Anita Datta

MD

Investigator, BC Children's Hospital
Pediatric Neurologist and Epileptologist, Pediatric Neurology
Program Director, Epilepsy Fellowship

Epilepsy, the most common chronic neurological disorder in children, is characterized by recurrent unprovoked seizures due to uncontrolled brain activity, over 30% of epilepsy cases do not respond to standard anti-seizure medications. Alternative treatments include surgery, neuromodulation, the ketogenic diet, and experimental therapies.

I actively engage in investigator-driven studies and serve as the principal investigator on several clinical trials. My interests include identifying EEG findings as clinical predictors, exploring epilepsy-related psychiatric comorbidities, evaluating epilepsy surgery outcomes, and investigating innovative treatments for the condition.

Academic Affiliations

  • Clinical Associate Professor, , Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Brain, Behaviour & Development
  • Research Group(s): Mental Health and Behaviour; Neurodevelopmental and Neurological Disorders; Visualizing the Brain

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

Clinical Significance of Positive Spike Wave Discharges in the Pediatric Population: Insights Beyond Neonates

Journal of Clinical Neurophysiology

Shishir Duble and Anita N. Datta

DOI: 10.1097/WNP.0000000000001203

03 / 2026

Education Research: Shaping the Future of Epilepsy Fellowship Training in Canada

Neurology Education

Anita N. Datta and Kristin M. Ikeda and Carlos Ivan Salazar Cerda and Aristides Hadjinicolaou and Gianluca D'Onofrio and Julia Jacobs-LeVan and Juan Pablo Appendino and Eliane Kobayashi and Rajesh Ramachandrannair and Esther Bui

DOI: 10.1212/NE9.0000000000200287

03 / 2026

Landscape of Postgraduate Epilepsy Education in Canada: A Survey of Canadian Epilepsy Fellowship Programs

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Kristin M. Ikeda and Anita N. Datta and Aristides Hadjinicolaou and Gianluca DOnofrio and Juan Pablo Appendino and Julia Jacobs-Levan and Eliane Kobayashi and Rajesh Ramachandrannair and Esther Bui

DOI: 10.1017/cjn.2025.10519

02 / 2026

Highly Purified Cannabidiol Treatment Outcomes in Pediatric Patients with Highly Refractory Epilepsy at Tertiary Center

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Kyah Kang and Ria Grewal and Cyrus Boelman and Mary B. Connolly and Linda Huh and Anita N. Datta

DOI: 10.1017/cjn.2026.10554

01 / 2026

Not All Spikes Are Equal

Journal of Clinical Medicine

Anita N. Datta

DOI: 10.3390/jcm14228071

11 / 2025

Epidemiology and Healthcare Resource Utilization of Rett Syndrome in Canada: the Ontario experience

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Sunita Bond and Jillian Murray and Anita N. Datta and Mubeen F. Rafay and Laura McAdam and Calum S Neish and Elsa Rossignol

DOI: 10.1017/cjn.2025.10475

11 / 2025

Cerliponase alfa therapy leads to long-term seizure freedom in a patient with late infantile neuronal ceroid lipofuscinosis

Seizure: European Journal of Epilepsy

Anita N. Datta and Sylvia Stockler

DOI: 10.1016/j.seizure.2025.08.024

11 / 2025

Initial Experience with Cenobamate for Drug Refractory Epilepsy at a Canadian Pediatric Tertiary Care Center

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Alexander Freibauer and Linda Huh and Mary B. Connolly and Anita N. Datta

DOI: 10.1017/cjn.2025.10442 PubMed: 41063655

10 / 2025

Circumstances surrounding sudden unexpected death in epilepsy in children: A national case series

Epilepsia

Robyn Whitney and Anne Keller and Shelly-Anne Li and Anita N. Datta and Matthew MacDonald and Maryam Nabavi Nouri and Daniela Pohl and Erick Sell and Gabriel M. Ronen and Mandeep Sidhu and Elisabeth Simard-Tremblay and Michael S. Pollanen and Elizabeth J. Donner

DOI: 10.1111/epi.18339

06 / 2025

Evaluating family-centred care at BC Children's Hospital: Healthcare providers' perspectives

Journal of Evaluation in Clinical Practice

Tessa Kolar and Courtney B Cook and Anthony Cooper and Tom Blydt-Hansen and Mary B. Connolly and Cyrus Boelman and Harpreet Chhina and Michelle Demos and Kyla J. Hildebrand and Kathryn Selby and Ye Shen and Scott E. Wenderfer and GenCOUNSEL Study and Alison Elliott

DOI: 10.1111/jep.14187

02 / 2025

The curious case of the gene, the lesion, or neither

Epileptic Disorders

Alexander Freibauer and Bashayer Almohaimeed and Anita Datta

DOI: 10.1002/epd2.20293

02 / 2025

The Initial Experience of Eslicarbazepine in Children at Three Canadian Tertiary Pediatric Care Centers

Journal of Child Neurology

Yvonne Nyakeri and Qi Xu and Maryam Nouri and Denait Haile and Anita N. Datta

DOI: 10.1177/08830738241282903

01 / 2025

Circumstances Surrounding Sudden Unexpected Death in Epilepsy in Children: A National Case-Series

Epilepsia

Competency-based EEG Training in Neurology: A More Measured Approach

The Canadian Journal of Neurological Sciences

Developmental and epileptic encephalopathies after successful treatment of pediatric ALL: A case series and review of literature

Epileptic Disorders

Vanita Shukla and Sylvia Cheng and Juliette Hukin and Linda Huh and Anita N. Datta

DOI: 10.1002/epd2.20280

12 / 2024

Original Research: Clinical Significance of a Unique Pediatric EEG Configuration: Bi-Frontal Spikes With Simultaneous Bi-Occipital Positivity

Clinical EEG and Neuroscience

Jacqueline Crawford and Cassie McFarlane and Anita N Datta

DOI: 10.1177/15500594241246505

09 / 2024

Case Report: Successful complete open corpus callosotomy for refractory epilepsy in Rett syndrome

Brain and Development Case Reports

Anita N. Datta and Mandeep Tamber

DOI: 10.1016/j.bdcasr.2024.100032

09 / 2024

Dipolar EEG Spikes Are More Benign

Journal of Clinical Neurophysiology

Peter K.H. Wong

DOI: 10.1097/wnp.0000000000001112

08 / 2024

A video case vignette: Hypermotor activity, ictal aggression, and bolting in an adolescent with an anteromedial temporal lesion

Epileptic Disorders

Anita N. Datta

DOI: 10.1002/epd2.20176

04 / 2024

Effectiveness, safety and tolerability of perampanel by age group when used to treat people with focal and generalized epilepsy in clinical practice: The PERMIT Extension study

Epilepsy & Behavior

James Wheless and Robert T. Wechsler and Patricia Penovich and Eric Segal and Michael Chez and Antonietta Coppola and Anita Datta and Wendyl D'Souza and Imad Najm and Sheri Cappucci and Ricardo Sainz-Fuertes and Vicente Villanueva

DOI: 10.1016/j.yebeh.2023.109369

10 / 2023

Outcome of Absence Epilepsy With Onset at 8-11 Years of Age: Watershed Ages When Syndromes Overlap

Journal of Child Neurology

Anita N. Datta and Jacqueline Crawford and Laura Wallbank and Peter K. H. Wong

DOI: 10.1177/08830738231188397

08 / 2023

The impact of anti-seizure medications on psychiatric disorders among children with epilepsy: Both a challenge and an opportunity?

Journal of the Canadian Academy of Child and Adolescent Psychiatry / Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent

PubMed: 37534124

08 / 2023

Neurodevelopmental and Epilepsy Phenotypes in Individuals With Missense Variants in the Voltage-Sensing and Pore Domains of KCNH5

Neurology

Hannah Happ and Lynette G. Sadleir and Matthew Zemel and Guillem de Valles-Ibez and Michael S. Hildebrand and Allyn McConkie-Rosell and Marie McDonald and Halie May and Tristan Sands and Vimla Aggarwal and Christopher Elder and Timothy Feyma and Allan Bayat and Rikke S. Mller and Christina D. Fenger and Jens Erik Klint Nielsen and Anita N. Datta and Kathleen M. Gorman and Mary D. King and Natalia D. Linhares and Barbara K. Burton and Andrea Paras and Sian Ellard and Julia Rankin and Anju Shukla and Purvi Majethia and Rory J. Olson and Karthik Muthusamy and Lisa A. Schimmenti and Keith Starnes and Lucie Sedlckov and Katalin terbov and Markta Vlckov and Petra Lauthov and Alena Jahodov and Brenda E. Porter and Nathalie Couque and Estelle Colin and Clment Prouteau and Corinne Collet and Thomas Smol and Roseline Caumes and Fleur Vansenne and Francesca Bisulli and Laura Licchetta and Richard Person and Erin Torti and Kirsty McWalter and Richard Webster and Elizabeth E. Gerard a

DOI: 10.1212/wnl.0000000000201492

02 / 2023

Three consecutive epilepsy syndromes in one child

Epileptic Disorders

Min Jung Kim and Linda Huh and Anita N. Datta

DOI: 10.1002/epd2.20051

02 / 2023

Reversible Cerebral Vasoconstriction Syndrome following Exchange Transfusion and Steroids in a Child with Sickle Cell Disease: A Case Report

Journal of Pediatric Neurology and Neuroscience

DOI: 10.36959/595/444

12 / 2022

School performance in children at the time of new-onset seizures and at long-term follow-up: A retrospective cohort study

Journal of International Medical Research

Anita N. Datta and Peter K.H. Wong

DOI: 10.1177/03000605221081032

04 / 2022

Effect of Training on Visual Identification of High Frequency Oscillations"A Delphi-Style Intervention

Frontiers in Neurology

Aaron M. Spring and Daniel J. Pittman and Arsalan Rizwan and Yahya Aghakhani and Jeffrey Jirsch and Mary Connolly and Samuel Wiebe and Juan Pablo Appendino and Trevor Steve and Neelan Pillay and Manouchehr Javidan and Morris Scantlebury and Chantelle Hrazdil and Colin Bruce Josephson and Cyrus Boelman and Donald Gross and Shaily Singh and Luis Bello-Espinosa and Linda Huh and Nathalie Jett and Paolo Federico

DOI: 10.3389/fneur.2022.794668

02 / 2022

Resilience of adolescents and teenagers with self-limited and genetic-generalized epilepsy during the COVID-19 pandemic

Epilepsy & Behavior Reports

Stephanie Kwok and Jennifer Engle

DOI: 10.1016/j.ebr.2021.100520

Hypnagogic Frontal EEG Bursts in Children: Epileptic or Not?

Journal of Clinical Neurophysiology

DOI: 10.1097/wnp.0000000000000722

11 / 2021

Children With Trisomy 21 and Lennox-Gastaut Syndrome With Predominant Myoclonic Seizures

Journal of Child Neurology

Matthew Macdonald and Jacqueline Crawford and Anita N. Datta

DOI: 10.1177/08830738211026072

10 / 2021

Pediatric Occipital Spikes at a Single Center Over 26 Years and the Significance of Tangential Dipole

Journal of Child Neurology

Anita N. Datta and Laura Wallbank and Johann Micallef and Peter K. H. Wong

DOI: 10.1177/0883073820984042

06 / 2021

Infantile Spasms and Trisomy 21: Unfavorable Outcomes with First-line Vigabatrin Therapy

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Jacqueline Crawford and Peter K.H. Wong

DOI: 10.1017/cjn.2021.12

01 / 2021

At What Point Should We Discontinue Treatment in Super-Refractory Status Epilepticus?

Journal of Pediatric Epilepsy

Anita N. Datta

DOI: 10.1055/s-0040-1714389

09 / 2020

Childhood Small Vessel Primary Angiitis of the Central Nervous System: A Treatable Cause of Super-refractory Status Epilepticus

Journal of Child Neurology

Michelle Chiu and Anita Datta

DOI: 10.1177/0883073819872579

01 / 2020

Clinical Significance of Incidental Rolandic Spikes in Children With Absence Epilepsy

Journal of Child Neurology

Anita N. Datta and Laura Wallbank and Jeremy C. H. Mak and Peter K. H. Wong

DOI: 10.1177/0883073819848639

10 / 2019

Two Patients With KCNT1-Related Epilepsy Responding to Phenobarbital and Potassium Bromide

Journal of Child Neurology

Anita N. Datta and Aspasia Michoulas and Ilaria Guella and Michelle Demos

DOI: 10.1177/0883073819854853

10 / 2019

Diagnostic Yield and Treatment Impact of Targeted Exome Sequencing in Early-Onset Epilepsy.

Frontiers in neurology

Marna McKenzie and Sarah Elisabeth Buerki and Bruce H. Bjornson and Shelin Adam and Tanya Nelson and Corneliu Bolbocean

DOI: 10.3389/fneur.2019.00434 PubMed: 31164858

05 / 2019

mTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report

Journal of Child Neurology

Qi Xu and Shimrit Uliel-Sibony and Christopher Dunham and Harvey Sarnat and Laura Flores-Sarnat and Ledia Brunga and Scott Davidson and Winnie Lo and Adam Shlien and Mary Connolly and Cyrus Boelman

DOI: 10.1177/0883073818813238

03 / 2019

Co-existence of Rolandic and 3 Hz Spike-Wave Discharges on EEG in Children with Epilepsy

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Laura Wallbank and Peter K. H. Wong

DOI: 10.1017/cjn.2018.364

01 / 2019

Predictive Value of Midline Spikes on Pediatric EEG for Seizure and Developmental Outcome

Journal of Clinical Neurophysiology

Laura Wallbank and Qi Xu and Peter K. H. Wong

DOI: 10.1097/wnp.0000000000000516

11 / 2018

Lack of response to quinidine in KCNT-related neonatal epilepsy

Epilepsia

Adam L. Numis and Umesh Nair and Tristan T. Sands and Michael S. Oldham and Akash Patel and Melody Li and Elena Gazina and Steven Petrou and Maria Roberta Cilio

DOI: 10.1111/epi.14551

10 / 2018

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy

Journal of Human Genetics

DOI: 10.1016/j.ajhg.2017.05.016

06 / 2017

An Infant With Epilepsy and Recurrent Hemiplegia due to Compound Heterozygous Variants in ATP1A2

Pediatric Neurology

DOI: 10.1016/j.pediatrneurol.2017.06.003

06 / 2017

Clinical Experience With Perampanel For Refractory Pediatric Epilepsy In One Canadian Center

Journal of Child Neurology

DOI: 10.1177/0883073817709195

05 / 2017

Predictors of IQ After Pediatric Epilepsy Surgery

Scientific Times Journal of Paediatrics

02 / 2017

Case Report: QARS Deficiency and Favorable Outcomes Following Treatment of Seizures With Ketogenic Diet

Journal of Child Neurology

DOI: 10.1177/0883073816685508

01 / 2017

Manifestations of Tuberous Sclerosis Complex: The Experience of a Provincial Clinic

Canadian Journal Neurological Sciences

DOI: 10.1017/cjn.2016.311

Care of Children with Epilepsy at BC Children's Hospital

The Official Journal of the Hong Kong Society of Child Neurology and Developmental Paediatrics

DRESS and PRES in a Patient With Epilepsy: Unexpected Consequences of Adding Lamotrigine

Scientific Times Journal of Paediatrics

Discontinuation of antiepileptic drugs after successful epilepsy surgery. A Canadian survey

Epilepsy Research

Jos F. Tllez-Zenteno and Lizbeth Hernndez Ronquillo and Nathalie Jette and Jorge G. Burneo and Dang Khoa Nguyen and Elizabeth J. Donner and Mark Sadler and Mano Javidan M and Donald W. Gross and Samuel Wiebe

DOI: 10.1016/j.eplepsyres.2012.04.018

11 / 2012

Tuberous Sclerosis Complex: From Basic Science to Clinical Phenotypes. 2003. Edited by Paolo Curatolo. Published by Mac Keith Press. 314 pages. C$112 approx.

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Anita Datta

DOI: 10.1017/s0317167100050940

03 / 2012

Intelligence Quotient is Not Affected by Epilepsy Surgery in Childhood

Pediatric Neurology

Thomas J. Snyder and Matt B. Wheatley and Laura Jurasek and Nizam S. Ahmed and Donald W. Gross and D. Barry Sinclair

DOI: 10.1016/j.pediatrneurol.2010.10.011

02 / 2011

Trisomy 8 Mosaicism and Favorable Outcome After Treatment of Infantile Spasms: Case Report

Journal of Child Neurology

Jonathan Picker and Alexander Rotenberg

DOI: 10.1177/0883073809357361

10 / 2010

Selective amygdalohippocampectomy: surgical outcome in children versus adults.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

S. Nizam Ahmed

PubMed: 19378712

03 / 2009

A first stage genome-wide screen for regions shared identical-by-descent in hutterite families with multiple sclerosis

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

David Alexandre Dyment and M. Zameel Cader and S. John Broxholme and Stacey S. Cherny and Cristen J. Willer and Sreeram Ramagopalan and Blanca M. Herrera and Sarah Orton and Michael Chao and A. Dessa Sadovnick and Mary Hader and Walter Hader and George C. Ebers

DOI: 10.1002/ajmg.b.30620

06 / 2008

Clinical Presentation and Diagnosis of Tuberous Sclerosis Complex in Infancy

Journal of Child Neurology

Cecil D. Hahn and Mustafa Sahin

DOI: 10.1177/0883073807309250

03 / 2008

Discontinuation of Antiepileptic Drugs after Pediatric Epilepsy Surgery

Pediatric Neurology

D. Barry Sinclair and Laura Jurasek and Matt Wheatley and Donald Gross and Nizam Ahmed and Daphne Quigley and Thomas Snyder and Keith Aronyk and John McKean

DOI: 10.1016/j.pediatrneurol.2007.05.004

09 / 2007

Benign Epilepsy of Childhood With Rolandic Spikes: Typical and Atypical Variants

Pediatric Neurology

D. Barry Sinclair

DOI: 10.1016/j.pediatrneurol.2006.12.003

03 / 2007

Prognosis of seizures occurring in the first year

Pediatric Neurology

Elaine C Wirrell

DOI: 10.1016/s0887-8994(00)00130-2

05 / 2000

Impact of Spike Location and Frequency on Cognitive and Emotional Development in Children with Generalized and Self-Limited Epilepsy

The impact of interictal epileptiform discharges (IEDs) on cognitive and emotional dysfunction is not well understood, particularly in children who often experience frequent IEDs alongside mild cognitive or emotional issues. There are concerns that IEDs may negatively affect cognitive and emotional processes, leading to potential treatment needs. Since anti-seizure medications do not fully suppress IEDs and can have adverse effects, this prospective study aims to explore the connection between the frequency and location of IEDs and cognitive-emotional dysfunction in children with self-limited focal epilepsy and genetic generalized epilepsy.

Treatment of Medically Refractory Epilepsy due to Focal Cortical Dysplasia with mTOR inhibitors

Focal cortical dysplasia (FCD) is a malformation of cortical development and the primary cause of drug-resistant epilepsy in children, often leading to surgery in those under three. Increasing evidence suggests that the mTOR pathway is vital in various epilepsy syndromes, including FCD. This open-label pilot study evaluates the efficacy of the mTOR inhibitor, sirolimus, for treating refractory seizures due to FCD in children awaiting epilepsy surgery.

The Prevalence and Risk Factors for Avoidant Restrictive Food Intake Disorder of Children and Adolescents with Epilepsy

This prospective study aims to assess the prevalence of children and adolescents aged 8 to 18 at risk for Avoidant Restrictive Food Intake Disorder (ARFID) in a pediatric epilepsy clinic. We will identify clinical risk factors for ARFID, such as age of seizure onset, sex, seizure types, drug-resistant epilepsy, number of anti-seizure medications, epilepsy syndrome, neurodevelopmental status, and history of autism spectrum disorder. Additionally, we will screen for depression and anxiety, as these may independently contribute to ARFID risk in epilepsy patients.

Multi-centre study retrospective study: Comparison of treatment-response of Trisomy 21 patients with infantile spasms to first-line vigabatrin or hormonal therapies

In this retrospective multi-center study, we are reviewing clinical data from patients with Trisomy 21 syndrome and infantile spasms across various tertiary pediatric care centers in Canada and the United States. The aim is to compare the treatment responses and long-term outcomes of patients receiving first-line Vigabatrin versus those receiving first-line hormonal therapy for infantile spasms associated with Trisomy 21.

EEG predictors for clinical outcome in Rett syndrome

Rett syndrome (RTT) exhibits variability in EEG findings and clinical severity. Some patients maintain ambulation and have no seizure history into adulthood, while others become non-ambulatory early or experience drug-resistant epilepsy. Common EEG features associated with developmental delay and severe seizures include background suppression, slowed activity, poorly formed sleep architecture, and frequent epileptiform discharges. However, the relationship between these EEG findings and clinical features in RTT is not well understood. This study aims to identify EEG predictors of clinical severity by examining the initial EEG during the plateau or rapid regression phase.

Rett (RTT) Imaging Study

Further research is necessary to understand anatomical, metabolic, and functional changes in the brains of children with RTT, and to link these changes with measures of genetics, disease progression and clinical features. The primary aim of the current study will be to investigate white matter (WM) architectural and metabolic differences between girls with RTT (aged 5-12 years; n = 10) compared to healthy age-matched girls (aged 5-12 years; n = 5-10), as well as explore the relationship between these WM measures and RTT clinical severity scores, age, genetic MECP2 mutations, and seizures. Secondary aims will explore novel functional abnormalities in RTT and its association with severity, age, genetic mutations, and seizures.

Honours & Awards

Research Mentor Award (Neurology Program, UBC), 2019.

Research Mentor Award (Neurology Program, UBC), 2017.

Research Mentor Award (Neurology Program, UBC), 2016.

Research Mentor Award (Neurology Program, UBC), 2015.

Professional Development Grant from Royal College of Physicians and Surgeons of Canada ($5000), 2017

Brain Behavior and Development: Open Access Publication Award, October, 2024.

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