My primary area of interest is in the biology, management, and late effects of childhood brain and spinal cord tumors. I participate in the Children's Oncology Group (COG), a North American multi-institutional collaboration in treatment of childhood cancer and clinical and supportive care trials. I also participate in the Canadian Pediatric Brain Tumour Consortium, where we collaborate nationally in conducting research in pediatric brain tumors. Locally, I participate in research at the clinical level where treatments, quality of life, late effects of treatments, and other clinically-related questions are evaluated.


Accuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry
Lazow, M.A. and Fuller, C. and Dewire, M. and Lane, A. and Bandopadhayay, P. and Bartels, U. and Bouffet, E. and Cheng, S. and Cohen, K.J. and Cooney, T.M. and Coven, S.L. and Dholaria, H. and Diez, B. and Dorris, K. and El-Ayadi, M. and El-Sheikh, A. and Fisher, P.G. and Fonseca, A. and Garcia Lombardi, M. and Greiner, R.J. and Goldman, S. and Gottardo, N. and Gururangan, S. and Hansford, J.R. and Hassall, T. and Hawkins, C. and Kilburn, L. and Koschmann, C. and Leary, S.E. and Ma, J. and Minturn, J.E. and Monje-Deisseroth, M. and Packer, R. and Samson, Y. and Sandler, E.S. and Sevlever, G. and Tinkle, C.L. and Tsui, K. and Wagner, L.M. and Zaghloul, M. and Ziegler, D.S. and Chaney, B. and Black, K. and Asher, A. and Drissi, R. and Fouladi, M. and Jones, B.V. and Leach, J.L.
DOI: 10.1093/neuonc/noab245

Cutaneous precursor T-lymphoblastic lymphoma in a child
Pediatric Blood and Cancer
Kaur, D. and Arneja, J.S. and Senger, C. and Chipperfield, K. and Lam, J. and Cheng, S.
DOI: 10.1002/pbc.29635

Primary cutaneous follicle center lymphoma of the medial canthus of the eye in an 11-year old
Pediatric Blood and Cancer
D'Alessandro, P.R. and Lo, A.C. and Spencer, M.H. and Farinha, P. and Armstrong, L. and Dolman, P.J. and Cheng, S.
DOI: 10.1002/pbc.29630

Impact of Time to Diagnosis on Morbidity and Survival in Children with Malignant Central Nervous System Tumors
Journal of Pediatric Hematology/Oncology
Ronsley, R. and Crowell, C. and Irvine, M. and Kang, M. and Goldman, R.D. and Erker, C. and Cheng, S.
DOI: 10.1097/MPH.0000000000002424

Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC
Neuropathology and Applied Neurobiology
Hasselblatt, M. and Thomas, C. and Federico, A. and Bens, S. and Hellström, M. and Casar-Borota, O. and Kordes, U. and Neumann, J.E. and Dottermusch, M. and Rodriguez, F.J. and Lo, A.C. and Cheng, S. and Hendson, G. and Hukin, J. and Hartmann, C. and Koch, A. and Capper, D. and Siebert, R. and Paulus, W. and Nemes, K. and Johann, P.D. and Frühwald, M.C. and Kool, M.
DOI: 10.1111/nan.12797

A case series of pediatric survivors of anaplastic pleomorphic xanthoastrocytoma
Neuro-Oncology Advances
Ronsley, R. and Dunham, C. and Yip, S. and Brown, L. and Zuccato, J.A. and Karimi, S. and Zadeh, G. and Goddard, K. and Singhal, A. and Hukin, J. and Cheng, S.
DOI: 10.1093/noajnl/vdaa176

Trametinib therapy for children with neurofibromatosis type 1 and life-threatening plexiform neurofibroma or treatment-refractory low-grade glioma
Cancer Medicine
Ronsley, R. and Hounjet, C.D. and Cheng, S. and Rassekh, S.R. and Duncan, W.J. and Dunham, C. and Gardiner, J. and Ghag, A. and Ludemann, J.P. and Wensley, D. and Rehmus, W. and Sargent, M.A. and Hukin, J.
DOI: 10.1002/cam4.3910

Perceived Barriers to the Time to Diagnosis of Central Nervous System Tumors in Children: Surveying the Perspectives From the Frontline
Journal of pediatric hematology/oncology
Jogendran, M. and Ronsley, R. and Goldman, R.D. and Cheng, S.
DOI: 10.1097/MPH.0000000000002245

Anaphylaxis to parenteral nutrition in a pediatric oncology patient treated with induction of drug tolerance protocol
Journal of Allergy and Clinical Immunology: In Practice
Wachnian, C.J. and Baadjes, B. and Cheng, S. and Ramanzin, A. and Hildebrand, K.J.
DOI: 10.1016/j.jaip.2020.10.016

NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling
Clinical Case Reports
Britton, H.M. and Levine, A.B. and Shen, Y. and Mungall, K. and Serrano, J. and Snuderl, M. and Pleasance, E. and Jones, S.J.M. and Laskin, J. and Marra, M.A. and Rassekh, S.R. and Deyell, R. and Yip, S. and Cheng, S. and Dunham, C.
DOI: 10.1002/ccr3.3804

Lambert C and Goldman R and Cochrane D and Dahiya A and Mah H and Buttar A and Cheng S

Finding the Needle in the Hay Stack: Population-based Study of Prediagnostic Symptomatic Interval in Children With CNS Tumors.
Journal of pediatric hematology/oncology
Goldman RD and Cochrane DD and Dahiya A and Mah H and Buttar A and Lambert C and Cheng S
DOI: 10.1097/mph.0000000000002012
PubMed: 33235150

Canadian Pediatric Neuro-Oncology Standards of Practice
Frontiers in Oncology
Bennett, J. and Erker, C. and Lafay-Cousin, L. and Ramaswamy, V. and Hukin, J. and Vanan, M.I. and Cheng, S. and Coltin, H. and Fonseca, A. and Johnston, D. and Lo, A. and Zelcer, S. and Alvi, S. and Bowes, L. and Brossard, J. and Charlebois, J. and Eisenstat, D. and Felton, K. and Fleming, A. and Jabado, N. and Larouche, V. and Legault, G. and Mpofu, C. and Perreault, S. and Silva, M. and Sinha, R. and Strother, D. and Tsang, D.S. and Wilson, B. and Crooks, B. and Bartels, U.
DOI: 10.3389/fonc.2020.593192

Intracranial Germ Cell Tumors in Adolescents and Young Adults: A 40-Year Multi-Institutional Review of Outcomes
International Journal of Radiation Oncology Biology Physics
Lo, A.C. and Hodgson, D. and Dang, J. and Tyldesley, S. and Bouffet, E. and Bartels, U. and Cheng, S. and Hukin, J. and Bedard, P.L. and Goddard, K. and Laperriere, N.
DOI: 10.1016/j.ijrobp.2019.10.020

Long term toxicity of intracranial germ cell tumor treatment in adolescents and young adults
Journal of Neuro-Oncology
Wong, J. and Goddard, K. and Laperriere, N. and Dang, J. and Bouffet, E. and Bartels, U. and Hodgson, D. and Tyldesley, S. and Hukin, J. and Cheng, S. and Bedard, P.L. and Lo, A.C.
DOI: 10.1007/s11060-020-03642-1

Finding the Needle in the Hay Stack: Population-based Study of Prediagnostic Symptomatic Interval in Children with CNS Tumors
Journal of Pediatric Hematology/Oncology
Goldman, R.D. and Cochrane, D.D. and Dahiya, A. and Mah, H. and Buttar, A. and Lambert, C. and Cheng, S.
DOI: 10.1097/MPH.0000000000002012

Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
Nature Communications
Guerreiro Stucklin, A.S. and Ryall, S. and Fukuoka, K. and Zapotocky, M. and Lassaletta, A. and Li, C. and Bridge, T. and Kim, B. and Arnoldo, A. and Kowalski, P.E. and Zhong, Y. and Johnson, M. and Li, C. and Ramani, A.K. and Siddaway, R. and Nobre, L.F. and de Antonellis, P. and Dunham, C. and Cheng, S. and Boué, D.R. and Finlay, J.L. and Coven, S.L. and de Prada, I. and Perez-Somarriba, M. and Faria, C.C. and Grotzer, M.A. and Rushing, E. and Sumerauer, D. and Zamecnik, J. and Krskova, L. and Garcia Ariza, M. and Cruz, O. and Morales La Madrid, A. and Solano, P. and Terashima, K. and Nakano, Y. and Ichimura, K. and Nagane, M. and Sakamoto, H. and Gil-da-Costa, M.J. and Silva, R. and Johnston, D.L. and Michaud, J. and Wilson, B. and van Landeghem, F.K.H. and Oviedo, A. and McNeely, P.D. and Crooks, B. and Fried, I. and Zhukova, N. and Hansford, J.R. and Nageswararao, A. and Garzia, L. and Shago, M. and Brudno, M. and Irwin, M.S. and Bartels, U. and Ramaswamy, V. and Bouffet, E. and Taylor, M.D. and Tabori, U. and Hawkins, C.
DOI: 10.1038/s41467-019-12187-5

Canadian patterns of practice for intracranial germ cell tumors in adolescents and young adults
Journal of Neuro-Oncology
Lo, A.C. and Laperriere, N. and Hodgson, D. and Bouffet, E. and Nicholson, J. and McKenzie, M. and Hukin, J. and Cheng, S. and Goddard, K.J.
DOI: 10.1007/s11060-019-03159-2

Improving diagnosis of pediatric central nervous system tumours: Aiming for early detection
Goldman, R.D. and Cheng, S. and Cochrane, D.D.
DOI: 10.1503/cmaj.160074

Outcomes of children with central nervous system germinoma treated with multi-agent chemotherapy followed by reduced radiation
Journal of Neuro-Oncology
Sylvia Cheng and John-Paul Kilday and Normand Laperriere and Laura Janzen and James Drake and Eric Bouffet and Ute Bartels
DOI: 10.1007/s11060-015-2029-1

Pathological Findings of a Subependymal Giant Cell Astrocytoma Following Treatment With Rapamycin
Pediatric Neurology
Sylvia Cheng and Cynthia Hawkins and Michael D. Taylor and Ute Bartels
DOI: 10.1016/j.pediatrneurol.2015.05.020

Do we need a formalized humanism and professionalism curriculum in pediatric hematology and oncology training?
Pediatric Blood & Cancer
Sylvia Cheng and Meera Rayar and Angela Punnett
DOI: 10.1002/pbc.25638

Improving the Curriculum in the Pediatric Hematology and Oncology (PHO) Residency Program
Paediatric Blood and Cancer

Long term outcomes in children with intracranial germinoma: a single institution experience from 2000-2013

Early deaths in pediatric acute leukemia: A population-based study
Leukemia and Lymphoma
Cheng, S. and Pole, J.D. and Sung, L.
DOI: 10.3109/10428194.2013.850685

Pathological findings of subependymal giant cell astrocytoma following treatment with mammalian target of rapamycin (mTOR) inhibitor Rapamycin
Paediatric Blood and Cancer

Completing a scholarly project during paediatric residency: motivators, barriers, and enablers
Paediatric and Child Health

Discrete choice experiment produced estimates of acceptable risks of therapeutic options in cancer patients with febrile neutropenia
Journal of Clinical Epidemiology
Lillian Sung and Shabbir M. Alibhai and Marie-Chantal Ethier and Oliver Teuffel and Sylvia Cheng and David Fisman and Dean A. Regier
DOI: 10.1016/j.jclinepi.2011.11.008

Health-related quality of life anticipated with different management strategies for febrile neutropenia in adult cancer patients
Supportive Care in Cancer
O. Teuffel and S. Cheng and M. C. Ethier and C. Diorio and J. Martino and C. Mayo and R. Wing and L. Sung and S. M. H. Alibhai
DOI: 10.1007/s00520-012-1397-8

Health-related quality of life anticipated with different management strategies for paediatric febrile neutropaenia
British Journal of Cancer
S Cheng and O Teuffel and M C Ethier and C Diorio and J Martino and C Mayo and D Regier and R Wing and S M H Alibhai and L Sung
DOI: 10.1038/bjc.2011.213

Symptomatic Congenital Vallecular Cyst in a Neonate
The Journal of Pediatrics
Sylvia S. Cheng and Vito Forte and Vibhuti S. Shah
DOI: 10.1016/j.jpeds.2009.01.076


Delayed Diagnosis of CNS Tumors in Children
Central nervous system (CNS) tumors in chidlren account for a quarter of all cancers in children but diagnosis is often delayed as symptoms are not specific and more benign conditions are more common. Furthermore, the diagnosis of CNS tumors necessittes a comprehensive clinical history and complete examination in addition to advanced imaging. Delay in diagnosis of CNS tumors in children can be devastating for families and clinicians and time to diagnosis is critical in an effort to provide the best surgical and non-surgical care. Despite ample research and improvements in quality and access to diagnostic imaging, time to diagnosis in children has been less than optimal with reports of 5-8 months from time of symptom presentation to diagnosis. Therefore, we hope to retrospectively evaluate the time to diagnosis of CNS tumors in children in British Columbia with the aim of developing an algorithm and educational tools to aid health care providers in management prospectively.

International DIPG Registry
Diffuse Intrinsic Pontine Glioma (DIPG) is a devastating brainstem tumor that occurs in young children. Despite attempts of novel therapeutics or conventional radiation therapy, the prognosis remains dismal. Therefore, the primary aim of the DIPG Registry is to collaborate with all pediatric centers internationally to form a clinical, radiological, and tissue repository for the basis of a platform to provide collaborative efforts and research to occur in an extremely rare disease.

Headstart 4
Earlier generations of multi-center "Baby" protocols have demonstrated the feasibility of chemotherapy-only strategies for young children with newly diagnosed malignant brain tumors. The disease-free survivals attained with these regimens, however, remained worse compared to regimens that include radiation therapy. The previous generations of Headstart studies (1-3) demonstrated favourable outcomes for certain patient groups. Recent genomic advances in RNA and DNA profiling have identified four molecular subgroups of medulloblastoma that confer prognosis. However, all the analyses to date have been conducted on patients where the majority received radiation therapy. Therefore, the primary aims of Headstart 4 is to determine prospectively, in a randomized fashion, whether there is a difference in event-free and overall survival in those who receive a dose-intensive tandem consolidation vs. single consolidation in high risk patients with medulloblastoma and embryonal CNS tumors based on prospective molecular risk stratification.

Research Group Members

Arielle Locke, Research Student
Carla Willems