Why is this finding important? How might it help children?
This research suggests that if we could find a way to increase levels of NPAS4 or help this protein work more effectively, we might be able to stop the progression of type 2 diabetes or prevent it from developing in the first place. More research will have to be done to determine whether it’s possible to create drugs that improve NPAS4 function and whether these drugs would help people with type 2 diabetes, but this is an important early step.
People used to think of type 2 diabetes as an adult disease – in fact, the condition was sometimes called “adult-onset diabetes.” In the past few decades, however, the number of children and young adults with type 2 diabetes has been increasing. This is likely because of rising obesity rates, as obesity and lack of physical activity in genetically predisposed individuals are major risk factors for type 2 diabetes.
Type 2 diabetes is a serious condition at any age, but it’s particularly devastating in children, who will have to live with the condition for most of their lives. Complications of type 2 diabetes include heart disease, vision problems and limb amputation.
By developing new treatments and preventive measures for type 2 diabetes, we can help ensure children who develop this condition are able to grow up healthy.
How did you become interested in this area of research?
I have a close family member who has diabetes, and I wanted to do research that would improve the lives of people of people with this condition.
Joining the Lynn lab was the perfect opportunity to use my background in molecular biology to understand how diabetes develops and how we might be able to create new treatments to stop it.
If there is one thing about this research you’d like to share with the general public what would it be?
I would like to express my gratitude to the Canadian public for supporting health research, which is what made it possible for us to conduct this study in the first place. Scientific research can take a long time and the results aren’t always straightforward, but I’m grateful that Canadians recognize the importance of undertaking this work.
In the Lynn lab, we’re going down to the molecular level to understand how one particular type of protein can prevent a life-changing disease. By studying the inner-workings of the human body at such a basic level, we’re laying the groundwork for a future where we can prevent, treat and cure diabetes.
This work was supported by the Canucks for Kids Fund Childhood Diabetes Laboratories, the Canadian Institutes of Health Research, the Michael Smith Foundation for Health Research, the Canadian Diabetes Association, and BC Children’s Hospital Foundation.
Dr. Francis Lynn is an investigator at the Canucks for Kids Fund Childhood Diabetes Laboratories at BC Children’s Hospital and an Associate Professor in the Departments of Surgery and Cellular & Physiological Sciences, University of British Columbia.