Overview

Recent evidence suggests that a mother's diet during pregnancy can influence the development of cardiovascular disease (CVD) risk factors in their adult children. Currently my research focuses on determining how this occurs. I speculate that maternal diet during pregnancy can influence gene expression in children through epigenetic processes, defined as heritable changes in gene expression that occur without a change in the DNA sequence of the gene. I’m conducting studies in mice to determine the roles of prenatal and early postnatal diet and the role of epigenetic processes in the development of CVD, and am addressing the questions: if diet during adult life can change epigenetic processes, what happens to offspring exposed early in development to a similar nutrient insult, and are there consequences later in life? Overall determining how diet and epigenetic processes contribute to CVD will aid in the development of early screening tools for at-risk children, and novel therapeutic targets for prevention and treatment of CVD.

Publications

Women in Canada are consuming above the upper intake level of folic acid but few are meeting dietary choline recommendations in the second trimester of pregnancy: data from the CHILD cohort study
Applied Physiology, Nutrition, and Metabolism
Alejandra M. Wiedeman and Kozeta Miliku and Theo J. Moraes and Piushkumar J. Mandhane and Elinor Simons and Padmaja Subbarao and Stuart E. Turvey and Jill G. Zwicker and Angela M. Devlin
DOI: 10.1139/apnm-2023-0258
02/2024

Folic acid supplementation in a mouse model of diabetes in pregnancy alters insulin sensitivity in female mice and beta cell mass in offspring
The FASEB Journal
Ei-Xia Mussai and Zoe A. Lofft and Ben Vanderkruk and Nicha Boonpattrawong and Joshua W. Miller and Andre Smith and Teodoro Bottiglieri and Angela M. Devlin
DOI: 10.1096/fj.202301491R
11/2023

Maternal nutrition and effects on offspring vascular function
Pflügers Archiv - European Journal of Physiology
Taylor A. Ricci and Nicha Boonpattrawong and Ismail Laher and Angela M. Devlin
DOI: 10.1007/s00424-023-02807-x
07/2023

Prenatal serotonin reuptake inhibitor antidepressant exposure, SLC6A4 genetic variations, and cortisol activity in 6-year-old children of depressed mothers: A cohort study
Developmental Psychobiology
DOI: 10.1002/dev.22425
2023

Riboflavin intake and status and relationship to anemia
Nutrition Reviews
DOI: 10.1093/nutrit/nuac043
2023

Supplementation with (6 S)-5-methyltetrahydrofolic acid appears as effective as folic acid in maintaining maternal folate status while reducing unmetabolized folic acid in maternal plasma: A randomized trial of pregnant women in Canada
British Journal of Nutrition
DOI: 10.1017/S0007114523001733
2023

Human milk unmetabolized folic acid is increased following supplementation with synthetic folic acid as compared to (6S)-5-methyltetrahydrofolic acid
Scientific Reports
DOI: 10.1038/s41598-023-38224-4
2023

Children Aged 5–6 Years in Vancouver, Canada Meet Dietary Recommendations for Folate and Vitamin B12 but not Choline
Journal of Nutrition
DOI: 10.1016/j.tjnut.2022.11.012
2023

Thermoneutral Housing and a Western Diet Combination Exacerbates Dysferlin-Deficient Muscular Dystrophy
Muscle and Nerve
Donen, G.S. and White, Z. and Sauge, E. and Ritso, M. and Theret, M. and Boyd, J. and Devlin, A.M. and Rossi, F.M.V. and Bernatchez, P.
DOI: 10.1002/mus.27680
2022

The FTO rs9939609 Variant Is Associated with Cardiometabolic Disease Risk and Dietary Energy Intakes in Children with Mental Health Disorders
Current Developments in Nutrition
DOI: 10.1093/cdn/nzac014
2022

Sex-specific effects of neonatal oral sucrose treatment on growth and liver choline and glucocorticoid metabolism in adulthood
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Cynthia Y. Ramírez-Contreras and Arya E. Mehran and Melody Salehzadeh and Ei-Xia Mussai and Joshua W. Miller and Andre Smith and Manon Ranger and Liisa Holsti and Kiran K. Soma and Angela M. Devlin
DOI: 10.1152/ajpregu.00091.2021
11/2021

Greater Arterial Stiffness in Children with or without Second-generation Antipsychotic Treatment for Mental Health Disorders: Rigidité Artérielle Plus Importante Chez Les Enfants Avec ou Sans Traitement Par Antipsychotiques de la Deuxième Génération Pour des Troubles de Santé Mentale
The Canadian Journal of Psychiatry
Amanda M. Henderson and Nazrul Islam and George G. S. Sandor and Constadina Panagiotopoulos and Angela M. Devlin
DOI: 10.1177/0706743720974838
07/2021

Dietary Riboflavin Intake and Riboflavin Status in Young Adult Women Living in Metro Vancouver, Canada
Current Developments in Nutrition
Abeer M Aljaadi and Alejandra M Wiedeman and Susan I Barr and Angela M Devlin and Tim J Green
DOI: 10.1093/cdn/nzab021
04/2021

Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease.
Frontiers in nutrition
Williams BA and Mayer C and McCartney H and Devlin AM and Lamers Y and Vercauteren SM and Wu JK and Karakochuk CD
DOI: 10.3389/fnut.2021.642306
PubMed: 33968971
04/2021

Daily oral supplementation with 60 mg of elemental iron for 12 weeks alters blood mitochondrial dna content, but not leukocyte telomere length in cambodian women
Nutrients
Steele, S.L. and Hsieh, A.Y.Y. and Gadawski, I. and Kroeun, H. and Barr, S.I. and Devlin, A.M. and C{\^o}t{\'e}, H.C.F. and Karakochuk, C.D.
DOI: 10.3390/nu13061877
2021

Treatment-related weight gain and metabolic complications in children with mental health disorders: Potential role for lifestyle interventions1
Applied Physiology, Nutrition and Metabolism
Wiedeman, A.M. and Panagiotopoulos, C. and Devlin, A.M.
DOI: 10.1139/apnm-2020-0259
2021

Exercise during pregnancy mitigates the adverse effects of maternal obesity on adult male offspring vascular function and alters one-carbon metabolism
Physiological Reports
Nicha P. Boonpattrawong and Saeid Golbidi and Daven C. Tai and Rika E. Aleliunas and Pascal Bernatchez and Joshua W. Miller and Ismail Laher and Angela M. Devlin
DOI: 10.14814/phy2.14582
09/2020

Assessing the Effectiveness of Targeted Social Media and Printed Posters as Tools to Recruit Pregnant Women to a Nutrition Trial in Vancouver, Canada.
Current developments in nutrition
Cochrane K and Karakochuk C and Mayer C and Devlin A and Elango R and Hutcheon J
05/2020

Assessing the Effectiveness of Targeted Social Media and Printed Posters as Tools to Recruit Pregnant Women to a Nutrition Trial in Vancouver, Canada
Current Developments in Nutrition
Kelsey Cochrane and Crystal Karakochuk and Chantal Mayer and Angela Devlin and Rajavel Elango and Jennifer Hutcheon
DOI: 10.1093/cdn/nzaa056_012
05/2020

Folic Acid Supplementation in Children with Sickle Cell Disease: Study Protocol for a Double-Blind Randomized Cross-Over Trial
Williams BA and McCartney H and Adams E and Devlin AM and Singer J and Vercauteren S and Wu JK and Karakochuk CD
DOI: 10.21203/rs.3.rs-30458/v1
05/2020

Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study
Cochrane KM and Mayer C and Devlin AM and Elango R and Hutcheon JA and Karakochuk CD
DOI: 10.21203/rs.2.18214/v2
03/2020

Ambulatory blood pressure and carotid intima media thickness in children with type 1 diabetes
Pediatric Diabetes
Sinead Glackin and Nazrul Islam and Amanda M. Henderson and Janis M. Dionne and Kevin C. Harris and Constadina Panagiotopoulos and Angela M. Devlin
DOI: 10.1111/pedi.12960
03/2020

Folic acid supplementation in children with sickle cell disease: Study protocol for a double-blind randomized cross-over trial
Trials
Williams, B.A. and McCartney, H. and Adams, E. and Devlin, A.M. and Singer, J. and Vercauteren, S. and Wu, J.K. and Karakochuk, C.D.
DOI: 10.1186/s13063-020-04540-7
2020

Sheila M. Innis, PhD, RD (1953-2016): A Pioneer and Innovator Influencing the Maternal and Infant Nutrition Field
The Journal of nutrition
Field, C.J. and Devlin, A.M. and Atkinson, S.
DOI: 10.1093/jn/nxaa078
2020

Biomarkers of Docosahexaenoic Acid but Not Arachidonic Acid Reflect Dietary Intakes in Toddlers at Ages 1 and 2 Years Who Are Not Meeting Dietary Recommendations
Journal of Nutrition
Wiedeman, A.M. and Dyer, R.A. and McCarthy, D. and Yurko-Mauro, K. and Innis, S.M. and Devlin, A.M.
DOI: 10.1093/jn/nxz280
2020

Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study
Trials
Cochrane, K.M. and Mayer, C. and Devlin, A.M. and Elango, R. and Hutcheon, J.A. and Karakochuk, C.D.
DOI: 10.1186/s13063-020-04320-3
2020

290-LB: Repeated Neonatal Oral Sucrose Treatment Affects Growth and Insulin-Like Growth Factor-1 in Mice
Diabetes
CYNTHIA YAMILKA RAMIREZ CONTRERAS and EI-XIA MUSSAI and ALEJANDRA M. WIEDEMAN and ARYA MEHRAN and MELODY SALEHZADEH and NICHA BOONPATTRAWONG and MANON RANGER and KIRAN K. SOMA and LIISA HOLSTI and ANGELA M. DEVLIN
DOI: 10.2337/db19-290-lb
06/2019

70-LB: Fat Mass and Obesity-Associated rs9939609 Gene Variant Is Related to Fasting Glucose in Children with Mental Health Conditions
Diabetes
ALEJANDRA M. WIEDEMAN and YING FAI NGAI and AMANDA M. HENDERSON and CONSTADINA PANAGIOTOPOULOS and ANGELA M. DEVLIN
DOI: 10.2337/db19-70-lb
06/2019

459-P: Risk for Type 2 Diabetes and Cardiovascular Health in Children Treated with Second-Generation Antipsychotics
Diabetes
AMANDA M. HENDERSON and NAZRUL ISLAM and GEORGE GABOR SANDOR and CONSTADINA PANAGIOTOPOULOS and ANGELA M. DEVLIN
DOI: 10.2337/db19-459-p
06/2019

1395-P: Maternal Exercise during Pregnancy Affects Offspring Adiposity through One Carbon Metabolism Cycle
Diabetes
NICHA BOONPATTRAWONG and ARYA MEHRAN and ISMAIL LAHER and ANGELA M. DEVLIN
DOI: 10.2337/db19-1395-p
06/2019

Impact of Prenatal Selective Serotonin Reuptake Inhibitor Antidepressant Exposure and Maternal Mood on Physical Activity, Dietary Intake, and Markers of Adiposity at Age 6 Years
Journal of Developmental & Behavioral Pediatrics
Sarah M. Hutchison and Louise C. Mâsse and Melissa B. Glier and Ursula Brain and Angela M. Devlin and Tim F. Oberlander
DOI: 10.1097/dbp.0000000000000658
03/2019

Suboptimal Biochemical Riboflavin Status Is Associated with Lower Hemoglobin and Higher Rates of Anemia in a Sample of Canadian and Malaysian Women of Reproductive Age
Journal of Nutrition
Aljaadi, A.M. and How, R.E. and Loh, S.P. and Hunt, S.E. and Karakochuk, C.D. and Barr, S.I. and McAnena, L. and Ward, M. and McNulty, H. and Khor, G.L. and Devlin, A.M. and Green, T.J.
DOI: 10.1093/jn/nxz151
2019

Impact of prenatal selective serotonin reuptake inhibitor antidepressant exposure and maternal mood on physical activity, dietary intake, and markers of adiposity at age 6 years
Journal of Developmental and Behavioral Pediatrics
Hutchison, S.M. and Mâsse, L.C. and Glier, M.B. and Brain, U. and Devlin, A.M. and Oberlander, T.F.
DOI: 10.1097/DBP.0000000000000658
2019

Children's stress regulation mediates the association between prenatal maternal mood and child executive functions for boys, but not girls
Development and Psychopathology
Regula Neuenschwander and Kaia Hookenson and Ursula Brain and Ruth E. Grunau and Angela M. Devlin and Joanne Weinberg and Adele Diamond and Tim F. Oberlander
DOI: 10.1017/s095457941800041x
08/2018

Maternal Exercise Improves Glucose Homeostasis and Vascular Health in Male Offspring
Atherosclerosis Supplements
Nicha Boonpattrawong and Saeid Golbidi and Ismail Laher and Angela Devlin
DOI: 10.1016/j.atherosclerosissup.2018.04.048
06/2018

l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women
The Journal of Nutrition
Amanda M Henderson and Rika E Aleliunas and Su Peng Loh and Geok Lin Khor and Sarah Harvey-Leeson and Melissa B Glier and David D Kitts and Tim J Green and Angela M Devlin
DOI: 10.1093/jn/nxy057
06/2018

Abnormal Ambulatory Blood Pressure and Adiposity Predict Carotid Intima Media Thickness in Children with Type 1 Diabetes
Atherosclerosis Supplements
Sinead Glackin and Nazrul Islam and Janis Dionne and Constadina Panagiotopolous and Angela Devlin
DOI: 10.1016/j.atherosclerosissup.2018.04.066
06/2018

Adiposity and Carotid Intima Media Thickness in Children with Type 1 Diabetes
Atherosclerosis Supplements
Sinead Glackin and Nazrul Islam and Kevin Harris and Constadina Panagiotopolous and Angela Devlin
DOI: 10.1016/j.atherosclerosissup.2018.04.215
06/2018

Maternal folic acid supplementation with vitamin B 12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet
The FASEB Journal
Amanda M. Henderson and Daven C. Tai and Rika E. Aleliunas and Abeer M. Aljaadi and Melissa B. Glier and Eric E. Xu and Joshua W. Miller and C. Bruce Verchere and Tim J. Green and Angela M. Devlin
DOI: 10.1096/fj.201701503rr
04/2018

Comparison of a New Multiplex Immunoassay for Measurement of Ferritin, Soluble Transferrin Receptor, Retinol-Binding Protein, C-Reactive Protein and a1-Acid-glycoprotein Concentrations against a Widely-Used s-ELISA Method
Diagnostics
Crystal Karakochuk and Amanda Henderson and Kaitlyn Samson and Abeer Aljaadi and Angela Devlin and Elodie Becquey and James Wirth and Fabian Rohner
DOI: 10.3390/diagnostics8010013
02/2018

Risperidone But Not Quetiapine Treatment Is Associated With Increased Appetite But Not Satiety Hormones in Children During An Oral Glucose Tolerance Test
Journal of Clinical Psychopharmacology
Ying Fai Ngai and Angela M. Devlin and Constadina Panagiotopoulos
DOI: 10.1097/jcp.0000000000000956
2018

Diet and cardiometabolic side effects in children treated with second-generation antipsychotics
Clinical Nutrition ESPEN
Barker, M.K. and Sable, C.M. and Montgomery, S.E. and Chow, L. and Green, T.J. and Panagiotopoulos, C. and Devlin, A.M.
DOI: 10.1016/j.clnesp.2017.09.013
2018

CHIPS-Child: Testing the developmental programming hypothesis in the offspring of the CHIPS trial
Pregnancy Hypertension
Magee, L.A. and Synnes, A.R. and von Dadelszen, P. and Hutfield, A.M. and Chanoine, J.-P. and Côté, A.-M. and Devlin, A.M. and Dorling, J. and Gafni, A. and Ganzevoort, W. and Helewa, M.E. and Hutton, E.K. and Koren, G. and Lee, S.K. and Mcarthur, D. and Rey, E. and Robinson, W.P. and Roseboom, T.J. and Singer, J. and Wilson, S. and Moutquin, J.M.
DOI: 10.1016/j.preghy.2018.04.021
2018

Children's stress regulation mediates the association between prenatal maternal mood and child executive functions for boys, but not girls
Development and Psychopathology
Neuenschwander, R. and Hookenson, K. and Brain, U. and Grunau, R.E. and Devlin, A.M. and Weinberg, J. and Diamond, A. and Oberlander, T.F.
DOI: 10.1017/S095457941800041X
2018

Plasma betaine is positively associated with developmental outcomes in healthy toddlers at age 2 years who are not meeting the recommended adequate intake for dietary choline
Journal of Nutrition
Wiedeman, A.M. and Chau, C.M.Y. and Grunau, R.E. and McCarthy, D. and Yurko-Mauro, K. and Dyer, R.A. and Innis, S.M. and Devlin, A.M.
DOI: 10.1093/jn/nxy108
2018

Maternal folic acid supplementation with Vitamin B 12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet
FASEB Journal
Henderson, A.M. and Tai, D.C. and Aleliunas, R.E. and Aljaadi, A.M. and Glier, M.B. and Xu, E.E. and Miller, J.W. and Bruce Verchere, C. and Green, T.J. and Devlin, A.M.
DOI: 10.1096/fj.201701503RR
2018

Risperidone but not quetiapine treatment is associated with increased appetite but not satiety hormones in children during an oral glucose tolerance test: A pilot study
Journal of Clinical Psychopharmacology
Ngai, Y.F. and Devlin, A.M. and Panagiotopoulos, C.
DOI: 10.1097/JCP.0000000000000956
2018

Developmental Outcomes at 24 Months of Age in Toddlers Supplemented with Arachidonic Acid and Docosahexaenoic Acid: Results of a Double Blind Randomized, Controlled Trial.
Nutrients
DOI: 10.3390/nu9090975
PubMed: 28878181
09/2017

Serum Soluble Transferrin Receptor Concentrations Are Elevated in Congolese Children with Glucose-6-Phosphate Dehydrogenase Variants, but Not Sickle Cell Variants or a-Thalassemia.
The Journal of nutrition
DOI: 10.3945/jn.117.252635
PubMed: 28768839
09/2017

The effect of oral iron with or without multiple micronutrients on hemoglobin concentration and hemoglobin response among nonpregnant Cambodian women of reproductive age: a 2 x 2 factorial, double-blind, randomized controlled supplementation trial.
The American journal of clinical nutrition
DOI: 10.3945/ajcn.116.140996
PubMed: 28490515
07/2017

The Val66Met brain-derived neurotrophic factor gene variant interacts with early pain exposure to predict cortisol dysregulation in 7-year-old children born very preterm: Implications for cognition.
Neuroscience
DOI: 10.1016/j.neuroscience.2015.08.044
PubMed: 26318333
02/2017

Prevalence and Predictors of Low Vitamin B6 Status in Healthy Young Adult Women in Metro Vancouver
Nutrients
Chia-ling Ho and Teo Quay and Angela Devlin and Yvonne Lamers
DOI: 10.3390/nu8090538
09/2016

Sculpting infant soothability: the role of prenatal SSRI antidepressant exposure and neonatal SLC6A4 methylation status.
Developmental psychobiology
DOI: 10.1002/dev.21414
PubMed: 27254389
09/2016

Folic Acid Supplementation of Female Mice, with or without Vitamin B-12, before and during Pregnancy and Lactation Programs Adiposity and Vascular Health in Adult Male Offspring.
The Journal of nutrition
PubMed: 26962174
03/2016

Folic acid supplementation of female mice, with or without vitamin B-12, before and during pregnancy and lactation programs adiposity and vascular health in adult male offspring
Journal of Nutrition
Aleliunas, R.E. and Aljaadi, A.M. and Laher, I. and Glier, M.B. and Green, T.J. and Murphy, M. and Miller, J.W. and Devlin, A.M.
DOI: 10.3945/jn.115.227629
2016

High prevalence of suboptimal vitamin B12 status in young adult women of South Asian and European ethnicity.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
DOI: 10.1139/apnm-2015-0200
PubMed: 26579949
12/2015

Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain.
American journal of physiology. Regulatory, integrative and comparative physiology
DOI: 10.1152/ajpregu.00075.2015
PubMed: 26180184
09/2015

Metabolic side effects and pharmacogenetics of second-generation antipsychotics in children
Pharmacogenomics
Angela M Devlin and Constadina Panagiotopoulos
DOI: 10.2217/pgs.15.55
06/2015

Obesity and arterial stiffness in children: systematic review and meta-analysis.
Arteriosclerosis, thrombosis, and vascular biology
DOI: 10.1161/atvbaha.114.305062
PubMed: 25633314
04/2015

Interaction between the Val158Met catechol-O-methyltransferase gene variant and second-generation antipsychotic treatment on blood pressure in children.
The pharmacogenomics journal
DOI: 10.1038/tpj.2014.35
PubMed: 25048416
02/2015

Genetic hemoglobin disorders rather than iron deficiency are a major predictor of hemoglobin concentration in women of reproductive age in rural prey Veng, Cambodia.
The Journal of nutrition
DOI: 10.3945/jn.114.198945
PubMed: 25527668
01/2015

Obesity and arterial stiffness in children: Systematic review and meta-analysis
Arteriosclerosis, Thrombosis, and Vascular Biology
Cote, A.T. and Phillips, A.A. and Harris, K.C. and Sandor, G.G.S. and Panagiotopoulos, C. and Devlin, A.M.
DOI: 10.1161/ATVBAHA.114.305062
2015

Initial screening of children treated with second-generation antipsychotics points to an association between physical activity and insulin resistance.
Pediatric exercise science
DOI: 10.1123/pes.2014-0076
PubMed: 25372380
11/2014

Childhood obesity, arterial stiffness, and prevalence and treatment of hypertension.
Current treatment options in cardiovascular medicine
DOI: 10.1007/s11936-014-0339-9
PubMed: 25248796
11/2014

Quetiapine treatment in youth is associated with decreased insulin secretion.
Journal of clinical psychopharmacology
DOI: 10.1097/jcp.0000000000000118
PubMed: 24633003
06/2014

Chronic intermittent hypoxia causes endothelial dysfunction in a mouse model of diet-induced obesity.
Sleep medicine
DOI: 10.1016/j.sleep.2014.01.013
PubMed: 24767726
05/2014

Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age.
Frontiers in Behavioral Neuroscience
DOI: 10.3389/fnbeh.2014.00409
PubMed: 25520635
2014

Quetiapine treatment in youth is associated with decreased insulin secretion
Journal of Clinical Psychopharmacology
Ngai, Y.F. and Sabatini, P. and Nguyen, D. and Davidson, J. and Chanoine, J.-P. and Devlin, A.M. and Lynn, F.C. and Panagiotopoulos, C.
DOI: 10.1097/JCP.0000000000000118
2014

Methyl nutrients, DNA methylation, and cardiovascular disease
Molecular Nutrition and Food Research
Glier, M.B. and Green, T.J. and Devlin, A.M.
DOI: 10.1002/mnfr.201200636
2014

Left ventricular mechanics and arterial-ventricular coupling following high-intensity interval exercise.
Journal of applied physiology (Bethesda, Md. : 1985)
DOI: 10.1152/japplphysiol.00576.2013
PubMed: 24052036
12/2013

Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study.
Cardiovascular diabetology
DOI: 10.1186/1475-2840-12-170
PubMed: 24225161
11/2013

Childhood obesity and cardiovascular dysfunction.
Journal of the American College of Cardiology
DOI: 10.1016/j.jacc.2013.07.042
PubMed: 23954339
10/2013

Dysfunctional Cardiac Lipid Metabolism in Cystathionine-Beta-Synthase Deficient Mice With Diet-Induced Weight Gain
Canadian Journal of Cardiology
MB Glier and JD Olson and SL Gerrard and RE Aleliunas and DC Sulistyoningrum and TJ Green and AM Devlin and AM Devlin
DOI: 10.1016/j.cjca.2013.07.264
10/2013

Programming of Glucose Homeostasis by Developmental Exposure to Folic Acid and Vitamin B12 Imbalance in Female Mice
Canadian Journal of Diabetes
Jesse D. Olson and Rika E. Aleiunas and Melissa B. Glier and Abeer M. Aljaadi and Tim J. Green and Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.08.213
10/2013

Antidepressant use during pregnancy and serotonin transporter genotype (SLC6A4) affect newborn serum reelin levels.
Developmental psychobiology
DOI: 10.1002/dev.21056
PubMed: 22692766
07/2013

Visceral Adiposity and The Relationship Between Vitamin D and Adiponectin
Canadian Journal of Diabetes
Dian Sulistyoningrum and Danijela Gasevic and Scott Lear and Angela Devlin
DOI: 10.1016/j.jcjd.2013.03.226
04/2013

Dysfunctional Cardiac Lipid Metabolism in Cystathionine-Beta-Synthase Deficient Mice with Obesity-related Cardiac Lipotoxicity
Canadian Journal of Diabetes
Melissa Glier and Jesse D. Olsen and Rika E. Aleliunas and Diane C. Sulistyoningrum and Sanjoy Ghosh and Tim J. Green and Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.03.081
04/2013

Programming of Adiposity by Gestational Exposure to Folic Acid and Vitamin B12 Imbalance
Canadian Journal of Diabetes
Rika E. Aleliunas and Jesse D. Olson and Abeer Aljaad and Melissa Glier and Ismail Laher and Tim Green and Angela Devlin
DOI: 10.1016/j.jcjd.2013.03.352
04/2013

The Fat Mass and Obesity Associated (FTO) rs9939609 Variant and Cardiometabolic Side-effects in Children Treated With Second-Generation Antipsychotics
Canadian Journal of Diabetes
Anita Cote and Ying F. Ngai and Constadina Panagiotopoulos and Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.03.147
04/2013

Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia.
Epigenetics
DOI: 10.4161/epi.23063
PubMed: 23221482
01/2013

Short-term exercise worsens cardiac oxidative stress and fibrosis in 8-month-old db/db mice by depleting cardiac glutathione.
Free radical research
DOI: 10.3109/10715762.2012.737463
PubMed: 23039789
01/2013

Adiposity and the relationship between vitamin D and blood pressure
Metabolism
Dian C. Sulistyoningrum and Danijela Gasevic and Timothy J. Green and Scott A. Lear and Angela M. Devlin
DOI: 10.1016/j.metabol.2013.07.009
2013

Short Term Exercise Induces PGC-1a, Ameliorates Inflammation and Increases Mitochondrial Membrane Proteins but Fails to Increase Respiratory Enzymes in Aging Diabetic Hearts
PLoS ONE
Botta, A. and Laher, I. and Beam, J. and DeCoffe, D. and Brown, K. and Halder, S. and Devlin, A. and Gibson, D.L. and Ghosh, S.
DOI: 10.1371/journal.pone.0070248
2013

Ethnic-Specific Differences in Vitamin D Status Is Associated with Adiposity
PLoS ONE
Dian C. Sulistyoningrum and Timothy J. Green and Scott A. Lear and Angela M. Devlin
DOI: 10.1371/journal.pone.0043159
08/2012

Epigenetic regulation of glucocorticoid receptor expression in aorta from mice with hyperhomocysteinemia
Epigenetics
Dian C. Sulistyoningrum and Ranji Singh and Angela M. Devlin
DOI: 10.4161/epi.19836
05/2012

Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics.
Translational psychiatry
DOI: 10.1038/tp.2011.68
PubMed: 22832733
2012

Associations of the FTO rs9939609 variant with discrete body fat depots and dietary intake in a multi-ethnic cohort.
Genetics research
DOI: 10.1017/s001667231100036x
PubMed: 22189607
12/2011

Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice.
The Journal of biological chemistry
DOI: 10.1074/jbc.m111.304592
PubMed: 22021075
12/2011

Associations of the FTO rs9939609 variant with discrete body fat depots and dietary intake in a multi-ethnic cohort
Genetics Research
Lear, S.A. and Deng, W.Q. and Par?, G. and Sulistyoningrum, D.C. and Loos, R.J.F. and Devlin, A.
DOI: 10.1017/S001667231100036X
2011

Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice
Journal of Biological Chemistry
Ghosh, S. and Sulistyoningrum, D.C. and Glier, M.B. and Verchere, C.B. and Devlin, A.M.
DOI: 10.1074/jbc.M111.304592
2011

Prenatal Exposure to Maternal Depressed Mood and the MTHFR C677T Variant Affect SLC6A4 Methylation in Infants at Birth
PLoS ONE
Angela M. Devlin and Ursula Brain and Jehannine Austin and Tim F. Oberlander
DOI: 10.1371/journal.pone.0012201
08/2010

Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations.
The British journal of nutrition
DOI: 10.1017/s0007114509993552
PubMed: 20089204
06/2010

Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia.
The Journal of nutrition
DOI: 10.3945/jn.109.112920
PubMed: 20018805
02/2010

Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations
British Journal of Nutrition
Green, T.J. and Skeaff, C.M. and McMahon, J.A. and Venn, B.J. and Williams, S.M. and Devlin, A.M. and Innis, S.M.
DOI: 10.1017/S0007114509993552
2010

Mechanisms of altered fatty acid and phospholipid levels in hyperhomocysteinemia
Clinical Lipidology
Angela M Devlin and Tim J Green
DOI: 10.2217/clp.09.3
04/2009

Mechanisms of altered fatty acid and phospholipid levels in hyperhomocysteinemia
Future Lipidology
Devlin, A.M. and Green, T.J.
DOI: 10.2217/CLP.09.3
2009

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses.
Epigenetics
DOI: 10.4161/epi.3.2.6034
PubMed: 18536531
2008

Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia.
The Journal of biological chemistry
DOI: 10.1074/jbc.m704256200
PubMed: 17971455
12/2007

Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia
Journal of Biological Chemistry
Devlin, A.M. and Singh, R. and Wade, R.E. and Innis, S.M. and Bottiglieri, T. and Lentz, S.R.
DOI: 10.1074/jbc.M704256200
2007

Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population.
The American journal of clinical nutrition
PubMed: 16522921
03/2006

ApoA-I: a missing link between homocysteine and lipid metabolism?
Circulation research
DOI: 10.1161/01.res.0000214406.87060.e0
PubMed: 16514070
03/2006

ApoA-I: A missing link between homocysteine and lipid metabolism?
Circulation Research
Devlin, A.M. and Lentz, S.R.
DOI: 10.1161/01.RES.0000214406.87060.e0
2006

Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population
American Journal of Clinical Nutrition
Devlin, A.M. and Clarke, R. and Birks, J. and Evans, J.G. and Halsted, C.H.
DOI: 10.1093/ajcn.83.3.708
2006

Cerebral vascular dysfunction in methionine synthase-deficient mice.
Circulation
DOI: 10.1161/circulationaha.104.529248
PubMed: 16043641
08/2005

Tissue-specific Changes inH19Methylation and Expression in Mice with Hyperhomocysteinemia
Journal of Biological Chemistry
Angela M. Devlin and Teodoro Bottiglieri and Frederick E. Domann and Steven R. Lentz
DOI: 10.1074/jbc.m504815200
05/2005

Cerebral vascular dysfunction in methionine synthase-deficient mice
Circulation
Dayal, S. and Devlin, A.M. and McCaw, R.B. and Liu, M.-L. and Arning, E. and Bottiglieri, T. and Shane, B. and Faraci, F.M. and Lentz, S.R.
DOI: 10.1161/CIRCULATIONAHA.104.529248
2005

Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia
Journal of Biological Chemistry
Devlin, A.M. and Bottiglieri, T. and Domann, F.E. and Lentz, S.R.
DOI: 10.1074/jbc.M504815200
2005

Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.
Blood
DOI: 10.1182/blood-2003-09-3078
PubMed: 14630804
04/2004

Glutamate carboxipeptidase II (GCPII) His475Tyr polymorphism and association studies
American Journal of Medical Genetics
Alexandre R. Vieira and Angela M. Devlin
DOI: 10.1002/ajmg.a.30241
2004

Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk
Molecular Genetics and Metabolism
Isabelle Morin and Angela M Devlin and Daniel Leclerc and Nelly Sabbaghian and Charles H Halsted and Richard Finnell and Rima Rozen
DOI: 10.1016/s1096-7192(03)00086-6
07/2003

Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk
Molecular Genetics and Metabolism
Morin, I. and Devlin, A.M. and Leclerc, D. and Sabbaghian, N. and Halsted, C.H. and Finnell, R. and Rozen, R.
DOI: 10.1016/S1096-7192(03)00086-6
2003

Metabolic interactions of alcohol and folate.
The Journal of nutrition
PubMed: 12163694
08/2002

Folate deficiency, methionine metabolism, and alcoholic liver disease
Alcohol
Charles H Halsted and Jesus A Villanueva and Angela M Devlin
DOI: 10.1016/s0741-8329(02)00225-2
07/2002

Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.112336399
PubMed: 12122204
07/2002

Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig.
Transactions of the American Clinical and Climatological Association
PubMed: 12053707
2002

Metabolic interactions of alcohol and folate
Journal of Nutrition
Halsted, C.H. and Villanueva, J.A. and Devlin, A.M. and Chandler, C.J.
DOI: 10.1093/jn/132.8.2367s
2002

Folate deficiency, methionine metabolism, and alcoholic liver disease
Alcohol
Halsted, C.H. and Villanueva, J.A. and Devlin, A.M.
DOI: 10.1016/S0741-8329(02)00225-2
2002

Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig.
Transactions of the American Clinical and Climatological Association
Halsted, C.H. and Villanueva, J.A. and Devlin, A.M. and James, S.J.
2002

Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig.
Transactions of the American Clinical and Climatological Association
PubMed: 12053707
2002

Reduced folate carrier: tissue distribution and effects of chronic ethanol intake in the micropig.
Alcoholism, clinical and experimental research
DOI: 10.1111/j.1530-0277.2001.tb02229.x
PubMed: 11290853
03/2001

Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.
Human molecular genetics
DOI: 10.1093/hmg/9.19.2837
PubMed: 11092759
11/2000

Dietary phospholipid alters biliary lipid composition in formula-fed piglets
Lipids
Angela M. Devlin and Sheila M. Innis
DOI: 10.1007/s11745-999-0483-4
1999

Early Diet Influences Hepatic Lipogenesis
Lipids in Infant Nutrition
Sheila Innis and Angela Devlin
DOI: 10.1201/9781439831953.ch17
05/1998

Early diet influences hepatic hydroxymethyl glutaryl coenzyme A reductase and 7alpha-hydroxylase mRNA but not low-density lipoprotein receptor mRNA during development.
Metabolism: clinical and experimental
DOI: 10.1016/s0026-0495(98)90187-1
PubMed: 9440472
01/1998

Dietary long chain polyunsaturated fatty acids alter hepatic sterol metabolism in newborn piglets
FASEB Journal
Devlin, A.M. and Innis, S.M.
1998

Early diet influences hepatic hydroxymethyl glutaryl coenzyme a reductase and 7a-hydroxylase mRNA but not low-density lipoprotein receptor mRNA during development
Metabolism: Clinical and Experimental
Devlin, A.M. and Innis, S.M. and Shukin, R. and Rioux, M.F.
DOI: 10.1016/S0026-0495(98)90187-1
1998

Influence of early diet on hepatic lipid metabolism
FASEB Journal
Devlin, A.M. and Innis, S.M.
1997

Effect of medium-chain triglycerides on calbindin-D9k expression in the intestine
Lipids
Angela Devlin and Sheila M. Innis and Katharine Wall and John Krisinger
DOI: 10.1007/bf02522650
05/1996

Alterations in hepatic cholesterol metabolism during development
FASEB Journal
Devlin, A. and Rioux, F. and Innis, S.M.
1996

Effect of medium-chain triglycerides on calbindin-D9k expression in the intestine
Lipids
Devlin, A. and Innis, S.M. and Wall, K. and Krisinger, J.
DOI: 10.1007/BF02522650
1996

Research

Maternal Diet & Epigenetic Regulation of Gene Expression
The goal of this project is to determine the effect of in utero exposure to changes in maternal homocysteine levels on epigenetic regulation of vascular gene expression in mice. These studies are funded by the Hospital for Sick Children Foundation.

DNA Methylation & Vascular Gene Expression
The goal of this project is to determine the effect of hyperhomocysteinemia, a cardiovascular disease risk factor, on loss of genomic imprinting of H19 , and to determine the role of H19 in the vascular pathology associated with hyperhomocysteinemia in mice. These studies are funded by the American Heart Association.

Grants

NSERC Team Discovery Grant- Project

``Biological effects of folate/cobalamin inbalance in mammals`` (2014-2019)

2016-2017 Healthy Starts Catalyst Grant "Determining the Long Term Metabolic Effects of Neonatal Sucrose Treatment"

Honours & Awards

Establishment Award, BC Research Institute for Children's & Women's Health, 2004

McDonald Scholarship Award, 2006-2007

Research Group Members

Coralie Bergeron, Master Student
Makenna Clement-Ranney, NSERC USRA Student
Adam Hung, Doctoral Student
Mayu Kajino, Visiting researcher
Rida Khan
Aubrey Lee, Volunteer
Zoe Lofft, PhD Student
Taylor Ricci
Alejandra Wiedeman, Research Associate
Christopher Yuen, PhD Student