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Angela Devlin
PhD, BSc

Investigator, BC Children's Hospital
Co-Director, Women+ and Children’s Health Research Graduate Program, The University of British Columbia
Associate Director, Foundational Science, BC Children's Hospital Research Institute

Recent evidence suggests that a mother's diet during pregnancy can influence the development of cardiovascular disease (CVD) risk factors in their adult children. Currently my research focuses on determining how this occurs. I speculate that maternal diet during pregnancy can influence gene expression in children through epigenetic processes, defined as heritable changes in gene expression that occur without a change in the DNA sequence of the gene. I’m conducting studies in mice to determine the roles of prenatal and early postnatal diet and the role of epigenetic processes in the development of CVD, and am addressing the questions: if diet during adult life can change epigenetic processes, what happens to offspring exposed early in development to a similar nutrient insult, and are there consequences later in life? Overall determining how diet and epigenetic processes contribute to CVD will aid in the development of early screening tools for at-risk children, and novel therapeutic targets for prevention and treatment of CVD.

Academic Affiliations

  • Professor, Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Healthy Starts
  • Research Group(s): Diabetes; Origins of Child Health and Disease

Contact Information

Location

950 West 28th Ave, Vancouver, BC, Canada, V6Z 4H4

(604) 875-2000 ext. 5378

adevlin@bcchr.ubc.ca

Higher Prevalence of Inadequate Vitamin D Intake in Toddlers Not Consuming a Vitamin D Supplement in Vancouver, Canada

The Journal of Nutrition

Alejandra M Wiedeman and Victoria M Lampkemeyer and Timothy J Green and Constadina Panagiotopoulos and Rajavel Elango and Angela M Devlin

DOI: 10.1016/j.tjnut.2026.101382

04 / 2026

Exploring pulse wave velocity as a vascular hemodynamic stress marker: more than just arterial stiffening?

American Journal of Physiology-Heart and Circulatory Physiology

Christopher Yuen and Angela M. Devlin and Pascal Bernatchez

DOI: 10.1152/ajpheart.00638.2025

01 / 2026

Folate

Advances in Nutrition

Lofft, Z. and Green, T.J. and Devlin, A.M.

DOI: 10.1016/j.advnut.2025.100519

Folic acid supplementation in children with sickle cell disease: a randomized double-blind noninferiority cross-over trial

American Journal of Clinical Nutrition

Williams, B.A. and McCartney, H. and Singer, J. and Devlin, A.M. and Vercauteren, S. and Amid, A. and Wu, J.K. and Karakochuk, C.D.

DOI: 10.1016/j.ajcnut.2025.02.001

Understanding vascular complications in children from type 1 diabetes diagnosis: protocol for a prospective cohort study in Vancouver, Canada

BMJ Open

Wiedeman, A.M. and Panagiotopoulos, C. and Devlin, A.M.

DOI: 10.1136/bmjopen-2024-093842

Women in Canada are consuming above the upper intake level of folic acid but few are meeting dietary choline recommendations in the second trimester of pregnancy: data from the CHILD cohort study

Applied Physiology, Nutrition and Metabolism

Wiedeman, A.M. and Miliku, K. and Moraes, T.J. and Mandhane, P.J. and Simons, E. and Subbarao, P. and Turvey, S.E. and Zwicker, J.G. and Devlin, A.M.

DOI: 10.1139/apnm-2023-0258

Supplementation with (6S)-5-methyltetrahydrofolic acid appears as effective as folic acid in maintaining maternal folate status while reducing unmetabolised folic acid in maternal plasma: a randomised trial of pregnant women in Canada

British Journal of Nutrition

Cochrane, K.M. and Elango, R. and Devlin, A.M. and Mayer, C. and Hutcheon, J.A. and Karakochuk, C.D.

DOI: 10.1017/S0007114523001733

Vascular Complications in Children with Type 1 Diabetes: Protocol of a Scoping Review

OSF Registries

DOI: 10.17605/osf.io/kcxp2

Prenatal serotonin reuptake inhibitor antidepressant exposure, SLC6A4 genetic variations, and cortisol activity in 6-year-old children of depressed mothers: A cohort study

Developmental Psychobiology

Zusman, E.Z. and Chau, C.M.Y. and Bone, J.N. and Hookenson, K. and Brain, U. and Glier, M.B. and Grunau, R.E. and Weinberg, J. and Devlin, A.M. and Oberlander, T.F.

DOI: 10.1002/dev.22425

Folic acid supplementation in a mouse model of diabetes in pregnancy alters insulin sensitivity in female mice and beta cell mass in offspring

FASEB Journal

Mussai, E.-X. and Lofft, Z.A. and Vanderkruk, B. and Boonpattrawong, N. and Miller, J.W. and Smith, A. and Bottiglieri, T. and Devlin, A.M.

DOI: 10.1096/fj.202301491R

Children Aged 5"6 Years in Vancouver, Canada Meet Dietary Recommendations for Folate and Vitamin B12 but not Choline

Journal of Nutrition

Wiedeman, A.M. and Dhillon, A.K. and Wu, B.T. and Innis, S.M. and Elango, R. and Devlin, A.M.

DOI: 10.1016/j.tjnut.2022.11.012

Riboflavin intake and status and relationship to anemia

Nutrition Reviews

Aljaadi, A.M. and Devlin, A.M. and Green, T.J.

DOI: 10.1093/nutrit/nuac043

Maternal nutrition and effects on offspring vascular function

Pflugers Archiv European Journal of Physiology

Ricci, T.A. and Boonpattrawong, N. and Laher, I. and Devlin, A.M.

DOI: 10.1007/s00424-023-02807-x

Human milk unmetabolized folic acid is increased following supplementation with synthetic folic acid as compared to (6S)-5-methyltetrahydrofolic acid

Scientific Reports

Cochrane, K.M. and Elango, R. and Devlin, A.M. and Hutcheon, J.A. and Karakochuk, C.D.

DOI: 10.1038/s41598-023-38224-4

Global Vitamin D Intake and its Relation to Status in Children 1-10 Years of Age: A Scoping Review (Protocol)

OSF Registries

DOI: 10.17605/osf.io/a7vmb

The FTO rs9939609 Variant Is Associated with Cardiometabolic Disease Risk and Dietary Energy Intakes in Children with Mental Health Disorders

Current Developments in Nutrition

Wiedeman, A.M. and Ngai, Y.F. and Henderson, A.M. and Panagiotopoulos, C. and Devlin, A.M.

DOI: 10.1093/cdn/nzac014

Thermoneutral Housing and a Western Diet Combination Exacerbates Dysferlin-Deficient Muscular Dystrophy

Muscle and Nerve

Donen, G.S. and White, Z. and Sauge, E. and Ritso, M. and Theret, M. and Boyd, J. and Devlin, A.M. and Rossi, F.M.V. and Bernatchez, P.

DOI: 10.1002/mus.27680

Greater Arterial Stiffness in Children with or without Second-generation Antipsychotic Treatment for Mental Health Disorders: Rigidit Artrielle Plus Importante Chez Les Enfants Avec ou Sans Traitement Par Antipsychotiques de la Deuxime Gnration Pour des Troubles de Sant Mentale

The Canadian Journal of Psychiatry

Amanda M. Henderson and Nazrul Islam and George G. S. Sandor and Constadina Panagiotopoulos and Angela M. Devlin

DOI: 10.1177/0706743720974838

07 / 2021

Detectable Unmetabolized Folic Acid and Elevated Folate Concentrations in Folic Acid-Supplemented Canadian Children With Sickle Cell Disease.

Frontiers in nutrition

Williams BA and Mayer C and McCartney H and Devlin AM and Lamers Y and Vercauteren SM and Wu JK and Karakochuk CD

DOI: 10.3389/fnut.2021.642306 PubMed: 33968971

04 / 2021

Dietary Riboflavin Intake and Riboflavin Status in Young Adult Women Living in Metro Vancouver, Canada

Current Developments in Nutrition

Abeer M Aljaadi and Alejandra M Wiedeman and Susan I Barr and Angela M Devlin and Tim J Green

DOI: 10.1093/cdn/nzab021

04 / 2021

Sex-specific effects of neonatal oral sucrose treatment on growth and liver choline and glucocorticoid metabolism in adulthood

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Ram{\'i}rez-Contreras, C.Y. and Mehran, A.E. and Salehzadeh, M. and Mussai, E.-X. and Miller, J.W. and Smith, A. and Ranger, M. and Holsti, L. and Soma, K.K. and Devlin, A.M.

DOI: 10.1152/ajpregu.00091.2021

Daily oral supplementation with 60 mg of elemental iron for 12 weeks alters blood mitochondrial dna content, but not leukocyte telomere length in cambodian women

Nutrients

Steele, S.L. and Hsieh, A.Y.Y. and Gadawski, I. and Kroeun, H. and Barr, S.I. and Devlin, A.M. and C{\^o}t{\'e}, H.C.F. and Karakochuk, C.D.

DOI: 10.3390/nu13061877

Treatment-related weight gain and metabolic complications in children with mental health disorders: Potential role for lifestyle interventions

Applied Physiology, Nutrition, and Metabolism

Alejandra M Wiedeman and Constadina Panagiotopoulos and Angela M. Devlin

DOI: 10.1139/apnm-2020-0259

11 / 2020

Exercise during pregnancy mitigates the adverse effects of maternal obesity on adult male offspring vascular function and alters one-carbon metabolism

Physiological Reports

Nicha P. Boonpattrawong and Saeid Golbidi and Daven C. Tai and Rika E. Aleliunas and Pascal Bernatchez and Joshua W. Miller and Ismail Laher and Angela M. Devlin

DOI: 10.14814/phy2.14582

09 / 2020

Assessing the Effectiveness of Targeted Social Media and Printed Posters as Tools to Recruit Pregnant Women to a Nutrition Trial in Vancouver, Canada.

Current developments in nutrition

Cochrane K and Karakochuk C and Mayer C and Devlin A and Elango R and Hutcheon J

05 / 2020

Assessing the Effectiveness of Targeted Social Media and Printed Posters as Tools to Recruit Pregnant Women to a Nutrition Trial in Vancouver, Canada

Current Developments in Nutrition

Kelsey Cochrane and Crystal Karakochuk and Chantal Mayer and Angela Devlin and Rajavel Elango and Jennifer Hutcheon

DOI: 10.1093/cdn/nzaa056_012

05 / 2020

Folic Acid Supplementation in Children with Sickle Cell Disease: Study Protocol for a Double-Blind Randomized Cross-Over Trial

Williams BA and McCartney H and Adams E and Devlin AM and Singer J and Vercauteren S and Wu JK and Karakochuk CD

DOI: 10.21203/rs.3.rs-30458/v1

05 / 2020

Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study

Cochrane KM and Mayer C and Devlin AM and Elango R and Hutcheon JA and Karakochuk CD

DOI: 10.21203/rs.2.18214/v2

03 / 2020

Ambulatory blood pressure and carotid intima media thickness in children with type 1 diabetes

Pediatric Diabetes

Sinead Glackin and Nazrul Islam and Amanda M. Henderson and Janis M. Dionne and Kevin C. Harris and Constadina Panagiotopoulos and Angela M. Devlin

DOI: 10.1111/pedi.12960

03 / 2020

Biomarkers of Docosahexaenoic Acid but Not Arachidonic Acid Reflect Dietary Intakes in Toddlers at Ages 1 and 2 Years Who Are Not Meeting Dietary Recommendations

Journal of Nutrition

Wiedeman, A.M. and Dyer, R.A. and McCarthy, D. and Yurko-Mauro, K. and Innis, S.M. and Devlin, A.M.

DOI: 10.1093/jn/nxz280

Sheila M. Innis, PhD, RD (1953-2016): A Pioneer and Innovator Influencing the Maternal and Infant Nutrition Field

The Journal of nutrition

Field, C.J. and Devlin, A.M. and Atkinson, S.

DOI: 10.1093/jn/nxaa078

459-P: Risk for Type 2 Diabetes and Cardiovascular Health in Children Treated with Second-Generation Antipsychotics

Diabetes

AMANDA M. HENDERSON and NAZRUL ISLAM and GEORGE GABOR SANDOR and CONSTADINA PANAGIOTOPOULOS and ANGELA M. DEVLIN

DOI: 10.2337/db19-459-p

06 / 2019

290-LB: Repeated Neonatal Oral Sucrose Treatment Affects Growth and Insulin-Like Growth Factor-1 in Mice

Diabetes

CYNTHIA YAMILKA RAMIREZ CONTRERAS and EI-XIA MUSSAI and ALEJANDRA M. WIEDEMAN and ARYA MEHRAN and MELODY SALEHZADEH and NICHA BOONPATTRAWONG and MANON RANGER and KIRAN K. SOMA and LIISA HOLSTI and ANGELA M. DEVLIN

DOI: 10.2337/db19-290-lb

06 / 2019

1395-P: Maternal Exercise during Pregnancy Affects Offspring Adiposity through One Carbon Metabolism Cycle

Diabetes

NICHA BOONPATTRAWONG and ARYA MEHRAN and ISMAIL LAHER and ANGELA M. DEVLIN

DOI: 10.2337/db19-1395-p

06 / 2019

70-LB: Fat Mass and Obesity-Associated rs9939609 Gene Variant Is Related to Fasting Glucose in Children with Mental Health Conditions

Diabetes

ALEJANDRA M. WIEDEMAN and YING FAI NGAI and AMANDA M. HENDERSON and CONSTADINA PANAGIOTOPOULOS and ANGELA M. DEVLIN

DOI: 10.2337/db19-70-lb

06 / 2019

Impact of Prenatal Selective Serotonin Reuptake Inhibitor Antidepressant Exposure and Maternal Mood on Physical Activity, Dietary Intake, and Markers of Adiposity at Age 6 Years

Journal of Developmental & Behavioral Pediatrics

Sarah M. Hutchison and Louise C. Msse and Melissa B. Glier and Ursula Brain and Angela M. Devlin and Tim F. Oberlander

DOI: 10.1097/dbp.0000000000000658

03 / 2019

Suboptimal Biochemical Riboflavin Status Is Associated with Lower Hemoglobin and Higher Rates of Anemia in a Sample of Canadian and Malaysian Women of Reproductive Age

Journal of Nutrition

Aljaadi, A.M. and How, R.E. and Loh, S.P. and Hunt, S.E. and Karakochuk, C.D. and Barr, S.I. and McAnena, L. and Ward, M. and McNulty, H. and Khor, G.L. and Devlin, A.M. and Green, T.J.

DOI: 10.1093/jn/nxz151

Adiposity and Carotid Intima Media Thickness in Children with Type 1 Diabetes

Atherosclerosis Supplements

Sinead Glackin and Nazrul Islam and Kevin Harris and Constadina Panagiotopolous and Angela Devlin

DOI: 10.1016/j.atherosclerosissup.2018.04.215

06 / 2018

Abnormal Ambulatory Blood Pressure and Adiposity Predict Carotid Intima Media Thickness in Children with Type 1 Diabetes

Atherosclerosis Supplements

Sinead Glackin and Nazrul Islam and Janis Dionne and Constadina Panagiotopolous and Angela Devlin

DOI: 10.1016/j.atherosclerosissup.2018.04.066

06 / 2018

Maternal Exercise Improves Glucose Homeostasis and Vascular Health in Male Offspring

Atherosclerosis Supplements

Nicha Boonpattrawong and Saeid Golbidi and Ismail Laher and Angela Devlin

DOI: 10.1016/j.atherosclerosissup.2018.04.048

06 / 2018

Maternal folic acid supplementation with vitamin B 12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet

The FASEB Journal

Amanda M. Henderson and Daven C. Tai and Rika E. Aleliunas and Abeer M. Aljaadi and Melissa B. Glier and Eric E. Xu and Joshua W. Miller and C. Bruce Verchere and Tim J. Green and Angela M. Devlin

DOI: 10.1096/fj.201701503rr

04 / 2018

Comparison of a New Multiplex Immunoassay for Measurement of Ferritin, Soluble Transferrin Receptor, Retinol-Binding Protein, C-Reactive Protein and a1-Acid-glycoprotein Concentrations against a Widely-Used s-ELISA Method

Diagnostics

Crystal Karakochuk and Amanda Henderson and Kaitlyn Samson and Abeer Aljaadi and Angela Devlin and Elodie Becquey and James Wirth and Fabian Rohner

DOI: 10.3390/diagnostics8010013

02 / 2018

CHIPS-Child: Testing the developmental programming hypothesis in the offspring of the CHIPS trial

Pregnancy Hypertension

Magee, L.A. and Synnes, A.R. and von Dadelszen, P. and Hutfield, A.M. and Chanoine, J.-P. and Ct, A.-M. and Devlin, A.M. and Dorling, J. and Gafni, A. and Ganzevoort, W. and Helewa, M.E. and Hutton, E.K. and Koren, G. and Lee, S.K. and Mcarthur, D. and Rey, E. and Robinson, W.P. and Roseboom, T.J. and Singer, J. and Wilson, S. and Moutquin, J.M.

DOI: 10.1016/j.preghy.2018.04.021

Risperidone But Not Quetiapine Treatment Is Associated With Increased Appetite But Not Satiety Hormones in Children During An Oral Glucose Tolerance Test

Journal of Clinical Psychopharmacology

Ying Fai Ngai and Angela M. Devlin and Constadina Panagiotopoulos

DOI: 10.1097/jcp.0000000000000956

L-5-methyltetrahydrofolate supplementation increases blood folate concentrations to a greater extent than folic acid supplementation in Malaysian women

Journal of Nutrition

Henderson, A.M. and Aleliunas, R.E. and Loh, S.P. and Khor, G.L. and Harvey-Leeson, S. and Glier, M.B. and Kitts, D.D. and Green, T.J. and Devlin, A.M.

DOI: 10.1093/jn/nxy057

Children's stress regulation mediates the association between prenatal maternal mood and child executive functions for boys, but not girls

Development and Psychopathology

Neuenschwander, R. and Hookenson, K. and Brain, U. and Grunau, R.E. and Devlin, A.M. and Weinberg, J. and Diamond, A. and Oberlander, T.F.

DOI: 10.1017/S095457941800041X

Diet and cardiometabolic side effects in children treated with second-generation antipsychotics

Clinical Nutrition ESPEN

Barker, M.K. and Sable, C.M. and Montgomery, S.E. and Chow, L. and Green, T.J. and Panagiotopoulos, C. and Devlin, A.M.

DOI: 10.1016/j.clnesp.2017.09.013

Plasma betaine is positively associated with developmental outcomes in healthy toddlers at age 2 years who are not meeting the recommended adequate intake for dietary choline

Journal of Nutrition

Wiedeman, A.M. and Chau, C.M.Y. and Grunau, R.E. and McCarthy, D. and Yurko-Mauro, K. and Dyer, R.A. and Innis, S.M. and Devlin, A.M.

DOI: 10.1093/jn/nxy108

Serum soluble transferrin receptor concentrations are elevated in Congolese children with glucose-6-phosphate dehydrogenase variants, but not sickle cell variants or a-thalassemia

Journal of Nutrition

Barker, M.K. and Henderson, A.M. and Naguib, K. and Vercauteren, S.M. and Devlin, A.M. and Albert, A.Y. and Bahizire, E. and Tugirimana, P.L. and Akilimali, P.Z. and Boy, E. and Green, T.J. and Karakochuk, C.D.

DOI: 10.3945/jn.117.252635

Developmental Outcomes at 24 Months of Age in Toddlers Supplemented with Arachidonic Acid and Docosahexaenoic Acid: Results of a Double Blind Randomized, Controlled Trial

Nutrients

Devlin, A.M. and Chau, C.M.Y. and Dyer, R. and Matheson, J. and McCarthy, D. and Yurko-Mauro, K. and Innis, S.M. and Grunau, R.E.

DOI: 10.3390/nu9090975

The effect of oral iron with or without multiple micronutrients on hemoglobin concentration and hemoglobin response among nonpregnant Cambodian women of reproductive age: A 2 - 2 factorial, double-blind, randomized controlled supplementation trial

American Journal of Clinical Nutrition

Karakochuk, C.D. and Barker, M.K. and Whitfield, K.C. and Barr, S.I. and Vercauteren, S.M. and Devlin, A.M. and Hutcheon, J.A. and Houghton, L.A. and Prak, S. and Hou, K. and Chai, T.L. and Stormer, A. and Ly, S. and Devenish, R. and Oberkanins, C. and Phringer, H. and Harding, K.B. and De-Regil, L.M. and Kraemer, K. and Green, T.J.

DOI: 10.3945/ajcn.116.140996

The Val66Met brain-derived neurotrophic factor gene variant interacts with early pain exposure to predict cortisol dysregulation in 7-year-old children born very preterm: Implications for cognition

Neuroscience

Chau, C.M.Y. and Cepeda, I.L. and Devlin, A.M. and Weinberg, J. and Grunau, R.E.

DOI: 10.1016/j.neuroscience.2015.08.044

Folic Acid Supplementation of Female Mice, with or without Vitamin B-12, before and during Pregnancy and Lactation Programs Adiposity and Vascular Health in Adult Male Offspring.

The Journal of nutrition

PubMed: 26962174

03 / 2016

Folic acid supplementation of female mice, with or without vitamin B-12, before and during pregnancy and lactation programs adiposity and vascular health in adult male offspring

Journal of Nutrition

Aleliunas, R.E. and Aljaadi, A.M. and Laher, I. and Glier, M.B. and Green, T.J. and Murphy, M. and Miller, J.W. and Devlin, A.M.

DOI: 10.3945/jn.115.227629

Sculpting infant soothability: the role of prenatal SSRI antidepressant exposure and neonatal SLC6A4 methylation status

Developmental Psychobiology

Gartstein, M.A. and Hookenson, K.V. and Brain, U. and Devlin, A.M. and Grunau, R.E. and Oberlander, T.F.

DOI: 10.1002/dev.21414

Prevalence and predictors of low vitamin B6 status in healthy young adult women in metro vancouver

Nutrients

Ho, C.-L. and Quay, T.A.W. and Devlin, A.M. and Lamers, Y.

DOI: 10.3390/nu8090538

High prevalence of suboptimal vitamin B12 status in young adult women of South Asian and European ethnicity

Applied Physiology Nutrition and Metabolism

Quay, T.A.W. and Schroder, T.H. and Jeruszka-Bielak, M. and Li, W. and Devlin, A.M. and Barr, S.I. and Lamers, Y.

DOI: 10.1139/apnm-2015-0200

Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Ngai, Y.F. and Sulistyoningrum, D.C. and O?Neill, R. and Innis, S.M. and Weinberg, J. and Devlin, A.M.

DOI: 10.1152/ajpregu.00075.2015

Obesity and arterial stiffness in children: Systematic review and meta-analysis

Arteriosclerosis, Thrombosis, and Vascular Biology

Cote, A.T. and Phillips, A.A. and Harris, K.C. and Sandor, G.G.S. and Panagiotopoulos, C. and Devlin, A.M.

DOI: 10.1161/ATVBAHA.114.305062

Genetic hemoglobin disorders rather than iron deficiency are a major predictor of hemoglobin concentration in women of reproductive age in rural prey veng, Cambodia

Journal of Nutrition

Karakochuk, C.D. and Whitfield, K.C. and Barr, S.I. and Lamers, Y. and Devlin, A.M. and Vercauteren, S.M. and Kroeun, H. and Talukder, A. and McLean, J. and Green, T.J.

DOI: 10.3945/jn.114.198945

Metabolic side effects and pharmacogenetics of second-generation antipsychotics in children

Pharmacogenomics

Devlin, A.M. and Panagiotopoulos, C.

DOI: 10.2217/pgs.15.55

Interaction between the Val158Met catechol-O-methyltransferase gene variant and second-generation antipsychotic treatment on blood pressure in children

Pharmacogenomics Journal

Cote, A.T. and Panagiotopoulos, C. and Devlin, A.M.

DOI: 10.1038/tpj.2014.35

Initial screening of children treated with second-generation antipsychotics points to an association between physical activity and insulin resistance

Pediatric Exercise Science

Cote, A.T. and Devlin, A.M. and Panagiotopoulos, C.

DOI: 10.1123/pes.2014-0076

Childhood Obesity, Arterial Stiffness, and Prevalence and Treatment of Hypertension

Current Treatment Options in Cardiovascular Medicine

Armstrong, K.R. and Cote, A.T. and Devlin, A.M. and Harris, K.C.

DOI: 10.1007/s11936-014-0339-9

Methyl nutrients, DNA methylation, and cardiovascular disease

Molecular Nutrition and Food Research

Glier, M.B. and Green, T.J. and Devlin, A.M.

DOI: 10.1002/mnfr.201200636

Neonatal pain and comt Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age

Frontiers in Behavioral Neuroscience

Chau, C.M.Y. and Ranger, M. and Sulistyoningrum, D. and Devlin, A.M. and Obertander, T.F. and Grunau, R.E.

DOI: 10.3389/fnbeh.2014.00409

Quetiapine treatment in youth is associated with decreased insulin secretion

Journal of Clinical Psychopharmacology

Ngai, Y.F. and Sabatini, P. and Nguyen, D. and Davidson, J. and Chanoine, J.-P. and Devlin, A.M. and Lynn, F.C. and Panagiotopoulos, C.

DOI: 10.1097/JCP.0000000000000118

Chronic intermittent hypoxia causes endothelial dysfunction in a mouse model of diet-induced obesity

Sleep Medicine

Badran, M. and Golbidi, S. and Devlin, A. and Ayas, N. and Laher, I.

DOI: 10.1016/j.sleep.2014.01.013

Programming of Glucose Homeostasis by Developmental Exposure to Folic Acid and Vitamin B12 Imbalance in Female Mice

Canadian Journal of Diabetes

Jesse D. Olson and Rika E. Aleiunas and Melissa B. Glier and Abeer M. Aljaadi and Tim J. Green and Angela M. Devlin

DOI: 10.1016/j.jcjd.2013.08.213

10 / 2013

Dysfunctional Cardiac Lipid Metabolism in Cystathionine-Beta-Synthase Deficient Mice With Diet-Induced Weight Gain

Canadian Journal of Cardiology

MB Glier and JD Olson and SL Gerrard and RE Aleliunas and DC Sulistyoningrum and TJ Green and AM Devlin and AM Devlin

DOI: 10.1016/j.cjca.2013.07.264

10 / 2013

The Fat Mass and Obesity Associated (FTO) rs9939609 Variant and Cardiometabolic Side-effects in Children Treated With Second-Generation Antipsychotics

Canadian Journal of Diabetes

Anita Cote and Ying F. Ngai and Constadina Panagiotopoulos and Angela M. Devlin

DOI: 10.1016/j.jcjd.2013.03.147

04 / 2013

Programming of Adiposity by Gestational Exposure to Folic Acid and Vitamin B12 Imbalance

Canadian Journal of Diabetes

Rika E. Aleliunas and Jesse D. Olson and Abeer Aljaad and Melissa Glier and Ismail Laher and Tim Green and Angela Devlin

DOI: 10.1016/j.jcjd.2013.03.352

04 / 2013

Dysfunctional Cardiac Lipid Metabolism in Cystathionine-Beta-Synthase Deficient Mice with Obesity-related Cardiac Lipotoxicity

Canadian Journal of Diabetes

Melissa Glier and Jesse D. Olsen and Rika E. Aleliunas and Diane C. Sulistyoningrum and Sanjoy Ghosh and Tim J. Green and Angela M. Devlin

DOI: 10.1016/j.jcjd.2013.03.081

04 / 2013

Visceral Adiposity and The Relationship Between Vitamin D and Adiponectin

Canadian Journal of Diabetes

Dian Sulistyoningrum and Danijela Gasevic and Scott Lear and Angela Devlin

DOI: 10.1016/j.jcjd.2013.03.226

04 / 2013

Adiposity and the relationship between vitamin D and blood pressure

Metabolism: Clinical and Experimental

Sulistyoningrum, D.C. and Gasevic, D. and Green, T.J. and Lear, S.A. and Devlin, A.M.

DOI: 10.1016/j.metabol.2013.07.009

Left ventricular mechanics and arterial-ventricular coupling following high-intensity interval exercise

Journal of Applied Physiology

Cote, A.T. and Bredin, S.S.D. and Phillips, A.A. and Koehle, M.S. and Glier, M.B. and Devlin, A.M. and Warburton, D.E.R.

DOI: 10.1152/japplphysiol.00576.2013

Short Term Exercise Induces PGC-1a, Ameliorates Inflammation and Increases Mitochondrial Membrane Proteins but Fails to Increase Respiratory Enzymes in Aging Diabetic Hearts

PLoS ONE

Botta, A. and Laher, I. and Beam, J. and DeCoffe, D. and Brown, K. and Halder, S. and Devlin, A. and Gibson, D.L. and Ghosh, S.

DOI: 10.1371/journal.pone.0070248

Childhood obesity and cardiovascular dysfunction

Journal of the American College of Cardiology

Cote, A.T. and Harris, K.C. and Panagiotopoulos, C. and Sandor, G.G.S. and Devlin, A.M.

DOI: 10.1016/j.jacc.2013.07.042

Antidepressant use during pregnancy and serotonin transporter genotype (SLC6A4) Affect newborn serum reelin levels

Developmental Psychobiology

Brummelte, S. and Galea, L.A.M. and Devlin, A.M. and Oberlander, T.F.

DOI: 10.1002/dev.21056

Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: A cross-sectional study

Cardiovascular Diabetology

Sulistyoningrum, D.C. and Gasevic, D. and Lear, S.A. and Ho, J. and Mente, A. and Devlin, A.M.

DOI: 10.1186/1475-2840-12-170

Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia

Epigenetics

Glier, M.B. and Ngai, Y.F. and Sulistyoningrum, D.C. and Aleliunas, R.E. and Bottiglieri, T. and Devlin, A.M.

DOI: 10.4161/epi.23063

Short-term exercise worsens cardiac oxidative stress and fibrosis in 8-month-old db/db mice by depleting cardiac glutathione

Free Radical Research

Laher, I. and Beam, J. and Botta, A. and Barendregt, R. and Sulistyoningrum, D. and Devlin, A. and Rheault, M. and Ghosh, S.

DOI: 10.3109/10715762.2012.737463

Ethnic-Specific Differences in Vitamin D Status Is Associated with Adiposity

PLoS ONE

Sulistyoningrum, D.C. and Green, T.J. and Lear, S.A. and Devlin, A.M.

DOI: 10.1371/journal.pone.0043159

Epigenetic regulation of glucocorticoid receptor expression in aorta from mice with hyperhomocysteinemia

Epigenetics

Sulistyoningrum, D.C. and Singh, R. and Devlin, A.M.

DOI: 10.4161/epi.19836

Cardiometabolic risk and the MTHFR C677T variant in children treated with second-generation antipsychotics

Translational Psychiatry

Devlin, A.M. and Ngai, Y.F. and Ronsley, R. and Panagiotopoulos, C.

DOI: 10.1038/tp.2011.68

Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice

Journal of Biological Chemistry

Ghosh, S. and Sulistyoningrum, D.C. and Glier, M.B. and Verchere, C.B. and Devlin, A.M.

DOI: 10.1074/jbc.M111.304592

Associations of the FTO rs9939609 variant with discrete body fat depots and dietary intake in a multi-ethnic cohort

Genetics Research

Lear, S.A. and Deng, W.Q. and Par?, G. and Sulistyoningrum, D.C. and Loos, R.J.F. and Devlin, A.

DOI: 10.1017/S001667231100036X

Homocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations

British Journal of Nutrition

Green, T.J. and Skeaff, C.M. and McMahon, J.A. and Venn, B.J. and Williams, S.M. and Devlin, A.M. and Innis, S.M.

DOI: 10.1017/S0007114509993552

Hepatic acyl-coenzyme A:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia

Journal of Nutrition

Devlin, A.M. and Singh, R. and Bottiglieri, T. and Innis, S.M. and Green, T.J.

DOI: 10.3945/jn.109.112920

Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birth

PLoS ONE

Devlin, A.M. and Brain, U. and Austin, J. and Oberlander, T.F.

DOI: 10.1371/journal.pone.0012201

Mechanisms of altered fatty acid and phospholipid levels in hyperhomocysteinemia

Future Lipidology

Devlin, A.M. and Green, T.J.

DOI: 10.2217/CLP.09.3

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

Epigenetics

Oberlander, T.F. and Weinberg, J. and Papsdorf, M. and Grunau, R. and Misri, S. and Devlin, A.M.

DOI: 10.4161/epi.3.2.6034

Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia

Journal of Biological Chemistry

Devlin, A.M. and Singh, R. and Wade, R.E. and Innis, S.M. and Bottiglieri, T. and Lentz, S.R.

DOI: 10.1074/jbc.M704256200

Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population.

The American journal of clinical nutrition

PubMed: 16522921

03 / 2006

Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population

American Journal of Clinical Nutrition

Devlin, A.M. and Clarke, R. and Birks, J. and Evans, J.G. and Halsted, C.H.

DOI: 10.1093/ajcn.83.3.708

ApoA-I: A missing link between homocysteine and lipid metabolism?

Circulation Research

Devlin, A.M. and Lentz, S.R.

DOI: 10.1161/01.RES.0000214406.87060.e0

Cerebral vascular dysfunction in methionine synthase-deficient mice

Circulation

Dayal, S. and Devlin, A.M. and McCaw, R.B. and Liu, M.-L. and Arning, E. and Bottiglieri, T. and Shane, B. and Faraci, F.M. and Lentz, S.R.

DOI: 10.1161/CIRCULATIONAHA.104.529248

Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia

Journal of Biological Chemistry

Devlin, A.M. and Bottiglieri, T. and Domann, F.E. and Lentz, S.R.

DOI: 10.1074/jbc.M504815200

Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice

Blood

Devlin, A.M. and Arning, E. and Bottiglieri, T. and Faraci, F.M. and Rozen, R. and Lentz, S.R.

DOI: 10.1182/blood-2003-09-3078

Glutamate carboxipeptidase II (GCPII) His475Tyr polymorphism and association studies [5]

American Journal of Medical Genetics

Vieira, A.R. and Devlin, A.M.

DOI: 10.1002/ajmg.a.30241

Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk

Molecular Genetics and Metabolism

Morin, I. and Devlin, A.M. and Leclerc, D. and Sabbaghian, N. and Halsted, C.H. and Finnell, R. and Rozen, R.

DOI: 10.1016/S1096-7192(03)00086-6

Metabolic interactions of alcohol and folate.

The Journal of nutrition

PubMed: 12163694

08 / 2002

Folate deficiency, methionine metabolism, and alcoholic liver disease

Alcohol

Halsted, C.H. and Villanueva, J.A. and Devlin, A.M.

DOI: 10.1016/S0741-8329(02)00225-2

Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig

Proceedings of the National Academy of Sciences of the United States of America

Halsted, C.H. and Villanueva, J.A. and Devlin, A.M. and Niemel, O. and Parkkila, S. and Garrow, T.A. and Wallock, L.M. and Shigenaga, M.K. and Melnyk, S. and James, S.J.

DOI: 10.1073/pnas.112336399

Metabolic interactions of alcohol and folate

Journal of Nutrition

Halsted, C.H. and Villanueva, J.A. and Devlin, A.M. and Chandler, C.J.

DOI: 10.1093/jn/132.8.2367s

Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the micropig.

Transactions of the American Clinical and Climatological Association

Halsted, C.H. and Villanueva, J.A. and Devlin, A.M. and James, S.J.

Reduced folate carrier: Tissue distribution and effects of chronic ethanol intake in the micropig

Alcoholism: Clinical and Experimental Research

Villanueva, J.A. and Devlin, A.M. and Halsted, C.H.

DOI: 10.1111/j.1530-0277.2001.tb02229.x

Glutamate carboxypeptidase II: A polymorphism associated with lower levels of serum folate and hyperhomocysteinemia

Human Molecular Genetics

Devlin, A.M. and Ling, E.-H. and Peerson, J.M. and Fernando, S. and Clarke, R. and Smith, A.D. and Halsted, C.H.

DOI: 10.1093/hmg/9.19.2837

Dietary phospholipid alters biliary lipid composition in formula-fed piglets

Lipids

Devlin, A.M. and Innis, S.M.

DOI: 10.1007/s11745-999-0483-4

Early Diet Influences Hepatic Lipogenesis

Lipids in Infant Nutrition

Sheila Innis and Angela Devlin

DOI: 10.1201/9781439831953.ch17

05 / 1998

Dietary long chain polyunsaturated fatty acids alter hepatic sterol metabolism in newborn piglets

FASEB Journal

Devlin, A.M. and Innis, S.M.

Early diet influences hepatic hydroxymethyl glutaryl coenzyme a reductase and 7a-hydroxylase mRNA but not low-density lipoprotein receptor mRNA during development

Metabolism: Clinical and Experimental

Devlin, A.M. and Innis, S.M. and Shukin, R. and Rioux, M.F.

DOI: 10.1016/S0026-0495(98)90187-1

Influence of early diet on hepatic lipid metabolism

FASEB Journal

Devlin, A.M. and Innis, S.M.

Alterations in hepatic cholesterol metabolism during development

FASEB Journal

Devlin, A. and Rioux, F. and Innis, S.M.

Effect of medium-chain triglycerides on calbindin-D9k expression in the intestine

Lipids

Devlin, A. and Innis, S.M. and Wall, K. and Krisinger, J.

DOI: 10.1007/BF02522650

Maternal Diet & Epigenetic Regulation of Gene Expression

The goal of this project is to determine the effect of in utero exposure to changes in maternal homocysteine levels on epigenetic regulation of vascular gene expression in mice. These studies are funded by the Hospital for Sick Children Foundation.

DNA Methylation & Vascular Gene Expression

The goal of this project is to determine the effect of hyperhomocysteinemia, a cardiovascular disease risk factor, on loss of genomic imprinting of H19 , and to determine the role of H19 in the vascular pathology associated with hyperhomocysteinemia in mice. These studies are funded by the American Heart Association.

Grants

"Biological effects of folate/cobalamin imbalance in mammals" (2014-2019)

NSERC Team Discovery Grant- Project

2016-2017 Healthy Starts Catalyst Grant "Determining the Long Term Metabolic Effects of Neonatal Sucrose Treatment"

Honours & Awards

Establishment Award, BC Research Institute for Children's & Women's Health, 2004

McDonald Scholarship Award, 2006-2007

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