Christopher Maxwell

PhD

Lead, Childhood Cancer and Blood Research group, BC Children's Hospital
Investigator, Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital

We all arose from one fertilized egg cell; in the precise and correct ratios, ~50 trillion cells arose from the division of one primitive cell. This requires incredible balance- too many divisions of the same clone equals cancer. The division of primitive cells that reside in human tissues must also strike this balance. By studying how molecules work together during the division of these cells, my group hopes to better detect, monitor, and treat the childhood and hereditary cancers that arise as a result of too many cell divisions and inflict 1,400 kids and 2,200 young adults each year in Canada.

Academic Affiliations

  • Professor, , Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Childhood Diseases
  • Research Group(s): Childhood Cancer and Blood Research

Contact Information

Location

950 West 28th Avenue, Vancouver, British Columbia, Canada, V5Z 4H4

ATAD1 prevents clogging of TOM and damage caused by un-imported mitochondrial proteins.

Cell reports

Kim J and Goldstein M and Zecchel L and Ghorayeb R and Maxwell CA and Weidberg H

DOI: 10.1016/j.celrep.2024.114473 PubMed: 39024102

07 / 2024

The E-Ret mouse is a novel model of hyperdiploid B-cell acute lymphoblastic leukemia.

Leukemia

Farrokhi A and Tanmaya Atre and Jenna Rever and Fidanza M and Duey W and Samuel Salitra and Myung J and Guo M and Sumin Jo and Uzozie A and Fatemeh (Shakiba) Baharvand and Nina Rolf and Franziska Auer and Hauer J and Stephan Grupp and Eydoux P and Philipp F. Lange and Alix Seif and Christopher Maxwell and Gregor Reid

DOI: 10.1038/s41375-024-02221-x PubMed: 38519798

03 / 2024

Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia

Nature Communications

AC Lorentzian, J Rever, M Guo, EK Ergin, NM Akella, N Rolf, C J Lim, GSD Reid, CA Maxwell** and PF Lange** **senior authors

DOI: 10.1038/s41467-023-42701-9

11 / 2023

Pathogenic BRCA1 variants disrupt PLK1-regulation of mitotic spindle orientation

Nature Communications

Z He, R Ghorayeb, S Tan, K Chen, AC Lorentzian, J Bottyan, SM Musheer Aalam, MA Pujana, PF Lange, N Kannan, CJ Eaves, CA Maxwell

DOI: 10.1038/s41467-022-29885-2

12 / 2022

Modification of BRCA1-associated breast cancer risk by HMMR overexpression

Nature Communications

F Mateo*, Z He*, L Mei*, G Ruiz de Garibay, C Herranz, N Garcia, A Lorentzian, A Baiges, E Blommaert, A Gomez, O Mirallas, A Garrido-Utrilla, L Palomero, R Espin, AI Extremera, MT Soler-Monso, A Petit, R Li, J Brunet, K Chen, S Tan, CJ Eaves, C McCloskey, R Hakem, R Khokha, PF Lange, C Lazaro, CA Maxwell** and MA Pujana** **senior authors

DOI: 10.1038/s41467-022-29335-z

12 / 2022

Centrosome Amplification Is a Potential Molecular Target in Paediatric Acute Lymphoblastic Leukemia

Cancers

Meiyun Guo and Jenna Rever and Phuong N.U. Nguyen and Neha M. Akella and Gregor S. D. Reid and Christoper A. Maxwell

DOI: 10.3390/cancers15010154

12 / 2022

A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-a6 Inheritance.

Cell reports

Morris EJ**, Gillespie JA, Maxwell CA** and Dedhar S** **senior authors

DOI: 10.1016/j.celrep.2020.02.079 PubMed: 32187533

03 / 2020

Parity, breastfeeding, and the risk of early-onset breast cancer in women with a BRCA1 pathogenic variant

British Journal of Cancer

Joanne Kotsopoulos and Christopher A. Maxwell and Jan Lubinski and Tomasz Huzarski and Raymond H. Kim and Nadine Tung and Andrea Eisen and William Foulkes and Amber Aeilts and Susan L. Neuhausen and Louise Bordeleau and Rama Khokha and Tuya Pal and Beth Karlan and Robert Fruscio and Fergus Couch and Ping Sun and Jacek Gronwald and Steven A. Narod and Georgia Wiesner and Aletta Poll and Jeanna McCuaig and Dana Zakalik and Linda Steele and Howard Saal and Edmond Lemire and Kim Serfas and Kevin Sweet and Seema Panchal and Christine Elser and Robert E. Reilly and Joanne L. Blum and Cezary Cybulski and Daniel Rayson and Teresa Ramn y. Cajal and Jeffrey Dungan and Stefania Zovato and Antonella Rastelli and Pal Moller and Stephanie Cohen and Christian F. Singer and Charis Eng and Olufunmilayo Olopade

DOI: 10.1038/s41416-025-03029-x

07 / 2025

Proteomics and personalized PDX models identify treatment for a progressive malignancy within an actionable timeframe.

EMBO molecular medicine

Barnabas GD and Bhat TA and Goebeler V and Leclair P and Azzam N and Melong N and Anderson C and Gom A and An S and Ergin EK and Shen Y and Conrrero A and Mungall AJ and Mungall KL and Lange PF

DOI: 10.1038/s44321-025-00212-8 PubMed: 40204966

04 / 2025

Adaptation of the Th-MYCN Mouse Model of Neuroblastoma for Evaluation of Disseminated Disease

International Journal of Molecular Sciences

Seyed M. Rahavi and Maryam Aletaha and Ali Farrokhi and Amanda Lorentzian and Philipp F. Lange and Christoper A. Maxwell and Chinten James Lim and Gregor S. D. Reid

DOI: 10.3390/ijms241512071

07 / 2023

A cross-standardized flow cytometry platform to assess phenotypic stability in B-ALL xenografts.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Rolf N, Liu LYT, Tsang A, Lange PF, Lim CJ, Maxwell CA, Vercauteren SM, Reid GSD

DOI: 10.1002/cyto.a.24473 PubMed: 34128309

06 / 2021

PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways.

Journal of experimental & clinical cancer research : CR

DOI: 10.1186/s13046-021-01835-8 PubMed: 33722259

03 / 2021

Diet as a Potential Moderator for Genome Stability and Immune Response in Pediatric Leukemia

Cancers

Shanshan Wang and Christopher Maxwell and Neha Manjari Akella

DOI: 10.3390/cancers13030413

01 / 2021

Hyaluronan Mediated Motility Receptor (HMMR) Encodes an Evolutionarily Conserved Homeostasis, Mitosis, and Meiosis Regulator Rather than a Hyaluronan Receptor

Cells

Zhengcheng He and Lin Mei and Marisa Connell and Christopher A. Maxwell

DOI: 10.3390/cells9040819

03 / 2020

FAM83D directs protein kinase CK1a to the mitotic spindle for proper spindle positioning.

EMBO reports

Fulcher LJ, He Z, Mei L, Macartney TJ, Wood NT, Prescott AR, Whigham AJ, Varghese J, Gourlay R, Ball G, Clarke R, Campbell DG, Maxwell CA, Sapkota GP

DOI: 10.15252/embr.201847495 PubMed: 31338967

07 / 2019

Genetic Instability

Encyclopedia of Cancer (3rd edition)

M Guo*, L Mei*, CA Maxwell

DOI: 10.1016/b978-0-12-801238-3.65013-4

Tumor Variant Identification That Accounts for the Unique Molecular Landscape of Pediatric Malignancies.

Jnci Cancer Spectrum

Lorentzian A, Biegel JA, Ostrow DG, Rolf N, Liu CC, Rassekh SR, Deyell RJ, Triche T, Schultz KR, Rozmus J, Reid GSD, Lim CJ, Lange PF** and Maxwell CA** **senior authors

DOI: 10.1093/jncics/pky079 PubMed: 30976750

10 / 2018

CD44-mediated hyaluronan binding marks proliferating hematopoietic progenitor cells and promotes bone marrow engraftment.

PloS one

Lee-Sayer SSM, Dougan MN, Cooper J, Sanderson L, Dosanjh M, Maxwell CA, Johnson P

DOI: 10.1371/journal.pone.0196011 PubMed: 29684048

04 / 2018

Hyaluronan-binding by CD44 reduces the memory potential of activated murine CD8 T cells.

European journal of immunology

Lee-Sayer SSM, Maeshima N, Dougan MN, Dahiya A, Arif AA, Dosanjh M, Maxwell CA, Johnson P

DOI: 10.1002/eji.201747263 PubMed: 29315518

01 / 2018

The non-motor adaptor HMMR dampens Eg5-mediated forces to preserve the kinetics and integrity of chromosome segregation.

Molecular biology of the cell

Chen H, Connell M, Mei L, Reid GSD, Maxwell CA

DOI: 10.1091/mbc.E17-08-0531 PubMed: 29386294

01 / 2018

HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.

eLife

Connell M*, Chen H*, Jiang J, Kuan CW, Fotovati A, Chu TL , He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel MS, Maxwell CA

DOI: 10.7554/eLife.28672 PubMed: 28994651

10 / 2017

Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A.

Molecular cancer research : MCR

Chu TLH*, Connell M*, Zhou L, He Z, Won J, Chen H, Rahavi SMR, Mohan P, Nemirovsky O, Fotovati A, Pujana MA, Reid GSD, Nielsen TO, Pante N, Maxwell CA

DOI: 10.1158/1541-7786.mcr-17-0417 PubMed: 28993511

10 / 2017

BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells.

Oncotarget

He Z*, Kannan N*, Nemirovsky O, Chen H, Connell M, Taylor B, Jiang J, Pilarski LM, Fleisch MC, Niederacher D, Pujana MA, Eaves CJ** and Maxwell CA** **senior authors

DOI: 10.18632/oncotarget.15688 PubMed: 28427147

05 / 2017

Anti-angiogenic treatment for breast cancer?

Cancer treatment reviews

van Netten JP and Cann SH and Thornton I and Finegan RP and Maxwell C

DOI: 10.1016/j.ctrv.2017.02.008 PubMed: 28320564

03 / 2017

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Seminars in cancer biology

Block KI and Gyllenhaal C and Lowe L and Amedei A and Amin ARMR and Amin A and Aquilano K and Arbiser J and Arreola A and Arzumanyan A and Ashraf SS and Azmi AS and Benencia F and Zollo M

DOI: 10.1016/j.semcancer.2015.09.007 PubMed: 26590477

12 / 2015

Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.

Seminars in cancer biology

Ferguson LR and Chen H and Collins AR and Connell M and Damia G and Dasgupta S and Malhotra M and Meeker AK and Amedei A and Amin A and Ashraf SS and Aquilano K and Azmi AS and Bhakta D and Maxwell CA

DOI: 10.1016/j.semcancer.2015.03.005 PubMed: 25869442

04 / 2015

Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers.

PloS one

Blanco I and Kuchenbaecker K and Cuadras D and Wang X and Barrowdale D and de Garibay GR and Librado P and Snchez-Gracia A and Rozas J and Bonifaci N and McGuffog L and Pankratz VS and Pujana MA

DOI: 10.1371/journal.pone.0120020 PubMed: 25830658

04 / 2015

Genomic Instability and Cancer Metastasis

Cancer Metastasis - Biology and Treatment

Chris Maxwell and Cal Roskelley

DOI: 10.1007/978-3-319-12136-9

YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer.

Stem cells (Dayton, Ohio)

Davies AH and Reipas KM and Pambid MR and Berns R and Stratford AL and Fotovati A and Firmino N and Astanehe A and Hu K and Maxwell C and Mills GB and Dunn SE

DOI: 10.1002/stem.1707 PubMed: 24648416

06 / 2014

Spatial regulation of Aurora A activity during mitotic spindle assembly requires RHAMM to correctly localize TPX2.

Cell cycle (Georgetown, Tex.)

Chen H and Mohan P and Jiang J and Nemirovsky O and He D and Fleisch MC and Niederacher D and Pilarski LM and Lim CJ and Maxwell CA

DOI: 10.4161/cc.29270 PubMed: 24875404

05 / 2014

Tubers from patients with tuberous sclerosis complex are characterized by changes in microtubule biology through ROCK2 signalling.

The Journal of pathology

Ferrer I and Mohan P and Chen H and Castellsague J and Gmez-Bald L and Carmona M and Garca N and Aguilar H and Jiang J and Skowron M and Nellist M and Ampuero I and Russi A and Pujana MA

DOI: 10.1002/path.4343 PubMed: 24604753

04 / 2014

The Generation, Detection, and Prevention of Genomic Instability During Cancer Progression and Metastasis

Genomic Instability and Cancer Metastasis

Helen Chen and Christopher Maxwell and Marisa Connell

DOI: 10.1007/978-3-319-12136-9_2

The cytoskeletal protein RHAMM and ERK1/2 activity maintain the pluripotency of murine embryonic stem cells.

PloS one

Jiang J and Mohan P and Maxwell CA

DOI: 10.1371/journal.pone.0073548 PubMed: 24019927

09 / 2013

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition.

Oncotarget

Mohan P and Castellsague J and Jiang J and Allen K and Chen H and Nemirovsky O and Spyra M and Hu K and Kluwe L and Pujana MA and Villanueva A and Mautner VF and Keats JJ and Dunn SE and Maxwell CA

DOI: 10.18632/oncotarget.793 PubMed: 23328114

01 / 2013

Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.

PLoS biology

Maxwell CA and Bentez J and Gmez-Bald L and Osorio A and Bonifaci N and Fernndez-Ramires R and Costes SV and Guin E and Chen H and Evans GJ and Mohan P and Catal I and Petit A and Pujana MA

DOI: 10.1371/journal.pbio.1001199 PubMed: 22110403

11 / 2011

Exploring the link between MORF4L1 and risk of breast cancer.

Breast cancer research : BCR

Martrat G and Maxwell CM and Tominaga E and Porta-de-la-Riva M and Bonifaci N and Gmez-Bald L and Bogliolo M and Lzaro C and Blanco I and Brunet J and Aguilar H and Pujana MA

DOI: 10.1186/bcr2862 PubMed: 21466675

04 / 2011

YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification.

Oncogene

Davies AH and Barrett I and Pambid MR and Hu K and Stratford AL and Freeman S and Berquin IM and Pelech S and Hieter P and Maxwell C and Dunn SE

DOI: 10.1038/onc.2011.82 PubMed: 21423216

03 / 2011

Targeting tumour-initiating cells to improve the cure rates for triple-negative breast cancer.

Expert reviews in molecular medicine

Stratford AL and Reipas K and Maxwell C and Dunn SE

DOI: 10.1017/s1462399410001535 PubMed: 20653987

07 / 2010

Multifunctional proteins bridge mitosis with motility and cancer with inflammation and arthritis.

TheScientificWorldJournal

Jiang J and Casalegno-Garduno R and Chen H and Schmitt A and Schmitt M and Maxwell CA

DOI: 10.1100/tsw.2010.141 PubMed: 20602082

06 / 2010

TACC3-TSC2 maintains nuclear envelope structure and controls cell division.

Cell cycle (Georgetown, Tex.)

Gmez-Bald L and Schmidt S and Maxwell CA and Bonifaci N and Gabaldn T and Vidalain PO and Senapedis W and Kletke A and Rosing M and Barnekow A and Rottapel R and Capell G and Pujana MA

DOI: 10.4161/cc.9.6.11018 PubMed: 20237422

03 / 2010

Biological convergence of cancer signatures.

PloS one

Sol X and Bonifaci N and Lpez-Bigas N and Berenguer A and Hernndez P and Reina O and Maxwell CA and Aguilar H and Urruticoechea A and de Sanjos S and Comellas F and Capell G and Pujana MA

DOI: 10.1371/journal.pone.0004544 PubMed: 19229342

02 / 2009

Targeted and nontargeted effects of ionizing radiation that impact genomic instability.

Cancer research

Maxwell CA and Fleisch MC and Costes SV and Erickson AC and Boissire A and Gupta R and Ravani SA and Parvin B and Barcellos-Hoff MH

DOI: 10.1158/0008-5472.can-08-1212 PubMed: 18922902

10 / 2008

Cell-surface and mitotic-spindle RHAMM: moonlighting or dual oncogenic functions?

Journal of cell science

Maxwell CA and McCarthy J and Turley E

DOI: 10.1242/jcs.022038 PubMed: 18354082

04 / 2008

Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells.

Leukemia & lymphoma

Evans R and Naber C and Steffler T and Checkland T and Keats J and Maxwell C and Perry T and Chau H and Belch A and Pilarski L and Reiman T

DOI: 10.1080/10428190701824544 PubMed: 18297535

03 / 2008

Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility.

BMC genomics

Sol X and Hernndez P and de Heredia ML and Armengol L and Rodrguez-Santiago B and Gmez L and Maxwell CA and Aguil F and Condom E and Abril J and Prez-Jurado L and Estivill X and Pujana MA

DOI: 10.1186/1471-2164-9-12 PubMed: 18190704

01 / 2008

Genetic interactions: the missing links for a better understanding of cancer susceptibility, progression and treatment.

Molecular cancer

Maxwell CA and Moreno V and Sol X and Gmez L and Hernndez P and Urruticoechea A and Pujana MA

DOI: 10.1186/1476-4598-7-4 PubMed: 18186929

01 / 2008

The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma.

British journal of haematology

Evans RP and Naber C and Steffler T and Checkland T and Maxwell CA and Keats JJ and Belch AR and Pilarski LM and Lai R and Reiman T

DOI: 10.1111/j.1365-2141.2007.06913.x PubMed: 18076711

12 / 2007

Geometric approach to segmentation and protein localization in cell culture assays.

Journal of microscopy

Raman S and Maxwell CA and Barcellos-Hoff MH and Parvin B

DOI: 10.1111/j.1365-2818.2007.01712.x PubMed: 17286692

01 / 2007

Targeting aurora kinases as therapy in multiple myeloma.

Blood

Shi Y and Reiman T and Li W and Maxwell CA and Sen S and Pilarski L and Daniels TR and Penichet ML and Feldman R and Lichtenstein A

DOI: 10.1182/blood-2006-07-037671 PubMed: 17213289

01 / 2007

Intensity-based signal separation algorithm for accurate quantification of clustered centrosomes in tissue sections.

Microscopy research and technique

Fleisch MC and Maxwell CA and Kuper CK and Brown ET and Barcellos-Hoff MH and Costes SV

DOI: 10.1002/jemt.20372 PubMed: 16941664

12 / 2006

The pleiotropic roles of transforming growth factor beta in homeostasis and carcinogenesis of endocrine organs.

Endocrine-related cancer

Fleisch MC and Maxwell CA and Barcellos-Hoff MH

DOI: 10.1677/erc.1.01112 PubMed: 16728569

06 / 2006

Hyaluronan and Hyaluronan Synthases: Potential Therapeutic Targets in Cancer

Current Drug Target -Cardiovascular & Hematological Disorders

Sophia Adamia and Christopher Maxwell and Linda Pilarski

DOI: 10.2174/1568006053005056

02 / 2005

Receptor for hyaluronan-mediated motility correlates with centrosome abnormalities in multiple myeloma and maintains mitotic integrity.

Cancer research

Maxwell CA and Keats JJ and Belch AR and Pilarski LM and Reiman T

PubMed: 15705883

02 / 2005

Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients.

Blood

Keats JJ and Maxwell CA and Taylor BJ and Hendzel MJ and Chesi M and Bergsagel PL and Larratt LM and Mant MJ and Reiman T and Belch AR and Pilarski LM

DOI: 10.1182/blood-2004-09-3704 PubMed: 15677557

01 / 2005

A potential role for centrosomal deregulation within IgH translocation-positive myeloma.

Medical hypotheses

Maxwell CA and Pilarski LM

DOI: 10.1016/j.mehy.2005.05.031 PubMed: 16023302

01 / 2005

RHAMM expression and isoform balance predict aggressive disease and poor survival in multiple myeloma.

Blood

Maxwell CA and Rasmussen E and Zhan F and Keats JJ and Adamia S and Strachan E and Crainie M and Walker R and Belch AR and Pilarski LM and Barlogie B and Shaughnessy J and Reiman T

DOI: 10.1182/blood-2003-11-4079 PubMed: 15105292

04 / 2004

Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications.

Cancer research

Mitsiades CS and Mitsiades NS and Bronson RT and Chauhan D and Munshi N and Treon SP and Maxwell CA and Pilarski L and Hideshima T and Hoffman RM and Anderson KC

PubMed: 14583463

10 / 2003

RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability.

Molecular biology of the cell

Maxwell CA and Keats JJ and Crainie M and Sun X and Yen T and Shibuya E and Hendzel M and Chan G and Pilarski LM

DOI: 10.1091/mbc.E02-07-0377 PubMed: 12808028

03 / 2003

In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression.

Blood

Keats JJ and Reiman T and Maxwell CA and Taylor BJ and Larratt LM and Mant MJ and Belch AR and Pilarski LM

DOI: 10.1182/blood-2002-06-1675 PubMed: 12393535

10 / 2002

The integration of tissue structure and nuclear function.

Biochemistry and cell biology = Biochimie et biologie cellulaire

Maxwell CA and Hendzel MJ

DOI: 10.1139/o01-078 PubMed: 11467740

01 / 2001

Lymphagenesis and cancer metastasis.

British journal of cancer

van Netten JP and Cann SA and Maxwell CA and Finegan RP

DOI: 10.1038/bjc.1998.481 PubMed: 9683308

07 / 1998

Current Projects

The objectives for my research program are to more completely understand cell division at a molecular level and apply that knowledge to the study of cells that maintain the growth and development of the human brain and breast. We focus on a small set of key genes and study how their products are involved in human development and cancer using a variety of systems, including cells that grow indefinitely in the lab, mice, flies, and human tissues from both healthy and diseased individuals.

Grants

The Maxwell lab is a member of the Michael Cuccione Childhood Cancer Research program. We have received research funding support from the following organizations

Avon Foundation, Canadian Breast Cancer Foundation, Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada, Terry Fox Research Institute and the Michael Cuccione Foundation. We are very grateful for their support.

Honours & Awards

2014-2019

New Investigator, NIC category, CIHR

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