- Overview
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Immune white cells, such as cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, protect us from infectious diseases and cancer by killing infected or unwanted cells. Conversely, defects in the function or regulation of these cells can lead to immunodeficiency or autoimmunity. Currently we are studying the role of these cells in two diseases: type 1 diabetes and X-linked lymphoproliferative disease. In both these disorders, we have described defects in CTL and NK cells. By identifying these defects in detail we hope that we will be able to develop novel therapies for disease.
- Publications
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A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes
Immunotherapy Advances
Marwaha, A.K. and Chow, S. and Pesenacker, A.M. and Cook, L. and Sun, A. and Long, S.A. and Yang, J.H.M. and Ward-Hartstonge, K.A. and Williams, E. and Domingo-Vila, C. and Halani, K. and Harris, K.M. and Tree, T.I.M. and Levings, M.K. and Elliott, T. and Tan, R. and Dutz, J.P.
DOI: 10.1093/immadv/ltab022
2022Virome-wide serological profiling reveals association of herpesviruses with obesity
Scientific Reports
Hasan, M.R. and Rahman, M. and Khan, T. and Saeed, A. and Sundararaju, S. and Flores, A. and Hawken, P. and Rawat, A. and Elkum, N. and Hussain, K. and Tan, R. and Tang, P. and Marr, N.
DOI: 10.1038/s41598-021-82213-4
2021A metagenomics-based diagnostic approach for central nervous system infections in hospital acute care setting
Scientific Reports
Hasan, M.R. and Sundararaju, S. and Tang, P. and Tsui, K.-M. and Lopez, A.P. and Janahi, M. and Tan, R. and Tilley, P.
DOI: 10.1038/s41598-020-68159-z
2020Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: A case report
BMC Infectious Diseases
Hasan, M.R. and Sundaram, M.S. and Sundararaju, S. and Tsui, K.-M. and Karim, M.Y. and Roscoe, D. and Imam, O. and Janahi, M.A. and Thomas, E. and Dobson, S. and Tan, R. and Tang, P. and Lopez, A.P.
DOI: 10.1186/s12879-020-04966-z
2020BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis
Science Translational Medicine
Brook, B. and Harbeson, D.J. and Shannon, C.P. and Cai, B. and He, D. and Ben-Othman, R. and Francis, F. and Huang, J. and Varankovich, N. and Liu, A. and Bao, W. and Bjerregaard-Andersen, M. and Schaltz-Buchholzer, F. and Sanca, L. and Golding, C.N. and Larsen, K.L. and Levy, O. and Kampmann, B. and Tan, R. and Charles, A. and Wynn, J.L. and Shann, F. and Aaby, P. and Benn, C.S. and Tebbutt, S.J. and Kollmann, T.R. and Amenyogbe, N. and Lee, A.H. and Bennike, T.B. and Diray-Arce, J. and Idoko, O. and Pomat, W.S. and van Haren, S. and Cox, M. and Darboe, A. and Falsafi, R. and Hinshaw, S.H. and Ndure, J. and Njie-Jobe, J. and Pettengill, M.A. and Marchant, A. and Richmond, P.C. and Ford, R. and Saleu, G. and Masiria, G. and Matlam, J.P. and Kirarock, W. and Roberts, E. and Malek, M. and Sanchez-Schmitz, G. and Singh, A. and Angelidou, A. and Smolen, K.K. and Brinkman, R.R. and Ozonoff, A. and Hancock, R.E.W. and van den Biggelaar, A.H.J. and Steen, H. and Vo, D. and Kraft, K. and McEnaney, K. and Vignolo, S.
DOI: 10.1126/SCITRANSLMED.AAX4517
2020A novel real-time PCR assay panel for detection of common respiratory pathogens in a convenient, strip-tube array format
Journal of Virological Methods
Hasan, M.R. and Al Mana, H. and Young, V. and Tang, P. and Thomas, E. and Tan, R. and Tilley, P.
DOI: 10.1016/j.jviromet.2018.12.013
2019A Metagenomics – Based Diagnostic Approach for Central Nervous System Infections in Hospital Acute Care Setting
bioRxiv
Hasan, M.R. and Sundararaju, S. and Tang, P. and Tsui, K.-M. and Lopez, A.P. and Janahi, M. and Tan, R. and Tilley, P.
DOI: 10.1101/752618
2019Treg gene signatures predict and measure type 1 diabetes trajectory
JCI Insight
Pesenacker, A.M. and Chen, V. and Gillies, J. and Speake, C. and Marwaha, A.K. and Sun, A. and Chow, S. and Tan, R. and Elliott, T. and Dutz, J.P. and Tebbutt, S.J. and Levings, M.K.
DOI: 10.1172/jci.insight.123879
2019Profiling of circulating microRNAs in children with recent onset of type 1 diabetes
JCI Insight
Suheda Erener and Ashish Marwaha and Rusung Tan and Constadina Panagiotopoulos and Timothy J. Kieffer
DOI: 10.1172/jci.insight.89656
02/2017Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+ IL-17+ cells
Genes and Immunity
Marwaha, A.K. and Panagiotopoulos, C. and Biggs, C.M. and Staiger, S. and Del Bel, K.L. and Hirschfeld, A.F. and Priatel, J.J. and Turvey, S.E. and Tan, R.
DOI: 10.1038/gene.2016.44
2017T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression
Journal of Clinical Investigation
Patterson, S.J. and Pesenacker, A.M. and Wang, A.Y. and Gillies, J. and Mojibian, M. and Morishita, K. and Tan, R. and Kieffer, T.J. and Verchere, C.B. and Panagiotopoulos, C. and Levings, M.K.
DOI: 10.1172/JCI83987
2016Comparative evaluation of laboratory developed real-time PCR assays and RealStar® BKV PCR Kit for quantitative detection of BK polyomavirus
Journal of Virological Methods
Hasan, M.R. and Tan, R. and Al-Rawahi, G. and Thomas, E. and Tilley, P.
DOI: 10.1016/j.jviromet.2016.04.009
2016Depletion of human DNA in spiked clinical specimens for improvement of sensitivity of pathogen detection by next-generation sequencing
Journal of Clinical Microbiology
Hasan, M.R. and Rawat, A. and Tang, P. and Jithesh, P.V. and Thomas, E. and Tan, R. and Tilley, P.
DOI: 10.1128/JCM.03050-15
2016Multiple sclerosis-associated CLEC16A controls HLA class II expression via late endosome biogenesis
Brain
Van Luijn, M.M. and Kreft, K.L. and Jongsma, M.L. and Mes, S.W. and Wierenga-Wolf, A.F. and Van Meurs, M. and Melief, M.-J. and Van Der Kant, R. and Janssen, L. and Janssen, H. and Tan, R. and Priatel, J.J. and Neefjes, J. and Laman, J.D. and Hintzen, R.Q.
DOI: 10.1093/brain/awv080
2015Nocardia asteroides sinusitis in a pediatric patient: Case report with 20 year follow-up and review of the literature
International Journal of Pediatric Otorhinolaryngology
Sorichetti, B. and Westerberg, B.D. and Tan, R. and Kozak, F.K.
DOI: 10.1016/j.ijporl.2015.04.022
2015CCL22 prevents rejection of mouse islet allografts and induces donor-specific tolerance
Cell Transplantation
Montane, J. and Obach, M. and Alvarez, S. and Bischoff, L. and Dai, D.L. and Soukhatcheva, G. and Priatel, J.J. and Hardenberg, G. and Levings, M.K. and Tan, R. and Orban, P.C. and Verchere, C.B.
DOI: 10.3727/096368914X685249
2015CD1d expression and invariant NKT cell responses in herpesvirus infections
Frontiers in Immunology
Chung, B.K. and Priatel, J.J. and Tan, R.
DOI: 10.3389/fimmu.2015.00312
2015Natural killer T cell strategies to combat Epstein-Barr virus infection
OncoImmunology
Priatel, J.J. and Chung, B.K. and Tsai, K. and Tan, R.
DOI: 10.4161/onci.28329
2014Combined immunodeficiency associated with homozygous MALT1 mutations
Journal of Allergy and Clinical Immunology
McKinnon, M.L. and Rozmus, J. and Fung, S.-Y. and Hirschfeld, A.F. and Del Bel, K.L. and Thomas, L. and Marr, N. and Martin, S.D. and Marwaha, A.K. and Priatel, J.J. and Tan, R. and Senger, C. and Tsang, A. and Prendiville, J. and Junker, A.K. and Seear, M. and Schultz, K.R. and Sly, L.M. and Holt, R.A. and Patel, M.S. and Friedman, J.M. and Turvey, S.E.
DOI: 10.1016/j.jaci.2013.10.045
2014Evaluation of amplification targets for the specific detection of Bordetella pertussis using real-time polymerase chain reaction
Canadian Journal of Infectious Diseases and Medical Microbiology
Hasan, M.R. and Tan, R. and Al-Rawahi, G.N. and Thomas, E. and Tilley, P.
DOI: 10.1155/2014/763128
2014Insulin-producing intestinal K cells protect nonobese diabetic mice from autoimmune diabetes
Gastroenterology
Mojibian, M. and Lam, A.W.Y. and Fujita, Y. and Asadi, A. and Grassl, G.A. and Dickie, P. and Tan, R. and Cheung, A.T. and Kieffer, T.J.
DOI: 10.1053/j.gastro.2014.03.020
2014SLAM-SAP signaling promotes differentiation of IL-17-producing T cells and progression of experimental autoimmune encephalomyelitis
Journal of Immunology
Huang, Y.-H. and Tsai, K. and Ma, C. and Vallance, B.A. and Priatel, J.J. and Tan, R.
DOI: 10.4049/jimmunol.1301435
2014Innate immune control of EBV-infected B cells by invariant natural killer T cells
Blood
Chung, B.K. and Tsai, K. and Allan, L.L. and Zheng, D.J. and Nie, J.C. and Biggs, C.M. and Hasan, M.R. and Kozak, F.K. and Van Den Elzen, P. and Priatel, J.J. and Tan, R.
DOI: 10.1182/blood-2013-01-480665
2013Optimal use of MRSASelect and PCR to maximize sensitivity and specificity of MRSA detection
Current Microbiology
Hasan, M.R. and Brunstein, J.D. and Al-Rawahi, G. and Tan, R. and Thomas, E. and Tilley, P.
DOI: 10.1007/s00284-012-0241-1
2013Amino acid structure determines the immune responses generated by peptide-gold nanoparticle hybrids
Particle and Particle Systems Characterization
Yang, H. and Zhou, Y. and Fung, S.-Y. and Wu, L. and Tsai, K. and Tan, R. and Turvey, S.E. and Machuca, T. and De Perrot, M. and Waddell, T.K. and Liu, M.
DOI: 10.1002/ppsc.201300213
2013PP065. dNK and dNK-CM mediated alterations of DNA methylation in extravillous cytotrophoblasts (EVTS)
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health
Y. Hu and R. Yuen and G. Eastabrook and J. Dutz and R. Tan and P. von Dadelszen and W. Robinson
DOI: 10.1016/j.preghy.2012.04.176
07/2012Decidual NK Cell-Derived Conditioned Medium (dNK-CM) Mediates VEGF-C Secretion in Extravillous Cytotrophoblasts
American Journal of Reproductive Immunology
Eastabrook, G.D.M. and Hu, Y. and Tan, R. and Dutz, J.P. and Maccalman, C.D. and Von Dadelszen, P.
DOI: 10.1111/j.1600-0897.2011.01075.x
2012Short-term stability of pathogen-specific nucleic acid targets in clinical samples
Journal of Clinical Microbiology
Hasan, M.R. and Tan, R. and Al-Rawahi, G.N. and Thomas, E. and Tilley, P.
DOI: 10.1128/JCM.02659-12
2012NKT cells are required for complete freund's adjuvant-mediated protection from autoimmune diabetes
Journal of Immunology
Lee, I.-F. and Van Den Elzen, P. and Tan, R. and Priatel, J.J.
DOI: 10.4049/jimmunol.1002551
2011The Ca
V 1.4 Calcium Channel Is a Critical Regulator of T Cell Receptor Signaling and Naive T Cell Homeostasis
Immunity
Omilusik, K. and Priatel, J. and Chen, X. and Wang, Y. and Xu, H. and Choi, K. and Gopaul, R. and McIntyre-Smith, A. and Teh, H.-S. and Tan, R. and Bech-Hansen, N. and Waterfield, D. and Fedida, D. and Hunt, S. and Jefferies, W.
DOI: 10.1016/j.immuni.2011.07.011
2011CD1d and CD1c expression in human B cells is regulated by activation and retinoic acid receptor signaling
Journal of Immunology
Allan, L.L. and Stax, A.M. and Zheng, D.-J. and Chung, B.K. and Kozak, F.K. and Tan, R. and Van Den Elzen, P.
DOI: 10.4049/jimmunol.1003615
2011The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation
Virology
Kwun, H.J. and da Silva, S.R. and Qin, H. and Ferris, R.L. and Tan, R. and Chang, Y. and Moore, P.S.
DOI: 10.1016/j.virol.2011.01.026
2011Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets
Journal of Clinical Investigation
Montane, J. and Bischoff, L. and Soukhatcheva, G. and Dai, D.L. and Hardenberg, G. and Levings, M.K. and Orban, P.C. and Kieffer, T.J. and Tan, R. and Verchere, C.B.
DOI: 10.1172/JCI43048
2011Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling
Diabetes
Qin, H. and Lee, I.-F. and Panagiotopoulos, C. and Wang, X. and Chu, A.D. and Utz, P.J. and Priatel, J.J. and Tan, R.
DOI: 10.2337/db09-1706
2011Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes
Journal of Immunology
Marwaha, A.K. and Crome, S.Q. and Panagiotopoulos, C. and Berg, K.B. and Qin, H. and Ouyang, Q. and Xu, L. and Priatel, J.J. and Levings, M.K. and Tan, R.
DOI: 10.4049/jimmunol.1001860
2010RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells
Journal of Immunology
Priatel, J.J. and Chen, X. and Huang, Y.-H. and Chow, M.T. and Zenewicz, L.A. and Coughlin, J.J. and Shen, H. and Stone, J.C. and Tan, R. and Teh, H.S.
DOI: 10.4049/jimmunol.0803521
2010Decidual NK cell-derived conditioned medium enhances capillary tube and network organization in an extravillous cytotrophoblast cell line
Placenta
Hu, Y. and Eastabrook, G. and Tan, R. and MacCalman, C.D. and Dutz, J.P. and von Dadelszen, P.
DOI: 10.1016/j.placenta.2009.12.011
2010Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells
Blood
Allan, L.L. and Hoefl, K. and Zheng, D.-J. and Chung, B.K. and Kozak, F.K. and Tan, R. and Van Den Elzen, P.
DOI: 10.1182/blood-2009-04-211417
2009Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency
Clinical Immunology
Cuvelier, G.D.E. and Schultz, K.R. and Davis, J. and Hirschfeld, A.F. and Junker, A.K. and Tan, R. and Turvey, S.E.
DOI: 10.1016/j.clim.2009.01.003
2009Critical role for IFN-¿ in natural killer cell-mediated protection from diabetes
European Journal of Immunology
Lee, I.-F. and Qin, H. and Priatel, J.J. and Tan, R.
DOI: 10.1002/eji.200737189
2008The X-linked lymphoproliferative syndrome gene product SAP regulates B cell function through the Fc¿RIIB receptor
Cellular Signalling
Li, C. and Chung, B. and Tao, J. and Iosef, C. and Aoukaty, A. and Wang, Y. and Tan, R. and Li, S.S.-C.
DOI: 10.1016/j.cellsig.2008.07.004
2008IFN-¿-mediated extravillous trophoblast outgrowth inhibition in first trimester explant culture: A role for insulin-like growth factors
Molecular Human Reproduction
Hu, Y. and Tan, R. and Maccalman, C.D. and Eastabrook, G. and Park, S.-H. and Dutz, J.P. and Von Dadelszen, P.
DOI: 10.1093/molehr/gan018
2008Xenogeneic ß
2 -microglobulin substitution alters NK cell function
Journal of Immunology
Benoît, L.A. and Tan, R.
DOI: 10.4049/jimmunol.179.3.1466
2007Xenogeneic ß
2 -microglobulin substitution affects functional binding of MHC class I molecules by CD8+ T cells
Journal of Immunology
Benoit, L.A. and Tan, R.
DOI: 10.4049/jimmunol.179.6.3588
2007Prospective prediction of spontaneous but not recurrent autoimmune diabetes in the non-obese diabetic mouse
Diabetologia
Trudeau, J.D. and Chandler, T. and Soukhatcheva, G. and Verchere, C.B. and Tan, R.
DOI: 10.1007/s00125-007-0600-9
2007Recognition of HLA class I-restricted ß-cell epitopes in type 1 diabetes
Diabetes
Ouyang, Q. and Standifer, N.E. and Qin, H. and Gottlieb, P. and Verchere, C.B. and Nepom, G.T. and Tan, R. and Panagiotopoulos, C.
DOI: 10.2337/db06-0065
2006Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: A role for IFN-¿
Journal of Immunology
Hu, Y. and Dutz, J.P. and MacCalman, C.D. and Yong, P. and Tan, R. and Von Dadelszen, P.
DOI: 10.4049/jimmunol.177.12.8522
2006Identification of novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives
Diabetes
Standifer, N.E. and Ouyang, Q. and Panagiotopoulos, C. and Verchere, C.B. and Tan, R. and Greenbaum, C.J. and Pihoker, C. and Nepom, G.T.
DOI: 10.2337/db06-0066
2006Cutting edge: Signaling lymphocytic activation molecule-associated protein controls NKT cell functions
Journal of Immunology
Chung, B. and Aoukaty, A. and Dutz, J. and Terhorst, C. and Tan, R.
DOI: 10.4049/jimmunol.174.6.3153
2005The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts
Diabetes
Plesner, A. and Liston, P. and Tan, R. and Korneluk, R.G. and Verchere, C.B.
DOI: 10.2337/diabetes.54.9.2533
2005Current approaches for the prediction and identification of CD8 T-cell epitopes in type 1 diabetes
Current Opinion in Endocrinology and Diabetes
Standifer, N.E. and Panagiotopoulos, C. and Tan, R.
2005Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease
Journal of Immunology
Aoukaty, A. and Tan, R.
DOI: 10.4049/jimmunol.174.8.4551
2005Detection and enumeration of beta cell-specific cytotoxic T lymphocytes in type 1 diabetes: Is disease prediction possible?
Canadian Journal of Diabetes
Trudeau, J.D. and Panagiotopoulos, C. and Verchere, C.B. and Tan, R.
2005Current approaches for the prediction and identification of CD8 T cell epitopes in type 1 diabetes
Current Opinion in Endocrinology and Diabetes
N. Standifer, C. Panagiotopoulos and R. Tan. Current approaches for the prediction and identification of CD8 T cell epitopes in type 1 diabetes. Current Opinion in Endocrinology and Diabetes. 2005;12:298-302
DOI: 10.1097/01.med.0000169384.05495.20
2005Rapid and fatal meningococcal disease due to a strain of Neisseria meningitidis containing the capsule null locus.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Hoang, L.M. and Thomas, E. and Tyler, S. and Pollard, A.J. and Stephens, G. and Gustafson, L. and McNabb, A. and Pocock, I. and Tsang, R. and Tan, R.
DOI: 10.1086/427875
2005Murine CD160, Ig-like receptor on NK Cells and NKT cells, recognizes classical and nonclassical MHC class I and regulates NK cell activation
Journal of Immunology
Maeda, M. and Carpenito, C. and Russell, R.C. and Dasanjh, J. and Veinotte, L.L. and Ohta, H. and Yamamura, T. and Tan, R. and Takei, F.
DOI: 10.4049/jimmunol.175.7.4426
2005Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL
International Immunology
Qin, H. and Trudeau, J.D. and Reid, G.S.D. and Lee, I.-F. and Dutz, J.P. and Santamaria, P. and Verchere, C.B. and Tan, R.
DOI: 10.1093/intimm/dxh167
2004Regulation of Autoimmune Diabetes by Complete Freund's Adjuvant Is Mediated by NK Cells
Journal of Immunology
Lee, I.-F. and Qin, H. and Trudeau, J. and Dutz, J. and Tan, R.
DOI: 10.4049/jimmunol.172.2.937
2004Detection and Genotyping of Varicella-Zoster Virus by TaqMan Allelic Discrimination Real-Time PCR
Journal of Clinical Microbiology
Campsall, P.A. and Au, N.H.C. and Prendiville, J.S. and Speert, D.P. and Tan, R. and Thomas, E.E.
DOI: 10.1128/JCM.42.4.1409-1413.2004
2004T-cell epitopes in type 1 diabetes
Current Diabetes Reports
Panagiotopoulos, C. and Trudeau, J.D. and Tan, R.
DOI: 10.1007/s11892-004-0062-0
2004Molecular dissection of 2B4 signaling: Implications for signal transduction by SLAM-related receptors
Molecular and Cellular Biology
Chen, R. and Relouzat, F. and Roncagalli, R. and Aoukaty, A. and Tan, R. and Latour, S. and Veillette, A.
DOI: 10.1128/MCB.24.12.5144-5156.2004
2004Identification of a ß-Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes
Diabetes
Panagiotopoulos, C. and Qin, H. and Tan, R. and Verchere, C.B.
DOI: 10.2337/diabetes.52.11.2647
2003Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood
Journal of Clinical Investigation
Trudeau, J.D. and Kelly-Smith, C. and Verchere, C.B. and Elliott, J.F. and Dutz, J.P. and Finegood, D.T. and Santamaria, P. and Tan, R.
DOI: 10.1172/JCI200316409
2003Preventing tropical illness in elderly travellers: the older cruiser
Geriatrics and Aging
C. Penn and R. Tan. Preventing tropical illness in elderly travellers: the older cruiser. Geriatrics and Aging. 2003; 6:12-16.
2003Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells
Journal of Clinical Immunology
Aoukaty, A. and Lee, I.-F. and Wu, J. and Tan, R.
DOI: 10.1023/A:1022580929226
2003Prevention of tropical illness in older travellers: The older cruiser
Geriatrics and Aging
Penn, C. and Tan, R.
2003Optimization of epicutaneous immunization for the induction of CTL
Vaccine
Kahlon, R. and Hu, Y. and Orteu, C.H. and Kifayet, A. and Trudeau, J.D. and Tan, R. and Dutz, J.P.
DOI: 10.1016/S0264-410X(03)00141-5
2003Establishment and comprehensive analysis of a new human transformed follicular lymphoma B cell line, Tat-1
Leukemia
T Denyssevych and V S Lestou and S Knesevich and M Robichaud and C Salski and R Tan and R D Gascoyne and D E Horsman and L D Mayer
DOI: 10.1038/sj.leu.2402372
02/2002In situ ß cell death promotes priming of diabetogenic CD8 T lymphocytes
Journal of Immunology
Zhang, Y. and O'Brien, B. and Trudeau, J. and Tan, R. and Santamaria, P. and Dutz, J.P.
DOI: 10.4049/jimmunol.168.3.1466
2002Evaluation of a diagnostic polymerase chain reaction assay for Neisseria meningitidis in North America and field experience during an outbreak
Archives of Pathology and Laboratory Medicine
Pollard, A.J. and Probe, G. and Trombley, C. and Castell, A. and Whitehead, S. and Bigham, J.M. and Champagne, S. and Isaac-Renton, J. and Tan, R. and Guiver, M. and Borrow, R. and Speert, D.P. and Thomas, E.
2002Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase
Journal of Biological Chemistry
Aoukaty, A. and Tan, R.
DOI: 10.1074/jbc.M112029200
2002Expansion of the antigenic repertoire of a single T cell receptor upon T cell activation
Journal of Immunology
Amrani, A. and Serra, P. and Yamanouchi, J. and Trudeau, J.D. and Tan, R. and Elliott, J.F. and Santamaria, P.
DOI: 10.4049/jimmunol.167.2.655
2001Meningococcal Disease in British Columbia
BC Medical Journal
A. Pollard, J. Bigham, K. Bhachu, C. Shaw, J. Isaac-Renton, R. Tan, E. Thomas. Meningococcal Disease in British Columbia. 2001, B.C. Med. J. 43(1):21-27.
2001Manifestations of X-linked lymphoproliferative disease without prior Epstein-Barr virus exposure [2] (multiple letter)
Blood
Schuster, V. and Steppberger, K. and Borte, M. and Tan, R. and Dutz, J. and Benoit, L. and De Sa, D. and Junker, A.
DOI: 10.1182/blood.V98.6.1986
2001Lymphocytic vasculitis in X-linked lymphoproliferative disease
Blood
Dutz, J.P. and Benoit, L. and Wang, X. and Demetrick, D.J. and Junker, A. and De Sa, D. and Tan, R.
DOI: 10.1182/blood.V97.1.95
2001The expanding clinical phenotype of SAP/SH2D1A mutations
Blood
R. Tan, J. Dutz, L. Benoit, D. de Sa and A. Junker. The expanding clinical phenotype of SAP/SH2D1A mutations. Blood. 2001; 98:1986-1987.
2001Utilization of herpes simplex PCR assays for cerebrospinal fluid in a pediatric health care setting
Canadian Journal of Microbiology
Cimolai, N. and Thomas, E.E. and Tan, R. and Hill, A.
DOI: 10.1139/w01-028
2001Expansion of human cytotoxic T lymphocytes for immunotherapy
Lymphocytes: A Practical Approach (2nd edition)
R. Tan. Expansion of human cytotoxic T lymphocytes for immunotherapy. In: Lymphocytes: A Practical Approach (2nd edition), Rowland-Jones & McMichael (ed.), Oxford University Press, Oxford, 2000
2000Progression of autoimmune diabetes driven by avidity maturation of a T- cell population
Nature
Amranl, A. and Verdaguer, J. and Serra, P. and Tafuro, S. and Tan, R. and Santamaria, P.
DOI: 10.1038/35021081
2000Creating HIV-1 reverse transcriptase cytotoxic T lymphocyte target structures by HLA-A2 heavy chain modifications
International Immunology
Dela Cruz, C.S. and Tan, R. and Rowland-Jones, S.L. and Barber, B.H.
DOI: 10.1093/intimm/12.9.1293
2000Cutting edge: Defective NK cell activation in X-linked lymphoproliferative disease
Journal of Immunology
Benoit, L. and Wang, X. and Pabst, H.F. and Dutz, J. and Tan, R.
DOI: 10.4049/jimmunol.165.7.3549
2000Rapid death of adoptively transferred T cells in acquired immunodeficiency syndrome
Blood
Tan, R. and Xu, X. and Ogg, G.S. and Hansasuta, P. and Dong, T. and Rostron, T. and Luzzi, G. and Conlon, C.P. and Screaton, G.R. and McMichael, A.J. and Rowland-Jones, S.
DOI: 10.1182/blood.v93.5.1506.405a38_1506_1510
1999Case-Control Study of Primary Human Herpesvirus 6 Infection in Children With Febrile Seizures
PEDIATRICS
J. Hukin and K. Farrell and L. M MacWilliam and M. Colbourne and E. Waida and R. Tan and L. Mroz and E. Thomas
DOI: 10.1542/peds.101.2.e3
02/1998Antigen-specific release of ß-chemokines by anti-HIV-1 cytotoxic T lymphocytes
Current Biology
Price, D.A. and Sewell, A.K. and Dong, T. and Tan, R. and Goulder, P.J.R. and Rowland-Jones, S.L. and Phillips, R.E.
DOI: 10.1016/s0960-9822(98)70138-1
1998Prolonged CD8+ T-cell expansions after adoptive transfer of syngeneic lymphocytes between HIV-discordant identical twins [10]
AIDS
Tan, R. and Wilson, J.D. and Rostron, T. and Peto, T. and McMichael, A.J. and Rowland-Jones, S.L.
1998Prolonged CD8+ T-cell expansions after adoptive transfer of syngeneic lymphocytes to a patient with AIDS
AIDS
R. Tan, J.D. Wilson, T. Rostron, T. Peto, A.J. McMichael and S. Rowland-Jones. Prolonged CD8+ T-cell expansions after adoptive transfer of syngeneic lymphocytes to a patient with AIDS. 1998 AIDS 12:2240-2241.
PubMed: 9833875
1998Immunogenicities of intravenous and intramuscular administrations of modified vaccinia virus Ankara-based multi-CTL epitope vaccine for human immunodeficiency virus type 1 in mice
Journal of General Virology
Hanke, T. and Blanchard, T.J. and Schneider, J. and Ogg, G.S. and Tan, R. and Becker, M. and Gilbert, S.C. and Hill, A.V.S. and Smith, G.L. and McMichael, A.
DOI: 10.1099/0022-1317-79-1-83
1998Role of cellular immunity in protection against HIV infection
Advances in Immunology
Rowland-Jones, S. and Tan, R. and McMichael, A.
1997LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing
Proceedings of the National Academy of Sciences of the United States of America
Screaton, G.R. and Xu, X.-N. and Olsen, A.L. and Cowper, A.E. and Tan, R. and Mcmichael, A.J. and Bell, J.I.
DOI: 10.1073/pnas.94.9.4615
1997Evasion of cytotoxic T lymphocyte (CTL) responses by nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus- infected cells
Journal of Experimental Medicine
Xu, X.-N. and Screaton, G.R. and Gotch, F.M. and Dong, T. and Tan, R. and Almond, N. and Walker, B. and Stebbings, R. and Kent, K. and Nagata, S. and Stott, J.E. and McMichael, A.J.
DOI: 10.1084/jem.186.1.7
1997Immunology of HIV infection
Molecular Medicine Today
Tan, R.
DOI: 10.1016/S1357-4310(97)01063-0
1997Control of hiv co-receptor expression: Implications for pathogenesis and treatment
Trends in Microbiology
Rowland-Jones, S. and Tan, R.
DOI: 10.1016/S0966-842X(97)01092-5
1997Immunizations for travel to tropical and developing countries
BC Medical Journal
R. Tan Immunizations for travel to tropical and developing countries. 1994. British Columbia Medical Journal 36:248-251.
1994The Four "I’s"
Journal of Travel Medicine
R. Tan The Four "I’s" (letter). 1994. J Trav Med. 1(4):238.
1994Postoperative endophthalmitis caused by stomatococcus mucilaginosus
Clinical Infectious Diseases
Tan, R. and White, V. and Servais, G. and Bryce, E.A.
DOI: 10.1093/clinids/18.3.492
1994Sharps utilization and disposal in British Columbia physicians’ offices
Canadian Journal of Public Health
R. Tan, and M. Noble. Sharps utilization and disposal in British Columbia physicians’ offices. 1993 Canadian Journal of Public Health 84:31-4.
PubMed: 8500054
1993B7 costimulates proliferation of CD4-8+ T lymphocytes but is not required for the deletion of immature CD4+8+ thymocytes.
The Journal of Immunology
Tan, R and Teh, S J and Ledbetter, J A and Linsley, P S and Teh, H S
1992Guidelines for HIV screening
BC Medical Journal
R. Tan and M. Noble. Guidelines for HIV screening. 1992. British Columbia Medical Journal 33:587.
1992B7 costimulates proliferation of CD4-8+ T lymphocytes but is not required for the deletion of immature CD4+8+ thymocytes
Journal of Immunology
Tan, R. and Teh, S.-J. and Ledbetter, J.A. and Linsley, P.S. and Teh, H.-S.
1992 - Research
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Medical microbiology, virology and infection control (clinical)
The medical microbiology laboratory in the Department of Pathology & Laboratory Medicine at BC Children's Hospital (BCCH) is a leader in the development of molecular diagnostic assays for pediatric infectious diseases. For example, molecular assays have been developed for human herpesvirus 6 (HHV-6), enteroviruses and Epstein-Barr virus, for the diagnosis and typing of Neisseria meningitidis (meningococcus) and for novel agents such as human metapneumovirus. The laboratory is continually adapting and developing new real-time (Taqman) and rapid Smart Cycler PCR diagnostics for a variety of bacterial and viral pathogens. In addition, the laboratory is engaged in changing the primary care management of common respiratory illnesses by providing a VIral RAPid testing program (VIRAP) that allows for the rapid (less than 4 hour) diagnosis of common respiratory pathogens.Autoimmunity in type 1 diabetes
Type 1 (juvenile-onset) diabetes mellitus arises from a T-cell-mediated autoimmune process directed against pancreatic beta cells in both humans and non-obese diabetic (NOD) mice. The destruction of beta cells is mediated by CD8+ cytotoxic T lymphocytes (CTL). Using MHC Class 1 tetrameric complexes to detect and determine the frequency of autoreactive CTL in NOD mice we have developed a predictive algorithm for disease. In collaboration with Drs. Bruce Verchere and Dina Panagiotopoulos we are hoping to extend these findings to humans through the identification of human MHC class I restricted epitopes. The laboratory is also studying several different areas of the pathogenesis of type 1 diabetes including the role of autoreactive CTL and the role of natural killer cells.X-linked lymphoproliferative disease
We have cloned and sequenced a novel mutation in the gene responsible for the fatal childhood disease, X-linked lymphoproliferative disease (XLP), thus resolving a longstanding mystery of unexplained male deaths in a large aboriginal family from northern Canada. The presence of the mutation in this extended family allows us to study the specific role of the lymphocyte cell protein, SLAM-associated protein (SAP) in human immunity to viruses and tumours. In particular, we are investigating the role of SAP in the cellular and molecular dysfunction of cytotoxic T lymphocytes and natural killer cells and the relationship between these abnormalities and the clinical phenotype of disease.Honours & AwardsMost Valuable Player, Department of Pathology & Laboratory Medicine, University of British Columbia - 2009
Michael Smith Foundation Senior Scholar 2006-
Green College Faculty Member, 2005-
Portrait
Rusung Tan
MD, FRCPC, PhD
Rusung Tan
Videos
Immunity 101: An Introduction to the Immune System
Explore the role of the immune system, different types of immunity (innate and adaptive), and organs of the immune system. Presented by Dr. Rusung Tan, Head, Immunity in Health & Disease, CFRI; Professor, Department of Pathology, UBC. | Dr. Stuart Turvey, Clinician Scientist & Co-Director, Immunity in Health & Disease, CRFI; Associate Professor, Division of Infectious & Immunological Diseases, Department of Pediatrics, UBC. (2011)
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