Recent evidence suggests that a mother's diet during pregnancy can influence the development of cardiovascular disease (CVD) risk factors in their adult children. Currently my research focuses on determining how this occurs. I speculate that maternal diet during pregnancy can influence gene expression in children through epigenetic processes, defined as heritable changes in gene expression that occur without a change in the DNA sequence of the gene. I’m conducting studies in mice to determine the roles of prenatal and early postnatal diet and the role of epigenetic processes in the development of CVD, and am addressing the questions: if diet during adult life can change epigenetic processes, what happens to offspring exposed early in development to a similar nutrient insult, and are there consequences later in life? Overall determining how diet and epigenetic processes contribute to CVD will aid in the development of early screening tools for at-risk children, and novel therapeutic targets for prevention and treatment of CVD.


Children's stress regulation mediates the association between prenatal maternal mood and child executive functions for boys, but not girls
Development and Psychopathology
Regula Neuenschwander and Kaia Hookenson and Ursula Brain and Ruth E. Grunau and Angela M. Devlin and Joanne Weinberg and Adele Diamond and Tim F. Oberlander
DOI: 10.1017/s095457941800041x

Maternal Exercise Improves Glucose Homeostasis and Vascular Health in Male Offspring
Atherosclerosis Supplements
Nicha Boonpattrawong and Saeid Golbidi and Ismail Laher and Angela Devlin
DOI: 10.1016/j.atherosclerosissup.2018.04.048

l-5-Methyltetrahydrofolate Supplementation Increases Blood Folate Concentrations to a Greater Extent than Folic Acid Supplementation in Malaysian Women
The Journal of Nutrition
Amanda M Henderson and Rika E Aleliunas and Su Peng Loh and Geok Lin Khor and Sarah Harvey-Leeson and Melissa B Glier and David D Kitts and Tim J Green and Angela M Devlin
DOI: 10.1093/jn/nxy057

Abnormal Ambulatory Blood Pressure and Adiposity Predict Carotid Intima Media Thickness in Children with Type 1 Diabetes
Atherosclerosis Supplements
Sinead Glackin and Nazrul Islam and Janis Dionne and Constadina Panagiotopolous and Angela Devlin
DOI: 10.1016/j.atherosclerosissup.2018.04.066

Adiposity and Carotid Intima Media Thickness in Children with Type 1 Diabetes
Atherosclerosis Supplements
Sinead Glackin and Nazrul Islam and Kevin Harris and Constadina Panagiotopolous and Angela Devlin
DOI: 10.1016/j.atherosclerosissup.2018.04.215

Comparison of a New Multiplex Immunoassay for Measurement of Ferritin, Soluble Transferrin Receptor, Retinol-Binding Protein, C-Reactive Protein and a1-Acid-glycoprotein Concentrations against a Widely-Used s-ELISA Method
Crystal Karakochuk and Amanda Henderson and Kaitlyn Samson and Abeer Aljaadi and Angela Devlin and Elodie Becquey and James Wirth and Fabian Rohner
DOI: 10.3390/diagnostics8010013

Diet and cardiometabolic side effects in children treated with second-generation antipsychotics
Clinical Nutrition ESPEN
Mikaela K. Barker and Carly M. Sable and Sarah E. Montgomery and Lorrie Chow and Timothy J. Green and Constadina Panagiotopoulos and Angela M. Devlin
DOI: 10.1016/j.clnesp.2017.09.013

Developmental Outcomes at 24 Months of Age in Toddlers Supplemented with Arachidonic Acid and Docosahexaenoic Acid: Results of a Double Blind Randomized, Controlled Trial.
DOI: 10.3390/nu9090975
PubMed: 28878181

Serum Soluble Transferrin Receptor Concentrations Are Elevated in Congolese Children with Glucose-6-Phosphate Dehydrogenase Variants, but Not Sickle Cell Variants or a-Thalassemia.
The Journal of nutrition
DOI: 10.3945/jn.117.252635
PubMed: 28768839

The effect of oral iron with or without multiple micronutrients on hemoglobin concentration and hemoglobin response among nonpregnant Cambodian women of reproductive age: a 2 x 2 factorial, double-blind, randomized controlled supplementation trial.
The American journal of clinical nutrition
DOI: 10.3945/ajcn.116.140996
PubMed: 28490515

The Val66Met brain-derived neurotrophic factor gene variant interacts with early pain exposure to predict cortisol dysregulation in 7-year-old children born very preterm: Implications for cognition.
DOI: 10.1016/j.neuroscience.2015.08.044
PubMed: 26318333

Prevalence and Predictors of Low Vitamin B6 Status in Healthy Young Adult Women in Metro Vancouver
Chia-ling Ho and Teo Quay and Angela Devlin and Yvonne Lamers
DOI: 10.3390/nu8090538

Sculpting infant soothability: the role of prenatal SSRI antidepressant exposure and neonatal SLC6A4 methylation status.
Developmental psychobiology
DOI: 10.1002/dev.21414
PubMed: 27254389

Folic Acid Supplementation of Female Mice, with or without Vitamin B-12, before and during Pregnancy and Lactation Programs Adiposity and Vascular Health in Adult Male Offspring.
The Journal of nutrition
PubMed: 26962174

High prevalence of suboptimal vitamin B12 status in young adult women of South Asian and European ethnicity.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
DOI: 10.1139/apnm-2015-0200
PubMed: 26579949

Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain.
American journal of physiology. Regulatory, integrative and comparative physiology
DOI: 10.1152/ajpregu.00075.2015
PubMed: 26180184

Metabolic side effects and pharmacogenetics of second-generation antipsychotics in children
Angela M Devlin and Constadina Panagiotopoulos
DOI: 10.2217/pgs.15.55

Obesity and arterial stiffness in children: systematic review and meta-analysis.
Arteriosclerosis, thrombosis, and vascular biology
DOI: 10.1161/atvbaha.114.305062
PubMed: 25633314

Interaction between the Val158Met catechol-O-methyltransferase gene variant and second-generation antipsychotic treatment on blood pressure in children.
The pharmacogenomics journal
DOI: 10.1038/tpj.2014.35
PubMed: 25048416

Genetic hemoglobin disorders rather than iron deficiency are a major predictor of hemoglobin concentration in women of reproductive age in rural prey Veng, Cambodia.
The Journal of nutrition
DOI: 10.3945/jn.114.198945
PubMed: 25527668

Initial screening of children treated with second-generation antipsychotics points to an association between physical activity and insulin resistance.
Pediatric exercise science
DOI: 10.1123/pes.2014-0076
PubMed: 25372380

Childhood obesity, arterial stiffness, and prevalence and treatment of hypertension.
Current treatment options in cardiovascular medicine
DOI: 10.1007/s11936-014-0339-9
PubMed: 25248796

Quetiapine treatment in youth is associated with decreased insulin secretion.
Journal of clinical psychopharmacology
DOI: 10.1097/jcp.0000000000000118
PubMed: 24633003

Chronic intermittent hypoxia causes endothelial dysfunction in a mouse model of diet-induced obesity.
Sleep medicine
DOI: 10.1016/j.sleep.2014.01.013
PubMed: 24767726

Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age.
Frontiers in Behavioral Neuroscience
DOI: 10.3389/fnbeh.2014.00409
PubMed: 25520635

Left ventricular mechanics and arterial-ventricular coupling following high-intensity interval exercise.
Journal of applied physiology (Bethesda, Md. : 1985)
DOI: 10.1152/japplphysiol.00576.2013
PubMed: 24052036

Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study.
Cardiovascular diabetology
DOI: 10.1186/1475-2840-12-170
PubMed: 24225161

Childhood obesity and cardiovascular dysfunction.
Journal of the American College of Cardiology
DOI: 10.1016/j.jacc.2013.07.042
PubMed: 23954339

Dysfunctional Cardiac Lipid Metabolism in Cystathionine-Beta-Synthase Deficient Mice With Diet-Induced Weight Gain
Canadian Journal of Cardiology
MB Glier and JD Olson and SL Gerrard and RE Aleliunas and DC Sulistyoningrum and TJ Green and AM Devlin and AM Devlin
DOI: 10.1016/j.cjca.2013.07.264

Programming of Glucose Homeostasis by Developmental Exposure to Folic Acid and Vitamin B12 Imbalance in Female Mice
Canadian Journal of Diabetes
Jesse D. Olson and Rika E. Aleiunas and Melissa B. Glier and Abeer M. Aljaadi and Tim J. Green and Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.08.213

Antidepressant use during pregnancy and serotonin transporter genotype (SLC6A4) affect newborn serum reelin levels.
Developmental psychobiology
DOI: 10.1002/dev.21056
PubMed: 22692766

Methyl nutrients, DNA methylation, and cardiovascular disease
Molecular Nutrition & Food Research
Melissa B. Glier and Timothy J. Green and Angela M. Devlin
DOI: 10.1002/mnfr.201200636

Visceral Adiposity and The Relationship Between Vitamin D and Adiponectin
Canadian Journal of Diabetes
Dian Sulistyoningrum and Danijela Gasevic and Scott Lear and Angela Devlin
DOI: 10.1016/j.jcjd.2013.03.226

Dysfunctional Cardiac Lipid Metabolism in Cystathionine-Beta-Synthase Deficient Mice with Obesity-related Cardiac Lipotoxicity
Canadian Journal of Diabetes
Melissa Glier and Jesse D. Olsen and Rika E. Aleliunas and Diane C. Sulistyoningrum and Sanjoy Ghosh and Tim J. Green and Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.03.081

Programming of Adiposity by Gestational Exposure to Folic Acid and Vitamin B12 Imbalance
Canadian Journal of Diabetes
Rika E. Aleliunas and Jesse D. Olson and Abeer Aljaad and Melissa Glier and Ismail Laher and Tim Green and Angela Devlin
DOI: 10.1016/j.jcjd.2013.03.352

The Fat Mass and Obesity Associated (FTO) rs9939609 Variant and Cardiometabolic Side-effects in Children Treated With Second-Generation Antipsychotics
Canadian Journal of Diabetes
Anita Cote and Ying F. Ngai and Constadina Panagiotopoulos and Angela M. Devlin
DOI: 10.1016/j.jcjd.2013.03.147

Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia.
DOI: 10.4161/epi.23063
PubMed: 23221482

Short-term exercise worsens cardiac oxidative stress and fibrosis in 8-month-old db/db mice by depleting cardiac glutathione.
Free radical research
DOI: 10.3109/10715762.2012.737463
PubMed: 23039789

Adiposity and the relationship between vitamin D and blood pressure
Dian C. Sulistyoningrum and Danijela Gasevic and Timothy J. Green and Scott A. Lear and Angela M. Devlin
DOI: 10.1016/j.metabol.2013.07.009

Short term exercise induces PGC-1a, ameliorates inflammation and increases mitochondrial membrane proteins but fails to increase respiratory enzymes in aging diabetic hearts.
PloS one
DOI: 10.1371/journal.pone.0070248
PubMed: 23936397

Ethnic-Specific Differences in Vitamin D Status Is Associated with Adiposity
Dian C. Sulistyoningrum and Timothy J. Green and Scott A. Lear and Angela M. Devlin
DOI: 10.1371/journal.pone.0043159

Epigenetic regulation of glucocorticoid receptor expression in aorta from mice with hyperhomocysteinemia
Dian C. Sulistyoningrum and Ranji Singh and Angela M. Devlin
DOI: 10.4161/epi.19836

Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics.
Translational psychiatry
DOI: 10.1038/tp.2011.68
PubMed: 22832733

Associations of the FTO rs9939609 variant with discrete body fat depots and dietary intake in a multi-ethnic cohort.
Genetics research
DOI: 10.1017/s001667231100036x
PubMed: 22189607

Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice.
The Journal of biological chemistry
DOI: 10.1074/jbc.m111.304592
PubMed: 22021075

Prenatal Exposure to Maternal Depressed Mood and the MTHFR C677T Variant Affect SLC6A4 Methylation in Infants at Birth
Angela M. Devlin and Ursula Brain and Jehannine Austin and Tim F. Oberlander
DOI: 10.1371/journal.pone.0012201

Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations.
The British journal of nutrition
DOI: 10.1017/s0007114509993552
PubMed: 20089204

Hepatic acyl-coenzyme a:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia.
The Journal of nutrition
DOI: 10.3945/jn.109.112920
PubMed: 20018805

Mechanisms of altered fatty acid and phospholipid levels in hyperhomocysteinemia
Clinical Lipidology
Angela M Devlin and Tim J Green
DOI: 10.2217/clp.09.3

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses.
DOI: 10.4161/epi.3.2.6034
PubMed: 18536531

Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia.
The Journal of biological chemistry
DOI: 10.1074/jbc.m704256200
PubMed: 17971455

Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population.
The American journal of clinical nutrition
PubMed: 16522921

ApoA-I: a missing link between homocysteine and lipid metabolism?
Circulation research
DOI: 10.1161/01.res.0000214406.87060.e0
PubMed: 16514070

Cerebral vascular dysfunction in methionine synthase-deficient mice.
DOI: 10.1161/circulationaha.104.529248
PubMed: 16043641

Tissue-specific Changes inH19Methylation and Expression in Mice with Hyperhomocysteinemia
Journal of Biological Chemistry
Angela M. Devlin and Teodoro Bottiglieri and Frederick E. Domann and Steven R. Lentz
DOI: 10.1074/jbc.m504815200

Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.
DOI: 10.1182/blood-2003-09-3078
PubMed: 14630804

Glutamate carboxipeptidase II (GCPII) His475Tyr polymorphism and association studies
American Journal of Medical Genetics
Alexandre R. Vieira and Angela M. Devlin
DOI: 10.1002/ajmg.a.30241

Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk
Molecular Genetics and Metabolism
Isabelle Morin and Angela M Devlin and Daniel Leclerc and Nelly Sabbaghian and Charles H Halsted and Richard Finnell and Rima Rozen
DOI: 10.1016/s1096-7192(03)00086-6

Metabolic interactions of alcohol and folate.
The Journal of nutrition
PubMed: 12163694

Folate deficiency, methionine metabolism, and alcoholic liver disease
Charles H Halsted and Jesus A Villanueva and Angela M Devlin
DOI: 10.1016/s0741-8329(02)00225-2

Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.112336399
PubMed: 12122204

Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig.
Transactions of the American Clinical and Climatological Association
PubMed: 12053707

Reduced folate carrier: tissue distribution and effects of chronic ethanol intake in the micropig.
Alcoholism, clinical and experimental research
DOI: 10.1111/j.1530-0277.2001.tb02229.x
PubMed: 11290853

Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.
Human molecular genetics
DOI: 10.1093/hmg/9.19.2837
PubMed: 11092759

Dietary phospholipid alters biliary lipid composition in formula-fed piglets
Angela M. Devlin and Sheila M. Innis
DOI: 10.1007/s11745-999-0483-4

Early Diet Influences Hepatic Lipogenesis
Lipids in Infant Nutrition
Sheila Innis and Angela Devlin
DOI: 10.1201/9781439831953.ch17

Early diet influences hepatic hydroxymethyl glutaryl coenzyme A reductase and 7alpha-hydroxylase mRNA but not low-density lipoprotein receptor mRNA during development.
Metabolism: clinical and experimental
DOI: 10.1016/s0026-0495(98)90187-1
PubMed: 9440472

Effect of medium-chain triglycerides on calbindin-D9k expression in the intestine
Angela Devlin and Sheila M. Innis and Katharine Wall and John Krisinger
DOI: 10.1007/bf02522650


Maternal Diet & Epigenetic Regulation of Gene Expression
The goal of this project is to determine the effect of in utero exposure to changes in maternal homocysteine levels on epigenetic regulation of vascular gene expression in mice. These studies are funded by the Hospital for Sick Children Foundation.

DNA Methylation & Vascular Gene Expression
The goal of this project is to determine the effect of hyperhomocysteinemia, a cardiovascular disease risk factor, on loss of genomic imprinting of H19 , and to determine the role of H19 in the vascular pathology associated with hyperhomocysteinemia in mice. These studies are funded by the American Heart Association.


NSERC Team Discovery Grant- Project

``Biological effects of folate/cobalamin inbalance in mammals`` (2014-2019)

2016-2017 Healthy Starts Catalyst Grant "Determining the Long Term Metabolic Effects of Neonatal Sucrose Treatment"

Honours & Awards

Establishment Award, BC Research Institute for Children's & Women's Health, 2004

McDonald Scholarship Award, 2006-2007

Research Group Members

Abeer Aljaadi, Trainee
Nicha Boonpattrawong, Graduate Research Assistant
Danielle Cohen, Undergraduate Student
Josef Goetz, Summer Student
Ashley Jang, Volunteer
Ei-Xia Mussai, Doctoral Student
Cynthia Yamilka Ramírez Contreras, Master Student, Master Student
Martina Stokes, Volunteer
Alejandra Wiedeman, Postdoctoral Fellow