BCCHR Researchers Find a Researcher

Nicholas Au

MD, FRCPC

Investigator, BC Children's Hospital
Hematopathologist, BC Children's and Women's Hospitals

My current research focuses on use of flow cytometry for assessing platelet function and whether it can be a viable method for clinical use.

Academic Affiliations

Clinical Assistant Professor, , Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia
Research Theme: Childhood Diseases
Research Group(s): Childhood Cancer and Blood Research

Contact Information

Location

4500 Oak St, Vancouver, BC, Canada, V6H 3N1

(604) 875-2549

nau2@cw.bc.ca

Evaluation of low-cost techniques to detect sickle cell disease and -thalassemia: an open-label, international, multicentre study

Lancet Regional Health Southeast Asia

Shrestha, P. and Lohse, H. and Bhatla, C. and McCartney, H. and Alzaki, A. and Sandhu, N. and Oli, P.K. and Chaudhary, S. and Amid, A. and Onell, R. and Au, N. and Merkeley, H. and Kapoor, V. and Pande, R. and Stoeber, B.

DOI: 10.1016/j.lansea.2025.100571

Monolobated megakaryocytes in Diamond"Blackfan anemia with RPL5 mutation at disease presentation mimicking myelodysplastic syndrome

Pediatric Blood and Cancer

Setiadi, A. and Singh, C. and Li, A. and Au, N. and Amid, A.

DOI: 10.1002/pbc.30771

Evaluation of Low-Cost Techniques to Detect Sickle Cell Disease and -Thalassemia: An International Multi-Center Study

SSRN

Morphology-based classification of sickle cell disease and -thalassemia using a low-cost automated microscope and machine learning

Medrxiv

Shrestha, P. and Lohse, H. and Bhatla, C. and McCartney, H. and Alzaki, A. and Sandhu, N. and Oli, P.K. and Li, H. and Prakash, M. and Amid, A. and Onell, R. and Au, N. and Merkeley, H. and Kapoor, V. and Pande, R. and Stoeber, B.

DOI: 10.1101/2024.09.21.24314128

Clinical and laboratory features associated with myeloperoxidase expression in pediatric B-lymphoblastic leukemia

Cytometry Part B: Clinical Cytometry

Eric McGinnis and David Yang and Nicholas Au and Douglas Morrison and Kate M. Chipperfield and Audi F. Setiadi and Lorraine Liu and Angela Tsang and Suzanne M. Vercauteren

DOI: 10.1002/cyto.b.21966

10 / 2020

Feasibility of manual white blood cell counts as a predictor of neonatal sepsis in a low-resource setting

Transactions of The Royal Society of Tropical Medicine and Hygiene

Christian N Golding and Frederik Schaltz-Buchholzer and Lilica Sanca and Clara Clipet-Jensen and Christine S Benn and Nicholas Au and Kate Chipperfield and Tobias R Kollmann and Nelly A Amenyogbe

DOI: 10.1093/trstmh/traa023

04 / 2020

Inter-hospital variation in use of obstetrical blood transfusion: a population-based cohort study

BJOG: An International Journal of Obstetrics and Gynaecology

Hutcheon, J.A. and Chapinal, N. and Skoll, A. and Au, N. and Lee, L.

DOI: 10.1111/1471-0528.16203

Accuracy of Blood Transfusion Records in a Population-based Perinatal Data Registry

Epidemiology

Hutcheon, J.A. and Chapinal, N. and Skoll, M.A. and Au, N. and Lee, L.

DOI: 10.1097/EDE.0000000000001183

Severe hemolytic disease of the fetus and newborn due to allo-anti-D in a patient with a partial DEL phenotype arising from the variant allele described as RHD148+1T (RHD01EL.31)

Transfusion

Turley, E. and McGowan, E.C. and Hyland, C.A. and Schoeman, E.M. and Flower, R.L. and Skoll, A. and Delisle, M.-F. and Nelson, T. and Clarke, G. and Au, N.

DOI: 10.1111/trf.14944

JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome

Journal of Allergy and Clinical Immunology

Del Bel, K.L. and Ragotte, R.J. and Saferali, A. and Lee, S. and Vercauteren, S.M. and Mostafavi, S.A. and Schreiber, R.A. and Prendiville, J.S. and Phang, M.S. and Halparin, J. and Au, N. and Dean, J.M. and Priatel, J.J. and Jewels, E. and Junker, A.K. and Rogers, P.C. and Seear, M. and McKinnon, M.L. and Turvey, S.E.

DOI: 10.1016/j.jaci.2016.12.957

Impact of preoperative laboratory investigation and blood cross-match on clinical management of pediatric neurosurgical patients

Child's Nervous System

Yang, M.M.H. and Singhal, A. and Au, N. and Hengel, A.R.

DOI: 10.1007/s00381-015-2617-6

Acute encephalopathy in a kidney transplant recipient following infusion of intravenous immunoglobulin

Transplant International

Wang, L. and Larkins, N. and Jung, B. and Au, N.H.C. and Mammen, C.

DOI: 10.1111/tri.12384

Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking

Orphanet Journal of Rare Diseases

Stockler, S. and Corvera, S. and Lambright, D. and Fogarty, K. and Nosova, E. and Leonard, D. and Steinfeld, R. and Ackerley, C. and Shyr, C. and Au, N. and Selby, K. and Van Allen, M. and Vallance, H. and Wevers, R. and Watkins, D. and Rosenblatt, D. and Ross, C.J. and Conibear, E. and Wasserman, W. and Van Karnebeek, C.

DOI: 10.1186/s13023-014-0141-5

Microdeletion of exon 3 in the HBA2 gene associated with mild a-thalassemia trait

Hemoglobin

Lambert, A. and Wong, A.Y.K. and Kominami, Y. and Smith, V.C. and Reddy, S. and Wadsworth, L.D. and Au, N.H.C. and MacGillivray, R.T.A.

DOI: 10.3109/03630269.2013.763257

Blueberry muffin rash and thrombocytopenia in a newborn with mucolipidosis type II (I-cell disease) masquerading as congenital infections

Molecular Genetics and Metabolism

Ting, J. and Hochwald, O. and Au, N. and Mercimek-Mahmutoglu, S.

DOI: 10.1016/j.ymgme.2011.09.003

Two new examples of Hb st. etienne [92(F8)HisGln] in association with venous thrombosis

Hemoglobin

Au, N.H.C. and Wong, A.Y.K. and Vickars, L. and MacGillivray, R.T.A. and Wadsworth, L.D.

DOI: 10.1080/03630260902817206

Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: A tissue microarray study of 284 cases and 18 markers

Journal of Pathology

Au, N.H.C. and Cheang, M. and Huntsman, D.G. and Yorida, E. and Coldman, A. and Elliott, W.M. and Bebb, G. and Flint, J. and English, J. and Gilks, C.B. and Grimes, H.L.

DOI: 10.1002/path.1612

Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells

Cancer Research

Kazanjian, A. and Wallis, D. and Au, N. and Nigam, R. and Venken, K.J.T. and Cagle, P.T. and Dickey, B.F. and Bellen, H.J. and Gilks, C.B. and Grimes, H.L.

DOI: 10.1158/0008-5472.CAN-04-0633

P63 expression in lung carcinoma: a tissue microarray study of 408 cases.

Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry

Au, N.H. and Gown, A.M. and Cheang, M. and Huntsman, D. and Yorida, E. and Elliott, W.M. and Flint, J. and English, J. and Gilks, C.B. and Grimes, H.L.

DOI: 10.1097/00129039-200409000-00010

Detection and Genotyping of Varicella-Zoster Virus by TaqMan Allelic Discrimination Real-Time PCR

Journal of Clinical Microbiology

Campsall, P.A. and Au, N.H.C. and Prendiville, J.S. and Speert, D.P. and Tan, R. and Thomas, E.E.

DOI: 10.1128/JCM.42.4.1409-1413.2004

Current Projects

Neonatal alloimmune thrombocytopenia (NAIT) is a blood disease in newborns which develops when the pregnant mother produces antibodies that destroy the newborns' platelets. According to current guidelines, NAIT should be treated by transfusing a certain type of platelets (HPA-1a negative platelets). However, the availability of HPA-1a negative platelets is limited. I am currently conducting a study to determine if transfusion with random donor platelets is effective in treating NAIT.

Red blood cells are frequently transfused in acute care institutions for the management of anemia, however research has shown that approximately 30% of red cell transfusions may be inappropriate. Red blood cells are derived from voluntary human donors and represent a precious medical resource. Transfusions also carry risks to the recipient, some of which may lead to morbidity and even mortality. I am participating in a quality study to assess the appropriateness of medical red cell transfusions.

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Nicholas Au

MD, FRCPC

Investigator, BC Children's Hospital
Hematopathologist, BC Children's and Women's Hospitals

Academic Affiliations

Contact Information

Location

Publications

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Expand

Evaluation of low-cost techniques to detect sickle cell disease and -thalassemia: an open-label, international, multicentre study

Monolobated megakaryocytes in Diamond"Blackfan anemia with RPL5 mutation at disease presentation mimicking myelodysplastic syndrome

Evaluation of Low-Cost Techniques to Detect Sickle Cell Disease and -Thalassemia: An International Multi-Center Study

Morphology-based classification of sickle cell disease and -thalassemia using a low-cost automated microscope and machine learning

Clinical and laboratory features associated with myeloperoxidase expression in pediatric B-lymphoblastic leukemia

Feasibility of manual white blood cell counts as a predictor of neonatal sepsis in a low-resource setting

Inter-hospital variation in use of obstetrical blood transfusion: a population-based cohort study

Accuracy of Blood Transfusion Records in a Population-based Perinatal Data Registry

Severe hemolytic disease of the fetus and newborn due to allo-anti-D in a patient with a partial DEL phenotype arising from the variant allele described as RHD148+1T (RHD01EL.31)

JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome

Impact of preoperative laboratory investigation and blood cross-match on clinical management of pediatric neurosurgical patients

Acute encephalopathy in a kidney transplant recipient following infusion of intravenous immunoglobulin

Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking

Microdeletion of exon 3 in the HBA2 gene associated with mild a-thalassemia trait

Blueberry muffin rash and thrombocytopenia in a newborn with mucolipidosis type II (I-cell disease) masquerading as congenital infections

Two new examples of Hb st. etienne [92(F8)HisGln] in association with venous thrombosis

Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: A tissue microarray study of 284 cases and 18 markers

Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells

P63 expression in lung carcinoma: a tissue microarray study of 408 cases.

Detection and Genotyping of Varicella-Zoster Virus by TaqMan Allelic Discrimination Real-Time PCR

Research

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Our Research

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Our Research

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Organization

Nicholas Au

MD, FRCPC

Investigator, BC Children's Hospital Hematopathologist, BC Children's and Women's Hospitals

Academic Affiliations

Contact Information

Location

Publications

Collapse

Expand

Evaluation of low-cost techniques to detect sickle cell disease and -thalassemia: an open-label, international, multicentre study

Monolobated megakaryocytes in Diamond"Blackfan anemia with RPL5 mutation at disease presentation mimicking myelodysplastic syndrome

Evaluation of Low-Cost Techniques to Detect Sickle Cell Disease and -Thalassemia: An International Multi-Center Study

Morphology-based classification of sickle cell disease and -thalassemia using a low-cost automated microscope and machine learning

Clinical and laboratory features associated with myeloperoxidase expression in pediatric B-lymphoblastic leukemia

Feasibility of manual white blood cell counts as a predictor of neonatal sepsis in a low-resource setting

Inter-hospital variation in use of obstetrical blood transfusion: a population-based cohort study

Accuracy of Blood Transfusion Records in a Population-based Perinatal Data Registry

Severe hemolytic disease of the fetus and newborn due to allo-anti-D in a patient with a partial DEL phenotype arising from the variant allele described as RHD*148+1T (RHD*01EL.31)

JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome

Impact of preoperative laboratory investigation and blood cross-match on clinical management of pediatric neurosurgical patients

Acute encephalopathy in a kidney transplant recipient following infusion of intravenous immunoglobulin

Single point mutation in Rabenosyn-5 in a female with intractable seizures and evidence of defective endocytotic trafficking

Microdeletion of exon 3 in the HBA2 gene associated with mild a-thalassemia trait

Blueberry muffin rash and thrombocytopenia in a newborn with mucolipidosis type II (I-cell disease) masquerading as congenital infections

Two new examples of Hb st. etienne [92(F8)HisGln] in association with venous thrombosis

Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: A tissue microarray study of 284 cases and 18 markers

Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells

P63 expression in lung carcinoma: a tissue microarray study of 408 cases.

Detection and Genotyping of Varicella-Zoster Virus by TaqMan Allelic Discrimination Real-Time PCR

Research

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Expand

Current Projects

Our Research

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Contact

Our Research

Training

Services

Organization

Investigator, BC Children's Hospital
Hematopathologist, BC Children's and Women's Hospitals

Severe hemolytic disease of the fetus and newborn due to allo-anti-D in a patient with a partial DEL phenotype arising from the variant allele described as RHD148+1T (RHD01EL.31)