My research program is comprised of projects to describe patterns and outcomes of critical illness among children living in remote and resource-limited places in British Columbia and across the world. My aim is to understand the infrastructure of healthcare for critically ill children in settings where high-cost, high-technology, and specialized care are less readily available and to evaluate strategies to improve the quality of care in these settings.


Lower Versus Higher Exposure to Vasopressor Therapy in Vasodilatory Hypotension: A Systematic Review with Meta-Analysis*
Critical Care Medicine
Richards-Belle, A. and Hylands, M. and Muttalib, F. and Taran, S. and Rochwerg, B. and Day, A. and Mouncey, P.R. and Radermacher, P. and Couban, R. and Asfar, P. and Adhikari, N.K.J. and Lamontagne, F.
DOI: 10.1097/CCM.0000000000005736

Lower Versus Higher Exposure to Vasopressor Therapy in Vasodilatory Hypotension: A Systematic Review With Meta-Analysis*
Critical Care Medicine
Alvin Richards-Belle and Mathieu Hylands and Fiona Muttalib and Shaurya Taran and Bram Rochwerg and Andrew Day and Paul R. Mouncey and Peter Radermacher and Rachel Couban and Pierre Asfar and Neill K. J. Adhikari and Francois Lamontagne
DOI: 10.1097/ccm.0000000000005736

Amplifying voices: providing quality critical care to Canada’s remote and rural children during pediatric transport
Canadian Journal of Emergency Medicine
Katie O’Hearn and Samir Shaheen-Hussain and Fiona Muttalib
DOI: 10.1007/s43678-022-00300-5

Cost-effectiveness analysis of implementing an integrated neonatal care kit to reduce neonatal infection in rural Pakistan
BMJ Open
Fiona Muttalib and Karen Chung and Lisa Grace Pell and Shabina Ariff and Sajid Soofi and Shaun K Morris and Beate Sander
DOI: 10.1136/bmjopen-2020-047793

Challenges and Opportunities for Implementing Pediatric Early Warning Systems in Low- and Middle-Income Countries - Using Resources Wisely
JAMA Network Open
Nyandat, J. and Murthy, S. and Muttalib, F.
DOI: 10.1001/jamanetworkopen.2022.1553

Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings
Frontiers in Pediatrics
Abbas, Q. and Holloway, A. and Caporal, P. and L{\'o}pez-Bar{\'o}n, E. and Agulnik, A. and Remy, K.E. and Appiah, J.A. and Attebery, J. and Fink, E.L. and Lee, J.H. and Hooli, S. and Kissoon, N. and Miller, E. and Murthy, S. and Muttalib, F. and Nielsen, K. and Puerto-Torres, M. and Rodrigues, K. and Sakaan, F. and Rodrigues, A.T. and Tabor, E.A. and von Saint Andre-von Arnim, A. and Wiens, M.O. and Blackwelder, W. and He, D. and Kortz, T.B. and Bhutta, A.T.
DOI: 10.3389/fped.2021.793326

Application of systems dynamics and group model building to identify barriers and facilitators to acute care delivery in a resource limited setting
BMC Health Services Research
Fiona Muttalib and Ellis Ballard and Josephine Langton and Sara Malone and Yudy Fonseca and Andreas Hansmann and Kenneth Remy and Peter Hovmand and Allan Doctor
DOI: 10.1186/s12913-020-06014-7

Pediatric Emergency and Critical Care Resources and Infrastructure in Resource-Limited Settings: A Multicountry Survey*
Critical Care Medicine
Muttalib, F. and González-Dambrauskas, S. and Lee, J.H. and Steere, M. and Agulnik, A. and Murthy, S. and Adhikari, N.K.J.
DOI: 10.1097/CCM.0000000000004769

Essential Emergency and Critical Care: A consensus among global clinical experts
BMJ Global Health
Schell, C.O. and Khalid, K. and Wharton-Smith, A. and Oliwa, J. and Sawe, H.R. and Roy, N. and Sanga, A. and Marshall, J.C. and Rylance, J. and Hanson, C. and Kayambankadzanja, R.K. and Wallis, L.A. and Jirwe, M. and Baker, T. and Asghar, A. and Laytin, A.D. and Holloway, A.J. and El Adib, A.R. and Michaelides, A. and Munoz, A.C. and Muzuka, A. and Fern{\'a}ndez, A. and Pembe, A.B. and Wellhagen, A. and Smith, A.G. and Gadgil, A. and Hvarfner, A. and Abayadeera, A. and Agulnik, A. and Godard, A. and Venkatesh, B. and Yousif, B.M. and Morton, B. and Sarang, B. and Vijayaraghavan, B.K.T. and King, B. and Rice, B. and Thwaites, C.L. and Tai, C.W. and Owoo, C. and Sendagire, C. and Petersen, D.B. and Tatay, D. and Skinner, D.L. and Kinyua, D. and Ghosh, D. and Aryal, D. and Mlombwa, D. and Bui, D.T.H. and Lugazia, E.R. and Riviello, E. and Molyneux, E.M. and Heyns, E. and Nsutebu, E.F. and Montalvo, E. and Moreno, E.G. and Kanyangira, E.B. and Muttalib, F. and Mupeta, F. and Diaz, F. and Bulamba, F. and Pascal, F.N.B. and Wooldridge, G. and Mwakisambwe, G. and Richards, G.A. and Ammar, H. and Mangat, H.S. and Ghali, H.H. and Shah, H.A. and Shum, H.P. and Abdullahi, I.S. and Martin-Loeches, I. and von der Osten, I.T. and McKnight, J. and Lee, J.S. and Namagga, J.K. and Eriksen, J. and Armour-Marshall, J. and Kellett, J. and Metcalfe, J.Z. and Moore, J. and Blixt, J. and Langton, J. and Mejia, J.G. and Silesky-Jim{\'e}nez, J.I. and Soni, K.D. and Kohne, K.M. and Rowan, K. and Yokobatake, K. and Doi, K. and Rudd, K.E. and Akuamoah-Boateng, K.A. and Irestedt, L. and Losonczy, L.I. and Zhang, L. and Kurland, L. and Guinness, L. and Bains, L. and Nyaika, M. and Castegren, M. and Loftus, M. and Reinikainen, M. and Cox, M. and Mer, M. and Jaung, M. and Lipnick, M.S. and English, M. and Lipcey, M. and Khajanchi, M. and Ulisubisya, M. and Nyirenda, M. and Halmin, M.A. and Shah, N. and Cobb, N.L. and Nielsen, N.D. and Adhikari, N.K.J. and Vlok, N. and Risko, N. and Kissoon, N. and Kobuh, N.D. and Rostello, O.F. and Duque, P. and Sonenthal, P.D. and Mwasapi, P.P. and Baker, P. and Bjurling-Sj{\"o}berg, P. and Sarmiento, P. and Relan, P. and Towey, R. and Silvers, R. and Mlay, R. and Branson, R. and Wang, R.J. and Kojan, R. and Von Rahden, R.P. and Venn, R. and Sweeney, R.M. and Arduini, R.G. and Gundo, R. and Sixtus, R. and Mndolo, S.K. and Akech, S. and Rouhani, S.A. and Massawe, S.N. and Peterson, S.S. and Webb, S.A. and Touray, S. and Guido, S. and Kortz, T. and Aslanidis, T. and Weiser, T.G. and Bashford, T. and Wolbrink, T.A. and Lalla, U. and Barnett, V.T. and Kannan, V.C. and Ioos, V. and Eldebsy, W.S. and Waweru-Siika, W. and Mwafulirwa, W.K. and Obeng, W. and Van Damme, W. and Omer, Y. and Banda, Z.
DOI: 10.1136/bmjgh-2021-006585

Challenges of implementing the Paediatric Surviving Sepsis Campaign International Guidelines 2020 in resource-limited settings: A real-world view beyond the academia,Desafíos de la utilización de las Guías Pediátricas Internacionales 2020 de la Campaña Sobreviviendo a la Sepsis en contextos de recursos limitados: Una visión del mundo real más allá de la academia
Andes Pediatrica
Wooldridge, G. and O?brien, N. and Muttalib, F. and Abbas, Q. and Appiah, J.A. and Baker, T. and Bansal, A. and Basnet, S. and Campos-Mi{\~n}o, S. and de Souza, D.C. and D{\'i}az, F. and Dramowski, A. and Fern{\'a}ndez-Sarmiento, J. and Fusti{\~n}ana, A. and Gonz{\'a}lez, G. and Jabornisky, R. and Jaramillo-Bustamante, J.C. and Kee, C.Y.K.Y. and Lang, H.-J. and Lanziotti, V.S. and Loncarica, G.K. and Mohsenibod, H. and Ode, B. and Murthy, S. and Arnim, A.V.S.A.-V. and Hansmann, A. and Gonz{\'a}lez-Dambrauskas, S.
DOI: 10.32641/ANDESPEDIATR.V92I6.4030

Risk of dispersion or aerosol generation and infection transmission with nasopharyngeal and oropharyngeal swabs for detection of COVID-19: A systematic review
BMJ Open
Agarwal, A. and Fernando, S.M. and Honarmand, K. and Bakaa, L. and Brar, S. and Granton, D. and Chaudhuri, D. and Chetan, D. and Hu, M. and Basmaji, J. and Muttalib, F. and Rochwerg, B. and Adhikari, N.K.J. and Lamontagne, F. and Murthy, S. and Hui, D.S. and Gomersall, C.D. and Mubareka, S. and Diaz, J. and Burns, K.E.A. and Couban, R. and Vandvik, P.O.
DOI: 10.1136/bmjopen-2020-040616

Hospital outcomes of children admitted to intensive care in British Columbia via interfacility transfer versus direct admission from 2015 to 2017: a descriptive analysis
CMAJ open
Fung, J.S.T. and Wong, S. and Murthy, S. and Muttalib, F.
DOI: 10.9778/cmajo.20200263

Clinical characteristics, treatment and outcomes of paediatric COVID-19: A systematic review and meta-analysis
Archives of Disease in Childhood
Irfan, O. and Muttalib, F. and Tang, K. and Jiang, L. and Lassi, Z.S. and Bhutta, Z.
DOI: 10.1136/archdischild-2020-321385

High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission,Les canules nasales à haut débit pour le traitement de l’insuffisance respiratoire hypoxémique aiguë chez les patients atteints de la COVID-19: comptes rendus systématiques de l’efficacité et des risqu
Canadian Journal of Anesthesia
Agarwal, A. and Basmaji, J. and Muttalib, F. and Granton, D. and Chaudhuri, D. and Chetan, D. and Hu, M. and Fernando, S.M. and Honarmand, K. and Bakaa, L. and Brar, S. and Rochwerg, B. and Adhikari, N.K. and Lamontagne, F. and Murthy, S. and Hui, D.S.C. and Gomersall, C. and Mubareka, S. and Diaz, J.V. and Burns, K.E.A. and Couban, R. and Ibrahim, Q. and Guyatt, G.H. and Vandvik, P.O.
DOI: 10.1007/s12630-020-01740-2

Performance of Pediatric Mortality Prediction Models in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis
Journal of Pediatrics
Muttalib, F. and Clavel, V. and Yaeger, L.H. and Shah, V. and Adhikari, N.K.J.
DOI: 10.1016/j.jpeds.2020.05.016

Psychological Consequences of Admission to the ICU: Helping Patients and Families
JAMA - Journal of the American Medical Association
Rose, L. and Muttalib, F. and Adhikari, N.K.J.
DOI: 10.1001/jama.2019.9059

How to push the limit: Developing informed research and implementation programs in resource-limited settings
Pediatric Critical Care Medicine
Muttalib, F. and Doctor, A.
DOI: 10.1097/PCC.0000000000001565

The gap between coverage and care-what can Canadian paediatricians do about access to health services for refugee claimant children?
Paediatrics and Child Health (Canada)
Rink, N. and Muttalib, F. and Morantz, G. and Chase, L. and Cleveland, J. and Rousseau, C. and Li, P.
DOI: 10.1093/pch/pxx115

Absence of pleocytosis alone is insufficient to exclude encephalitis caused by herpes simplex virus in children
Journal of Clinical Microbiology
Muttalib, F. and Papenburg, J.
DOI: 10.1128/JCM.03262-13


Infrastructure of Pediatric Emergency and Critical Care in Resource-Limited Settings
The aim of this study is to describe global infrastructure for the care of critically ill children in resource-limited settings through a multi-national research collaboration. We will explore regional differences in structural, human, and material resources for emergency and critical care with particular focus on global regions with the highest burden of preventable child mortality.

Predictors of Mortality among Children and Young Adolescents Hospitalized in Low- and Middle-Income Countries
To date, school-age children and early adolescents have been relatively neglected in global health literature due to perceived lower risk of death. Recent estimates suggest that there remains a significant burden of preventable mortality among these children. The aim of this research is to describe the epidemiology of critical illness among children and early adolescents across the age spectrum (including age 5 – 14 years) and to identify early predictors of hospital mortality. We will explore cause of illness among older children and validate/update existing prognostic models for hospital and early post-discharge mortality in these older age groups.

Honours & Awards

Canadian Institutes for Health Research Frederick Banting and Charles Best Canada Graduate Scholarship Doctoral Award