As a Clinician-Scientist, I have a strong interest in conducting translational research that bridges our understanding on the neurobiology of psychiatric illnesses with the clinical applications of this knowledge. I am particularly interested in applying this strategy to severe psychiatric disorders such as refractory psychosis and treatment resistant depression. My clinical practice is actively focused in those most severely afflicted by such conditions, and my research interests are directed at finding novel therapeutic interventions within Non-Invasive Neurostimulation Therapies (NINETs) that can help mitigate the suffering of those with severe and refractory forms of psychosis and depression, including pediatric populations. I strongly believe that understanding NINETs’ mechanism(s) of action is a critical step towards translating this knowledge to clinical practice. More important, translating that knowledge to clinical practice will have a direct, immediate, and positive impact on the life’s of those who struggle and suffer the most devastating forms of mental illness and their families.


The role of low-frequency repetitive transcranial magnetic stimulation in major depression: A call to increase the evidence base
Brain Stimulation
Jean-Philippe Miron and Jack Sheen and Farrokh Mansouri and Daniel M. Blumberger and Zafiris J. Daskalakis and Fidel Vila-Rodriguez and Jonathan Downar
DOI: 10.1016/j.brs.2020.06.013

Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada
PLOS Medicine
Andrea A. Jones and Kristina M. Gicas and Sam Seyedin and Taylor S. Willi and Olga Leonova and Fidel Vila-Rodriguez and Ric M. Procyshyn and Geoffrey N. Smith and Toby A. Schmitt and A. Talia Vertinsky and Tari Buchanan and Alex Rauscher and Donna J. Lang and G. William MacEwan and Viviane D. Lima and Julio S. G. Montaner and William J. Panenka and Alasdair M. Barr and Allen E. Thornton and William G. Honer
DOI: 10.1371/journal.pmed.1003172

Impact of cannabis mass gathering events on mental health and health service utilization
Patrick Lombardo and Andrew Lim and Andrea Jones and Daniel Vigo and William G Honer and Jennifer Duff and G William MacEwan and Fidel Vila-Rodriguez
DOI: 10.1101/2020.04.20.20073387

Evaluation of the effects of rTMS on self-reported quality of life and disability in treatment-resistant depression: A THREE-D study.
Journal of affective disorders
DOI: 10.1016/j.jad.2020.03.002
PubMed: 32174470

Towards Competency-Based Medical Education in Neurostimulation.
Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
DOI: 10.1007/s40596-020-01195-z
PubMed: 32048176

Caution When Continuing Benzodiazepines During rTMS: Response to Hunter and Leuchter.
The American journal of psychiatry
DOI: 10.1176/appi.ajp.2019.19060603r
PubMed: 32008395

Cognitive decline and mortality in a community-based sample of homeless and precariously housed adults: 9-year prospective study.
BJPsych open
DOI: 10.1192/bjo.2020.3
PubMed: 32043436

Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness.
The American journal of psychiatry
DOI: 10.1176/appi.ajp.2019.19060583
PubMed: 32046535

Cardiovascular differences between sham and active iTBS related to treatment response in MDD
Brain Stimulation
Tabitha A. Iseger and Martijn Arns and Jonathan Downar and Daniel M. Blumberger and Zafiris J. Daskalakis and Fidel Vila-Rodriguez
DOI: 10.1016/j.brs.2019.09.016

Use of Machine Learning for Predicting Escitalopram Treatment Outcome From Electroencephalography Recordings in Adult Patients With Depression.
JAMA network open
DOI: 10.1001/jamanetworkopen.2019.18377
PubMed: 31899530

Functional connectivity of the anterior cingulate cortex predicts treatment outcome for rTMS in treatment-resistant depression at 3-month follow-up
Brain Stimulation
Ruiyang Ge and Jonathan Downar and Daniel M. Blumberger and Zafiris J. Daskalakis and Fidel Vila-Rodriguez
DOI: 10.1016/j.brs.2019.10.012

Accelerated magnetic seizure therapy (aMST) for treatment of major depressive disorder: A pilot study.
Journal of affective disorders
DOI: 10.1016/j.jad.2019.12.022
PubMed: 32056753

Mixing Apples and Oranges in Assessing Outcomes of Repetitive Transcranial Stimulation Meta-Analyses.
Psychotherapy and psychosomatics
DOI: 10.1159/000504653
PubMed: 31794971

International Consortium on the Genetics of Electroconvulsive Therapy and Severe Depressive Disorders (Gen-ECT-ic).
European archives of psychiatry and clinical neuroscience
DOI: 10.1007/s00406-019-01087-w
PubMed: 31802253

Impact of prior treatment on remission with intermittent theta burst versus high-frequency repetitive transcranial magnetic stimulation in treatment resistant depression
Brain Stimulation
Jonathan H. Hsu and Jonathan Downar and Fidel Vila-Rodriguez and Zafiris J. Daskalakis and Daniel M. Blumberger
DOI: 10.1016/j.brs.2019.07.011

Effects of Ketamine Anesthesia on Efficacy, Tolerability, Seizure Response, and Neurocognitive Outcomes in Electroconvulsive Therapy: A Comprehensive Meta-analysis of Double-Blind Randomized Controlled Trials.
The journal of ECT
DOI: 10.1097/yct.0000000000000632
PubMed: 31725054

Considerable evidence supports rTMS for treatment-resistant depression.
Journal of affective disorders
DOI: 10.1016/j.jad.2019.11.017
PubMed: 31727396

Interleaved Transcranial Magnetic Stimulation and Functional Magnetic Resonance Imaging: A Translational Tool
Clinical Pharmacology & Therapeutics
Fidel Vila-Rodriguez and Ruiyang Ge and David Long
DOI: 10.1002/cpt.1575

Longer Repetition Time Proton MR Spectroscopy Shows Increasing Hippocampal and Parahippocampal Metabolite Concentrations with Aging
Journal of Neuroimaging
Leo Sporn and Erin L. MacMillan and Ruiyang Ge and Kyle Greenway and Fidel Vila-Rodriguez and Cornelia Laule
DOI: 10.1111/jon.12648

Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis.
PloS one
DOI: 10.1371/journal.pone.0222546
PubMed: 31513675

The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols
Journal of psychiatry & neuroscience : JPN
DOI: 10.1503/jpn.180036
PubMed: 30840428

Cognitive profiles and associated structural brain networks in a multimorbid sample of marginalized adults.
PloS one
DOI: 10.1371/journal.pone.0218201
PubMed: 31194834

A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia.
DOI: 10.1007/s00213-019-05298-w
PubMed: 31230145

Accelerated Magnetic Seizure Therapy for Treatment of Major Depressive Disorder: A Report of 3 Cases.
The journal of ECT
DOI: 10.1097/yct.0000000000000521
PubMed: 29979250

Volumes of the Hippocampal Formation Differentiate Component Processes of Memory in a Community Sample of Homeless and Marginally Housed Persons.
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
DOI: 10.1093/arclin/acy066
PubMed: 30407496

Parcellation of the human hippocampus based on gray matter volume covariance: Replicable results on healthy young adults.
Human brain mapping
DOI: 10.1002/hbm.24628
PubMed: 31115118

Lifesaving Electroconvulsive Therapy for a Child With Autism Spectrum Disorder, Severe Self-Injurious Behavior, and Neuroleptic Malignant Syndrome.
The journal of ECT
DOI: 10.1097/yct.0000000000000598
PubMed: 31022044

Functional disconnectivity of the hippocampal network and neural correlates of memory impairment in treatment-resistant depression.
Journal of affective disorders
DOI: 10.1016/j.jad.2019.04.096
PubMed: 31060011

Repetitive transcranial magnetic stimulation for depression - Authors' reply.
Lancet (London, England)
DOI: 10.1016/s0140-6736(18)32837-x
PubMed: 30712896

Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report.
The Journal of clinical psychiatry
DOI: 10.4088/jcp.18m12202
PubMed: 30840787

Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study.
The American journal of psychiatry
DOI: 10.1176/appi.ajp.2018.18091096
PubMed: 30764649

Diffusion tensor imaging of neurocognitive profiles in a community cohort living in marginal housing.
Brain and behavior
DOI: 10.1002/brb3.1233
PubMed: 30724486

Intermittent theta burst stimulation for major depression during pregnancy.
Brain stimulation
DOI: 10.1016/j.brs.2019.01.003
PubMed: 30665752

Structural network integrity of the central executive network is associated with the therapeutic effect of rTMS in treatment resistant depression.
Progress in neuro-psychopharmacology & biological psychiatry
DOI: 10.1016/j.pnpbp.2019.01.012
PubMed: 30685322

Non-linear Entropy Analysis in EEG to Predict Treatment Response to Repetitive Transcranial Magnetic Stimulation in Depression.
Frontiers in Pharmacology
DOI: 10.3389/fphar.2018.01188
PubMed: 30425640

Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size.
Molecular psychiatry
DOI: 10.1038/s41380-018-0078-5
PubMed: 29895892

Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation.
Depression and anxiety
DOI: 10.1002/da.22738
PubMed: 29637656

Clinical and functional characteristics of young adults living in single room occupancy housing: preliminary findings from a 10-year longitudinal study.
Canadian journal of public health = Revue canadienne de sante publique
DOI: 10.17269/s41997-018-0087-9
PubMed: 29981045

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial.
Lancet (London, England)
DOI: 10.1016/s0140-6736(18)30295-2
PubMed: 29726344

Verbal memory improvement in first-episode psychosis APOE-ε4 carriers: a pleiotropic effect?
Neuropsychiatric Disease and Treatment
Fidel Vila-Rodriguez and Donna Lang and Heather Baitz and Kristina Gicas and Allen Thornton and Thomas Ehmann and Geoff N. Smith and Alasdair Barr and Ivan J. Torres and Lili Kopala and G. William MacEwan and Daniel Müller and James Kennedy and William Honer
DOI: 10.2147/NDT.S150488

Abnormal Functional Connectivity of Frontopolar Subregions in Treatment-Nonresponsive Major Depressive Disorder.
Biological psychiatry. Cognitive neuroscience and neuroimaging
DOI: 10.1016/j.bpsc.2017.12.003
PubMed: 29628066

Early symptom improvement at 10 sessions as a predictor of rTMS treatment outcome in major depression.
Brain stimulation
DOI: 10.1016/j.brs.2017.10.010
PubMed: 29107623

Traumatic Brain Injury in a Community-Based Cohort of Homeless and Vulnerably Housed Individuals.
Journal of neurotrauma
DOI: 10.1089/neu.2017.5076
PubMed: 28741437

Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: insights from the canadian biomarker integration network in depression.
Scientific reports
DOI: 10.1038/s41598-017-07613-x
PubMed: 28785082

A sparse representation-based method for parcellation of the resting brain and its application to treatment-resistant major depressive disorder.
Journal of neuroscience methods
DOI: 10.1016/j.jneumeth.2017.07.017
PubMed: 28739164

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence
DOI: 10.1007/s00213-017-4551-7

Prefrontal fatty acid composition in schizophrenia and bipolar disorder: Association with reelin expression
Schizophrenia Research
DOI: 10.1016/j.schres.2017.05.033

Abnormal functional connectivity within resting-state networks is related to rTMS-based therapy effects of treatment resistant depression: A pilot study
Journal of Affective Disorders
DOI: 10.1016/j.jad.2017.04.060

Dynamic Cross-Entropy
Journal of Neuroscience Methods
DOI: 10.1016/j.jneumeth.2016.10.015

Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users
Addiction Biology
DOI: 10.1111/adb.12363

Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness
DOI: 10.1037/neu0000304

Sinus Tachycardia Induced by Methocarbamol and Repetitive Transcranial Magnetic Stimulation (rTMS)
Brain Stimulation
DOI: 10.1016/j.brs.2015.10.012

Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: Section 4. Neurostimulation treatments
Canadian Journal of Psychiatry
DOI: 10.1177/0706743716660033

Index electroconvulsive therapy course to treat severe suicidality and depression in fahr disease
Journal of ECT
DOI: 10.1097/YCT.0000000000000264

The positive and negative syndrome scale (PANSS): A three-factor model of psychopathology in marginally housed persons with substance dependence and psychiatric illness
DOI: 10.1371/journal.pone.0151648

Unilateral and bilateral MRI-targeted repetitive transcranial magnetic stimulation for treatmentresistant depression: A randomized controlled study
Journal of Psychiatry and Neuroscience
DOI: 10.1503/jpn.150265

Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence
Psychiatry Research
DOI: 10.1016/j.psychres.2016.04.059

Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users
Schizophrenia Research
DOI: 10.1016/j.schres.2016.08.001

A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene
Genetic Testing and Molecular Biomarkers
DOI: 10.1089/gtmb.2015.0304

Discovering biomarkers for antidepressant response: Protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort
BMC Psychiatry
DOI: 10.1186/s12888-016-0785-x

Dimenhydrinate use disorder with chronic psychosis
Journal of Clinical Psychopharmacology

Response trajectories to clozapine in a secondary analysis of pivotal trials support using treatment response to subtype schizophrenia
Canadian journal of psychiatry. Revue canadienne de psychiatrie

Depression and Anxiety
DOI: 10.1002/da.22424

Electroconvulsive therapy treatment in patients with somatic symptom and related disorders
Neuropsychiatric Disease and Treatment
DOI: 10.2147/NDT.S90969

Single occurrence of intraictal cessation during index course of electroconvulsive therapy
Journal of ECT
DOI: 10.1097/YCT.0000000000000168

Neurobiological mechanisms of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in depression: A systematic review
Psychological Medicine
DOI: 10.1017/S0033291715001609

Development of a cost-efficient novel method for rapid, concurrent genotyping of five common single nucleotide polymorphisms of the brain derived neurotrophic factor (BDNF) gene by tetra-primer amplification refractory mutation system
International Journal of Methods in Psychiatric Research
DOI: 10.1002/mpr.1475

Risk of seizures in transcranial magnetic stimulation: A clinical review to inform consent process focused on bupropion
Neuropsychiatric Disease and Treatment
DOI: 10.2147/NDT.S91126

Occurrence of postictal a/ß activity during maintenance course of electroconvulsive therapy
Journal of ECT
DOI: 10.1097/YCT.0000000000000231

Mortality from treatable illnesses in marginally housed adults: A prospective cohort study
BMJ Open
DOI: 10.1136/bmjopen-2015-008876

White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection Psychiatry
BMC Research Notes
DOI: 10.1186/s13104-015-1501-5

A case of pseudo-Stauffer's syndrome related to asenapine use
Schizophrenia Research
DOI: 10.1016/j.schres.2015.10.015

Neuroleptic malignant syndrome: A review from a clinically oriented perspective
Current Neuropharmacology

Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness
Journal of Clinical and Experimental Neuropsychology
DOI: 10.1080/13803395.2014.963519

48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination
NeuroImage: Clinical
DOI: 10.1016/j.nicl.2014.10.006

Clozapine administered once versus twice daily: Does it make a difference?
Medical Hypotheses
DOI: 10.1016/j.mehy.2013.11.043

Idiopathic burning mouth syndrome: A common treatment-refractory somatoform condition responsive to ECT
Psychiatry Research
DOI: 10.1016/j.psychres.2014.01.048

Electroconvulsive therapy in patients with deep brain stimulators
Journal of ECT
DOI: 10.1097/YCT.0000000000000074

Normal Pressure Hydrocephalus: Etiology, Diagnosis, Treatment, and Putative Nutritional and Lifestyle Risk Factors
Diet and Nutrition in Dementia and Cognitive Decline
DOI: 10.1016/B978-0-12-407824-6.00010-0

Repetitive transcranial magnetic stimulation in depression: A changing landscape
Psychiatric Times

The hotel study: Multimorbidity in a community sample living in marginal housing
American Journal of Psychiatry
DOI: 10.1176/appi.ajp.2013.12111439

Chronic benign neutropenia/agranulocytosis associated with non-clozapine antipsychotics
American Journal of Psychiatry
DOI: 10.1176/appi.ajp.2013.13020215

Personalized risk assessment of drug-related harm is associated with health outcomes
DOI: 10.1371/journal.pone.0079754

The relevance of eeg artifact identification: A case of delta-wave blinking due to tardive dyskinesia
Journal of ECT
DOI: 10.1097/YCT.0b013e3182621c4a

Structural brain changes associated with tardive dyskinesia in schizophrenia
British Journal of Psychiatry
DOI: 10.1192/bjp.bp.112.114538

White matter tract abnormalities in first-episode psychosis
Schizophrenia Research
DOI: 10.1016/j.schres.2012.06.042

Methamphetamine, perceptual disturbances, and the peripheral drift illusion
American Journal on Addictions
DOI: 10.1111/j.1521-0391.2011.00161.x

ApoE and cholesterol in schizophrenia and bipolar disorder: Comparison of grey and white matter and relation with APOE genotype
Journal of Psychiatry and Neuroscience
DOI: 10.1503/jpn.090116

Complex interaction between symptoms, social factors, and gender in social functioning in a community-dwelling sample of schizophrenia
Psychiatric Quarterly
DOI: 10.1007/s11126-011-9168-0

Medial prefrontal cortex pathology in schizophrenia as revealed by convergent findings from multimodal imaging
Molecular Psychiatry
DOI: 10.1038/mp.2009.146

Overall brain connectivity maps show cortico-subcortical abnormalities in schizophrenia
Human Brain Mapping
DOI: 10.1002/hbm.20993

Thalamic shape: A possible endophenotype
Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.0553-08.2008

Delusional parasitosis facilitated by web-based dissemination
American Journal of Psychiatry
DOI: 10.1176/appi.ajp.2008.08081283

A simple view of the brain through a frequency-specific functional connectivity measure
DOI: 10.1016/j.neuroimage.2007.08.018

Failure to deactivate in the prefrontal cortex in schizophrenia: Dysfunction of the default mode network?
Psychological Medicine
DOI: 10.1017/S0033291708003565

One year prevalence of mental disorders comorbidity and associated socio-demographic risk factors in the general population of Spain. Results of the ESEMeD-Spain study | Prevalencia-año de la comorbilidad de los trastornos mentales y factores de riesgo sociodemográficos asociados en la población general de España. Resultados del estudio ESEMeD-España.
Actas españolas de psiquiatría