Overview

My research program focuses on congenital kidney anomalies- from understanding the causes of childhood kidney diseases to identifying specific characteristics that predict long-term outcomes. Through the development of a dedicated Clinical Pathway Development (CPD) team we continue to translate this innovative research into best practices, standardized clinical care, and improved outcomes.

Publications

Outcomes of solitary functioning kidneys—renal agenesis is different than multicystic dysplastic kidney disease
Pediatric Nephrology
Douglas G. Matsell and Carol Bao and Teagan Po White and Ella Chan and Eli Matsell and Dan Cojocaru and Marisa Catapang and
DOI: 10.1007/s00467-021-05064-1
11/2021

Dietary intakes of children with nephrotic syndrome
Pediatric Nephrology
Nonnie Polderman and Meredith Cushing and Kirsten McFadyen and Marisa Catapang and Robert Humphreys and Cherry Mammen and Douglas G. Matsell and
DOI: 10.1007/s00467-021-05055-2
09/2021

Fluid overload and acute kidney injury in children with tumor lysis syndrome
Pediatric Blood & Cancer
Kayla Flood and Jacob Rozmus and Peter Skippen and Douglas G. Matsell and Cherry Mammen
DOI: 10.1002/pbc.29255
07/2021

Advancing Palliative Care in Patients With CKD: From Ideas to Practice
American Journal of Kidney Diseases
Helen H.-L. Chiu and Donna M. Murphy-Burke and Sarah A. Thomas and Yuriy Melnyk and Alexandra L. Kruthaup-Harper and Janghu (James) Dong and Ognjenka Djurdjev and Sushila Saunders and Adeera Levin and Mohamud Karim and Gaylene M. Hargrove and Dennis McCann and Jan Uzick and Douglas Matsell and Lori Paille and Tanya Strubin and Alexandra Kuthrup-Harper and Bobbi Preston and Bonnie Wood and Doris Barwich and Jan Olsen and Jane Lin and Lee Beliveau and Mohamud Karim and Ruth Burns and Sarb Basra and Sherri Kensall and Susan Cooper and Terry Satchwill and Victoria Lakusta-Lamberton and Blanche Hanes and Brian Forzley and Carla Williams and Christine Topley and Connie Poling and Dawn Pethybridge and Deb Hignell and Eveline Lenoble and Gerry Karr and Joanne Richardson and Julie Loverin and Lauren Gardner and Laurie Bates and Leslie Godwin and Marie Michaud and Paula Hann and Sheri Johnson and Yves Clouatre and Zhila Schofield and Andrina Perry and Anne Gloster and Dan Martinusen and Dawn Dompierre and Elizabeth Olson Glover and Gaylene Hargrove and Gillian Vincent and Jenny Di Castri and Joyce Mulgrew and Kelli-Ann van Hest and Kendra Fowler and Lorna Fischer and Malca Casiro and Monica O'Donnell and Rachel Carson and Teresa Backx and Angela Robinson and Carolle Roy and Diana Sloan and Jacqui Abernethy and Robin Lowry and Sheri Yeast and Sherri Leon Torres and Tammy Rizmayer and Teri Benedict and Wanda Dean and Beverly Jung and Clifford Chan-Yan and Jennifer Simm and Judith Marin and Lawrence Cheung and Marianna Leung and Michaela Leicht and Monica Beaulieu and Ronald Werb and Sue Young and Wallace Robinson and Bert Cameron and Alice Soo and Angela Fuller and Betty Bjornson and Claire Skjelvik and Douglas McGregor and Florence Ng and John Duncan and Kaillie Kangro and Karen Mahoney and Kit Yeung and Lisa Harrison and Meganne Sholdice and Oi Man Chan and Patricia Porterfield and Tara Tombari and Toni Trewern and Clair Hsieh and Donna Murphy-Burke and Helen Chiu and Janghu Dong and Jocelyn Beretta and Lee Er and Lynn Pelletier and Morgan Lam and Sanford Kong and Sidonie Buicliu and Stephanie Allan and Simone Hall and Sushila Saunders and Victoria Spooner and Yuriy Melnyk
DOI: 10.1053/j.ajkd.2020.09.012
03/2021

Henoch-Schönlein purpura in children
Canadian Family Physician
Amir Gohari and Douglas G. Matsell and Cherry Mammen and Ran D. Goldman
DOI: 10.46747/cfp.6612895
12/2020

Predicting outcomes and improving care in children with congenital kidney anomalies
Pediatric Nephrology
Douglas G. Matsell and Marisa Catapang
DOI: 10.1007/s00467-020-04677-2
10/2020

Baclofen Toxicity in Children With Acute Kidney Injury: Case Reports and Review of the Literature.
Child neurology open
Mishaal RA and Lanphear NE and Armarnik E and van Rensburg ER and Matsell DG
DOI: 10.1177/2329048x20937113
PubMed: 32637443
01/2020

Induction prednisone dosing for childhood nephrotic syndrome: how low should we go?
Pediatric Nephrology
DOI: 10.1007/s00467-018-3975-6
2018

Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy
Physiological Reports
DOI: 10.14814/phy2.13654
2018

A Randomized Trial of a Multicomponent Intervention to Promote Medication Adherence: The Teen Adherence in Kidney Transplant Effectiveness of Intervention Trial (TAKE-IT)
American Journal of Kidney Diseases
DOI: 10.1053/j.ajkd.2017.12.012
2018

Acute kidney injury in children with sickle cell disease—compounding a chronic problem
Pediatric Nephrology
DOI: 10.1007/s00467-017-3650-3
2017

Indications for kidney biopsy in idiopathic childhood nephrotic syndrome
Pediatric Nephrology
DOI: 10.1007/s00467-017-3687-3
2017

Antenatal Determinants of Long-Term Kidney Outcome in Boys with Posterior Urethral Valves
Fetal Diagnosis and Therapy
DOI: 10.1159/000439302
2016

The impact of small kidneys
Pediatric Nephrology
DOI: 10.1007/s00467-015-3079-5
2015

Plasticity within the Collecting Ducts: What Role Does This Play in Response to Injury?
Kidney Development, Disease, Repair and Regeneration
Hiatt, M.J. and Matsell, D.G.
DOI: 10.1016/B978-0-12-800102-8.00025-4
2015

Tacrolimus therapeutic drug monitoring and pediatric renal transplant graft outcomes
Pediatric Transplantation
DOI: 10.1111/petr.12369
2014

Chylous pericardial effusion in granulomatosis with polyangiitis
Nephrology
DOI: 10.1111/nep.12262
2014

The importance of clinical pathways and protocols in pediatric nephrology
Pediatric Nephrology
Mammen, C. and Matsell, D.G. and Lemley, K.V.
DOI: 10.1007/s00467-013-2577-6
2014

Urinary tract obstruction in the mouse: The kinetics of distal nephron injury
Laboratory Investigation
DOI: 10.1038/labinvest.2013.90
2013

Epidemiology of cardiac surgery-associated acute kidney injury in neonates: A retrospective study
Pediatric Nephrology
DOI: 10.1007/s00467-013-2454-3
2013

A rare cause of hypertension in a healthy 2-year-old female: Answers
Pediatric Nephrology
DOI: 10.1007/s00467-012-2164-2
2012

Urinary biomarkers in obstructive nephropathy
Clinical Journal of the American Society of Nephrology
DOI: 10.2215/CJN.09640911
2012

A rare cause of hypertension in a healthy 2-year-old female: Questions
Pediatric Nephrology
DOI: 10.1007/s00467-012-2161-5
2012

Congenital urinary tract obstruction: Defining markers of developmental kidney injury
Pediatric Research
DOI: 10.1038/pr.2012.113
2012

Long-term risk of CKD in children surviving episodes of acute kidney injury in the intensive care unit: A prospective cohort study
American Journal of Kidney Diseases
DOI: 10.1053/j.ajkd.2011.10.048
2012

Nephrotic syndrome developing during induction chemotherapy for childhood acute lymphoblastic leukemia
Clinical and Experimental Nephrology
DOI: 10.1007/s10157-010-0401-1
2011

Ontogeny of CD24 in the human kidney
Kidney International
DOI: 10.1038/ki.2010.39
2010

The authors reply
Kidney International
DOI: 10.1038/ki.2010.244
2010

Remodeling of the fetal collecting duct epithelium
American Journal of Pathology
DOI: 10.2353/ajpath.2010.090389
2010

Phenotypic transition of the collecting duct epithelium in congenital urinary tract obstruction
Journal of Biomedicine and Biotechnology
DOI: 10.1155/2010/696034
2010

Outcome of kidney transplantation in Canadian Aboriginal children in the province of British Columbia
Pediatric Transplantation
DOI: 10.1111/j.1399-3046.2008.01074.x
2009

Characterization and culture of fetal rhesus monkey renal cortical cells
Pediatric Research
DOI: 10.1203/PDR.0b013e3181b45565
2009

Renal ontogeny in the rhesus monkey (Macaca mulatta) and directed differentiation of human embryonic stem cells towards kidney precursors
Differentiation
DOI: 10.1016/j.diff.2009.05.001
2009

An outbreak of diarrhea-associated childhood hemolytic uremic syndrome: The Walkerton epidemic
Kidney International
DOI: 10.1038/ki.2008.628
2009

The role of the type I insulin-like growth factor receptor (IGF-IR) in glomerular integrity
Growth Hormone and IGF Research
DOI: 10.1016/j.ghir.2007.06.003
2008

Mesenchymal transition in kidney collecting duct epithelial cells
American Journal of Physiology - Renal Physiology
DOI: 10.1152/ajprenal.00326.2007
2008

Albuminuria and Estimated GFR 5 Years After Escherichia coli O157 Hemolytic Uremic Syndrome: An Update
American Journal of Kidney Diseases
DOI: 10.1053/j.ajkd.2007.10.042
2008

Quiz page. Acute rheumatic fever with concomitant poststreptococcal glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation
DOI: 10.1053/j.ajkd.2007.04.001
2007

Selected primary care issues and comorbidities in children who are on maintenance dialysis: A review for the pediatric nephrologist
Clinical Journal of the American Society of Nephrology
DOI: 10.2215/CJN.04021206
2007

Collecting duct epithelial-mesenchymal transition in fetal urinary tract obstruction
Kidney International
DOI: 10.1038/sj.ki.5002457
2007

Absence of renal sequelae after childhood Escherichia coli O157:H7 gastroenteritis
Kidney International
DOI: 10.1038/sj.ki.5001645
2006

A gradient of acute gastroenteritis was characterized, to assess risk of long-term health sequelae after drinking bacterial-contaminated water
Journal of Clinical Epidemiology
DOI: 10.1016/j.jclinepi.2005.08.014
2006

Long-term health sequelae following E.coli and Campylobacter contamination of municipal water: Population sampling and assessing non-participation biases
Canadian Journal of Public Health
2005

Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway
Kidney International
DOI: 10.1111/j.1523-1755.2005.00208.x
2005

Microalbuminuria three years after recovery from Escherichia coli O157 hemolytic uremic syndrome due to municipal water contamination
Kidney International
DOI: 10.1111/j.1523-1755.2005.00225.x
2005

Renal leiomyoma associated with Epstein-Barr virus in a pediatric transplant patient
American Journal of Kidney Diseases
DOI: 10.1053/j.ajkd.2005.04.028
2005

Risk of hypertension and reduced kidney function after acute gastroenteritis from bacteria-contaminated drinking water
CMAJ
DOI: 10.1503/cmaj.050581
2005

Cytochrome P450 3A and 2B6 in the developing kidney: Implications for ifosfamide nephrotoxicity
Pediatric Nephrology
DOI: 10.1007/s00467-004-1807-3
2005

Neonatal renal venous thrombosis: Clinical outcomes and prevalence of prothrombotic disorders
Journal of Pediatrics
DOI: 10.1016/j.jpeds.2005.02.022
2005

Antiproteinuric effects of enlapril and losartan: A pilot study
Pediatric Nephrology
DOI: 10.1007/s00467-003-1190-5
2003

Increased expression of insulin-like growth factors in progressive glomerulonephritis of the MRL/lpr mouse
Lupus
DOI: 10.1191/0961203303lu422oa
2003

Long-term Renal Prognosis of Diarrhea-Associated Hemolytic Uremic Syndrome: A Systematic Review, Meta-analysis, and Meta-regression
Journal of the American Medical Association
DOI: 10.1001/jama.290.10.1360
2003

Insulin-like growth factor binding protein-2 modulates podocyte mitogenesis
Pediatric Nephrology
DOI: 10.1007/s00467-003-1242-x
2003

Experimental models of fetal obstructive nephropathy
Pediatric Nephrology
DOI: 10.1007/s00467-002-0910-6
2002

Altered primate glomerular development due to in utero urinary tract obstruction
Kidney International
DOI: 10.1046/j.1523-1755.2002.00274.x
2002

A G339R mutation in the CTNS gene is a common cause of nephropathic cystinosis in the south western Ontario Amish Mennonite population.
Journal of medical genetics
Rupar CA and Matsell D and Surry S and Siu V
DOI: 10.1136/jmg.38.9.615
PubMed: 11565547
09/2001

Children's UTIs in the new millennium. Diagnosis, investigation, and treatment of childhood urinary tract infections in the year 2001.
Canadian family physician Medecin de famille canadien
White CT and Matsell DG
PubMed: 11561337
08/2001

Fetal rhesus monkey model of obstructive renal dysplasia
Kidney International
DOI: 10.1046/j.1523-1755.2001.059002446.x
2001

Expression of complement regulatory proteins in the developing human kidney
Pediatric Nephrology
DOI: 10.1007/s004670000390
2000

Evaluation of metanephric maturation in a human fetal kidney explant model
In Vitro Cellular and Developmental Biology - Animal
DOI: 10.1007/s11626-998-0096-8
1998

Risk of hemolytic uremic syndrome after sporadic Escherichia coli O157:H7 infection: Results of a Canadian collaboratlve study
Journal of Pediatrics
DOI: 10.1016/S0022-3476(98)70303-8
1998

Renal dysplasia: New approaches to an old problem
American Journal of Kidney Diseases
DOI: 10.1016/S0272-6386(98)70014-9
1998

Insulin-like growth factor (IGF) and IGF binding protein gene expression in multicystic renal dysplasia.
Journal of the American Society of Nephrology : JASN
Matsell DG and Bennett T and Armstrong RA and Goodyer P and Goodyer C and Han VK
PubMed: 9013452
01/1997

Regulation of the taurine transporter gene in the S3 segment of the proximal tubule
Kidney International
DOI: 10.1038/ki.1997.391
1997

Characterization of fetal ovine renal dysplasia after mid-gestation ureteral obstruction.
Clinical and investigative medicine. Medecine clinique et experimentale
Matsell DG and Bennett T and Bocking AD
PubMed: 8959354
12/1996

The pathogenesis of multicystic dysplastic kidney disease: Insights from the study of fetal kidneys
Laboratory Investigation
1996

IGF-binding protein mrnas in the human fetus: Tissue and cellular distribution of developmental expression
Human Heredity
DOI: 10.1159/000184780
1996

Escherichia coli verotoxin binding to human paediatric glomerular mesangial cells
Pediatric Nephrology
DOI: 10.1007/BF00868715
1995

Cytokine stimulation of prostaglandin production inhibits the proliferation of serum-stimulated mesangial cells
Kidney International
DOI: 10.1038/ki.1994.19
1994

Terminal complement complexes in acute poststreptococcal glomerulonephritis
Pediatric Nephrology
DOI: 10.1007/BF00869086
1994

Clinical quiz
Pediatric Nephrology
DOI: 10.1007/BF00869124
1994

Febrile infants at low risk for serious bacterial infection - An appraisal of the Rochester criteria and implications for management
Pediatrics
1994

Expression of insulin-like growth factor and binding protein genes during nephrogenesis
Kidney International
DOI: 10.1038/ki.1994.364
1994

The role of I and B in peritonitis associated with the nephrotic syndrome of childhood.
Pediatric research
Matsell DG and Wyatt RJ
DOI: 10.1203/00006450-199307000-00019
PubMed: 8356024
07/1993

Interleukin 1 and interleukin 6 inhibition of mesangial cell proliferation: role of PGE2.
Journal of lipid mediators
Matsell DG and Gaber LW and Sehic E and Malik KU
PubMed: 8357993
03/1993

Arteriovenous fistula after biopsy of renal transplant kidney: diagnosis and treatment
Pediatric Nephrology
DOI: 10.1007/BF00866508
1992

Plasma Terminal Complement Complexes in Acute Poststreptococcal Glomerulonephritis
American Journal of Kidney Diseases
DOI: 10.1016/S0272-6386(12)80480-X
1991

Reliability and validity of the objective structured clinical examination in paediatrics
Medical Education
DOI: 10.1111/j.1365-2923.1991.tb00069.x
1991

Acute poststreptococcal glomerulonephritis and acute rheumatic fever: occurrence in the same patient.
Child nephrology and urology
Matsell DG and Baldree LA and DiSessa TG and Gaber LS and Stapleton FB
PubMed: 2253249
01/1990

Isolated Angiitis of the Central Nervous System in Childhood
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
DOI: 10.1017/S0317167100030377
1990

Nephrosis, peritonitis and complement deficiency
Pediatric Nephrology
DOI: 10.1007/BF00869845
1990

Short of the mark: Paediatric Data Interpretation.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Matsell D
06/1988

Research
Research Group Members

Marisa Catapang, Clinical Research Coordinator
Alice So, Division Administrative Supervisor