As an academic pediatric cardiologist, I am interested in optimizing outcomes for all children with cardiovascular disease. My research program ranges from preventive cardiology – where we evaluate and promote physical activity in children with congenital and non-congenital cardiovascular disease – to interventional pediatric cardiology– where we are interested in optimizing outcomes of interventional cardiac catheterizations and pediatric cardiac surgery.
I currently serve as President of the Canadian Pediatric Cardiology Association and am also a member of the Canadian Hypertension Education Program, where I lead the development of the inaugural Guidelines for Blood Pressure Measurement, Diagnosis, and Assessment of Risk of Pediatric Hypertension.
Oscillometric and auscultatory blood pressure measurement methods in children: a systematic review and meta-analysis.
Duncombe SL and Voss C and Harris KC
Outcomes of Radiofrequency Perforation for Pulmonary Atresia and Intact Ventricular Septum: A Single-Centre Experience.
Rathgeber S and Auld B and Duncombe S and Hosking MC and Harris KC
Hybrid stenting for left ventricular outflow tract obstruction in congenitally corrected transposition of the great arteries.
Rathgeber SL and Gandhi SK and Harris KC
Valvar aortico-ventricular tunnel: an insight into the development of the great arteries.
Maghrabi K and Gandhi S and Harris KC
Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension.
Leung AA and Nerenberg K and Daskalopoulou SS and McBrien K and Zarnke KB and Dasgupta K and Cloutier L and Gelfer M and Lamarre-Cliche M and Milot A and Bolli P and Tremblay G and McLean D and Tobe SW and Ruzicka M and Burns KD and Vallée M and Prasad GV and Lebel M and Feldman RD
Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, and Assessment of Risk of Pediatric Hypertension.
Harris KC and Benoit G and Dionne J and Feber J and Cloutier L and Zarnke KB and Padwal RS and Rabi DM and Fournier A and CHEP Guidelines Task Force
The 2015 Canadian Hypertension Education Program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension.
Daskalopoulou SS and Rabi DM and Zarnke KB and Dasgupta K and Nerenberg K and Cloutier L and Gelfer M and Lamarre-Cliche M and Milot A and Bolli P and McKay DW and Tremblay G and McLean D and Tobe SW and Ruzicka M and Burns KD and Vallée M and Ramesh Prasad GV and Lebel M and Feldman RD
Obesity and arterial stiffness in children: systematic review and meta-analysis.
Cote AT and Phillips AA and Harris KC and Sandor GG and Panagiotopoulos C and Devlin AM
Should early extubation be the goal for children after congenital cardiac surgery?
Harris KC and Holowachuk S and Pitfield S and Sanatani S and Froese N and Potts JE and Gandhi SK
Feasibility of optical coherence tomography in children with Kawasaki disease and pediatric heart transplant recipients.
Harris KC and Manouzi A and Fung AY and De Souza A and Bezerra HG and Potts JE and Hosking MC
A prospective observational multicenter study of balloon angioplasty for the treatment of native and recurrent coarctation of the aorta.
Harris KC and Du W and Cowley CG and Forbes TJ and Kim DW and Congenital Cardiac Intervention Study Consortium (CCISC)
Single-ventricle anatomy predicts delayed microstructural brain development.
Sethi V and Tabbutt S and Dimitropoulos A and Harris KC and Chau V and Poskitt K and Campbell A and Azakie A and Xu D and Barkovich AJ and Miller SP and McQuillen PS
Biophysical properties of the aorta and left ventricle and exercise capacity in obese children.
Harris KC and Al Saloos HA and De Souza AM and Sanatani S and Hinchliffe M and Potts JE and Sandor GG
Economic evaluation of palivizumab in children with congenital heart disease: a Canadian perspective.
Harris KC and Anis AH and Crosby MC and Cender LM and Potts JE and Human DG
Effect of school-based physical activity interventions on body mass index in children: a meta-analysis.
Harris KC and Kuramoto LK and Schulzer M and Retallack JE
Right ventricular outflow tract tachycardia in children.
Harris KC and Potts JE and Fournier A and Gross GJ and Kantoch MJ and Cote JM and Sanatani S
Interventional Pediatric Cardiology
Through collaborations with cardiac surgery and cardiac anesthesia we aim to optimize care delivery before, during and after interventional procedures for children with congenital heart disease and cardiac transplant recipients. We are currently evaluating the clinical impact of a new high resolution intravascular imaging technique called ‘Optical Coherence Tomography (OCT)’. We have successfully established an International Pediatric OCT Registry and the Children’s Heart Centre serves as the lead centre, and hosts both the core imaging laboratory and data coordinating centre for evaluating this exciting new imaging modality in children and adolescents.
I am interested in the childhood origins of non-congenital cardiovascular disease. We previously found that at-risk children – for example, individuals with obesity or congenital heart disease – have significant cardiovascular changes already in childhood, such as aortic stiffness and elevated blood pressure. We are presently conducting interventional and longitudinal observational studies to evaluate the impact of physical activity and exercise on cardiovascular health in these children.
Vascular health is also a concern in children who have had Kawasaki disease. I am actively involved in evaluating the coronary artery changes in children with Kawasaki disease. I serve as the site PI for a North American collaboration evaluating the long-term outcomes of coronary aneurysms in children with KD.
Physical activity is critical to optimize long-term cardiovascular health in children with congenital and non-congenital heart disease. We use state-of-the-art measurement tools and new technologies, such as commercial activity trackers, to better understand and promote physical activity levels in our patients. My research in this area also investigates perceived barriers and facilitators for physical activity in these children and their parents.Honours & Awards
Resident Research Mentor Award, Department of Pediatrics, BC Children’s Hospital, University of British Columbia (2015)
Young Investigator Award, Canadian Cardiovascular Society (2013)
UBC Fellow Research Award, Department of Pediatrics, BC Children’s Hospital, University of British Columbia (2011)Research Group Members
Adrija Chakrabarti, Undergraduate Student
Nicole Hemphill, Study Coordinator
Monica Hsieh, Medical Flex Student
Caroline Illmann, Experimental Medicine Masters Student
Mimi Kuan, Master's Student
Sabine Laguë, Graduate Research Assistant
Cameryn Meloche, Research Assistant
Ash Sharma, Research Assistant
A new study from BC Children’s Hospital and University of British Columbia (UBC) found that kids with heart disease – even the most severe form – are just as active as those with healthy hearts.