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Ramon Klein Geltink
PhD

Investigator, BC Children's Hospital

My research program aims to better understand how the immune system can be used to treat childhood diseases. In children with cancer, the immune system is no longer able to rid the body of cancerous cells. In children with autoimmune diseases the immune system gets rid of healthy cells of the body. We are particularly interested in the metabolism of immune cells. Metabolism consists of all the chemical processes that occur within a living organism that maintain life. In immune cells, this means that building blocks (metabolites) need to be brought in to allow the duplication of a cell by making all crucial parts of new cells. In fast growing immune cells this is especially demanding, since they need to duplicate themselves very rapidly to protect against attacks on the normal function of our bodies by, for instance, infections or cancer. This requires a variety of building blocks, and a lot of energy. For this process, cells can acquire these building blocks from their environment, or make them via intricate biochemical pathways. When the right building blocks are not available, immune cells fail to increase in numbers and cannot perform their job.

We use biochemical and metabolomic techniques to understand what fuel is needed for immune cell function, and how immune cells sense the fuel that is available in their environment.

By closely collaborating with Clinicians and Clinician scientists at BCCHR we are aiming to apply the findings to design better treatments for children with immune related diseases.

Academic Affiliations

  • Assistant Professor, , Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases
  • Research Group(s): Childhood Cancer and Blood Research; Diabetes; Immunity in Health and Disease; Rare Diseases

Contact Information

Location

950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4

Ramon.KleinGeltink@bcchr.ca

Metformin in necrobiotic xanthogranuloma

British Journal of Dermatology

Henning Klapproth and Manuel Huerta Arana and Jan W Lackmann and Luisa Bopp and MuhammadS Hussain and Ahlem Aloui and Kerstin Becker and Esther von Stebut and RamonI Klein Geltink and Iliana Tantcheva-Por and Mario Fabri

DOI: 10.1093/bjd/ljaf370

01 / 2026

Versatile electroporation protocols enable reproducible CRISPR-RNP delivery across multiple primary mouse cells of the hematopoietic lineage

Ju Hee Oh and Lucy F. Yang and Erin Tanaka and Lauar de Brito Monteiro and Dasol Wi and Anne-Sophie Archambault and Ramon I. Klein Geltink

DOI: 10.64898/2026.01.27.702081

01 / 2026

Assessment of protein synthesis rate enables metabolic profiling of resident-immune cells of the islets of Langerhans

Frontiers in Immunology

de Brito Monteiro, L. and Archambault, A.-S. and Soukhatcheva, G. and Dai, D. and Velghe, J. and Chen, Y.-C. and Verchere, C.B. and Klein Geltink, R.I.

DOI: 10.3389/fimmu.2025.1662986

Molecular subtyping of endometrial carcinoma cell lines uncovers subtype-specific targetable vulnerabilities

Npj Precision Oncology

Li, E.S. and Ho, R. and Tao, R. and Choi, Y.W.Y. and Shin, C.Y. and Chen, S.Y. and Gokbayrak, B. and Senz, J. and Yao, B. and Johnston, L. and Martin, S.D. and Yang, E. and Carey, M.S. and Hennessy, B.T. and Huntsman, D.G. and Klein Geltink, R.I. and Hoang, L. and Wang, Y.

DOI: 10.1038/s41698-025-01053-x

Lactic acid improves Treg manufacturing and in vivo function

Molecular Therapy Methods and Clinical Development

Tuomela, K. and Leong, E.S.Y. and Haque, M. and Mangat, S. and Fung, V.C.W. and Garcia, R.V. and Archambault, A.-S. and Boardman, D.A. and Klein Geltink, R.I. and Mojibian, M. and Levings, M.K.

DOI: 10.1016/j.omtm.2025.101600

A multi-kingdom genetic barcoding system for precise clone isolation

Nature Biotechnology

Ishiguro, S. and Ishida, K. and Sakata, R.C. and Ichiraku, M. and Takimoto, R. and Yogo, R. and Kijima, Y. and Mori, H. and Tanaka, M. and King, S. and Tarumoto, S. and Tsujimura, T. and Bashth, O. and Masuyama, N. and Adel, A. and Toyoshima, H. and Seki, M. and Oh, J.H. and Archambault, A.-S. and Nishida, K. and Kondo, A. and Kuhara, S. and Aburatani, H. and Klein Geltink, R.I. and Yamamoto, T. and Shakiba, N. and Takashima, Y. and Yachie, N.

DOI: 10.1038/s41587-025-02649-1

Inhibition of xanthine oxidoreductase with febuxostat, but not allopurinol, prevents inflammasome assembly and IL-1 release

Life Science Alliance

Monteiro, L.B. and Archambault, A.-S. and Starchuk, L.F. and Alcazar, A. and Oh, J.H. and Dubland, J.A. and Raki?, B. and Patterson, A.E. and Verchere, C.B. and Geltink, R.I.K.

DOI: 10.26508/lsa.202403191

The unique metabolome of clear cell ovarian carcinoma

Journal of Pathology

Ji, J.X. and Hoang, L.N. and Cochrane, D.R. and Lum, A. and Senz, J. and Farnell, D. and Tessier-Cloutier, B. and Huntsman, D.G. and Klein Geltink, R.I.

DOI: 10.1002/path.6329

Glutamine promotes human CD8+ T cells and counteracts imiquimod-induced T cell hyporesponsiveness

Iscience

Bopp, L. and Martinez, M.L. and Schumacher, C. and Seitz, R. and Arana, M.H. and Klapproth, H. and Lukas, D. and Oh, J.H. and Neumayer, D. and Lackmann, J.W. and Mueller, S. and von Stebut, E. and Brachvogel, B. and Brodesser, S. and Klein Geltink, R.I. and Fabri, M.

DOI: 10.1016/j.isci.2024.109767

Expansion and characterization of immune suppressive CD56(bright)Perforin(-) regulatory-like natural killer cells in chronic graft-versus-host disease

Cytotherapy

Lauener, M.P. and Tanaka, E. and Mei, A. and Abdossamadi, S. and Ostroumov, E. and Geltink, R.I.K. and Malarkannan, S. and Schultz, K.R.

DOI: 10.1016/j.jcyt.2024.07.013

DDIT4L regulates mitochondrial and innate immune activities in early life

JCI Insight

Michalski, C. and Cheung, C. and Oh, J.H. and Ackermann, E. and Popescu, C.R. and Archambault, A.-S. and Prusinkiewicz, M.A. and Da Silva, R. and Majdoubi, A. and Paramo, M.V. and Xu, R.Y. and Reicherz, F. and Patterson, A.E. and Golding, L. and Sharma, A.A. and Lim, C.J. and Orban, P.C. and Klein Geltink, R.I. and Lavoie, P.M.

DOI: 10.1172/jci.insight.172312

Phosphoinositide acyl chain saturation drives CD8+ effector T cell signaling and function

Nature Immunology

Joy Edwards-Hicks and Petya Apostolova and Joerg M. Buescher and Hannes Maib and Michal A. Stanczak and Mauro Corrado and Ramon I. Klein Geltink and Maria Elena Maccari and Matteo Villa and Gustavo E. Carrizo and David E. Sanin and Francesc Baixauli and Beth Kelly and Jonathan D. Curtis and Fabian Haessler and Annette Patterson and Cameron S. Field and George Caputa and Ryan L. Kyle and Melanie Soballa and Minsun Cha and Harry Paul and Jacob Martin and Katarzyna M. Grzes and Lea Flachsmann and Michael Mitterer and Liang Zhao and Frances Winkler and David Ali Rafei-Shamsabadi and Frank Meiss and Bertram Bengsch and Robert Zeiser and Daniel J. Puleston and David OSullivan and Edward J. Pearce and Erika L. Pearce

DOI: 10.1038/s41590-023-01419-y

03 / 2023

CD8+ T cells pass the acid test

Nature Metabolism

Ju Hee Oh and Anne-Sophie Archambault and Ramon I. Klein Geltink

DOI: 10.1038/s42255-023-00738-6

01 / 2023

Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts

bioRxiv

Nagalingam, R.S. and Jayousi, F. and Hamledari, H. and Baygi, D.H. and Dababneh, S. and Lindsay, C. and Geltink, R.K. and Lange, P.F. and Dixon, I.M.C. and Rose, R.A. and Czubryt, M.P. and Tibbits, G.F.

DOI: 10.1101/2023.10.08.561455

Tree-structured topic modelling of single-cell gene expression data uncovers hierarchical relationships between immune cell types

bioRxiv

Ye, P.E. and Zhang, Y. and Klein Geltink, R.I. and Park, Y.P.

DOI: 10.1101/2023.11.06.565879

Title: Inducing an oxidized redox-balance improves anti-tumor CD8+ T cell function

Biorxiv

Oh, J.H. and Cederberg, R.A. and Tanaka, E. and Bopp, L. and Ser, T. and Niyyati, S. and Patterson, A.E. and Amanat, N. and Dutra, J. and Ye, P. and Clark, M. and Ward-Hartstonge, K. and Archambault, A.-S. and Tsui, J. and Lange, P.F. and Tsai, S. and Bruce Verchere, C. and Park, Y. and Fabri, M. and Bennewith, K.L. and Klein Geltink, R.I.

DOI: 10.1101/2023.03.27.533229

Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss

Nature Communications

Zhu, X. and Fu, Z. and Chen, S.Y. and Ong, D. and Aceto, G. and Ho, R. and Steinberger, J. and Monast, A. and Pilon, V. and Li, E. and Ta, M. and Ching, K. and Adams, B.N. and Negri, G.L. and Choiniere, L. and Fu, L. and Pavlakis, K. and Pirrotte, P. and Avizonis, D.Z. and Trent, J. and Weissman, B.E. and Klein Geltink, R.I. and Morin, G.B. and Park, M. and Huntsman, D.G. and Foulkes, W.D. and Wang, Y. and Huang, S.

DOI: 10.1038/s41467-023-38594-3

Deletion of Carboxypeptidase E in b-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice

Diabetes

Chen, Y.-C. and Taylor, A.J. and Fulcher, J.M. and Swensen, A.C. and Dai, X.-Q. and Komba, M. and Wrightson, K.L.C. and Fok, K. and Patterson, A.E. and Geltink, R.I.K. and Macdonald, P.E. and Qian, W.-J. and Verchere, C.B.

DOI: 10.2337/db22-0945

A multi-kingdom genetic barcoding system for precise target clone isolation

bioRxiv

Ishiguro, S. and Ishida, K. and Sakata, R.C. and Mori, H. and Takana, M. and King, S. and Bashth, O. and Ichiraku, M. and Masuyama, N. and Takimoto, R. and Kijima, Y. and Adel, A. and Toyoshima, H. and Seki, M. and Oh, J.H. and Archambault, A.-S. and Nishida, K. and Kondo, A. and Kuhara, S. and Aburatani, H. and Klein Geltink, R.I. and Takashima, Y. and Shakiba, N. and Yachie, N.

DOI: 10.1101/2023.01.18.524633

Consequences of adjusting cell density and feed frequency on serum-free expansion of thymic regulatory T cells

Cytotherapy

Katherine N. MacDonald and Michael G. Hall and Sabine Ivison and Sanjiv Gandhi and Ramon I. Klein Geltink and James M. Piret and Megan K. Levings

DOI: 10.1016/j.jcyt.2022.06.006

11 / 2022

Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing and alters beta cell identity in mice

Yi-Chun Chen and Austin J. Taylor and James M. Fulcher and Adam C. Swensen and Xiao-Qing Dai and Mitsuhiro Komba and Kenzie L.C. Wrightson and Kenny Fok and Annette E. Patterson and Ramon I. Klein-Geltink and Patrick E. MacDonald and Wei-Jun Qian and C. Bruce Verchere

DOI: 10.1101/2022.10.20.512925

10 / 2022

PTEN is required for human Treg suppression of costimulation in vitro

European Journal of Immunology

Avery J. Lam and Manjurul Haque and Kirsten A. Ward-Hartstonge and Prakruti Uday and Christine M. Wardell and Jana K. Gillies and Madeleine Speck and Majid Mojibian and Ramon I. Klein Geltink and Megan K. Levings

DOI: 10.1002/eji.202249888

09 / 2022

PTEN is required for human Treg suppression of costimulation

Avery J. Lam and Manjurul Haque and Kirsten A. Ward-Hartstonge and Prakruti Uday and Christine M. Wardell and Jana K. Gillies and Madeleine Speck and Majid Mojibian and Ramon I. Klein Geltink and Megan K. Levings

DOI: 10.1101/2022.03.06.483188

03 / 2022

A low-sugar diet enhancesDrosophilabody size in males and females via sex-specific mechanisms

Development

Jason W. Millington and Puja Biswas and Charlotte Chao and Yi Han Xia and Lianna W. Wat and George P. Brownrigg and Ziwei Sun and Paige J. Basner-Collins and Ramon I. Klein Geltink and Elizabeth J. Rideout

DOI: 10.1242/dev.200491

03 / 2022

Metabolomic identification of a-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease

Blood

Subburaj, D. and Ng, B. and Kariminia, A. and Abdossamadi, S. and Lauener, M. and Nemecek, E.R. and Rozmus, J. and Kharbanda, S. and Kitko, C.L. and Lewis, V.A. and Schechter-Finklestein, T. and Jacobsohn, D.A. and Harris, A.C. and Pulsipher, M.A. and Bittencourt, H. and Choi, S.W. and Caywood, E.H. and Kasow, K.A. and Bhatia, M. and Oshrine, B.R. and Coulter, D. and Chewning, J.H. and Joyce, M. and Pawlowska, A.B. and Megason, G.C. and Lawitschka, A. and Ostroumov, E. and Klein Geltink, R. and Cuvelier, G.D.E. and Schultz, K.R.

DOI: 10.1182/blood.2021013244

Using human induced pluripotent stem cell-derived cardiomyocytes to understand the mechanisms driving cardiomyocyte maturation

Frontiers in Cardiovascular Medicine

Hamledari, H. and Asghari, P. and Jayousi, F. and Aguirre, A. and Maaref, Y. and Barszczewski, T. and Ser, T. and Moore, E. and Wasserman, W. and Klein Geltink, R. and Teves, S. and Tibbits, G.F.

DOI: 10.3389/fcvm.2022.967659

Executive CoAching unleashes Tc22 anti-tumor capacity

Science immunology

Klein Geltink, R.I. and Pillai, A.

DOI: 10.1126/sciimmunol.abn9190

Transsulfuration, minor player or crucial for cysteine homeostasis in cancer

Trends in Cell Biology

Zhang, H.-F. and Klein Geltink, R.I. and Parker, S.J. and Sorensen, P.H.

DOI: 10.1016/j.tcb.2022.02.009

In macrophages fatty acid oxidation spares glutamate for use in diverse metabolic pathways required for alternative activation

bioRxiv

van Teijlingen Bakker, N. and Flachsman, L. and Carrizo, G.E. and Sanin, D.E. and Lawless, S. and Castoldi, A. and Monteiro, L. and Kabat, A.M. and Matsushita, M. and Haessler, F. and Patterson, A. and Geltink, R.K. and O?Sullivan, D. and Pearce, E.L. and Pearce, E.J.

DOI: 10.1101/2022.04.13.487890

Loss of FBXO11 function establishes a stem cell program in acute myeloid leukemia through dysregulation of the mitochondrial protease LONP1

bioRxiv

Mo, A.Y.-C. and Kincross, H. and Wang, X. and Chang, L.Y.-T. and Duns, G. and Kwan, H. and Lau, T. and Roderick Docking, T. and Tran, J. and Colborne, S. and Cheng, S.-W.G. and Huang, S. and Gharaee, N. and Willie, E. and Jiang, J. and Parker, J. and Bridgers, J. and Wood, D. and Geltink, R.K. and Morin, G.B. and Karsan, A.

DOI: 10.1101/2022.09.10.507366

Fever supports CD8 + effector T cell responses by promoting mitochondrial translation

Proceedings of the National Academy of Sciences

David OSullivan and Michal A. Stanczak and Matteo Villa and Franziska M. Uhl and Mauro Corrado and Ramon I. Klein Geltink and David E. Sanin and Petya Apostolova and Nisha Rana and Joy Edwards-Hicks and Katarzyna M. Grzes and Agnieszka M. Kabat and Ryan L. Kyle and Mario Fabri and Jonathan D. Curtis and Michael D. Buck and Annette E. Patterson and Annamaria Regina and Cameron S. Field and Francesc Baixauli and Daniel J. Puleston and Edward J. Pearce and Robert Zeiser and Erika L. Pearce

DOI: 10.1073/pnas.2023752118

06 / 2021

Proteomic screens for suppressors of anoikis identify IL1RAP as a promising surface target in ewing sarcoma

Cancer Discovery

Zhang, H.-F. and Hughes, C.S. and Li, W. and He, J.-Z. and Surdez, D. and El-Naggar, A.M. and Cheng, H. and Prudova, A. and Delaidelli, A. and Negri, G.L. and Li, X. and ?rum-Madsen, M.S. and Lizardo, M.M. and Oo, H.Z. and Colborne, S. and Shyp, T. and Scopim-Ribeiro, R. and Hammond, C.A. and Dhez, A.-C. and Langman, S. and Lim, J.K.M. and Kung, S.H.Y. and Li, A. and Steino, A. and Daugaard, M. and Parker, S.J. and Geltink, R.I.K. and Orentas, R.J. and Xu, L.-Y. and Morin, G.B. and Delattre, O. and Dimitrov, D.S. and Sorensen, P.H.

DOI: 10.1158/2159-8290.CD-20-1690

Dynamic Cardiolipin Synthesis Is Required for CD8+ T Cell Immunity.

Cell metabolism

DOI: 10.1016/j.cmet.2020.11.003 PubMed: 33264603

12 / 2020

EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism.

Genes & development

Ramamoorthy S and Kometani K and Herman JS and Bayer M and Boller S and Edwards-Hicks J and Ramachandran H and Li R and Klein-Geltink R and Pearce EL and Grn D and Grosschedl R

DOI: 10.1101/gad.340216.120 PubMed: 33004416

10 / 2020

IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection.

PLoS pathogens

Montes de Oca M and de Labastida Rivera F and Winterford C and Frame TCM and Ng SS and Amante FH and Edwards CL and Bukali L and Wang Y and Uzonna JE and Kuns RD and Zhang P and Engwerda CR

DOI: 10.1371/journal.ppat.1008994 PubMed: 33049000

10 / 2020

Triacylglycerol synthesis enhances macrophage inflammatory function.

Nature communications

Castoldi A and Monteiro LB and van Teijlingen Bakker N and Sanin DE and Rana N and Corrado M and Cameron AM and Hssler F and Matsushita M and Caputa G and Klein Geltink RI and Pearce EJ

DOI: 10.1038/s41467-020-17881-3 PubMed: 32796836

08 / 2020

Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy.

Nature metabolism

Klein Geltink RI and Edwards-Hicks J and Apostolova P and O'Sullivan D and Sanin DE and Patterson AE and Puleston DJ and Ligthart NAM and Buescher JM and Grzes KM and Kabat AM and Pearce EL

DOI: 10.1038/s42255-020-0256-z PubMed: 32747793

08 / 2020

Triacylglycerol synthesis enhances macrophage inflammatory function

Castoldi A and Monteiro LB and van Teijlingen Bakker N and Sanin DE and Rana N and Corrado M and Cameron AM and Hssler F and Matsushita M and Caputa G and Klein Geltink RI and Pearce EJ

DOI: 10.1101/2020.02.03.932079

02 / 2020

The metabolic tug of war between HIV and T cells

Nature Metabolism

Ramon I. Klein Geltink

DOI: 10.1038/s42255-019-0091-2

07 / 2019

The importance of methionine metabolism

eLife

Ramon I Klein Geltink and Erika L Pearce

DOI: 10.7554/elife.47221

05 / 2019

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.

Cell metabolism

Puleston DJ and Buck MD and Klein Geltink RI and Kyle RL and Caputa G and O'Sullivan D and Cameron AM and Castoldi A and Musa Y and Kabat AM and Zhang Y and Flachsmann LJ and Field CS and Pearce EL

DOI: 10.1016/j.cmet.2019.05.003 PubMed: 31130465

05 / 2019

Acetate Promotes T Cell Effector Function during Glucose Restriction.

Cell reports

Qiu J and Villa M and Sanin DE and Buck MD and O'Sullivan D and Ching R and Matsushita M and Grzes KM and Winkler F and Chang CH and Curtis JD and Kyle RL and Van Teijlingen Bakker N and Pearce EL

DOI: 10.1016/j.celrep.2019.04.022 PubMed: 31091446

05 / 2019

Establishment of a transgenic mouse to model ETV7 expressing human tumors

Transgenic Research

DOI: 10.1007/s11248-018-0104-z

02 / 2019

Unraveling the Complex Interplay between T Cell Metabolism and Function

Annual Review of Immunology

Geltink, R.I.K. and Kyle, R.L. and Pearce, E.L.

DOI: 10.1146/annurev-immunol-042617-053019

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2

Immunity

Sanin, D.E. and Matsushita, M. and Klein Geltink, R.I. and Grzes, K.M. and van Teijlingen Bakker, N. and Corrado, M. and Kabat, A.M. and Buck, M.D. and Qiu, J. and Lawless, S.J. and Cameron, A.M. and Villa, M. and Baixauli, F. and Patterson, A.E. and Hssler, F. and Curtis, J.D. and O'Neill, C.M. and O'Sullivan, D. and Wu, D. and Mittler, G. and Huang, S.C.-C. and Pearce, E.L. and Pearce, E.J.

DOI: 10.1016/j.immuni.2018.10.011

A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways

Nature Communications

Piragyte, I. and Clapes, T. and Polyzou, A. and Klein Geltink, R.I. and Lefkopoulos, S. and Yin, N. and Cauchy, P. and Curtis, J.D. and Klaeyl, L. and Langa, X. and Beckmann, C.C.A. and Wlodarski, M.W. and Mller, P. and Van Essen, D. and Rambold, A. and Kapp, F.G. and Mione, M. and Buescher, J.M. and Pearce, E.L. and Polyzos, A. and Trompouki, E.

DOI: 10.1038/s41467-018-05311-4

ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer

Science Advances

Harwood, F.C. and Klein Geltink, R.I. and O?Hara, B.P. and Cardone, M. and Janke, L. and Finkelstein, D. and Entin, I. and Paul, L. and Houghton, P.J. and Grosveld, G.C.

DOI: 10.1126/sciadv.aar3938

Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming

Immunity

Klein Geltink, R.I. and O'Sullivan, D. and Pearce, E.L.

DOI: 10.1016/j.immuni.2017.03.022

Mitochondrial Priming by CD28

Cell

Klein Geltink, R.I. and O'Sullivan, D. and Corrado, M. and Bremser, A. and Buck, M.D. and Buescher, J.M. and Firat, E. and Zhu, X. and Niedermann, G. and Caputa, G. and Kelly, B. and Warthorst, U. and Rensing-Ehl, A. and Kyle, R.L. and Vandersarren, L. and Curtis, J.D. and Patterson, A.E. and Lawless, S. and Grzes, K. and Qiu, J. and Sanin, D.E. and Kretz, O. and Huber, T.B. and Janssens, S. and Lambrecht, B.N. and Rambold, A.S. and Pearce, E.J. and Pearce, E.L.

DOI: 10.1016/j.cell.2017.08.018

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

Cell

Buck, M.D. and O'Sullivan, D. and Klein~Geltink, R.I. and Curtis, J.D. and Chang, C.-H. and Sanin, D.E. and Qiu, J. and Kretz, O. and Braas, D. and van~der~Windt, G.J.W. and Chen, Q. and Huang, S.C.-C. and O'Neill, C.M. and Edelson, B.T. and Pearce, E.J. and Sesaki, H. and Huber, T.B. and Rambold, A.S. and Pearce, E.L.

DOI: 10.1016/j.cell.2016.05.035

High MN1 expression increases the in vitro clonogenic activity of primary mouse B-cells

Leukemia Research

Numata, M. and Yener, M.D. and Ekmek?i, S.S. and Aydin, M. and Grosveld, G. and Cardone, M. and Terranova, S. and Geltink, R.K. and zbek, U. and z?elik, E. and Gle?, T. and Anak, S. and Karaman, S. and ztrk, G. and Akbiyik, M. and Kandilci, A.

DOI: 10.1016/j.leukres.2015.05.013

Zebrafish etv7 regulates red blood cell development through the cholesterol synthesis pathway

DMM Disease Models and Mechanisms

Quintana, A.M. and Picchione, F. and Geltink, R.I.K. and Taylor, M.R. and Grosveld, G.C.

DOI: 10.1242/dmm.015123

PAX3-FOXO1 induces up-regulation of Noxa sensitizing alveolar rhabdomyosarcoma cells to apoptosis

Neoplasia (United States)

Marshall, A.D. and Picchione, F. and Klein Geltink, R.I. and Grosveld, G.C.

DOI: 10.1593/neo.121888

MN1 overexpression is an important step in the development of inv(16) AML

Leukemia

Carella, C. and Bonten, J. and Sirma, S. and Kranenburg, T.A. and Terranova, S. and Klein-Geltink, R. and Shurtleff, S. and Downing, J.R. and Zwarthoff, E.C. and Liu, P.P. and Grosveld, G.C.

DOI: 10.1038/sj.leu.2404778

Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes

Blood

Schreurs, M.W.J. and Hermsen, M.A.J.A. and Geltink, R.I.K. and Scholten, K.B.J. and Brink, A.A.T.P. and Kueter, E.W.M. and Tijssen, M. and Meijer, C.J.L.M. and Ylstra, B. and Meijer, G.A. and Hooijberg, E.

DOI: 10.1182/blood-2004-09-3742

The role of metabolism in regulation of function in immune cells

My lab aims to better understand the role of metabolism in regulation of function in immune cells. We aim to expand our understanding of the role of metabolism in the dysfunction of immune cells in cancer, and their hyperactivation in autoimmune conditions.

When cells are confronted with changing environments they have to adapt to their new surroundings to maintain cellular function. This adaptation is especially relevant for immune cells that move throughout the body and encounter different levels of metabolites and nutrients in the blood, tissues or tumours they traverse. The availability of nutrients influences immune cell metabolism, but having a metabolite available does not mean a cell will necessarily use it.

Cellular metabolism consists of an interconnected network that is influenced by at least 4 factors which we aim to better understand:

1. Metabolite availability
How do immune cells sense their nutritional environment, and how are these signals transmitted?

2. Metabolite transport into the cell
How are metabolite transporters regulated during immune cell activation?

3. Metabolic enzyme expression
Metabolic enzymes are often considered "household genes" for control experiments. How is activity of these enzymes modulated?

4. Availability of enzyme cofactors
Most, if not all, metabolic enzymes are dependent on substrate and cofactors. We are interested in the sensing of cofactor status and their effects on metabolic pathway flux.

Not all immune cells use the same metabolic pathways even if metabolites are abundant, transporters and enzymes are expressed, and cofactors are available. The response can be regulated by growth factors, cytokines, or immune cell receptor signaling, and we aim to better understand the signals that provide the instructions for which metabolic pathway to use.

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