My research program aims at investigating how early-life adversity (e.g. stress, pain, inflammation, clinical treatments) affects the developing brain of very preterm infants, using an animal model that closely captures critical aspects of what preterm infants are like and what they may experience in the NICU. The use of preclinical models allows mechanistic studies on how exposure to early-life adversity alters the normal trajectory of brain development. This research, in turn, better informs clinical studies in preterm infants and the development of novel treatments to mitigate adverse effects from these exposures.
This work is motivated by my clinical nursing background as a paediatric clinical nurse specialist in acute pain, and builds upon my doctoral training in infant brain reactivity to pain (McGill University/Harvard University/Boston Children’s Hospital) and postdoctoral fellowship in pediatrics/neuroscience at UBC, as well as my recent work as a research scientist at Columbia University in the division of Developmental Neuroscience.
The international Perinatal Outcomes in the Pandemic (iPOP) study: protocol [version 1; peer review: 2 approved]
Sarah J. Stock and Helga Zoega and Meredith Brockway and Rachel H. Mulholland and Jessica E. Miller and Jasper V. Been and Rachael Wood and Ishaya I. Abok and Belal Alshaikh and Adejumoke I. Ayede and Fabiana Bacchini and Zulfiqar A. Bhutta and Bronwyn K. Brew and Jeffrey Brook and Clara Calvert and Marsha Campbell-Yeo and Deborah Chan and James Chirombo and Kristin L. Connor and Mandy Daly and Kristjana Einarsdóttir and Ilaria Fantasia and Meredith Franklin and Abigail Fraser and Siri Eldevik Håberg and Lisa Hui and Luis Huicho and Maria C. Magnus and Andrew D. Morris and Livia Nagy-Bonnard and Natasha Nassar and Sylvester Dodzi Nyadanu and Dedeke Iyabode Olabisi and Kirsten R. Palmer and Lars Henning Pedersen and Gavin Pereira and Amy Racine-Poon and Manon Ranger and Tonia Rihs and Christoph Saner and Aziz Sheikh and Emma M. Swift and Lloyd Tooke and Marcelo L. Urquia and Clare Whitehead and Christopher Yilgwan and Natalie Rodriguez and David Burgner and Meghan B. Azad and iPOP Study
Is near infrared spectroscopy valid for the detection of procedural pain in postoperative cardiac surgery intensive care unit adults?
Journal of Near Infrared Spectroscopy
Internalizing behaviours in school-age children born very preterm are predicted by neonatal pain and morphine exposure
European Journal of Pain (United Kingdom)
Neonatal pain and comt Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age
Frontiers in Behavioral Neuroscience
Cerebral near-infrared spectroscopy as a measure of nociceptive evoked activity in critically ill infants
Pain Research and Management
Toward a new approach for the detection of pain in adult patients undergoing cardiac surgery: Near-infrared spectroscopy—A pilot study
Heart and Lung: Journal of Acute and Critical Care
Developing synergy to enhance the impact of nursing intervention research on patient health
Canadian Journal of Nursing Research
Controlling bias in complex nursing intervention studies: A checklist
Canadian Journal of Nursing Research
The role of neuroinflammation in early life pain/sucrose-induced neurodevelopment impairments
Brain-to-brain synchrony in mother-child and father-child dyads: a novel biomarker of brain development
Creating a Calmer NICU: Pilot Testing a Robot for Optimizing Brain Development in Preterm Infants in the NICU
Exploring the experiences of NICU mothers during the COVID-19 pandemicGrants
Healthy Starts Catalyst grant (2021-2023)
Sheena Davidson Nursing Research Fund (2020-2022)Research Group Members
Maria Jose Castro Babbini, Graduate Trainee
Fermin Hoq, Graduate trainee, Research Assistant
Mary Ibitoye, Graduate Trainee
Rujun Kang, Research Assistant/Lab Technician Level 4
Connie Ku, Graduate Research Assistant :Graduate Trainee
Olivia Moretti, Graduate student
Scott Ramsay, Graduate Student
Donna Seraj, Undergraduate trainee
Dr. Manon Ranger is a new investigator at BC Children's Hospital and UBC studying new ways to reduce the impact of pain and early life stress on preterm babies.