Overview

I am involved in diverse studies that include defining clinically relevant pharmacodynamic endpoints for drugs used in paediatric anaesthetic and perioperative care, and providing feedback on aspects of quality of intraoperative care, with the common goal of improving patients' experiences & safety.

Examples of such work include: examining the effects of anaesthetic drugs on myocardial repolarization; investigating relationships between anesthetic pharmacodynamics and pharmacogenetics; exploring relationships between intraoperative homeostasis and post-operative outcomes; contributing to and leading the set-up of multi-centre registries.

Publications

Caudal and Intravenous Anesthesia Without Airway Instrumentation for Laparoscopic Inguinal Hernia Repair in Infants: A Case Series
A&A practice
Krishnan, P. and Whyte, S.D. and Baird, R. and Malherbe, S.
DOI: 10.1213/XAA.0000000000001251
2020

Using physiological monitoring data for performance feedback: an initiative using thermoregulation metrics.
Görges M and West NC and Whyte SD
DOI: 10.1007/s12630-016-0762-3
PubMed: 27785761
03/2017

Preoperative warming and undesired surgical and anesthesia outcomes in pediatric spinal surgery-a retrospective cohort study.
Görges M and West NC and Cheung W and Zhou G and Miyanji F and Whyte SD
DOI: 10.1111/pan.12939
PubMed: 27312044
09/2016

The safety of modern anesthesia for children with long QT syndrome.
Whyte SD and Nathan A and Myers D and Watkins SC and Kannankeril PJ and Etheridge SP and Andrade J and Collins KK and Law IH and Hayes J and Sanatani S
DOI: 10.1213/ane.0000000000000389
PubMed: 25076102
10/2014

ACS national surgical quality improvement program: targeting quality improvement in Canadian pediatric surgery.
Skarsgard ED and Bedford J and Chan T and Whyte S and Afshar K
DOI: 10.1016/j.jpedsurg.2014.02.047
PubMed: 24851748
05/2014

Pediatric Airway Management in COVID-19 Patients: Consensus Guidelines from the Society for Pediatric Anesthesia's Pediatric Difficult Intubation Collaborative and the Canadian Pediatric Anesthesia Society
Anesthesia and Analgesia
Matava, C.T. and Kovatsis, P.G. and Lee, J.K. and Castro, P. and Denning, S. and Yu, J. and Park, R. and Lockman, J.L. and Von Ungern-Sternberg, B. and Sabato, S. and Lee, L.K. and Ayad, I. and Mireles, S. and Lardner, D. and Whyte, S. and Szolnoki, J. and Jagannathan, N. and Thompson, N. and Stein, M.L. and Dalesio, N. and Greenberg, R. and McCloskey, J. and Peyton, J. and Evans, F. and Haydar, B. and Reynolds, P. and Chiao, F. and Taicher, B. and Templeton, T. and Bhalla, T. and Raman, V.T. and Garcia-Marcinkiewicz, A. and Gálvez, J. and Tan, J. and Rehman, M. and Crockett, C. and Olomu, P. and Szmuk, P. and Glover, C. and Matuszczak, M. and Galvez, I. and Hunyady, A. and Polaner, D. and Gooden, C. and Hsu, G. and Gumaney, H. and Pérez-Pradilla, C. and Kiss, E.E. and Theroux, M.C. and Lau, J. and Asaf, S. and Ingelmo, P. and Engelhardt, T. and Herviás, M. and Greenwood, E. and Javia, L. and Disma, N. and Yaster, M. and Fiadjoe, J.E.
DOI: 10.1213/ANE.0000000000004872
2020

Effects of Dexmedetomidine on Blood Glucose and Serum Potassium Levels in Children Undergoing General Anesthesia: A Secondary Analysis of Safety Endpoints During a Randomized Controlled Trial
Anesthesia and analgesia
Görges, M. and Poznikoff, A.K. and West, N.C. and Brodie, S.M. and Brant, R.F. and Whyte, S.D.
DOI: 10.1213/ANE.0000000000004154
2019

Effects of Dexmedetomidine on Myocardial Repolarization in Children Undergoing General Anesthesia: A Randomized Controlled Trial
Anesthesia and analgesia
Görges, M. and Sherwin, E.D. and Poznikoff, A.K. and West, N.C. and Brodie, S.M. and Whyte, S.D.
DOI: 10.1213/ANE.0000000000004135
2019

Integrating intraoperative physiology data into outcome analysis for the ACS Pediatric National Surgical Quality Improvement Program
Paediatric Anaesthesia
Görges, M. and Afshar, K. and West, N. and Pi, S. and Bedford, J. and Whyte, S.D.
DOI: 10.1111/pan.13531
2019

Audit and feedback: to tell or not to tell? That is not the question,Audit et rétroaction: dire ou ne pas dire? Telle n’est pas la question
Canadian Journal of Anesthesia
Whyte, S.
DOI: 10.1007/s12630-018-1206-z
2018

Identification of Requirements for a Postoperative Pediatric Pain Risk Communication Tool: Focus Group Study With Clinicians and Family Members
JMIR Pediatrics and Parenting
Michael D Wood and Kim Correa and Peijia Ding and Rama Sreepada and Kent C Loftsgard and Isabel Jordan and Nicholas C West and Simon D Whyte and Elodie Portales-Casamar and Matthias Görges
DOI: 10.2196/37353
07/2022

A pharmacogenomic investigation of the cardiac safety profile of ondansetron in children and pregnant women.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Drögemöller BI and Wright GEB and Trueman J and Shaw K and Staub M and Chaudhry S and Miao F and Higginson M and Groeneweg GSS and Brown J and Magee LA and Whyte SD and West N and Carleton BC
DOI: 10.1016/j.biopha.2022.112684
PubMed: 35149390
02/2022

Identification of Requirements for a Postoperative Pediatric Pain Risk Communication Tool: Focus Group Study With Clinicians and Family Members (Preprint)
Michael D Wood and Kim Correa and Peijia Ding and Rama Sreepada and Kent C Loftsgard and Isabel Jordan and Nicholas C West and Simon D Whyte and Elodie Portales-Casamar and Matthias Görges
DOI: 10.2196/preprints.37353
02/2022

Blood pressure nomograms for children undergoing general anesthesia, stratified by age and anesthetic type, using data from a retrospective cohort at a tertiary pediatric center
Journal of Clinical Monitoring and Computing
Rosa J. Hillgruber and Pavel Lutskov and Nicholas C. West and Simon Whyte and Matthias Görges
DOI: 10.1007/s10877-022-00811-7
01/2022

Association of dexmedetomidine with recovery room and hospital discharge times: A retrospective cohort analysis
Pediatric Anesthesia
Nicholas West and Matthias Görges and Andrew Poznikoff and Simon Whyte and Stephan Malherbe
DOI: 10.1111/pan.14257
11/2021

The Effect of Carbetocin Dose on Transmural Dispersion of Myocardial Repolarization in Healthy Parturients Scheduled for Elective Cesarean Delivery under Spinal Anesthesia: A Prospective, Randomized Clinical Trial
Anesthesia and Analgesia
Clunies-Ross, N. and Roston, T.M. and Taylor, J. and Whyte, S. and Albert, A. and Görges, M. and Chau, A.
DOI: 10.1213/ANE.0000000000004712
2021

A survey of the global impact of COVID-19 on the practice of pediatric anesthesia: A study from the pediatric anesthesia COVID-19 Collaborative Group
Paediatric Anaesthesia
Soneru, C.N. and Fernandez, A.M. and Bradford, V. and Staffa, S.J. and Raman, V.T. and Cravero, J. and Zurakowski, D. and Meier, P.M. and Balakrishnan, S. and Bansal, V. and Torres, A.B. and Beethe, A. and Benzon, H.A. and Bhandari, A. and Bocanegra, A. and Bould, D. and Peterson, M.B. and Brzenski, A. and Busso, V. and Cain, J.G. and Cassidy, M. and Cheon, E.C. and Chhabada, S. and Correll, L.R. and Dalesio, N.M. and Davidson, A. and Derderian, C. and Dhumak, V. and Disma, N. and D'Mello, A. and Echeverry, P. and Ellison, P.R. and Erb, T. and Fajardo, A. and Falcon, R.J. and Frugoni, B. and García, J. and Giraldo, O.L. and Glover, C.D. and Goeller, J. and Goobie, S.M. and Gooch, I. and Granados, L.M. and Grivoyannis, A. and Guruswamy, V. and Hesselink, E. and Hobbs, J. and Hunyady, A. and Jain, R. and Jorge-Reynolds, L. and Kato, M.A. and King, M.R. and Kitzman, J. and Koh, J. and Lester, A. and Lorinc, A. and Lozano, C. and Manupipatpong, K. and Matava, C. and McLuckie, D. and Merchant, K. and Levy, H.M. and Muldowney, B.L. and Navarro, J.A. and Nelson, J. and Patel, A. and Patel, R. and Ravula, N. and Reddy, D. and Reddy, S.K. and McCormick, M.R. and Roque, R. and Rosen, D. and Beel, E.R. and Rothschild, L. and Sarmiento, L. and Shadrina, A. and Shaw, R. and Sheth, M. and Simpao, A.F. and Singh, N. and Smith, T.E. and Soria, C. and Szmuk, P. and Taicher, B.M. and Tan, G.M. and Teng, H. and Edala, T. and Tighe, N. and Tom, S. and Trujillo, A. and Vishneski, S.R. and Vivas, J.P. and Samek, A.V. and von Ungern-Sternberg, B.S. and Whyte, S. and Wilder, R.T.
DOI: 10.1111/pan.14174
2021

A comparison of videolaryngoscopy using standard blades or non-standard blades in children in the Paediatric Difficult Intubation Registry
British Journal of Anaesthesia
Peyton, J. and Park, R. and Staffa, S.J. and Sabato, S. and Templeton, T.W. and Stein, M.L. and Garcia-Marcinkiewicz, A.G. and Kiss, E. and Fiadjoe, J.E. and von Ungern-Sternberg, B. and Chiao, F. and Olomu, P. and Zurakowski, D. and Kovatsis, P.G. and Sommerfield, D. and Holmes, C. and Ravula, N. and Jette, C. and Mireles, S. and Matava, C. and Whyte, S. and Vega, E. and Yang, L. and Echeverry-Marin, P. and Perez-Pradilla, C. and Starker, E. and Zieg, J. and Szolnoki, J. and Lee, A. and Heitmiller, E. and Rehman, M. and Zamora, L. and Fernandez, A. and Meserve, J. and Bhattacharya, S. and Reynolds, P. and Lewis, I. and Haydar, B. and Therrian, M. and Sarmiento, L. and Richtsfeld, M. and Belani, K. and Robertson, S. and Sathyamoorthy, K. and Schrock, C. and de Graaff, J. and Soneru, C. and Singh, N. and Taicher, B. and Castro, P. and Riveros Perez, N.R. and Stricker, P. and Lockman, J.L. and Galvez, J. and Isserman, R. and Struyk, B. and Ward, C. and Hsu, G. and Nishisaki, A. and Kodavatiganti, R. and Ramos, L.S. and Scheu, E. and Bruins, B. and Goldfarb, T. and Szmuk, P. and Jain, R. and Matuszczak, M. and Polaner, D. and Hunyady, A. and Bosenberg, A. and Tham, S. and Low, D. and Rosas, G.B. and Lee, L.K. and Iyah, I. and Dalesio, N. and Greenberg, R.
DOI: 10.1016/j.bja.2020.08.010
2021

A systematic review of outcomes reported in pediatric perioperative research: A report from the Pediatric Perioperative Outcomes Group
Paediatric Anaesthesia
Muhly, W.T. and Taylor, E. and Razavi, C. and Walker, S.M. and Yang, L. and de Graaff, J.C. and Vutskits, L. and Davidson, A. and Zuo, Y. and Pérez-Pradilla, C. and Echeverry, P. and Torborg, A.M. and Xu, T. and Rawlinson, E. and Subramanyam, R. and Whyte, S. and Seal, R. and Meyer, H.M. and Yaddanapudi, S. and Goobie, S.M. and Cravero, J.P. and Keaney, A. and Graham, M.R. and Ramos, T. and Stricker, P.A. and Malic, C.C. and von Ungern-Sternberg, B.S. and Shivera, T. and Yu, G.
DOI: 10.1111/pan.13981
2020

Effects of Dexmedetomidine on Blood Glucose and Serum Potassium Levels in Children Undergoing General Anesthesia: A Secondary Analysis of Safety Endpoints During a Randomized Controlled Trial.
Anesthesia and analgesia
Görges M and Poznikoff AK and West NC and Brodie SM and Brant RF and Whyte SD
DOI: 10.1213/ane.0000000000004154
PubMed: 31008751
04/2019

Effects of Dexmedetomidine on Myocardial Repolarization in Children Undergoing General Anesthesia: A Randomized Controlled Trial.
Anesthesia and analgesia
Görges M and Sherwin ED and Poznikoff AK and West NC and Brodie SM and Whyte SD
DOI: 10.1213/ane.0000000000004135
PubMed: 30985379
04/2019

Changes in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective study.
Görges M and Whyte SD and Sanatani S and Dawes J and Montgomery CJ and Ansermino JM
DOI: 10.1111/pan.12780
PubMed: 26507917
12/2015

Paediatrics
Surgeon's Guide to Anaesthesia and Perioperative Care
2014

The safety of modern anesthesia for children with long QT syndrome
Anesthesia and Analgesia
Whyte, S.D. and Nathan, A. and Myers, D. and Watkins, S.C. and Kannankeril, P.J. and Etheridge, S.P. and Andrade, J. and Collins, K.K. and Law, I.H. and Hayes, J. and Sanatani, S.
DOI: 10.1213/ANE.0000000000000389
2014

Paediatric cases
A Surgeon's Guide to Anaesthesia and Peri-Operative Care
Whyte, S. and Butterworth, S.
DOI: 10.1017/CBO9781139628808.016
2014

A retrospective audit to examine the effectiveness of preoperative warming on hypothermia in spine deformity surgery patients.
Görges M and Ansermino JM and Whyte SD
DOI: 10.1111/pan.12204
PubMed: 23738627
11/2013

Usability and performance characteristics of the pediatric air-Q® intubating laryngeal airway.
Whyte SD and Cooke E and Malherbe S
DOI: 10.1007/s12630-013-9918-6
PubMed: 23519724
06/2013

Normal Tp-e values in children.
Sanatani S and Whyte S
DOI: 10.1213/ane.0b013e31823554ac
PubMed: 22184612
01/2012

Normal Tp-e values in children
Anesthesia and Analgesia
Sanatani, S. and Whyte, S.
DOI: 10.1213/ANE.0b013e31823554ac
2012

Anaesthesia for elective ear, nose and throat surgery in children
Anaesthesia and Intensive Care Medicine
Brown, Z. and Whyte, S.
DOI: 10.1016/j.mpaic.2012.02.010
2012

Dexmedetomidine for co-analgesia in chemotherapy-induced severe enterocolitis.
Winton P and Whyte E and Reimer EJ and Davis J and Whyte S
DOI: 10.1111/j.1460-9592.2011.03575.x
PubMed: 21793978
09/2011

The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children
Pediatric Anesthesia
DISHA MEHTA and SHUBHAYAN SANATANI and SIMON D. WHYTE
DOI: 10.1111/j.1460-9592.2010.03408.x
09/2010

Total intravenous anesthesia and spontaneous respiration for airway endoscopy in children--a prospective evaluation.
Malherbe S and Whyte S and Singh P and Amari E and King A and Ansermino JM
DOI: 10.1111/j.1460-9592.2010.03290.x
PubMed: 20337953
05/2010

Intubation via the intubating laryngeal airway in two pediatric patients with predicted difficult airways.
Peiris K and Traynor M and Whyte S
DOI: 10.1111/j.1460-9592.2009.03222.x
PubMed: 20078820
02/2010

Anaesthesia for elective ear, nose and throat surgery in children
Anaesthesia & Intensive Care Medicine
Permendra Singh and Simon Whyte
DOI: 10.1016/j.mpaic.2009.02.002
04/2009

Perioperative fluid and electrolyte balance in children
Anaesthesia & Intensive Care Medicine
Simon D. Whyte
DOI: 10.1016/j.mpaic.2008.10.006
02/2009

The effect of propofol concentration on dispersion of myocardial repolarization in children.
Hume-Smith HV and Sanatani S and Lim J and Chau A and Whyte SD
DOI: 10.1213/ane.0b013e3181815ce3
PubMed: 18713888
09/2008

Editorial
Current Anaesthesia and Critical Care
Whyte, S.D.
DOI: 10.1016/j.cacc.2008.09.002
2008

A comparison of the effect on dispersion of repolarization of age-adjusted MAC values of sevoflurane in children.
Whyte SD and Sanatani S and Lim J and Booker PD
DOI: 10.1213/01.ane.0000252417.23986.6e
PubMed: 17242080
02/2007

Torsades de pointes with sevoflurane.
Whyte SD and Sanatani S and Booker PD
DOI: 10.1111/j.1460-9592.2006.01994.x
PubMed: 17040316
11/2006

Anesthetic considerations in the management of Wilms' tumor.
Whyte SD and Mark Ansermino J
DOI: 10.1111/j.1460-9592.2006.01866.x
PubMed: 16677259
05/2006

The effects of propofol and sevoflurane on the QT interval and transmural dispersion of repolarization in children.
Whyte SD and Booker PD and Buckley DG
DOI: 10.1213/01.ane.0000140781.18391.41
PubMed: 15616054
01/2005

The effects of propofol and sevoflurane on the QT interval and transmural dispersion of repolarization in children
Anesthesia and Analgesia
Whyte, S.D. and Booker, P.D. and Buckley, D.G.
DOI: 10.1213/01.ANE.0000140781.18391.41
2005

Newborn life support and the anaesthetist
Current Anaesthesia & Critical Care
Simon Whyte
DOI: 10.1016/j.cacc.2004.08.005
10/2004

Bispectral index during isoflurane anesthesia in pediatric patients.
Whyte SD and Booker PD
DOI: 10.1213/01.ane.0000117223.84646.36
PubMed: 15155318
06/2004

Bispectral index during isoflurane anesthesia in pediatric patients
Anesthesia and Analgesia
Whyte, S.D. and Booker, P.D.
DOI: 10.1213/01.ANE.0000117223.84646.36
2004

Usefulness of the Minute Ventilation Test in Predicting Successful Extubation in Newborn Infants: A Randomized Controlled Trial
Journal of Perinatology
Lorna M Gillespie and Simon D White and Sunil K Sinha and Steven M Donn
DOI: 10.1038/sj.jp.7210886
04/2003

Long QT syndrome and anaesthesia.
Booker PD and Whyte SD and Ladusans EJ
DOI: 10.1093/bja/aeg061
PubMed: 12594150
03/2003

Monitoring the depth of anaesthesia
British Journal of Anaesthesia
2003

Monitoring depth of anaesthesia by EEG
Continuing Education in Anaesthesia, Critical Care and Pain
Whyte, S.D. and Booker, P.D.
DOI: 10.1093/bjacepd/mkg106
2003

Paediatric applications of concentration-orientated anaesthesia
Best Practice & Research Clinical Anaesthesiology
Peter Driscoll Booker and Simon David Whyte
DOI: 10.1053/bean.2000.0138
03/2001

Premedication before intubation in UK neonatal units.
Whyte S and Birrell G and Wyllie J
DOI: 10.1136/fn.82.1.f38
PubMed: 10634840
01/2000

Premedication before intubation in UK neonatal units
Archives of Disease in Childhood: Fetal and Neonatal Edition
Whyte, S. and Birrell, G. and Wyllie, J.
DOI: 10.1136/fn.82.1.F38
2000

Paediatric basic life support: a practical assessment.
Whyte SD and Wyllie JP
DOI: 10.1016/s0300-9572(99)00056-8
PubMed: 10488937
07/1999

Patient-controlled analgesia: epidural fentanyl and i.v. morphine compared after caesarean section.
Cooper DW and Saleh U and Taylor M and Whyte S and Ryall D and Kokri MS and Desira WR and Day H and McArthur E
DOI: 10.1093/bja/82.3.366
PubMed: 10434817
03/1999

Neonatal resuscitation--a practical assessment.
Whyte SD and Sinha AK and Wyllie JP
DOI: 10.1016/s0300-9572(98)00143-9
PubMed: 10321844
01/1999

Neonatal resuscitation - A practical assessment
Resuscitation
Whyte, S.D. and Sinha, A.K. and Wyllie, J.P.
DOI: 10.1016/S0300-9572(98)00143-9
1999

Paediatric basic life support: A practical assessment
Resuscitation
Whyte, S.D. and Wyllie, J.P.
DOI: 10.1016/S0300-9572(99)00056-8
1999

Inability to adhere to current european neonatal resuscitation guidelines
Pediatric Research
Whyte, S.D. and Sinha, A.J. and Wyllie, J.P.
DOI: 10.1203/00006450-199809000-00110
1998

Research

CANadian PAediatric National Difficult Airway Registry (CANPANDA)
The first stage of this work was to establish a local difficult intubation database in our operating rooms. This went live in July 2017. The next stage was to expand the database to allow other Canadian tertiary paediatric anaesthesia departments to contribute data. This went live in May 2021.

G2ED50
This study measures 4 pharmacodynamic endpoints for progressively increasing depth of anaesthesia during induction, in children undergoing total intravenous anaesthesia. The goal is to better define the safety margin between loss of consciousness and cessation of breathing, in children of different ages, sex and - novelly - genetic ancestry. We'll undertake pharmacogenomic analyses for single nucleotide polymorphisms in potential anaesthetic receptor targets, to investigate any correlation between pharmacodynamic and pharmacogenomic variability.

Grants

2016-2017 Evidence to Innovation Seed Grant

“BCCH Pediatric Anesthesia Difficult Airway Database

A Quality Improvement Initiative to Improve Safety in Patients with Difficult Airways”

2019 CRSU. Genetic ancestral differences in pharmacodynamic safety endpoints with propofol anaesthesia in children

2019 BCCHRI E2i. Genetic ancestral differences in pharmacodynamic safety endpoints with propofol anaesthesia in children

Honours & Awards

Child & Family Research Institute Innovations in Acute Care & Technology Trainee Clinical Investigator Seed Grant - Project

"The effect of preoperative warming on surgical complications in pediatric scoliosis repair," $5,000. 2013.

Child & Family Research Institute Pharmaceutical Outcomes and Policy Innovations - Project

"5-HT3 Antagonists and Cardiac Safety," $42,667. 2014/15.

Research Group Members

Krystal Cardinal
Aanisah Golam, Research Assistant
Halle Golding, Research Assistant
Laveniya Kugathasan
Lindy Moxham
Andrew Poznikoff, Clinical Research Manager
Nick West, Clinical Research Coordinator