Overview

As a medical biochemist, my research focuses on developing and validating new laboratory biomarkers for the diagnosis and prognosis of different diseases. Based on clinical and laboratory standards institute guidelines, I am interested in bringing these novel biomarkers to clinical laboratories which would meet the laboratory accreditation standards. Currently, I am conducting research related to transplantation immunology and peanut allergy. I am also interested in auditing how laboratory tests are utilized in healthcare systems and promote the cost-effectiveness of laboratory tests with evidence-based medicine.

Publications

Intrapartum Fetal Scalp Lactate Testing: Considerations for Implementation and Clinical Decision Making
Journal of Obstetrics and Gynaecology Canada
Angela W.S. Fung and Andre Mattman and Li Wang and Teralee Burton and Lori A. Beach and A.K. Füzéry
DOI: 10.1016/j.jogc.2021.06.006
11/2021

Interference of ketone bodies on laboratory creatinine measurement in children with DKA: a call for change in testing practices
Pediatric Nephrology
Damian Feldman-Kiss and Dailin Li and Richard Cleve and Graham Sinclair and Joshua A. Dubland and Li Wang
DOI: 10.1007/s00467-021-05324-0
11/2021

Comparative evaluation of neonatal bilirubin using Radiometer whole blood co-oximetry and plasma bilirubin methods from Roche Diagnostics and Ortho Clinical Diagnostics
Clinical Biochemistry
Ian Marie Lano and Andrew W. Lyon and Li Wang and Rob Ruskin and Martha E. Lyon
DOI: 10.1016/j.clinbiochem.2017.12.009
03/2018

Limitations and opportunities of whole blood bilirubin measurements by GEM premier 4000®
BMC Pediatrics
Li Wang and Arianne Y. K. Albert and Benjamin Jung and Keyvan Hadad and Martha E. Lyon and Melanie Basso
DOI: 10.1186/s12887-017-0842-8
12/2017

Visual or automated dipstick testing for proteinuria in pregnancy?
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health
Mauricio E. Correa and Anne-Marie Côté and Dane A. De Silva and Li Wang and Prianthiny Packianathan and Peter von Dadelszen and Laura A. Magee
DOI: 10.1016/j.preghy.2017.01.005
01/2017

Acute encephalopathy in a kidney transplant recipient following infusion of intravenous immunoglobulin
Transplant Intern 2014 Nov; 27 (11):e115-7.
DOI: 10.1111/tri.12384
PubMed: 24964219
11/2014

Hematocrit correction does not improve glucose monitor accuracy in the assessment of neonatal hypoglycemia.
Clinical chemistry and laboratory medicine
DOI: 10.1515/cclm-2012-0436
PubMed: 23420286
08/2013

Measurement uncertainty for serum free light chain assays: estimation and implication on result interpretation
Clinical Biochemistry
DOI: 10.1016/j.clinbiochem.2012.11.015
PubMed: 23200885
2013

Assessing pneumatic tube systems with patient-specific populations and laboratory-derived criteria.
Clinical chemistry
DOI: 0.1373/clinchem.2011.179044
PubMed: 22291142
04/2012

Roche acetaminophen assay negative bias at low concentrations is imprvoved using the TDM diluent as the zero calibrator
Clinical Biochemistry
P. Kavsak and N. Wakefied and L. Clark and L. Lyko and R. Pickersgill and L. Wang and J. Zeidler
DOI: 10.1016/j.clinbiochem.2010.04.026
06/2010

Pediatric critical values: Laboratory–pediatrician discourse
Clinical Biochemistry
Andrew C. Don-Wauchope and Li Wang and Vijaylaxmi Grey
DOI: 10.1016/j.clinbiochem.2009.06.029
11/2009

Rescue of Munc18-1 and -2 Double Knockdown Reveals the Essential Functions of Interaction between Munc18 and Closed Syntaxin in PC12 Cells
Molecular Biology of the Cell
L. Han and T. Jiang and G. A. Han and N. T. Malintan and L. Xie and L. Wang and F. W. Tse and H. Y. Gaisano and B. M. Collins and F. A. Meunier and S. Sugita
DOI: 10.1091/mbc.e09-08-0712
10/2009

RalA and RalB Function as the Critical GTP Sensors for GTP-Dependent Exocytosis
Journal of Neuroscience
G. Li and L. Han and T.-C. Chou and Y. Fujita and L. Arunachalam and A. Xu and A. Wong and S.-K. Chiew and Q. Wan and L. Wang and S. Sugita
DOI: 10.1523/jneurosci.2537-06.2007
01/2007

N-Terminal Insertion and C-Terminal Ankyrin-Like Repeats of  -Latrotoxin Are Critical for Ca2+-Dependent Exocytosis
Journal of Neuroscience
G. Li
DOI: 10.1523/jneurosci.3560-05.2005
11/2005

A Central Kinase Domain of Type I Phosphatidylinositol Phosphate Kinases Is Sufficient to Prime Exocytosis: ISOFORM SPECIFICITY AND ITS UNDERLYING MECHANISM
Journal of Biological Chemistry
L. Wang and G. Li and S. Sugita
DOI: 10.1074/jbc.m413263200
02/2005

RalA-Exocyst Interaction Mediates GTP-dependent Exocytosis
Journal of Biological Chemistry
Li Wang and Gang Li and Shuzo Sugita
DOI: 10.1074/jbc.m400522200
02/2004

Research

Current Projects
1) Assessment of the cost-effectiveness of Ara h 2 and Arah 8 component testing for peanut allergy diagnosis in Canadian children
2) Clinical testing of urine CXCL-10 for children post kidney transplant to predict early kidney rejections
3) Application of whole blood bilirubin for the diagnosis of neonatal hyperbilirubinemia to reduce the length of hospital stay

Grants

2019: “A study of whether selectively ordering peanut component resolved diagnostics increases diagnostic accuracy in children in a cost-effective manner”, Dr. Donald B. Rix and Laboratory Medicine Research Grant

2018: "Optimization of pre-analytical issues relevant to urinary CXCL-10 measurements in clinical research”, BCCHR QI Grant

2017: “Fast, accurate bilirubin screening with only a drop of blood”, Medical & Allied Staff Engagement Society (MASES) Engagement Fund

Honours & Awards

Young Investigator Travel Award, MSACL (Association for Mass Spectrometry: Applications to the Clinical Lab), Salt Springs, USA. February 2016

NACB’s Distinguished Abstract Award, AACC (American Association of Clinical Chemistry) annual meeting, Atlanta, USA. July 2015

Best poster presentation, XIII International Congress of Pediatric Laboratory Medicine, Istanbul, Turkey. June 2014

First place for oral presentation, CAMB (Canadian Association of Medical Biochemists) annual meeting, Montreal, Canada. November 2012

First place for best case report/series presentation, Department of Pathology & Molecular Medicine, Resident Research Day, McMaster University. May 2012

Research Group Members

Michelle Dittrick, Clinical Research Program Manager