Based on my interest in adherence research, socio-cultural aspects of medicine, child development and neurology I developed, in collaboration with medical anthropology and educational psychology, a comprehensive functional sleep/wake-behaviours assessment concept and began to transform physiological knowledge with questions of sleep health and management.
In collaboration with the Cognitive Systems Lab at UBC, I have developed a 'Virtual-Sleep-Lab' concept, where Videosomnography is used for screening ‘visible’ and ‘recognizable’ sleep disorders in children with neurodevelopmental and mental health disorders in their natural setting, at home. Based on this research, the Inter. RLS Consensus Group has included children with NDD in their recent Consensus Statement.
Our current research focuses on children with NDD, who often have a combination of voluntary and involuntary movements. These movements are associated with hyperactivity and hyper-/hypo-arousability in the wake state, and hypermotor-restlessness in the sleep state, all summarized as H-Behaviours. H-Behaviours occur across a spectrum of the most frequent developmental, neurologic and mental health conditions such as ADHD, Restless Legs Syndrome (RLS) or Willis-Ekbom Disease, tics, Tourette syndrome, anxiety, ASD and FASD. While the H-Behaviour associated movement patterns are very well described in children with ADHD, tics and Tourette syndrome, they are less so in RLS/WED. Additionally, they have not been clearly defined across age, different symptoms and presentations.
Targeting single aspects of such behaviours with pharmacological interventions (stimulants, anti-depressants, anti-psychotics) increases the likelihood for adverse drug reactions – usually these children/youth are trialed with multiple psychotropic substances. In order to reduce the epidemic of psychotropic substance use, we created an international clinical and technical research consortium. Clinician backgrounds include paediatrics, neurology, psychiatry, psychology, and occupational therapy, while technician backgrounds include computing, bio-mechanical engineering, and signal processing engineering, Most members joined at the 4th Conference of International Pediatric Sleep Association (IPSA - Taipei 2015) under the Video Working Group, which offers members a roof for collaborative action.
"Emplotted Narratives" and Structured "Behavioral Observations" Supporting the Diagnosis of Willis-Ekbom Disease/Restless Legs Syndrome in Children with Neurodevelopmental Conditions.
Ipsiroglu OS and Beyzaei N and Berger M and Wagner AL and Dhalla S and Garden J and Stockler S
A randomized controlled trial of an intervention for infants' behavioral sleep problems.
Hall WA and Hutton E and Brant RF and Collet JP and Gregg K and Saunders R and Ipsiroglu O and Gafni A and Triolet K and Tse L and Bhagat R and Wooldridge J
"Diagnosis by behavioral observation" home-videosomnography - a rigorous ethnographic approach to sleep of children with neurodevelopmental conditions.
Ipsiroglu OS and Hung YH and Chan F and Ross ML and Veer D and Soo S and Ho G and Berger M and McAllister G and Garn H and Kloesch G and Barbosa AV and Stockler S and McKellin W and Vatikiotis-Bateson E
"They silently live in terror…" why sleep problems and night-time related quality-of-life are missed in children with a fetal alcohol spectrum disorder.
Ipsiroglu OS and McKellin WH and Carey N and Loock C
Neurophysiology of circadian rhythm sleep disorders of children with neurodevelopmental disabilities.
Jan JE and Bax MC and Owens JA and Ipsiroglu OS and Wasdell MB
Sleep Health Issues for Children with FASD: Clinical Considerations.
Jan JE and Asante KO and Conry JL and Fast DK and Bax MC and Ipsiroglu OS and Bredberg E and Loock CA and Wasdell MB
Sleep hygiene for children with neurodevelopmental disabilities.
Jan JE and Owens JA and Weiss MD and Johnson KP and Wasdell MB and Freeman RD and Ipsiroglu OS
Transcultural pediatrics: compliance and outcome of phenylketonuria patients from families with an immigration background.
Ipsiroglu OS and Herle M and Spoula E and Möslinger D and Wimmer B and Burgard P and Bode H and Stöckler-Ipsiroglu S
Effects of open vs. closed system endotracheal suctioning on cerebral blood flow velocities in mechanically ventilated extremely low birth weight infants.
Rieger H and Kuhle S and Ipsiroglu OS and Heinzl H and Popow CN
A novel technique to measure position-dependent resistance changes in the vertebral arteries postmortem: new insights into the aetiology of SIDS?
Wald M and Klupp N and Lawrenz K and Puig S and Heimberger K and Reiter C and Pollak A and Ipsiroglu O
Risk factors and natural history of habitual snoring.
Urschitz MS and Guenther A and Eitner S and Urschitz-Duprat PM and Schlaud M and Ipsiroglu OS and Poets CF
Classification of sudden infant death (SID) cases in a multidisciplinary setting. Ten years experience in Styria (Austria).
Kerbl R and Zotter H and Einspieler C and Roll P and Ratschek M and Köstl G and Strenger V and Hoffmann E and Perrogon A and Zötsch W and Schober P and Gränz A and Sauseng W and Bachler I and Kenner T and Ipsiroglu O and Kurz R and Styrian Sudden Infant Death Study Group
[Snoring as an sign of sleep disorders in 11- to 15-year-old school children--initial results of a Vienna epidemiologic study].
Török K and Fatemi A and Werner I and Kerbl R and Schwarz B and Ipsiroglu OS
Self-reported organic and nonorganic sleep problems in schoolchildren aged 11 to 15 years in Vienna.
Ipsiroglu OS and Fatemi A and Werner I and Paditz E and Schwarz B
[Sudden infant death in Austria--status quo and recommendations of the SIDS Consensus Working Group for Improved Registration].
Ipsiroglu OS and Fatemi A and Rabl W and Klupp N and Roll P and Meyer H and Kerbl R and Kurz R
Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy.
Plecko B and Stoeckler-Ipsiroglu S and Schober E and Harrer G and Mlynarik V and Gruber S and Moser E and Moeslinger D and Silgoner H and Ipsiroglu O
Effects of oral creatine supplementation in a patient with MELAS phenotype and associated nephropathy.
Barisic N and Bernert G and Ipsiroglu O and Stromberger C and Müller T and Gruber S and Prayer D and Moser E and Bittner RE and Stöckler-Ipsiroglu S
Sudden infant death: no evidence for linkage to common polymorphisms in the uncoupling protein-1 and the beta3-adrenergic receptor genes.
Fatemi A and Item C and Stöckler-Ipsiroglu S and Ipsiroglu O and Sperl W and Patsch W and Strobl W
Position dependent changes of cerebral blood flow velocities in premature infants.
Eichler F and Ipsiroglu O and Arif T and Popow C and Heinzl H and Urschitz M and Pollak A
Can hypocapnia reduce cerebral embolization during cardiopulmonary bypass?
Plöchl W and Krenn CG and Cook DJ and Gollob E and Pezawas T and Schima H and Ipsiroglu O and Wollenek G and Grubhofer G
Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species.
Ipsiroglu OS and Stromberger C and Ilas J and Höger H and Mühl A and Stöckler-Ipsiroglu S
[Communication barriers in the management of immigrants and their children. An analysis and possible solutions based on case reports]
Wimmer B and Ipsiroglu OS
[Prevalence of sleep disorders in school children between 11 and 15 years of age]
Ipsiroglu OS and Fatemi A and Werner I and Tiefenthaler M and Urschitz MS and Schwarz B
[Sleep medicine between science and clinical practice--how long can we avoid the issue?]
Ipsiroglu OS and Saletu B
[Orthostasis in halothane anesthesia. A model situation for studying cerebrovascular autoregulation in infants]
Ipsiroglu OS and Köhler J and Meger B and Pumberger W and Grabner C and Semsroth M
Estimating percentage total body fat and determining subcutaneous adipose tissue distribution with a new noninvasive optical device LIPOMETER.
Möller R and Tafeit E and Smolle KH and Pieber TR and Ipsiroglu O and Duesse M and Huemer C and Sudi K and Reibnegger G
[Heart rate variability--physiology, methods of registration and application in pediatric sleep laboratory]
Patzak A and Mrowka R and Springer S and Eckard T and Ipsiroglu OS and Erler T and Hofmann S
[Evaluation of the cardiorespiratory monitor SpiroGuard C for infants. Improved registration of respiratory events by new sensors and intelligent alarm management system]
Urschitz MS and Eichler F and Popow C and Ipsiroglu OS
[Viennese SIDS prevention campaign-- a quality management project]
Ipsiroglu OS and Stekel H and Pollak A and Kaspar L
SIDS related anxiety--a risk factor analysis.
Leitich H and Tiefenthaler M and Popow C and Seyfried-Holzer G and Urschitz M and Ipsiroglu OS and Pollak A
[4th Austrian SIDS Consensus-Consultation and the Viennese SIDS prevention campaign "Secure Sleep"]
Ipsiroglu OS and Kerbl R and Urschitz M and Kurz R
[Secure Sleep--SIDS prevention campaign by children's hospitals of Vienna]
Ipsiroglu OS and Lischka A and Sacher M and Stögmann W and Pollak A
Systemic blood pressure and cerebral blood flow velocity during carotid surgery.
Grubhofer G and Lassnigg A and Pernerstorfer T and Ipsiroglu O and Czerny M and Polterauer P and Hiesmayr M
Cerebral Doppler sonography of the neonate. A resume after 20 years and future aspects.
Ipsiroglu OS and Eichler F and Stoeckler-Ipsiroglu S
Are adult transcranial Doppler systems suitable for application in neonates?
Ipsiroglu OS and Steck J and Michel E and Pessenhofer H and Jorch G and Pollak A
Cerebral blood flow velocities in the first minutes of life.
Ipsiroglu OS and Stöckler S and Häusler MC and Kainer F and Rosegger H and Weiss PA and Winter R
[Dys-tocolysis: modified vaginal delivery of premature infants?]
Ipsiroglu OS and Rosegger H and Weiss PA
[The value of umbilical cord blood cortisol]
Ipsiroglu OS and Semmelrock J and Gmoser G and Stöckler S and Rosegger H
[Pregnancy and neonatal screening in Austria]
Stöckler S and Ipsiroglu OS and Häusler M
[The value of prenatal ultrasound screening exemplified by abnormalities of the urogenital system. Data from the Styrian malformation register 1985 to 1987]
Häusler M and Hofmann HM and Schaffer M and Hofer P and Rollett H and Ring E and Ipsiroglu OS
[Congenital metabolic diseases as a cause of acute illnesses in the neonatal period]
Stöckler S and Ipsiroglu OS and Paschke E
[Steiermark data of congenital abnormalities with regional classification and comparative international values]
Häusler M and Hofmann HM and Hofer P and Schaffer M and Ipsiroglu O
NeuroDevNet "Better Days/Better Nights"
SWAPPs 4KIDS with NDDs. Structured functional Sleep/Wake Behaviour assessment in children with neurodevelopmental disabilities/disorders & monitoring therapeutic interventions.
Overview: Our team has developed a web app (sleep/wake behaviours App, SWAPP) to facilitate recognition, characterization and monitoring of sleep problems (SPs) and daytime sequelae in children and youth with neurodevelopmental disabilities (NDDs) [http://youtu.be/60Kx4jmU6Is]. The use of the SWAPP in clinical practice has created evidence for revisiting clinical practice guidelines and improving existing policies by highlighting the fundamental need, to recognize and appropriately treat sleep problems in most vulnerable populations. We collaborate with a network of multidisciplinary stakeholders, including non-governmental organizations (representing patients) and recently with decision makers to ensure rapid and sustainable implementation and policy change.
Objectives of our research: Further development of the SWAPP and associated database. We are particularly interested in medication strategies, captured by the medication module for monitoring psychotropic drug prescriptions and behavioural / neurologic adverse drug reactions. A free downloadable smart-phone version of our SWAPP for caregivers and practitioners to (self-)assess / recognize the concept of challenging sleep / wake behaviours will be ready around fall 2015.
Significance: At the end of the project we will have a series of validated and commercially available SWAPPs with patient driven self-assessment modules for participatory data collection on poorly understood challenging-disruptive sleep/wake behaviours. Patient and community tier input during all stages of development will result in effective implementation of the SWAPPs through knowledge translation activities in collaboration with non-governmental organizations.Grants
Canadian Institute of Health Research. Night waking reduction in Canadian infants
a randomized clinical trial of a parent based cognitive and behavioural intervention in community health units. (Co-PI, PI
Dr. Wendy Hall)
Peter Wall Institute for Advanced Studies
Visiting Scholar Funding for Dr. Karen Spruyt, Vrije Universiteit, Brussels (together with Dr. Sylvia Stockler)
Peter Wall Institute for Advanced Studies
Phenotyping Sleep Behaviours Lessons from the Past, Directions for the Future (together with Dr. Bruce Carleton)Honours & Awards
Excellence in Education Award, Learning & Development BC Children's hospital & BC Women's Hospital & Health Care
Transcultural Paediatrics Award, German Society for Socialpaediatrics & Adolescent Medicine and Austrian Society of PaediatricsResearch Group Members
Sera Bao, Undergrad Research Assistant
Nadia Beyzaei, Senior Research Assistant
Renee Boldut, Undergraduate Student, Research Assistant
Bu Bu, Undergraduate Student
Melvin Chan, Research Assistant
Linus Hung, Software Engineer
Katrina Kelly, Research Assistant
Scout McWilliams, Research Assistant
Ellison Richmond, Volunteer
Kevin Xiao, Undergrad Research Assistant
Ted Zhou, Volunteer