain work together. Studies in animals that have changes in their brain similar to those seen with TSC, have demonstrated that seizures can be reduced by use of the everolimus.

Honours & Awards

TopScholar Epilepsy Fellow, Seattle, WA; supported by an educational grant from Ortho-McNeil Neurologics, Inc. (December 2008)

Annual Meeting Resident Scholarship, American Academy of Neurology (2006)

Research Group Members

Vicky Cao, Summer Student
Katarina Krivokapic, Summer Student
River So, Summer Student