I am interested in the development of new tools that will help us detect lung disease in children. Specifically, this includes new, more sensitive breathing tests that will help us measure lung function in children. As well, I am interested in developing new imaging tests (such as MRI) that will help us see the structure of the lung.

My research focuses primarily, but not exclusively, on patients with cystic fibrosis.


Editorial for "Flow Volume Loop and Regional Ventilation Assessment Using Phase Resolved Functional Lung (PREFUL) MRI: Comparison With 129Xenon Ventilation MRI and Lung Function Testing".
Journal of magnetic resonance imaging : JMRI
Eddy RL and Rayment JH
DOI: 10.1002/jmri.27462
PubMed: 33314368

Free-breathing MRI for Monitoring Ventilation Changes following Antibiotic Treatment of Pulmonary Exacerbations in Pediatric Cystic Fibrosis.
The European respiratory journal
Munidasa S and Couch MJ and Rayment JH and Voskrebenzev A and Seethamraju R and Vogel-Claussen J and Ratjen F and Santyr G
DOI: 10.1183/13993003.03104-2020
PubMed: 33303537

Factors influencing clinical trial participation for adult and pediatric patients with cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Lee M and Hu XY and Desai S and Kwong E and Fu J and Flores E and Lazosky L and Wilcox PG and Mcllwaine M and Chilvers M and Yang C and Rayment JH and Quon BS
DOI: 10.1016/j.jcf.2020.08.019
PubMed: 32900673

Sustained recovery of exocrine pancreatic function in a teenager with cystic fibrosis treated with ivacaftor.
Pediatric pulmonology
Smith H and Rayment JH
DOI: 10.1002/ppul.24952
PubMed: 32678518

Comparison of Functional Free-Breathing Pulmonary 1H and Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Cystic Fibrosis.
Academic radiology
Couch MJ and Munidasa S and Rayment JH and Voskrebenzev A and Seethamraju RT and Vogel-Claussen J and Ratjen F and Santyr G
DOI: 10.1016/j.acra.2020.05.008
PubMed: 32532639

Assessing the feasibility of hyperpolarized 129Xe multiple-breath washout MRI in pediatric cystic fibrosis
Magnetic Resonance in Medicine
Couch, M.J. and Morgado, F. and Kanhere, N. and Kowalik, K. and Rayment, J.H. and Ratjen, F. and Santyr, G.
DOI: 10.1002/mrm.28099

An investigation into biomarkers for the diagnosis of ABPA and aspergillus disease in cystic fibrosis.
Pediatric pulmonology
Keown K and Abbott S and Kuzeljevic B and Rayment JH and Chilvers MA and Yang CL
DOI: 10.1002/ppul.24465
PubMed: 31359612

Hyperpolarised 129Xe magnetic resonance imaging to monitor treatment response in children with cystic fibrosis
European Respiratory Journal
DOI: 10.1183/13993003.02188-2018

Prolidase deficiency diagnosed by whole exome sequencing in a child with pulmonary capillaritis
ERJ Open Research
DOI: 10.1183/23120541.00205-2018

Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease
Academic Radiology
DOI: 10.1016/j.acra.2018.04.024

The lung clearance index as a monitoring tool in cystic fibrosis
Current Opinion in Pulmonary Medicine
DOI: 10.1097/mcp.0000000000000515

Back to the source – Modern insights into pulmonary exacerbations and lung function decline from CF registry data
Journal of Cystic Fibrosis
DOI: 10.1016/j.jcf.2018.05.001

Lung clearance index to monitor treatment response in pulmonary exacerbations in preschool children with cystic fibrosis.
Rayment JH and Stanojevic S and Davis SD and Retsch-Bogart G and Ratjen F
DOI: 10.1136/thoraxjnl-2017-210979
PubMed: 29449440

Reply to Verbanck and Vanderhelst: The Respective Roles of Lung Clearance Index and Magnetic Resonance Imaging in the Clinical Management of Patients with Cystic Fibrosis.
American journal of respiratory and critical care medicine
Kanhere N and Couch MJ and Rayment JH and Ratjen F and Santyr G and all authors
DOI: 10.1164/rccm.201707-1392le
PubMed: 28800249

Reply to Verbanck and Vanderhelst
American Journal of Respiratory and Critical Care Medicine
Kanhere, N. and Couch, M.J. and Rayment, J.H. and Ratjen, F. and Santyr, G.
DOI: 10.1164/rccm.201707-1392LE

The lung clearance index as a monitoring tool in cystic fibrosis: ready for the clinic?
Current opinion in pulmonary medicine
Perrem, L. and Rayment, J.H. and Ratjen, F.
DOI: 10.1097/MCP.0000000000000515

Correlation of Lung Clearance Index with Hyperpolarized 129Xe Magnetic Resonance Imaging in Pediatric Subjects with Cystic Fibrosis.
American journal of respiratory and critical care medicine
Kanhere N and Couch MJ and Kowalik K and Zanette B and Rayment JH and Manson D and Subbarao P and Ratjen F and Santyr G
DOI: 10.1164/rccm.201611-2228le
PubMed: 28245140

Another Brick in the Wall: Lung Clearance Index and Lower Airways Pathology in Preschool Cystic Fibrosis.
Annals of the American Thoracic Society
Rayment JH and Ratjen F
DOI: 10.1513/annalsats.201706-432ed
PubMed: 28862497

Chronic Hypoxemia in a 2-Year-Old Boy.
Annals of the American Thoracic Society
Rayment JH and Ahmareen O and John PR and Ratjen F
DOI: 10.1513/annalsats.201701-069cc
PubMed: 28763268

Concomitant Diffuse Alveolar Hemorrhage and Pulmonary Embolism in a Child with Isolated Pulmonary Capillaritis.
Annals of the American Thoracic Society
Rayment JH and Cutz E and Levy DM and Dell SD
DOI: 10.1513/annalsats.201610-783le
PubMed: 28248576

Correcting for tissue nitrogen excretion in multiple breath washout measurements.
PloS one
Kane M and Rayment JH and Jensen R and McDonald R and Stanojevic S and Ratjen F
DOI: 10.1371/journal.pone.0185553
PubMed: 29020072

Chronic Hypoxemia in a 2-Year-Old Boy
Annals of the American Thoracic Society
Rayment, J.H. and Ahmareen, O. and John, P.R. and Ratjen, F.
DOI: 10.1513/AnnalsATS.201701-069CC

Correlation of lung clearance index with hyperpolarized 129xe magnetic resonance imaging in pediatric subjects with cystic fibrosis
American Journal of Respiratory and Critical Care Medicine
Kanhere, N. and Couch, M.J. and Kowalik, K. and Zanette, B. and Rayment, J.H. and Manson, D. and Subbarao, P. and Ratjen, F. and Santyr, G.
DOI: 10.1164/rccm.201611-2228LE

Concomitant diffuse alveolar hemorrhage and pulmonary embolism in a child with isolated pulmonary capillaritis
Annals of the American Thoracic Society
Rayment, J.H. and Cutz, E. and Levy, D.M. and Dell, S.D.
DOI: 10.1513/AnnalsATS.201610-783LE

Another brick in the wall: Lung clearance index and lower airways pathology in preschool cystic fibrosis
Annals of the American Thoracic Society
Rayment, J.H. and Ratjen, F.
DOI: 10.1513/AnnalsATS.201706-432ED

Constrictive Bronchiolitis: A Distinct Phenotype of Cystic Fibrosis Lung Disease?
Annals of the American Thoracic Society
Rayment JH and Ratjen F
DOI: 10.1513/annalsats.201609-701ed
PubMed: 27925783

ATS Core Curriculum 2016: Part III. Pediatric Pulmonary Medicine.
Annals of the American Thoracic Society
Boyer D and Thomson CC and Cohen R and Rao D and Dell S and Rayment J and Wang R and Dy FJ and Wambach J and Tam-Williams J and Simon D and Price E and Oermann CM and Singh A and Rettig JS and Moore PE
DOI: 10.1513/annalsats.201602-097cme
PubMed: 27295156

Culture-positive Pediatric Tuberculosis in Toronto, Ontario: Sources of Infection and Relationship of Birthplace and Mycobacterial Lineage to Phenotype.
The Pediatric infectious disease journal
Rayment JH and Guthrie JL and Lam K and Whelan M and Lee B and Jamieson FB and Kitai I
DOI: 10.1097/inf.0000000000000915
PubMed: 26379168

Pulmonary Aspergillosis in a Previously Healthy 13-Year-Old Boy.
Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
Rayment JH and Narang I
DOI: 10.1155/2016/4575942
PubMed: 27445540

Constrictive bronchiolitis: A distinct phenotype of cystic fibrosis lung disease?
Annals of the American Thoracic Society
Rayment, J.H. and Ratjen, F.
DOI: 10.1513/AnnalsATS.201609-701ED

ATS core curriculum 2016: Part III. Pediatric pulmonary medicine
Annals of the American Thoracic Society
Boyer, D. and Thomson, C.C. and Cohen, R. and Rao, D. and Dell, S. and Rayment, J. and Wang, R. and Dy, F.J. and Wambach, J. and Tam-Williams, J. and Simon, D. and Price, E. and Oermann, C.M. and Singh, A. and Rettig, J.S. and Duncan, E.D. and Baker, C.D. and Liptzin, D.R. and Moore, P.E.
DOI: 10.1513/AnnalsATS.201602-097CME

Culture-positive pediatric tuberculosis in Toronto, Ontario
Pediatric Infectious Disease Journal
Rayment, J.H. and Guthrie, J.L. and Lam, K. and Whelan, M. and Lee, B. and Jamieson, F.B. and Kitai, I.
DOI: 10.1097/INF.0000000000000915

An unusual cause of empyema in a teenage boy.
CMAJ : Canadian Medical Association Journal
Rayment JH and Weinstein M
DOI: 10.1503/cmaj.122089
PubMed: 23798451

Impact of the sentinel node frozen section result on the probability of additional nodal metastases as predicted by the MSKCC nomogram in breast cancer.
Japanese journal of clinical oncology
Jamal MH and Rayment JH and Meguerditchian A and Doi SA and Meterissian S
DOI: 10.1093/jjco/hyq225
PubMed: 21149238

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.
Pontier SM and Huck L and White DE and Rayment J and Sanguin-Gendreau V and Hennessy B and Zuo D and St-Arnaud R and Mills GB and Dedhar S and Marshall CJ and Muller WJ
DOI: 10.1038/onc.2010.86
PubMed: 20305688

Addressing the role of cell adhesion in tumor cell dormancy.
Cell cycle (Georgetown, Tex.)
White DE and Rayment JH and Muller WJ
DOI: 10.4161/cc.5.16.2993
PubMed: 16880738

Amino acids as placeholders: base-composition pressures on protein length in malaria parasites and prokaryotes.
Applied bioinformatics
Rayment JH and Forsdyke DR
DOI: 10.2165/00822942-200504020-00005
PubMed: 16128613


Current Projects
Due to the remarkable advances in the care of children with cystic fibrosis (CF) over the past 3 decades, the traditional pulmonary function tests in most paediatric CF patients are normal. Despite this, we know that there is structural damage, inflammation and infection in the lungs of these children from an early age. In addition, new medical therapies for CF are leading to a monumental shift in how this disease is treated -- but again, if traditional pulmonary function testing is "normal" at the onset of therapy, it will not be sufficient to monitor response to treatment. For these reasons, new markers of lung health and disease are needed in this population. My research interests focus on the development of two types or pulmonary biomarkers: pulmonary function and imaging.

Multiple breath washout (MBW) testing is an old technique that has re-emerged in the literature over the past decade because it is extremely sensitive to the small airways disease that we see in early CF lung disease. There is, however, much that we don't know about this testing modality: how can/should it be used in a clinical setting? What constitutes a significant change between visits? Should a significant change in MBW outcomes prompt a change in clinical management? Through industry-initiated clinical trials and investigator-initiated studies, we hope to address these questions about this exciting new test.

Magnetic responance imaging is traditionally ineffective for imaging lung tissues, to its low proton density and high number of air/tissue interfaces. Novel techniques such as ultrashort echo time (UTE) MRI are improving the spatial resolution of pulmonary MRI, and are now being tested in children with CF. In addition, gas contrast imaging of the lungs using inhaled hyperpolarized noble gases (helium or xenon) allows for functional imaging. In collaboration with partners at UBC and St Paul's Hospital, I hope to develop a pediatric lung imaging research group at BCCH to use these emerging technologies in the investigation and care of children with lung disease.


CF Canada Clinical Fellowship 2016-17

Honours & Awards

2017 North American Cystic Fibrosis Conference Junior Clinical Investigator of the Year

Research Group Members

Vanessa Diamond, Undergraduate Research Assistant
Rachel Eddy, Postdoctoral Fellow, Postdoctoral Fellow
Ajay Kevat, Co-Investigator
Rodrigo Sandoval, Clinical Research Coordinator
Wendy Song