Overview

My research program has focused on defining mechanisms of abnormal kidney development. I am now applying this knowledge to our understanding of the causes of common childhood kidney diseases and towards identifying specific characteristics that predict long-term outcomes. In addition we have established a Clinical Pathway Development (CPD) team to help translate these and other innovative research findings into best practices and standardized clinical care.

Publications

Induction prednisone dosing for childhood nephrotic syndrome: how low should we go?
Pediatric Nephrology
DOI: 10.1007/s00467-018-3975-6
2018

Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy
Physiological Reports
DOI: 10.14814/phy2.13654
2018

A Randomized Trial of a Multicomponent Intervention to Promote Medication Adherence: The Teen Adherence in Kidney Transplant Effectiveness of Intervention Trial (TAKE-IT)
American Journal of Kidney Diseases
DOI: 10.1053/j.ajkd.2017.12.012
2018

Acute kidney injury in children with sickle cell disease—compounding a chronic problem
Pediatric Nephrology
DOI: 10.1007/s00467-017-3650-3
2017

Indications for kidney biopsy in idiopathic childhood nephrotic syndrome
Pediatric Nephrology
DOI: 10.1007/s00467-017-3687-3
2017

Antenatal Determinants of Long-Term Kidney Outcome in Boys with Posterior Urethral Valves
Fetal Diagnosis and Therapy
DOI: 10.1159/000439302
2016

The impact of small kidneys
Pediatric Nephrology
DOI: 10.1007/s00467-015-3079-5
2015

Tacrolimus therapeutic drug monitoring and pediatric renal transplant graft outcomes
Pediatric Transplantation
DOI: 10.1111/petr.12369
2014

Chylous pericardial effusion in granulomatosis with polyangiitis
Nephrology
DOI: 10.1111/nep.12262
2014

Urinary tract obstruction in the mouse: The kinetics of distal nephron injury
Laboratory Investigation
DOI: 10.1038/labinvest.2013.90
2013

Epidemiology of cardiac surgery-associated acute kidney injury in neonates: A retrospective study
Pediatric Nephrology
DOI: 10.1007/s00467-013-2454-3
2013

The importance of clinical pathways and protocols in pediatric nephrology
Pediatric Nephrology
DOI: 10.1007/s00467-013-2577-6
2013

A rare cause of hypertension in a healthy 2-year-old female: Answers
Pediatric Nephrology
DOI: 10.1007/s00467-012-2164-2
2012

Urinary biomarkers in obstructive nephropathy
Clinical Journal of the American Society of Nephrology
DOI: 10.2215/CJN.09640911
2012

A rare cause of hypertension in a healthy 2-year-old female: Questions
Pediatric Nephrology
DOI: 10.1007/s00467-012-2161-5
2012

Congenital urinary tract obstruction: Defining markers of developmental kidney injury
Pediatric Research
DOI: 10.1038/pr.2012.113
2012

Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: A prospective cohort study
American Journal of Kidney Diseases
DOI: 10.1053/j.ajkd.2011.10.048
2012

Nephrotic syndrome developing during induction chemotherapy for childhood acute lymphoblastic leukemia
Clinical and Experimental Nephrology
DOI: 10.1007/s10157-010-0401-1
2011

Ontogeny of CD24 in the human kidney
Kidney International
DOI: 10.1038/ki.2010.39
2010

The authors reply
Kidney International
DOI: 10.1038/ki.2010.244
2010

Remodeling of the fetal collecting duct epithelium
American Journal of Pathology
DOI: 10.2353/ajpath.2010.090389
2010

Phenotypic transition of the collecting duct epithelium in congenital urinary tract obstruction
Journal of Biomedicine and Biotechnology
DOI: 10.1155/2010/696034
2010

An outbreak of diarrhea-associated childhood hemolytic uremic syndrome: the Walkerton epidemic.
Kidney international. Supplement
2009

Characterization and culture of fetal rhesus monkey renal cortical cells
Pediatric Research
DOI: 10.1203/PDR.0b013e3181b45565
2009

Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors
Differentiation
DOI: 10.1016/j.diff.2009.05.001
2009

An outbreak of diarrhea-associated childhood hemolytic uremic syndrome: The Walkerton epidemic
Kidney International
DOI: 10.1038/ki.2008.628
2009

Outcome of kidney transplantation in Canadian Aboriginal children in the province of British Columbia
Pediatric Transplantation
DOI: 10.1111/j.1399-3046.2008.01074.x
2009

The role of the type I insulin-like growth factor receptor (IGF-IR) in glomerular integrity
Growth Hormone and IGF Research
DOI: 10.1016/j.ghir.2007.06.003
2008

Mesenchymal transition in kidney collecting duct epithelial cells
American Journal of Physiology - Renal Physiology
DOI: 10.1152/ajprenal.00326.2007
2008

Albuminuria and Estimated GFR 5 Years After Escherichia coli O157 Hemolytic Uremic Syndrome: An Update
American Journal of Kidney Diseases
DOI: 10.1053/j.ajkd.2007.10.042
2008

Quiz page. Acute rheumatic fever with concomitant poststreptococcal glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation
DOI: 10.1053/j.ajkd.2007.04.001
2007

Selected primary care issues and comorbidities in children who are on maintenance dialysis: A review for the pediatric nephrologist
Clinical Journal of the American Society of Nephrology
DOI: 10.2215/CJN.04021206
2007

Collecting duct epithelial-mesenchymal transition in fetal urinary tract obstruction
Kidney International
DOI: 10.1038/sj.ki.5002457
2007

Absence of renal sequelae after childhood Escherichia coli O157:H7 gastroenteritis
Kidney International
DOI: 10.1038/sj.ki.5001645
2006

A gradient of acute gastroenteritis was characterized, to assess risk of long-term health sequelae after drinking bacterial-contaminated water
Journal of Clinical Epidemiology
DOI: 10.1016/j.jclinepi.2005.08.014
2006

Long-term health sequelae following E.coli and Campylobacter contamination of municipal water: Population sampling and assessing non-participation biases
Canadian Journal of Public Health
2005

Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway
Kidney International
DOI: 10.1111/j.1523-1755.2005.00208.x
2005

Microalbuminuria three years after recovery from Escherichia coli O157 hemolytic uremic syndrome due to municipal water contamination
Kidney International
DOI: 10.1111/j.1523-1755.2005.00225.x
2005

Renal leiomyoma associated with Epstein-Barr virus in a pediatric transplant patient
American Journal of Kidney Diseases
DOI: 10.1053/j.ajkd.2005.04.028
2005

Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water
CMAJ
DOI: 10.1503/cmaj.050581
2005

Cytochrome P450 3A and 2B6 in the developing kidney: Implications for ifosfamide nephrotoxicity
Pediatric Nephrology
DOI: 10.1007/s00467-004-1807-3
2005

Neonatal renal venous thrombosis: Clinical outcomes and prevalence of prothrombotic disorders
Journal of Pediatrics
DOI: 10.1016/j.jpeds.2005.02.022
2005

Antiproteinuric effects of enlapril and losartan: A pilot study
Pediatric Nephrology
DOI: 10.1007/s00467-003-1190-5
2003

Increased expression of insulin-like growth factors in progressive glomerulonephritis of the MRL/lpr mouse
Lupus
DOI: 10.1191/0961203303lu422oa
2003

Long-term Renal Prognosis of Diarrhea-Associated Hemolytic Uremic Syndrome: A Systematic Review, Meta-analysis, and Meta-regression
Journal of the American Medical Association
DOI: 10.1001/jama.290.10.1360
2003

Insulin-like growth factor binding protein-2 modulates podocyte mitogenesis
Pediatric Nephrology
DOI: 10.1007/s00467-003-1242-x
2003

Experimental models of fetal obstructive nephropathy
Pediatric Nephrology
DOI: 10.1007/s00467-002-0910-6
2002

Altered primate glomerular development due to in utero urinary tract obstruction
Kidney International
DOI: 10.1046/j.1523-1755.2002.00274.x
2002

A G339R mutation in the CTNS gene is a common cause of nephropathic cystinosis in the south western Ontario Amish Mennonite population [2]
Journal of Medical Genetics
2001

Fetal rhesus monkey model of obstructive renal dysplasia
Kidney International
DOI: 10.1046/j.1523-1755.2001.059002446.x
2001

Children's UTIs in the new millennium: Diagnosis, investigation, and treatment of childhood urinary tract infections in the year 2001
Canadian Family Physician
2001

Expression of complement regulatory proteins in the developing human kidney
Pediatric Nephrology
DOI: 10.1007/s004670000390
2000

Evaluation of metanephric maturation in a human fetal kidney explant model
In Vitro Cellular and Developmental Biology - Animal
DOI: 10.1007/s11626-998-0096-8
1998

Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: Results of a Canadian collaboratlve study
Journal of Pediatrics
DOI: 10.1016/S0022-3476(98)70303-8
1998

Renal dysplasia: New approaches to an old problem
American Journal of Kidney Diseases
DOI: 10.1016/S0272-6386(98)70014-9
1998

Regulation of the taurine transporter gene in the S3 segment of the proximal tubule
Kidney International
DOI: 10.1038/ki.1997.391
1997

Insulin-like growth factor (IGF) and IGF binding protein gene expression in multicystic renal dysplasia
Journal of the American Society of Nephrology
1997

Characterization of fetal ovine renal dysplasia after mid-gestation ureteral obstruction
Clinical and Investigative Medicine
1996

IGF-binding protein mrnas in the human fetus: Tissue and cellular distribution of developmental expression
Human Heredity
DOI: 10.1159/000184780
1996

The pathogenesis of multicystic dysplastic kidney disease: Insights from the study of fetal kidneys
Laboratory Investigation
1996

Escherichia coli verotoxin binding to human paediatric glomerular mesangial cells
Pediatric Nephrology
DOI: 10.1007/BF00868715
1995

Cytokine stimulation of prostaglandin production inhibits the proliferation of serum-stimulated mesangial cells
Kidney International
DOI: 10.1038/ki.1994.19
1994

Terminal complement complexes in acute poststreptococcal glomerulonephritis
Pediatric Nephrology
DOI: 10.1007/BF00869086
1994

Clinical quiz
Pediatric Nephrology
DOI: 10.1007/BF00869124
1994

Febrile infants at low risk for serious bacterial infection - An appraisal of the Rochester criteria and implications for management
Pediatrics
1994

Expression of insulin-like growth factor and binding protein genes during nephrogenesis
Kidney International
DOI: 10.1038/ki.1994.364
1994

The role of I and B in peritonitis associated with the nephrotic syndrome of childhood
Pediatric Research
1993

Interleukin 1 and interleukin 6 inhibition of mesangial cell proliferation: Role of PGE2
Journal of Lipid Mediators
1992

Arteriovenous fistula after biopsy of renal transplant kidney: diagnosis and treatment
Pediatric Nephrology
DOI: 10.1007/BF00866508
1992

Plasma Terminal Complement Complexes in Acute Poststreptococcal Glomerulonephritis
American Journal of Kidney Diseases
DOI: 10.1016/S0272-6386(12)80480-X
1991

Reliability and validity of the objective structured clinical examination in paediatrics
Medical Education
DOI: 10.1111/j.1365-2923.1991.tb00069.x
1991

Acute poststreptococcal glomerulonephritis and acute rheumatic fever: Occurrence in the same patient
Child Nephrology and Urology
1990

Isolated Angiitis of the Central Nervous System in Childhood
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
DOI: 10.1017/S0317167100030377
1990

Nephrosis, peritonitis and complement deficiency
Pediatric Nephrology
DOI: 10.1007/BF00869845
1990

Short of the mark: Paediatric Data Interpretation.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Matsell D
06/1988

Research
Research Group Members

Marisa Catapang, Clinical Research Coordinator
Ella Chan, Summer Student
Pratichi Kadam, Research Staff
Meaghan Maclean, Pediatric Resident
Alice So, Division Administrative Supervisor