Natalie Chan

MD, MPH

Affiliate Investigator, BC Children's Hospital
Assistant Professor, Division of Neonatology, Department of Pediatrics, University of California, San Francisco (UCSF)
Neonatologist and Medical Director of High-Risk Infant Follow-Up Program

My research aim is to understand the long-term outcomes of children who need neonatal intensive care, the predictors and exposures that influence these outcomes, and ultimately the modifiable factors that can improve health and developmental outcomes. By identifying strategies to better protect the vulnerable developing brain of these infants, my goal is to improve their care and help each of them live to their fullest potential.

Academic Affiliations

  • Research Theme: Brain, Behaviour & Development
  • Research Group(s): Neurodevelopmental and Neurological Disorders; Pain and Stress; Visualizing the Brain

Contact Information

Location

Dept of Pediatrics, Box 0734, 550 16th Street, 5th Floor, San Francisco, California, United States of America (USA), 94158

Neuroprotection for neonatal hypoxic"ischemic encephalopathy: Areview of novel therapies evaluated in clinical studies

Developmental Medicine and Child Neurology

Chan, N.H. and Hawkins, C.C. and Rodrigues, B.V. and Cornet, M.-C. and Gonzalez, F.F. and Wu, Y.W.

DOI: 10.1111/dmcn.16184

Long-term health outcomes of preterm birth: a narrative review

Frontiers in Pediatrics

Gette, F. and Aziz Ali, S. and Ho, M.S.P. and Richter, L.L. and Chan, E.S. and Yang, C.L. and Kieran, E. and Mammen, C. and Roberts, A. and Kang, K.T. and Wong, J. and Rassekh, S.R. and Castaldo, M. and Harris, K.C. and Lee, J. and Lam, C.K.L. and Chan, N.H. and Lisonkova, S. and Ting, J.Y.

DOI: 10.3389/fped.2025.1565897

Sociodemographic Characteristics and Behavioral Outcomes in Infants With Hypoxic-Ischemic Encephalopathy Treated With Therapeutic Hypothermia

Pediatric Neurology

Taketa, E.S. and Chan, N. and Rogers, E.E. and Glass, H.C. and Heagerty, P.J. and Juul, S.E. and Wu, Y.W. and Cornet, M.-C.

DOI: 10.1016/j.pediatrneurol.2025.04.006

Assessing Early Severity of Hypoxic-Ischemic Encephalopathy: The Role of Electroencephalogram Background in Addition to Sarnat Exam

Journal of Pediatrics

Cornet, M.-C. and Numis, A.L. and Monsell, S.E. and Chan, N.H. and Gonzalez, F.F. and Comstock, B.A. and Juul, S.E. and Wusthoff, C.J. and Wu, Y.W. and Glass, H.C.

DOI: 10.1016/j.jpeds.2024.114411

Cumulative caffeine exposure predicts neurodevelopmental outcomes in premature infants

Pediatric Research

Ostrem, B.E.L. and Odell, E. and Grelli, K.N. and Kramer, K. and Chan, N. and Jiang, F. and Xu, D. and Barkovich, A.J. and Barkovich, M.J. and Ferriero, D.M. and Gano, D.

DOI: 10.1038/s41390-025-04387-1

Assessing Semiregional Cerebral Oxygen Consumption (CMRO2) in Preterm Neonates: A Quantitative MRI Cohort Study With Exploratory Analysis of Respiratory Support

NMR in Biomedicine

Zhu, C. and Chan, N. and Chacko, A. and Holsti, L. and Grunau, R. and Weber, A.

DOI: 10.1002/nbm.70065

The impact of a care bundle with an emphasis on hemodynamic assessment on the short-term outcomes in neonates with congenital diaphragmatic hernia

Journal of Perinatology

Kuan, M.T.Y. and Yadav, K. and Castaldo, M. and Tan, J. and Chan, N.H. and Traynor, M. and Hosking, M. and Skarsgard, E. and Ting, J.Y.

DOI: 10.1038/s41372-023-01807-0

Utilization of a novel mobile application, HBB Prompt, to reduce Helping Babies Breathe skills decay

Plos Global Public Health

Chan, N.H.-M. and Merali, H.S. and Mistry, N. and Kealey, R. and Campbell, D.M. and Morris, S.K. and Data, S.

DOI: 10.1371/journal.pgph.0000705

Impact of Differing Language Background Exposures on Bayley-III Language Assessment in a National Cohort of Children Born Less than 29 Weeks Gestation

Children

Chan, N.H.-M. and Synnes, A. and Grunau, R.E. and Colby, L. and Petrie, J. and Elfring, T. and Richter, L. and Hendson, L. and Banihani, R. and Luu, T.M.

DOI: 10.3390/children9071048

Development of a novel mobile application, HBB Prompt, with human factors and user-centred design for Helping Babies Breathe skills retention in Uganda

BMC Medical Informatics and Decision Making

Chan, N.H.-M. and Merali, H.S. and Mistry, N. and Kealey, R. and Campbell, D.M. and Morris, S.K. and Data, S.

DOI: 10.1186/s12911-021-01406-z

Call to Action: Children with Intestinal Failure Deserve Routine Screening for Neurodevelopmental Disabilities

Journal of Pediatric Gastroenterology and Nutrition

Chan, N. and Rogers, E.E. and Glass, H.C.

DOI: 10.1097/MPG.0000000000002570

A Simulation-Based Pilot Study of a Mobile Application (NRP Prompt) as a Cognitive Aid for Neonatal Resuscitation Training

Simulation in Healthcare

Chan, N.H. and Mistry, N. and Campbell, D.M.

DOI: 10.1097/SIH.0000000000000353

Designing and evaluating a novel mobile application for Helping Babies Breathe skills retention in Uganda: Comparative study protocol

BMJ Paediatrics Open

Merali, H.S. and Chan, N.H.-M. and Mistry, N. and Kealey, R. and Campbell, D. and Morris, S.K. and Data, S.

DOI: 10.1136/bmjpo-2019-000561

Feasibility and reliability of applying Prechtl’s Assessment of General Movements for preterm infants through telemedicine

Early identification of neurodevelopmental impairment allows for targeted early interventions that may ultimately improve developmental trajectories. I co-lead an ongoing clinical research study at University of California, Davis comparing standard video review versus real-time telemedicine assessment of Prechtl’s general movements, a validated tool to identify infants at high risk of cerebral palsy in the first months of life. Our work is funded by a grant from the Children’s Miracle Network. By testing the ability to capture recordings through telemedicine, we hope to expand the reach of Prechtl’s assessment to patients who live in remote communities and improve access to early identification of cerebral palsy, thereby improving functional outcomes.

Grants

Children’s Miracle Network Grant

Grand Challenges Canada Stars in Global Health

Honours & Awards

Sommer Scholar, Johns Hopkins Bloomberg School of Public Health, Class of 2015

Neonatal Resuscitation Program Young Investigator Award, 2013

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

EXPLORE OUR RESEARCH

Stay in the Know

Sign up for compelling stories about innovative science, the doctors and researchers who turn ideas into discoveries and treatments, and the kids and families whose lives are changed.

This field is for validation purposes and should be left unchanged.