As a clinician-scientist, my main research focus is on understanding why newborns are vulnerable to infection.

I conduct translational research that integrates clinical and lab-based research methodologies including human immunology & molecular biology research, “-omics”/bioinformatics, epidemiology and clinical/interventional studies.

As a neonatologist, I also spend part of my time providing medical care to newborns admitted to the neonatal intensive care unit at the BC Women’s Hospital.


Effect of Maternal Docosahexaenoic Acid Supplementation on Bronchopulmonary Dysplasia-Free Survival in Breastfed Preterm Infants: A Randomized Clinical Trial
Marc, I. and Piedboeuf, B. and Lacaze-Masmonteil, T. and Fraser, W. and Mâsse, B. and Mohamed, I. and Qureshi, M. and Afifi, J. and Lemyre, B. and Caouette, G. and Bartholomew, J. and Nuyt, A.M. and Julien, P. and Synnes, A. and Lucas, M. and Perreault, T. and Strueby, L. and Cieslak, Z. and Yusuf, K. and Pelligra, G. and Massé, E. and Larsen, B. and de Cabo, C. and Ruth, C. and Khurshid, F. and Lavoie, P.M.
DOI: 10.1001/jama.2020.8896

Attenuated innate immune defenses in very premature neonates during the neonatal period
Pediatric Research
Marchant, E.A. and Kan, B. and Sharma, A.A. and Van Zanten, A. and Kollmann, T.R. and Brant, R. and Lavoie, P.M.
DOI: 10.1038/pr.2015.132

Clinical correlates of human immunodeficiency virus-1 (HIV-1) DNA and inducible HIV-1 RNA reservoirs in peripheral blood in children with perinatally acquired HIV-1 infection with sustained virologic suppression for at least 5 years
Clinical Infectious Diseases
Bitnun, A. and Ransy, D.G. and Brophy, J. and Kakkar, F. and Hawkes, M. and Samson, L. and Annabi, B. and Pagliuzza, A. and Morand, J.-A. and Sauve, L. and Chomont, N. and Lavoie, S. and Kim, J. and Sandstrom, P. and Wender, P.A. and Lee, T. and Singer, J. and Read, S.E. and Soudeyns, H. and Alimenti, A. and Ancuta, P. and Bullard, J. and Chun, T.-W. and Côté, H.C.F. and Embree, J. and Hawkes, M.T. and Karatzios, C. and Kaul, R. and Lamarre, V. and Lapointe, N. and Lavoie, P. and Money, D.M. and Moore, D. and Read, S. and Reinhard, R. and Sandstorm, P. and Seigel, S. and Tan, B. and Vaudry, W.
DOI: 10.1093/cid/ciz251

Outcomes related to respiratory syncytial virus with an abbreviated palivizumab regimen in children with congenital heart disease: a descriptive analysis.
CMAJ open
DOI: 10.9778/cmajo.20180167
PubMed: 30782771

Rethinking management of neonates at risk of sepsis.
Lancet (London, England)
DOI: 10.1016/s0140-6736(19)31627-7
PubMed: 31354128

A Time-Based Analysis of Inflammation in Infants at Risk of Bronchopulmonary Dysplasia
Journal of Pediatrics
Leroy, S. and Caumette, E. and Waddington, C. and Hébert, A. and Brant, R. and Lavoie, P.M.
DOI: 10.1016/j.jpeds.2017.09.011

Antifungal immunological defenses in newborns
Frontiers in Immunology
Michalski, C. and Kan, B. and Lavoie, P.M.
DOI: 10.3389/fimmu.2017.00281

Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns
Clinical Epigenetics
de Goede, O.M. and Lavoie, P.M. and Robinson, W.P.
DOI: 10.1186/s13148-017-0339-1

The phenotype and function of preterm infant monocytes: Implications for susceptibility to infection
Journal of Leukocyte Biology
De Jong, E. and Strunk, T. and Burgner, D. and Lavoie, P.M. and Currie, A.
DOI: 10.1189/jlb.4RU0317-111R

An Immunological Perspective on Neonatal Sepsis
Trends in Molecular Medicine
Kan, B. and Razzaghian, H.R. and Lavoie, P.M.
DOI: 10.1016/j.molmed.2016.02.001

Outcomes of respiratory syncytial virus immunoprophylaxis in infants using an abbreviated dosing regimen of palivizumab
JAMA Pediatrics
Lavoie, P.M. and Solimano, A. and Taylor, R. and Kwan, E. and Claydon, J. and Turvey, S.E. and Marr, N.
DOI: 10.1001/jamapediatrics.2015.3235

Cellular metabolism constrains innate immune responses in early human ontogeny
Nature communications
Kan, B. and Michalski, C. and Fu, H. and Au, H.H.T. and Lee, K. and Marchant, E.A. and Cheng, M.F. and Anderson-Baucum, E. and Aharoni-Simon, M. and Tilley, P. and Mirmira, R.G. and Ross, C.J. and Luciani, D.S. and Jan, E. and Lavoie, P.M.
DOI: 10.1038/s41467-018-07215-9

Global health systems' data science approach for precision diagnosis of sepsis in early life
The Lancet Infectious Diseases
Iregbu, K. and Dramowski, A. and Milton, R. and Nsutebu, E. and Howie, S.R.C. and Chakraborty, M. and Lavoie, P.M. and Costelloe, C.E. and Ghazal, P.
DOI: 10.1016/S1473-3099(21)00645-9

School staff and teachers during the second year of COVID-19: Higher anxiety symptoms, higher psychological distress, and poorer mental health compared to the general population
Journal of Affective Disorders Reports
Hutchison, S.M. and Watts, A. and Gadermann, A. and Oberle, E. and Oberlander, T.F. and Lavoie, P.M. and Mâsse, L.C.
DOI: 10.1016/j.jadr.2022.100335

Effect of Maternal Docosahexaenoic Acid Supplementation on Very Preterm Infant Growth: Secondary Outcome of a Randomized Clinical Trial
Angoa, G. and Pronovost, E. and Ndiaye, A.B.K.T. and Lavoie, P.M. and Lemyre, B. and Mohamed, I. and Simonyan, D. and Qureshi, M. and Afifi, J. and Yusuf, K. and Sériès, T. and Guillot, M. and Piedboeuf, B. and Fraser, W.D. and Nuyt, A.-M. and Mâsse, B. and Lacaze-Masmonteil, T. and Marc, I.
DOI: 10.1159/000524147

Evaluation of the Performance of a Multiplexed Serological Assay in the Detection of SARS-CoV-2 Infections in a Predominantly Vaccinated Population
Microbiology Spectrum
Asamoah-Boaheng, M. and Goldfarb, D.M. and Barakauskas, V. and Kirkham, T.L. and Demers, P.A. and Ehsanul Karim, M. and Lavoie, P.M. and Marquez, A.C. and Jassem, A.N. and Jenneson, S. and MacDonald, C. and Grunau, B.
DOI: 10.1128/spectrum.01454-21

Comparative 6-Month Wild-Type and Delta-Variant Antibody Levels and Surrogate Neutralization for Adults Vaccinated with BNT162b2 versus mRNA-1273
Microbiology Spectrum
Grunau, B. and Golding, L. and Prusinkiewicz, M.A. and Asamoah-Boaheng, M. and Armour, R. and Marquez, A.C. and Jassem, A.N. and Barakauskas, V. and O?Brien, S.F. and Drews, S.J. and Haig, S. and Lavoie, P.M. and Goldfarb, D.M.
DOI: 10.1128/spectrum.02702-21

Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment
Development (Cambridge)
Shannon, M.J. and Baltayeva, J. and Castellana, B. and Wächter, J. and McNeill, G.L. and Yoon, J.S. and Treissman, J. and Le, H.T. and Lavoie, P.M. and Beristain, A.G.
DOI: 10.1242/dev.199840

Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals
JAMA - Journal of the American Medical Association
Grunau, B. and Goldfarb, D.M. and Asamoah-Boaheng, M. and Golding, L. and Kirkham, T.L. and Demers, P.A. and Lavoie, P.M.
DOI: 10.1001/jama.2021.21921

SARS-CoV-2 seroprevalence among Vancouver public school staff in British Columbia, Canada: A cross-sectional study
BMJ Open
Goldfarb, D.M. and Mâsse, L.C. and Watts, A.W. and Hutchison, S.M. and Muttucomaroe, L. and Bosman, E.S. and Barakauskas, V.E. and Choi, A. and Dhillon, N. and Irvine, M.A. and Reicherz, F. and O'Reilly, C. and Sediqi, S. and Xu, R.Y. and Razzaghian, H.R. and Sadarangani, M. and Coombs, D. and O'Brien, S.F. and Lavoie, P.M.
DOI: 10.1136/bmjopen-2021-057846

Determining the optimal SARS-CoV-2 mRNA vaccine dosing interval for maximum immunogenicity
Asamoah-Boaheng, M. and Goldfarb, D.M. and Prusinkiewicz, M.A. and Golding, L. and Karim, M.E. and Barakauskas, V. and Wall, N. and Jassem, A.N. and Marquez, A.C. and MacDonald, C. and O'Brien, S.F. and Lavoie, P. and Grunau, B.
DOI: 10.1101/2022.03.01.482592

A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2
JCI Insight
Majdoubi, A. and Michalski, C. and O?Connell, S.E. and Dada, S. and Narpala, S. and Gelinas, J. and Mehta, D. and Cheung, C. and Winkler, D.F.H. and Basappa, M. and Liu, A.C. and Görges, M. and Barakauskas, V.E. and Irvine, M. and Mehalko, J. and Esposito, D. and Sekirov, I. and Jassem, A.N. and Goldfarb, D.M. and Pelech, S. and Douek, D.C. and McDermott, A.B. and Lavoie, P.M.
DOI: 10.1172/jci.insight.146316

Interleukin-37 regulates innate immune signaling in human and mouse colonic organoids
Scientific Reports
Allaire, J.M. and Poon, A. and Crowley, S.M. and Han, X. and Sharafian, Z. and Moore, N. and Stahl, M. and Bressler, B. and Lavoie, P.M. and Jacobson, K. and Li, X. and Vallance, B.A.
DOI: 10.1038/s41598-021-87592-2

Neonatal T Helper 17 Responses Are Skewed Towards an Immunoregulatory Interleukin-22 Phenotype
Frontiers in Immunology
Razzaghian, H.R. and Sharafian, Z. and Sharma, A.A. and Boyce, G.K. and Lee, K. and Da Silva, R. and Orban, P.C. and Sekaly, R.-P. and Ross, C.J. and Lavoie, P.M.
DOI: 10.3389/fimmu.2021.655027

Possible résurgence du virus respiratoire syncytial au Canada
Lavoie, P.M. and Reicherz, F. and Solimano, A. and Langley, J.M.
DOI: 10.1503/CMAJ.210919-F

Docosahexaenoic acid-rich algae oil supplementation on breast milk fatty acid profile of mothers who delivered prematurely: a randomized clinical trial
Scientific Reports
Fougère, H. and Bilodeau, J.-F. and Lavoie, P.M. and Mohamed, I. and Rudkowska, I. and Pronovost, E. and Simonyan, D. and Berthiaume, L. and Guillot, M. and Piedboeuf, B. and Julien, P. and Marc, I.
DOI: 10.1038/s41598-021-01017-8

Potential resurgence of respiratory syncytial virus in Canada
Lavoie, P.M. and Reicherz, F. and Solimano, A. and Langley, J.M.
DOI: 10.1503/cmaj.210919

Whole blood genome-wide transcriptome profiling and metagenomics next-generation sequencing in young infants with suspected sepsis in a low-and middle-income country: A study protocol [version 2; peer review: 2 approved]
Constantin R. Popescu and Bentry Tembo and Rhoda Chifisi and Miranda M.M. Cavanagh and Amy Huei-Yi Lee and Blessings Chiluzi and Emily J. Ciccone and Gerald Tegha and Esther Alonso-Prieto and Jennifer Claydon and Dustin Dunsmuir and Mike Irvine and Guy Dumont and J. Mark Ansermino and Matthew O. Wiens and Jonathan J. Juliano and Niranjan Kissoon and Tisungane Mvalo and Norman Lufesi and Msandeni Chiume-Kayuni and Pascal M. Lavoie
DOI: 10.12688/gatesopenres.13172.2

Maternal Docosahexaenoic Acid Supplementation and Bronchopulmonary Dysplasia in Infants-Reply.
Marc I and Julien P and Lavoie PM
DOI: 10.1001/jama.2020.19410
PubMed: 33231656

Antibody reactivity to SARS-CoV-2 is common in unexposed adults and infants under 6 months
Majdoubi A and Michalski C and O’Connell SE and Dada S and Narpala S and Gelinas J and Mehta D and Cheung C and Basappa M and Liu AC and Görges M and Barakauskas VE and Mehalko J and Lavoie PM
DOI: 10.1101/2020.10.05.20206664

Maternal Immunological Adaptation During Normal Pregnancy
Frontiers in Immunology
Bahaa Abu-Raya and Christina Michalski and Manish Sadarangani and Pascal M. Lavoie
DOI: 10.3389/fimmu.2020.575197

Antibody Reactivity Against SARS-CoV-2 in Adults from the Vancouver Metropolitan Area, Canada
Majdoubi A and O’Connell SE and Michalski C and Dada S and Narparla S and Gelinas J and Mehta D and Cheung C and Basappa M and Görges M and Barakauska VE and Goldfarb DM and Douek DC and Lavoie P
DOI: 10.2139/ssrn.3708321

The Effect of Massage on the Cardiac Autonomic Nervous System and Markers of Inflammation in Night Shift Workers: a Pilot Randomized Crossover Trial.
International journal of therapeutic massage & bodywork
Fazeli MS and Pourrahmat MM and Massah G and Lee K and Lavoie PM and Fazeli M and Esser A and Collet JP
PubMed: 32922577

The effect of massage on the cardiac autonomic nervous system and markers of inflammation in night shift workers: A pilot randomized crossover trial
International Journal of Therapeutic Massage and Bodywork: Research, Education, and Practice
Fazeli, M.S. and Pourrahmat, M.-M. and Massah, G. and Lee, K. and Lavoie, P.M. and Fazeli, M. and Esser, A. and Collet, J.-P.
DOI: 10.3822/ijtmb.v13i3.501

Neonatal sepsis in low-income countries: epidemiology, diagnosis and prevention
Expert Review of Anti-Infective Therapy
Popescu, C.R. and Cavanagh, M.M.M. and Tembo, B. and Chiume, M. and Lufesi, N. and Goldfarb, D.M. and Kissoon, N. and Lavoie, P.M.
DOI: 10.1080/14787210.2020.1732818

Effect of Low Versus High Tidal-Volume Total Liquid Ventilation on Pulmonary Inflammation
Frontiers in Physiology
Sage, M. and See, W. and Nault, S. and Morin, C. and Michalski, C. and Chabot, B. and Marouan, S. and Lavoie, P.M. and Micheau, P. and Praud, J.-P. and Fortin-Pellerin, ?.
DOI: 10.3389/fphys.2020.00603

RAPIDOMICS: rapid genome-wide sequencing in a neonatal intensive care unit-successes and challenges.
European journal of pediatrics
DOI: 10.1007/s00431-019-03399-4
PubMed: 31172278

Congenital lactic acidosis, cerebral cysts and pulmonary hypertension in an infant with FOXRED1 related complex 1 deficiency.
Molecular genetics and metabolism reports
DOI: 10.1016/j.ymgmr.2019.100472
PubMed: 31065540

Evolution of Training Guidelines for Echocardiography Performed by the Neonatologist: Toward Hemodynamic Consultation.
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
DOI: 10.1016/j.echo.2019.02.002
PubMed: 30926403

Genetics of bronchopulmonary dysplasia: When things do not match up, it is only the beginning.
The Journal of pediatrics
DOI: 10.1016/j.jpeds.2019.01.014
PubMed: 30737034

Congenital lactic acidosis, cerebral cysts and pulmonary hypertension in an infant with FOXRED1 related complex I deficiency.
Molecular genetics and metabolism reports
DOI: 10.1016/j.ymgmr.2018.12.006
PubMed: 30723688

Rethinking management of neonates at risk of sepsis
The Lancet
Lavoie, P.M. and Popescu, C.R. and Molyneux, E.M. and Wynn, J.L. and Chiume, M. and Keitel, K. and Lufesi, N. and Levine, G.A. and Ansermino, J.M. and Kissoon, N.
DOI: 10.1016/S0140-6736(19)31627-7

Predictor variables for post-discharge mortality modelling in infants: a protocol development project
African Health Sciences
Brooklyn R Nemetchek and Li(Danny) Liang and Niranjan Kissoon and Mark J Ansermino and Jerome Kabakyenga and Pascal M Lavoie and Susan Fowler-Kerry and Matthew O Wiens
DOI: 10.4314/ahs.v18i4.43

Glucose control and autonomic response during acute stress in youth with type 1 diabetes: A pilot study
Pediatric Diabetes
Ling Guan and Daniel L Metzger and Pascal M Lavoie and Jean-Paul Collet
DOI: 10.1111/pedi.12680

Differences in DNA methylation of white blood cell types at birth and in adulthood reflect postnatal immune maturation and influence accuracy of cell type prediction
Jones, M.J. and Dinh, L. and Razzaghian, H.R. and de Goede, O. and MacIsaac, J.L. and Morin, A.M. and Gervin, K. and Ng, R. and Duijts, L. and van Zelm, M.C. and Moll, H.A. and Lyle, R. and Robinson, W.P. and Koestler, D.C. and Felix, J.F. and Lavoie, P.M. and Mostafavi, S. and Kobor, M.S.
DOI: 10.1101/399279

Predictor variables for post-discharge mortality modelling in infants: A protocol development project
African Health Sciences
Nemetchek, B.R. and Liang, L. and Kissoon, N. and Ansermino, J.M. and Kabakyenga, J. and Lavoie, P.M. and Fowler-Kerry, S. and Wiens, M.O.
DOI: 10.4314/AHS.V18I4.43

Predictors of mortality in neonates and infants hospitalized with sepsis or serious infections in developing countries: A systematic review
Frontiers in Pediatrics
(Danny) Liang, L. and Kotadia, N. and English, L. and Kissoon, N. and Mark Ansermino, J. and Kabakyenga, J. and Lavoie, P.M. and Wiens, M.O.
DOI: 10.3389/fped.2018.00277

Why haven't the documented benefits of probiotics on preterm babies led to their wider acceptance and use?
Acta Paediatrica
Constantin R. Popescu and Leah T. Stiemsma and Pascal M. Lavoie
DOI: 10.1111/apa.13893

Genome-wide association study of bronchopulmonary dysplasia: a potential role for variants near the CRP gene
Scientific Reports
Mari Mahlman and Minna K. Karjalainen and Johanna M. Huusko and Sture Andersson and M. Anneli Kari and Outi K. T. Tammela and Ulla Sankilampi and Liisa Lehtonen and Riitta H. Marttila and Dirk Bassler and Christian F. Poets and Thierry Lacaze-Masmonteil and Claude Danan and Christophe Delacourt and Aarno Palotie and Louis J. Muglia and Pascal M. Lavoie and Alice Hadchouel and Mika Rämet and Mikko Hallman
DOI: 10.1038/s41598-017-08977-w

The phenotype and function of preterm infant monocytes: implications for susceptibility to infection
Journal of Leukocyte Biology
Emma de Jong and Tobias Strunk and David Burgner and Pascal M. Lavoie and Andrew Currie
DOI: 10.1189/jlb.4ru0317-111r

Respiratory syncytial virus-neutralizing serum antibody titers in infants following palivizumab prophylaxis with an abbreviated dosing regimen
Jennifer Claydon and Amitava Sur and Allison Callejas and Mihoko Ladd and Eddie Kwan and Richard Taylor and Stuart E. Turvey and Alfonso Solimano and Pascal M. Lavoie and Nico Marr
DOI: 10.1371/journal.pone.0176152

Mononuclear Phagocyte System
Fetal and Neonatal Physiology
Pascal M. Lavoie and Ofer Levy
DOI: 10.1016/b978-0-323-35214-7.00125-6

A Potential Role for the NOD1 Variant (rs6958571) in Gram-Positive Blood Stream Infection in ELBW Infants
Sampath, V. and Mulrooney, N. and Patel, A.L. and Cohen, J. and Zhang, L. and Garland, J. and Lavoie, P.M. and Dagle, J. and Simpson, P.
DOI: 10.1159/000477433

A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants
Pediatric Research
Sampath, V. and Bhandari, V. and Berger, J. and Merchant, D. and Zhang, L. and Ladd, M. and Menden, H. and Garland, J. and Ambalavanan, N. and Mulrooney, N. and Quasney, M. and Dagle, J. and Lavoie, P.M. and Simpson, P. and Dahmer, M.
DOI: 10.1038/pr.2016.260

Characterizing the hypomethylated DNA methylation profile of nucleated red blood cells from cord blood
Olivia M de Goede and Pascal M Lavoie and Wendy P Robinson
DOI: 10.2217/epi-2016-0069

Multiple Successful Angioembolizations for Refractory Cardiac Failure in a Preterm with Rapidly Involuting Congenital Hemangioma
American Journal of Perinatology Reports
Amitava Sur and Heran Manraj and Pascal Lavoie and Ken Lim and Douglas Courtemanche and Paul Brooks and Susan Albersheim
DOI: 10.1055/s-0035-1570342

Genetics of Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia
Pascal M. Lavoie
DOI: 10.1007/978-3-319-28486-6_6

Cardiac Autonomic Function at Baseline and under Stress and Its Relationship to Circulatory Markers of Inflammation in Obese Compared to Nonobese Children: A Pilot Study
Hormone Research in Paediatrics
Hursh, B.E. and Fazeli, M.S. and Wang, S. and Marchant, E.A. and Woo, P. and Elango, R. and Lavoie, P.M. and Chanoine, J.-P. and Collet, J.-P.
DOI: 10.1159/000445685

Editor’s Focus
Pediatric Research
Elizabeth A. Marchant and Bernard Kan and Ashish A. Sharma and Alice van Zanten and Tobias R. Kollmann and Rollin Brant and Pascal M. Lavoie
DOI: 10.1038/pr.2015.171

A Randomized Controlled Trial of the Use of Oral Glucose with or without Gentle Facilitated Tucking of Infants during Neonatal Echocardiography
Pascal M. Lavoie and Amelie Stritzke and Joseph Ting and Mohammad Jabr and Amish Jain and Eddie Kwan and Ela Chakkarapani and Paul Brooks and Rollin Brant and Patrick J. McNamara and Liisa Holsti
DOI: 10.1371/journal.pone.0141015

Nucleated red blood cells impact DNA methylation and expression analyses of cord blood hematopoietic cells
Clinical Epigenetics
Olivia M. de Goede and Hamid R. Razzaghian and E. Magda Price and Meaghan J. Jones and Michael S. Kobor and Wendy P. Robinson and Pascal M. Lavoie
DOI: 10.1186/s13148-015-0129-6

The Crohn’s disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects
Genes & Immunity
E N Ngoh and H K Brugger and M Monajemi and S C Menzies and A F Hirschfeld and K L Del Bel and K Jacobson and P M Lavoie and S E Turvey and L M Sly
DOI: 10.1038/gene.2015.30

Malaria in immigrant and traveler children: Clinical presentation and risk factors for complications
Journal of Pediatric Infectious Diseases
Pascal Lavoie and Monique Robert and Marc Lebel and Dorothy Moore and Selim Rashed and Ana Carceller
DOI: 10.1055/s-0035-1557058

Oral glucose during targeted neonatal echocardiography: is it useful?: Table 1
Archives of Disease in Childhood - Fetal and Neonatal Edition
Pascal M Lavoie and Amelie Stritzke and Joseph Ting and Mohammad Jabr and Amish Jain and Eddie Kwan and Ela Chakkarapani and Paul Brooks and Rollin Brant and Patrick J McNamara and Liisa Holsti
DOI: 10.1136/archdischild-2015-308191

Genes Encoding Vascular Endothelial Growth Factor A (VEGF-A) and VEGF Receptor 2 (VEGFR-2) and Risk for Bronchopulmonary Dysplasia
Mari Mahlman and Johanna M. Huusko and Minna K. Karjalainen and Tuula Kaukola and Riitta Marttila and Marja Ojaniemi and Ritva Haataja and Pascal M. Lavoie and Mika Rämet and Mikko Hallman and on behalf of the Gen-BPD Study Group
DOI: 10.1159/000381279

Polymorphisms of the gene encoding Kit ligand are associated with bronchopulmonary dysplasia
Pediatric Pulmonology
Huusko, J.M. and Mahlman, M. and Karjalainen, M.K. and Kaukola, T. and Haataja, R. and Marttila, R. and Toldi, G. and Szabó, M. and Kingsmore, S.F. and Rämet, M. and Lavoie, P.M. and Hallman, M.
DOI: 10.1002/ppul.23018

Impaired NLRP3 inflammasome activity during fetal development regulates IL-1ß production in human monocytes
European Journal of Immunology
Sharma, A.A. and Jen, R. and Kan, B. and Sharma, A. and Marchant, E. and Tang, A. and Gadawski, I. and Senger, C. and Skoll, A. and Turvey, S.E. and Sly, L.M. and Côté, H.C.F. and Lavoie, P.M.
DOI: 10.1002/eji.201444707

Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation
Journal of Perinatology
Noori, S. and McNamara, P. and Jain, A. and Lavoie, P.M. and Wickremasinghe, A. and Merritt, T.A. and Solomon, T. and Sekar, K. and Attridge, J.T. and Swanson, J.R. and Gillam-Krakauer, M. and Reese, J. and Poindexter, B.B. and Brook, M. and Auchus, R.J. and Clyman, R.I. and Matthews, S. and Chomic, R. and Brown, S.C. and Kuhn, M. and El-Khuffash, A. and Luc, J. and McCoy, M. and Corff, K. and Claydon, J. and Lusney, N. and Finlay, K. and Blackman, A.E. and Law-Beller, A. and Wilson, L.D.
DOI: 10.1038/jp.2014.151

Cerebral Palsy and Polymorphism of the Chemokine CCL18 in Very Preterm Children
Kallankari, H. and Huusko, J.M. and Kaukola, T. and Ojaniemi, M. and Mahlman, M. and Marttila, R. and Kingsmore, S.F. and Haataja, L. and Lavoie, P.M. and Synnes, A. and Hallman, M.
DOI: 10.1159/000430765

A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia
BMC Medical Genetics
Johanna M Huusko and Minna K Karjalainen and Mari Mahlman and Ritva Haataja and M Anneli Kari and Sture Andersson and Gergely Toldi and Outi Tammela and Mika Rämet and Pascal M Lavoie and Mikko Hallman
DOI: 10.1186/s12881-014-0120-7

Assessment of Genetic Associations between Common Single Nucleotide Polymorphisms in RIG-I-Like Receptor and IL-4 Signaling Genes and Severe Respiratory Syncytial Virus Infection in Children: A Candidate Gene Case-Control Study
Nico Marr and Aaron F. Hirschfeld and Angie Lam and Shirley Wang and Pascal M. Lavoie and Stuart E. Turvey
DOI: 10.1371/journal.pone.0100269

Hypotension following Patent Ductus Arteriosus Ligation: The Role of Adrenal Hormones
The Journal of Pediatrics
Ronald I. Clyman and Andrea Wickremasinghe and T. Allen Merritt and Tabitha Solomon and Patrick McNamara and Amish Jain and Jaideep Singh and Alison Chu and Shahab Noori and Krishnamurthy Sekar and Pascal M. Lavoie and Joshua T. Attridge and Jonathan R. Swanson and Maria Gillam-Krakauer and Jeff Reese and Sara DeMauro and Brenda Poindexter and Sue Aucott and Monique Satpute and Erika Fernandez and Richard J. Auchus
DOI: 10.1016/j.jpeds.2014.01.058

Omega-3 Long-Chain Polyunsaturated Fatty Acids for Extremely Preterm Infants: A Systematic Review
P. Zhang and P. M. Lavoie and T. Lacaze-Masmonteil and M. Rhainds and I. Marc
DOI: 10.1542/peds.2014-0459

Preferential Cephalic Redistribution of Left Ventricular Cardiac Output during Therapeutic Hypothermia for Perinatal Hypoxic-Ischemic Encephalopathy
The Journal of Pediatrics
Ori Hochwald and Mohammad Jabr and Horacio Osiovich and Steven P. Miller and Patrick J. McNamara and Pascal M. Lavoie
DOI: 10.1016/j.jpeds.2014.01.028

Surgical site infections in infants admitted to the neonatal intensive care unit
Journal of Pediatric Surgery
Ilan Segal and Christine Kang and Susan G. Albersheim and Erik D. Skarsgard and Pascal M. Lavoie
DOI: 10.1016/j.jpedsurg.2013.08.001

Attenuation of Respiratory Syncytial Virus-Induced and RIG-I-Dependent Type I IFN Responses in Human Neonates and Very Young Children
The Journal of Immunology
N. Marr and T.-I. Wang and S. H. Y. Kam and Y. S. Hu and A. A. Sharma and A. Lam and J. Markowski and A. Solimano and P. M. Lavoie and S. E. Turvey
DOI: 10.4049/jimmunol.1302007

Hierarchical Maturation of Innate Immune Defences in Very Preterm Neonates
Ashish Arunkumar Sharma and Roger Jen and Rollin Brant and Mihoko Ladd and Qing Huang and Amanda Skoll and Christof Senger and Stuart E. Turvey and Nico Marr and Pascal M. Lavoie
DOI: 10.1159/000358550

Neonatal Pain-Related Stress and NFKBIA Genotype Are Associated with Altered Cortisol Levels in Preterm Boys at School Age
Ruth E. Grunau and Ivan L. Cepeda and Cecil M. Y. Chau and Susanne Brummelte and Joanne Weinberg and Pascal M. Lavoie and Mihoko Ladd and Aaron F. Hirschfeld and Evan Russell and Gideon Koren and Stan Van Uum and Rollin Brant and Stuart E. Turvey
DOI: 10.1371/journal.pone.0073926

Response to Comment on "Helios+ and Helios- Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans"
The Journal of Immunology
K. G. MacDonald and J. M. Han and M. E. Himmel and Q. Huang and B. Kan and A. I. M. Campbell and P. M. Lavoie and M. K. Levings
DOI: 10.4049/jimmunol.1390019

Functional Genetic Variation in NFKBIA and Susceptibility to Childhood Asthma, Bronchiolitis, and Bronchopulmonary Dysplasia
The Journal of Immunology
S. Ali and A. F. Hirschfeld and M. L. Mayer and E. S. Fortuno and N. Corbett and M. Kaplan and S. Wang and J. Schneiderman and C. D. Fjell and J. Yan and L. Akhabir and F. Aminuddin and N. Marr and T. Lacaze-Masmonteil and R. G. Hegele and A. Becker and M. Chan-Yeung and R. E. W. Hancock and T. R. Kollmann and D. Daley and A. J. Sandford and P. M. Lavoie and S. E. Turvey
DOI: 10.4049/jimmunol.1201015

Neonatal Sepsis due to Coagulase-Negative Staphylococci
Clinical and Developmental Immunology
Elizabeth A. Marchant and Guilaine K. Boyce and Manish Sadarangani and Pascal M. Lavoie
DOI: 10.1155/2013/586076

The developing human preterm neonatal immune system: A case for more research in this area
Clinical Immunology
Ashish Arunkumar Sharma and Roger Jen and Alison Butler and Pascal M. Lavoie
DOI: 10.1016/j.clim.2012.08.006

Inflammasome-Mediated IL-1ß Production in Humans with Cystic Fibrosis
Anthony Tang and Ashish Sharma and Roger Jen and Aaron F. Hirschfeld and Mark A. Chilvers and Pascal M. Lavoie and Stuart E. Turvey
DOI: 10.1371/journal.pone.0037689

Influence of Common Non-Synonymous Toll-like Receptor 4 Polymorphisms on Bronchopulmonary Dysplasia and Prematurity in Human Infants
Pascal M. Lavoie and Mihoko Ladd and Aaron F. Hirschfeld and Johanna Huusko and Mari Mahlman and David P. Speert and Mikko Hallman and Thierry Lacaze-Masmonteil and Stuart E. Turvey
DOI: 10.1371/journal.pone.0031351

Ex vivo purification and characterization of human invariant natural killer T cells
Journal of Immunological Methods
Ashish Arunkumar Sharma and Leon Chew and Mihoko Ladd and Roger Jen and Pascal M. Lavoie
DOI: 10.1016/j.jim.2011.08.002

Early inflammation in the absence of overt infection in preterm neonates exposed to intensive care
Brent A. Chang and Qing Huang and Joanne Quan and Vann Chau and Mihoko Ladd and Eddie Kwan and Deborah E. McFadden and Thierry Lacaze-Masmonteil and Steven P. Miller and Pascal M. Lavoie
DOI: 10.1016/j.cyto.2011.08.028

Ontogeny of Toll-Like Receptor Mediated Cytokine Responses of Human Blood Mononuclear Cells
Nathan P. Corbett and Darren Blimkie and Kevin C. Ho and Bing Cai and Darren P. Sutherland and Arlene Kallos and Juliet Crabtree and Annie Rein-Weston and Pascal M. Lavoie and Stuart E. Turvey and Natalie R. Hawkins and Steven G. Self and Christopher B. Wilson and Adeline M. Hajjar and Edgardo S. Fortuno and Tobias R. Kollmann
DOI: 10.1371/journal.pone.0015041

Inflammatory Response in Preterm Infants Is Induced Early in Life by Oxygen and Modulated by Total Parenteral Nutrition
Pediatric Research
Pascal M Lavoie and Jean-Claude Lavoie and Carla Watson and Thérèse Rouleau and Brent A Chang and Philippe Chessex
DOI: 10.1203/pdr.0b013e3181eb2f18

Natural killer T cells constitutively expressing the interleukin-2 receptor a chain early in life are primed to respond to lower antigenic stimulation
Mihoko Ladd and Ashish Sharma and Qing Huang and Adele Y. Wang and Lixin Xu and Indira Genowati and Megan K. Levings and Pascal M. Lavoie
DOI: 10.1111/j.1365-2567.2010.03304.x

Genetics of bronchopulmonary dysplasia in the age of genomics
Current Opinion in Pediatrics
Pascal M Lavoie and Marie-Pierre Dubé
DOI: 10.1097/mop.0b013e328336eb85

Incidence of septicemia immediately after elective gastrointestinal contrast procedures in infants: a cohort study
Journal of Pediatric Surgery
Ziad Abu-Sharar and Ashley Robinson and Pascal M. Lavoie
DOI: 10.1016/j.jpedsurg.2009.07.023

Constitutive Expression of CD25 on the Surface of Neonatal (invariant) Natural Killer T Cells Primes Them to Proliferate with Lower Antigenic Stimulation
Clinical Immunology
Ashish Sharma and Mihoko Whalen and Qing Huang and Adele Wang and Lixin Xu and Indira Genowati and Meghan Levings and Pascal Lavoie
DOI: 10.1016/j.clim.2010.03.151

Do neonatologists limit parental decision-making authority? A Canadian perspective
Early Human Development
Susan G. Albersheim and Pascal M. Lavoie and Yaron D. Keidar
DOI: 10.1016/j.earlhumdev.2010.09.007

Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis
Journal of Infectious Diseases
Lavoie, P.M. and Huang, Q. and Jolette, E. and Whalen, M. and Nuyt, A.M. and Audibert, F. and Speert, D.P. and Lacaze-Masmonteil, T. and Soudeyns, H. and Kollmann, T.R.
DOI: 10.1086/657143

Genetics of bronchopulmonary dysplasia in the age of genomics
Current Opinion in Pediatrics
Lavoie, P.M. and Dubé, M.-P.
DOI: 10.1097/MOP.0b013e328336eb85

Inflammatory response in preterm infants is induced early in life by oxygen and modulated by total parenteral nutrition
Pediatric Research
Lavoie, P.M. and Lavoie, J.-C. and Watson, C. and Rouleau, T. and Chang, B.A. and Chessex, P.
DOI: 10.1203/PDR.0b013e3181eb2f18

Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults
The Journal of Immunology
T. R. Kollmann and J. Crabtree and A. Rein-Weston and D. Blimkie and F. Thommai and X. Y. Wang and P. M. Lavoie and J. Furlong and E. S. Fortuno and A. M. Hajjar and N. R. Hawkins and S. G. Self and C. B. Wilson
DOI: 10.4049/jimmunol.0901481

Earlier initiation of enteral nutrition is associated with lower risk of late-onset bacteremia only in most mature very low birth weight infants
Journal of Perinatology
P M Lavoie
DOI: 10.1038/jp.2009.8

To the editor
Lavoie, P.M. and Brant, R.
DOI: 10.1542/peds.2008-3324

Heritability of Bronchopulmonary Dysplasia, Defined According to the Consensus Statement of the National Institutes of Health
P. M. Lavoie and C. Pham and K. L. Jang
DOI: 10.1542/peds.2007-2313

Gastrointestinal Presentation of Relative Adrenal Insufficiency in a Sick Preterm Neonate
American Journal of Perinatology
Pascal Lavoie and Gustavo Pelligra and Brian Lupton and Horacio Osiovich
DOI: 10.1055/s-2007-986694

Attitudes of Canadian Neonatologists in Delivery Room Resuscitation of Newborns at Threshold of Viability
Journal of Obstetrics and Gynaecology Canada
Pascal M. Lavoie and Yaron Keidar and Susan Albersheim
DOI: 10.1016/s1701-2163(16)32599-3

Attitudes of Canadian Neonatologists in Delivery Room Resuscitation of Newborns at Threshold of Viability
Journal of Obstetrics and Gynaecology Canada
Lavoie, P.M. and Keidar, Y. and Albersheim, S.
DOI: 10.1016/S1701-2163(16)32599-3

Delayed expansion of a restricted T cell repertoire by low-density TCR ligands
International Immunology
Pascal M. Lavoie and Alain R. Dumont and Helen McGrath and Anne-Elen Kernaleguen and Rafick-P. Sékaly
DOI: 10.1093/intimm/dxh273

Lead poisoning from "lead-free" paint
Canadian Medical Association Journal
P. M. Lavoie
DOI: 10.1503/cmaj.1031524

Quantitative Relationship Between MHC Class II-Superantigen Complexes and the Balance of T Cell Activation Versus Death
The Journal of Immunology
P. M. Lavoie and H. McGrath and N. H. Shoukry and P.-A. Cazenave and R.-P. Sekaly and J. Thibodeau
DOI: 10.4049/jimmunol.166.12.7229

Superantigen presenting capacity of human astrocytes
Journal of Neuroimmunology
Mina Hassan-Zahraee and Uma Ladiwala and Pascal M Lavoie and Ellie McCrea and Rafick P Sekaly and Trevor Owens and Jack P Antel
DOI: 10.1016/s0165-5728(99)00174-5

Superantigen presenting capacity of human astrocytes
Journal of Neuroimmunology
Hassan-Zahraee, M. and Ladiwala, U. and Lavoie, P.M. and McCrea, E. and Sekaly, R.P. and Owens, T. and Antel, J.P.
DOI: 10.1016/S0165-5728(99)00174-5

Understanding the mechanism of action of bacterial superantigens from a decade of research
Immunological Reviews
Pascal M. Lavoie and Jacques Thibodeau and Francois Erard and Rafick-Pierre Sekaly
DOI: 10.1111/j.1600-065x.1999.tb01297.x

Role of the T Cell Receptor a Chain in Stabilizing TCR-Superantigen-MHC Class II Complexes
Peter S Andersen and Pascal M Lavoie and Rafick-Pierre Sékaly and Hywyn Churchill and David M Kranz and Patrick M Schlievert and Klaus Karjalainen and Roy A Mariuzza
DOI: 10.1016/s1074-7613(00)80047-3

Role of the T cell receptor a chain in stabilizing TCR-superantigen- MHC class II complexes
Andersen, P.S. and Lavoie, P.M. and Sékaly, R.-P. and Churchill, H. and Kranz, D.M. and Schlievert, P.M. and Karjalainen, K. and Mariuzza, R.A.
DOI: 10.1016/S1074-7613(00)80047-3

Understanding the mechanism of action of bacterial superantigens from a decade of research
Immunological Reviews
Lavoie, P.M. and Thibodeau, J. and Erard, F. and Sékaly, R.-P.
DOI: 10.1111/j.1600-065X.1999.tb01297.x

Viewpoint Conserved structural features between HLA-DOß and -DRß
Molecular Immunology
J Thibodeau and P.M Lavoie and A Samaan and J.-P Corre and R.-P Sékaly and P.-a Cazenave
DOI: 10.1016/s0161-5890(98)00061-3

A Mutational Analysis of the Binding of Staphylococcal Enterotoxins B and C3 to the T Cell Receptor ß Chain and Major Histocompatibility Complex Class II
The Journal of Experimental Medicine
Lukas Leder and Andrea Llera and Pascal M. Lavoie and Marina I. Lebedeva and Hongmin Li and Rafick-Pierre Sékaly and Gregory A. Bohach and Pamala J. Gahr and Patrick M. Schlievert and Klaus Karjalainen and Roy A. Mariuzza
DOI: 10.1084/jem.187.6.823

L'infection par le VIH : importance des facteurs de l'hôte.
P Champagne and PM Lavoie and RP Sékaly and A Yachou
DOI: 10.4267/10608/1001

Conserved structural features between HLA-DOß and -DRß
Molecular Immunology
Thibodeau, J. and Lavoie, P.M. and Samaan, A. and Corre, J.-P. and Sékaly, R.-P. and Cazenave, P.-A.
DOI: 10.1016/S0161-5890(98)00061-3

Champagne, P. and Lavoie, P.M. and Sékaly, R.-P. and Yachou, A.

Selective binding of bacterial toxins to major histocompatibility complex class II-expressing cells is controlled by invariant chain and HLA-DM
Proceedings of the National Academy of Sciences
P. M. Lavoie and J. Thibodeau and I. Cloutier and R. Busch and R.-P. Sekaly
DOI: 10.1073/pnas.94.13.6892

MHC Class II-Dependent Peptide Antigen Versus Superantigen Presentation to T Cells
Human Immunology
Naglaa H Shoukry and Pascal M Lavoie and Jacques Thibodeau and Sushila D’Souza and Rafick P Sekaly
DOI: 10.1016/s0198-8859(97)00074-8

“Bazinc” instinct: how SEA attracts MHC class II molecules
Research in Immunology
J. Thibodeau and P.M. Lavoie and P.-A. Cazenave
DOI: 10.1016/s0923-2494(97)80864-4

Molecular characterization and role in T cell activation of staphylococcal enterotoxin A binding to the HLA-DR alpha-chain.
The Journal of Immunology

'Bazinc' instinct: How SEA attracts MCH class II molecules
Research in Immunology
Thibodeau, J. and Lavoie, P.M. and Cazenave, P.-A.
DOI: 10.1016/S0923-2494(97)80864-4

MHC class II-dependent peptide antigen versus superantigen presentation to T cells
Human Immunology
Shoukry, N.H. and Lavoie, P.M. and Thibodeau, J. and D'Souza, S. and Sekaly, R.P.
DOI: 10.1016/S0198-8859(97)00074-8

Molecular Characterization and Role in T Cell Activation of Staphylococcal Enterotoxin a Binding to the HLA-DR a-Chain
Journal of Immunology
Thibodeau, J. and Dohlsten, M. and Cloutier, I. and Lavoie, P.M. and Bjork, P. and Michel, F. and Léveillé, C. and Mourad, W. and Kalland, T. and Sékaly, R.-P.

Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding
J Thibodeau and I Cloutier and P. Lavoie and N Labrecque and W Mourad and T Jardetzky and R. Sekaly
DOI: 10.1126/science.7997881


Innate and adaptive immune defences in human neonates across development
This research aims to study of the development of the immune system in humans before and shortly at birth. We create and employ miniaturized immunoassays to characterize immunological responses in infants from 24 weeks of gestation at birth, until the first year. We employ molecular and cell-based approaches such as systems level transcriptomics and single-cell flow cytometry to understand how immune phenotypes link to health outcomes in these populations. Our studies in this area currently focus on neonatal sepsis, innate immunity, CD4 T cell differentiation, COVID-19 and respiratory syncytial virus antibody responses.

Anti-inflamatory treatment for bronchopulmonary dysplasia
We are one of the leading centres of the CIHR-funded MOBYDICK Canadian multi-centre randomized clinical trial to determine whether maternal omega-3 supplementation effectively reduces bronchopulmonary dysplasia in very preterm infants.

Serological responses to COVID-19
With the recent SARS-CoV-2 pandemic, we moved into projects aiming at understanding antibody immunity against this virus at the population level, in infants but also healthy adults. Check out our two ongoing studies by visiting the links below:




Canadian COVID-19 Immunity Task Force (Public Health Agency of Canada) - “Tracking COVID to Inform Interventions and Help Make our Schools Safer” (2021)

Peter Wall Institute for Advanced Studies - "VitalVideo: Early identification of critically ill infants using video monitoring" (2019-2021)

Gates Foundation - Global Grand Challenges - "Improving Diagnosis of Sepsis in Young Infants in Africa: Are We Using Antibiotics Appropriately?" (2019-2020)

Women's Health Research Institute - "BC Women's Preemie Biobank" (2019)

Healthy Starts Catalyst Grant - "Single-cell analysis of immune cells during fetal ontogeny" (2018-2019)

BCCHRI Healthy Starts Theme Catalyst Grant - "An in vitro neonatal gut model to understand necrotizing enterocolitis" (2020-2021)

National Institutes of Health - "Omics analysis of innate immunity in preterm infants in response to natural flu infection and influenza vaccination" (2018-2020)

CIHR Project Grant - "Metabolic regulation of immune defenses in newborns" (2019-2024)

Grand Challenges Canada - "Improving the early diagnosis of neonatal sepsis in Malawi" (2017-2019)

CIHR Operating Grant – "Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants" (2014-2019 - extended until 2021)

Honours & Awards

BC Children's Hospital Investigator Grant Award Program (IGAP) - 2014 - 2023

CFRI Clinician-Scientist Award – 2008-2013

Michael Smith Foundation for Health Research – Career Investigator Award – 2011-2019

Research Group Members

Bahaa Abu Raya, Postdoctoral Fellow
Esther Alonso, NICU Research Program Manager, PhD
Cheuk Au, research assistant
Lisa-Marie Candeias, Administrative Assistant
Claire Cheung
Liam Golding
Rujun Kang, Research Assistant/Lab Technician Level 4
azita Kang, Clinic nurse
Alexanne Lavoie
Ying Jie Li, Spring and summer student
Eugene Linetskyi, Research Assistant
Abdelilah Majdoubi, Postdoctoral Fellow
Tisha Montgomery, Research Assistant
Lauren Muttucomaroe, Research Coordinator
Laura Muñoz, Diagnostic and Screening Coordinator at Copeman Healthcare
Bethany Poon, Research Assistant
Constantin Radu Popescu, Doctoral Student , Doctoral Student
Martin Prusinkiewicz, Trainee
Naama Rozen, NICU Research Manager
Zohreh Sharafian, Research Assistant
Jacob Shew, coop student
Marina Vineta, Graduate Research Assistant
Allison Watts
Oscar Xu