James Lim
PhD
Investigator, Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital
Cell Death & Disease
Pascal Leclair and Chi-Chao Liu and Mahdis Monajemi and Gregor S. Reid and Laura M. Sly and Chinten James Lim
DOI: 10.1038/s41419-018-0601-205 / 2018
Cell Death & Disease
Lakshana Sreenivasan and Hui Wang and Shyong Quin Yap and Pascal Leclair and Anthony Tam and Chinten James Lim
DOI: 10.1038/s41419-020-03241-y12 / 2020
Cell Death Dis
Liu, C. C. and Leclair, P. and Monajemi, M. and Sly, L. M. and Reid, G. S. and Lim, C. J.
DOI: 10.1038/cddis.2016.176ACS Chemical Biology
Daniel He and Robin Lorenz and Choel Kim and Friedrich W. Herberg and Chinten James Lim
DOI: 10.1021/acschembio.7b0073212 / 2017
Molecular and Cellular Biology
Liu, C.-C. and Leclair, P. and Yap, S.Q. and Lim, C.J.
DOI: 10.1128/MCB.00580-13Frontiers in Oncology
Liu, Chi-Chao and Leclair, Pascal and Pedari, Foujan and Vieira, Heidi and Monajemi, Mahdis and Sly, Laura M. and Reid, Gregor S. and Lim, Chinten James
DOI: 10.3389/fonc.2019.0041105 / 2019
American Journal of Physiology-Lung Cellular and Molecular Physiology
Anthony Tam and Pascal Leclair and Ling Vicky Li and Chen X Yang and Xuan Li and Dominik Witzigmann and Jayesh A Kulkarni and Tillie-Louise Hackett and Delbert R. Dorscheid and Gurpreet K Singhera and James C. Hogg and Pieter R Cullis and Don D. Sin and Chinten James Lim
DOI: 10.1152/ajplung.00477.202006 / 2021
Chinten Lim and Pascal Leclair and Anuli Uzozie and Amanda Lorentzian and Nina Rolf and Christopher Maxwell and Gregor Reid and Philipp Lange
DOI: 10.21203/rs.3.rs-8940785/v103 / 2026
EMBO Molecular Medicine
Georgina D Barnabas and Tariq Ahmad Bhat and Verena Goebeler and Pascal Leclair and Nadine Azzam and Nicole Melong and Colleen Anderson and Alexis Gom and Seohee An and Enes K Ergin and Yaoqing Shen and Agustina Conrrero and Andrew Mungall and Karen L Mungall and Christopher Maxwell and Gregor Reid and Martin Hirst and Steven Jones and Jennifer Chan and Donna Senger and Jason Berman and Seth Parker and Jonathan Bush and Caron Strahlendorf and Rebecca Deyell and Chinten James Lim and Philipp F. Lange
DOI: 10.1038/s44321-025-00212-804 / 2025
Georgina D. Barnabas and Tariq A. Bhat and Verena Goebeler and Pascal Leclair and Nadine Azzam and Nicole Melong and Colleen Anderson and Alexis Gom and Seohee An and Enes K. Ergin and Yaoqing Shen and Andy J. Mungall and Karen L. Mungall and Christopher A. Maxwell and Gregor S.D. Reid and Martin Hirst and Steven Jones and Jennifer A. Chan and Donna L. Senger and Jason N. Berman and Seth J. Parker and Jonathan W. Bush and Caron Strahlendorf and Rebecca J. Deyell and Chinten J. Lim and Philipp F. Lange and PROFYLE Program
DOI: 10.1101/2024.07.04.2430992307 / 2024
JCI Insight
Christina Michalski and Claire Cheung and Ju Hee Oh and Emma Ackermann and Constantin R. Popescu and Anne-Sophie Archambault and Martin A. Prusinkiewicz and Rachel Da Silva and Abdelilah Majdoubi and Marina Vieta Paramo and Rui Yang Xu and Frederic Reicherz and Annette E. Patterson and Liam Golding and Ashish Arunkumar Sharma and Chinten J. Lim and Paul C. Orban and Ramon Klein Geltink and Pascal M. Lavoie
DOI: 10.1172/jci.insight.17231202 / 2024
Nature Communications
Amanda C. Lorentzian and Jenna Rever and Enes K. Ergin and Meiyun Guo and Neha M. Akella and Nina Rolf and C. James Lim and Gregor S. D. Reid and Christopher A. Maxwell and Philipp F. Lange
DOI: 10.1038/s41467-023-42701-911 / 2023
Cells
Anthony Tam and Osei ET and Chung Y. Cheung and Michael R. Hughes and Chen X. Yang and Kelly McNagny and Delbert R. Dorscheid and Gurpreet Singhera and Teal S. Hallstrand and Stephanie Warner and James C. Hogg and Tillie-Louise Hackett and Chinten James Lim and Don Sin
DOI: 10.3390/cells1119301609 / 2022
Cells
Lakshana Sreenivasan and Ling Vicky Li and Pascal Leclair and Chinten James Lim
DOI: 10.3390/cells1103038101 / 2022
Cell Transplantation
Ali Farrokhi and MohammadReza Rahavi and Sumin Jo and Reza Jalili and C. James Lim and Aziz Ghahsary and Gregor S. D. Reid
DOI: 10.1177/0963689722111380301 / 2022
Cytometry Part A
Nina Rolf and Lorraine Y. T. Liu and Angela Tsang and Philipp F. Lange and Chinten James Lim and Christopher A. Maxwell and Suzanne M. Vercauteren and Gregor S. D. Reid
DOI: 10.1002/cyto.a.2447301 / 2022
Journal of Experimental & Clinical Cancer Research
Anuli C. Uzozie and Enes K. Ergin and Nina Rolf and Janice Tsui and Amanda Lorentzian and Samuel S. H. Weng and Lorenz Nierves and Theodore G. Smith and C. James Lim and Christopher A. Maxwell and Gregor S. D. Reid and Philipp F. Lange
DOI: 10.1186/s13046-021-01835-812 / 2021
Animal Cells and Systems
Pascal Leclair and Chinten James Lim
DOI: 10.1080/19768354.2020.181861809 / 2020
PLOS ONE
Axel J. Chu and Eric Jiahua Zhao and Mu Chiao and Chinten James Lim
DOI: 10.1371/journal.pone.023096604 / 2020
Cancer Science
Pascal Leclair and Min Jung Kim and Chinten James Lim
DOI: 10.1111/cas.1431003 / 2020
American Journal of Transplantation
Hoeppli, R. E. and MacDonald, K. N. and Leclair, P. and Fung, V. C. W. and Mojibian, M. and Gillies, J. and Rahavi, S. M. R. and Campbell, A. I. M. and Gandhi, S. K. and Pesenacker, A. M. and Reid, G. and Lim, C. J. and Levings, M. K.
DOI: 10.1111/ajt.1493601 / 2019
JNCI cancer spectrum
DOI: 10.1093/jncics/pky079 PubMed: 3097675010 / 2018
Scientific Reports
Hok Khim Fam and Kunho Choi and Lauren Fougner and Chinten James Lim and Cornelius F. Boerkoel
DOI: 10.1038/s41598-018-22547-803 / 2018
Cell Death & Disease
Anthony C Tang and Seyed M Rahavi and Shan-Yu Fung and Henry Y Lu and Hong Yang and Chinten J Lim and Gregor S Reid and Stuart E Turvey
DOI: 10.1038/s41419-017-0194-102 / 2018
Review of Scientific Instruments
F. Khademolhosseini and C.-C. Liu and C. J. Lim and M. Chiao
DOI: 10.1063/1.496056708 / 2016
Biomedical microdevices
Khademolhosseini, F. and Liu, C.-C. and Lim, C.J. and Chiao, M.
DOI: 10.1007/s10544-016-0033-7RSC Advances
Ethan Lee and Hongbin Zhang and John K. Jackson and Chinten James Lim and Mu Chiao
DOI: 10.1039/C6RA16232KProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Khademolhosseini, F. and Liu, C.-C. and Lim, C.J. and Chiao, M.
DOI: 10.1109/MEMSYS.2015.7051033BMC Pharmacology and Toxicology
Robin Lorenz and Daniel He and Choel Kim and Chinten J Lim and Friedrich W Herberg
DOI: 10.1186/2050-6511-16-s1-a64European Journal of Immunology
Weisser, S.B. and Kozicky, L.K. and Brugger, H.K. and Ngoh, E.N. and Cheung, B. and Jen, R. and Menzies, S.C. and Samarakoon, A. and Murray, P.J. and Lim, C.J. and Johnson, P. and Boucher, J.-L. and van Rooijen, N. and Sly, L.M.
DOI: 10.1002/eji.201343981Cell Cycle
Chen, H. and Mohan, P. and Jiang, J. and Nemirovsky, O. and He, D. and Fleisch, M.C. and Niederacher, D. and Pilarski, L.M. and Lim, C.J. and Maxwell, C.A.
DOI: 10.4161/cc.29270PLoS ONE
Leclair, P. and Lim, C.J.
DOI: 10.1371/journal.pone.0098358Molecular Biology of the Cell
Lee, H.-S. and Anekal, P. and Lim, C.J. and Liu, C.-C. and Ginsberg, M.H.
DOI: 10.1091/mbc.E12-09-0695Blood
Liu, Chi-Chao and Leclair, Pascal and He, Daniel and Yap, Eva and Lim, Chinten James
Molecular and Cellular Biology
Sun, G. and Cheng, S.Y.S. and Chen, M. and Lim, C.J. and Pallen, C.J.
DOI: 10.1128/MCB.00214-12Journal of Biological Chemistry
Lee, H.-S. and Lim, C.J. and Puzon-McLaughlin, W. and Shattil, S.J. and Ginsberg, M.H.
DOI: 10.1074/jbc.M807117200Nature Cell Biology
Jones, C.A. and Nishiya, N. and London, N.R. and Zhu, W. and Sorensen, L.K. and Chan, A.C. and Lim, C.J. and Chen, H. and Zhang, Q. and Schultz, P.G. and Hayallah, A.M. and Thomas, K.R. and Famulok, M. and Zhang, K. and Ginsberg, M.H. and Li, D.Y.
DOI: 10.1038/ncb1976Journal of Biological Chemistry
Anthis, N.J. and Haling, J.R. and Oxley, C.L. and Memo, M. and Wegener, K.L. and Lim, C.J. and Ginsberg, M.H. and Campbell, I.D.
DOI: 10.1074/jbc.M109.061275Molecular Biology of the Cell
Lim, C.J. and Kain, K.H. and Tkachenko, E. and Goldfinger, L.E. and Gutierrez, E. and Allen, M.D. and Groisman, A. and Zhang, J. and Ginsberg, M.H.
DOI: 10.1091/mbc.E08-06-0564Nature Cell Biology
Lim, C.J. and Han, J. and Yousefi, N. and Ma, Y. and Amieux, P.S. and McKnight, G.S. and Taylor, S.S. and Ginsberg, M.H.
DOI: 10.1038/ncb1561Blood
Watanabe, Naohide and Han, Jaewon and Lim, C. James and Soriani, Alessandra and Puzon-McLaughlin, Wilma and LaFuente, Esther M. and Boussiotis, Vassiliki A. and Ginsberg, Mark H. and Shattil, Sanford J.
Current Biology
Han, J. and Lim, C.J. and Watanabe, N. and Soriani, A. and Ratnikov, B. and Calderwood, D.A. and Puzon-McLaughlin, W. and Lafuente, E.M. and Boussiotis, V.A. and Shattil, S.J. and Ginsberg, MarkH.
DOI: 10.1016/j.cub.2006.08.035Marine Biotechnology
Corley-Smith, G.E. and Wennerberg, L. and Schembri, J.A. and Lim, C.J. and Cooper, K.L. and Brandhorst, B.P.
DOI: 10.1007/s10126-004-4065-zExperimental Cell Research
Lim, C.J. and Zawadzki, K.A. and Khosla, M. and Secko, D.M. and Spiegelman, G.B. and Weeks, G.
DOI: 10.1016/j.yexcr.2005.02.002EMBO Reports
Kae, H. and Lim, C.J. and Spiegelman, G.B. and Weeks, G.
DOI: 10.1038/sj.embor.7400151Eukaryotic Cell
Wessels, D. and Brincks, R. and Kuhl, S. and Stepanovic, V. and Daniels, K.J. and Weeks, G. and Lim, C.J. and Spiegelman, G. and Fuller, D. and Iranfar, N. and Loomis, W.F. and Soll, D.R.
DOI: 10.1128/EC.3.3.646-662.2004Journal of Muscle Research and Cell Motility
Lim, C.J. and Spiegelman, G.B. and Weeks, G.
DOI: 10.1023/A:1024471527153EMBO Journal
Lim, C.J. and Spiegelman, G.B. and Weeks, G.
DOI: 10.1093/emboj/20.16.4490Biotechniques
CorleySmith, GE and Lim, CJ and Kalmar, GB and Brandhorst, BP
Genetics
CorleySmith, GE and Lim, CTJ and Brandhorst, BP
We have several active projects in the following areas:
1. Understanding the molecular basis of cell adhesion receptors and associated proteins in modifying therapeutic response in pediatric acute lymphoblastic leukemia. This work encompasses the cell death and immunomodulatory effects of the integrin-associated ‘eat me’ protein calreticulin, and the ‘don’t eat me’ protein CD47.
2. Interrogating the tumour microenvironmental sources of stimulatory cytokines that promote the aggressive transformation and treatment resistance of the childhood brain tumor, medulloblastoma.
3. Modeling for precision oncology at BCCH. This project is a multi-investigator led initiative that encompasses a bedside-to-bench approach to molecularly characterize a child’s tumor to identify particular vulnerabilities for therapeutic intervention. The Lim lab employs the chick chorioallantoic membrane (CAM) model as for PDX generation and for testing particular drug susceptibilities.
For additional context, applicants are directed to the list of lab publications available here:
https://orcid.org/0000-0001-6381-7585
Canadian Institutes of Health Research (CIHR) Operating Grant (2021-26)
Cancer Research Society & CIHR Operating Grant (2022-2024)
The Lim laboratory is a member of the Michael Cuccione Childhood Cancer Research Program of BC Children's Hospital
The Leukemia and Lymphoma Society of Canada (LLSC) OG (2010-2012)
CFI/BCKDF – Leaders Opportunity Fund (2010)
The Leukemia and Lymphoma Society (U.S.A.) – Fellow, Career Development Program (2004–07)
Every day, our researchers work towards breakthroughs to transform the lives of kids in BC and around the world. Learn about our latest innovations and advancements in child health.
When a child’s cancer returns after conventional treatment, families often find themselves in uncharted territory — scared, exhausted, and grasping for answers. But thanks to a remarkable collaboration between researchers, clinicians, and national research networks, new pediatric cancer treatment options are emerging.
A pan-Canadian team has developed a new way to quickly find personalized treatments for young cancer patients, by growing their tumours in chicken eggs and analyzing their proteins.
Unlike adult cancers, which are often linked to lifestyle and environmental risk factors, the cause of many childhood cancers remains unknown. While advances in research and care have greatly improved chances of survival, cancer remains the second-leading cause of non-accidental death among children in Canada.
At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.
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BC Children's Hospital Research Institute operates on the ancestral and unceded territory of the Coast Salish peoples — xʷməθkʷəy̓əm (Musqueam), Sḵwx̱wú7mesh (Squamish), and Səl̓ílwətaʔ/Selilwitulh (Tsleil-Waututh) Nations. Further, this acknowledgement, gratitude, and respect extends to all of the First Nations communities on whose territories the Research Institute builds relationships and operates in British Columbia.
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