Publications

Randomized Trial of 2 Schedules of Meningococcal B Vaccine in Adolescents and Young Adults, Canada1.
Emerging infectious diseases
Langley JM and Gantt S and Quach C and Bettinger JA and Halperin SA and Mutch J and McNeil SA and Ward BJ and MacKinnon-Cameron D and Ye L and Marty K and Scheifele D and Brown E and Canadian Immunization Research Network
DOI: 10.3201/eid2603.190160
PubMed: 32091358
03/2020

Estimating the Risk of Human Herpesvirus 6 and Cytomegalovirus Transmission to Ugandan Infants from Viral Shedding in Saliva by Household Contacts.
Viruses
Mayer BT and Krantz EM and Wald A and Corey L and Casper C and Gantt S and Schiffer JT
DOI: 10.3390/v12020171
PubMed: 32028569
02/2020

Waning vaccine immunity and vaccination responses in children treated for acute lymphoblastic leukemia: A Canadian Immunization Research Network Study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Top KA and Vaudry W and Morris SK and Pham-Huy A and Pernica JM and Tapiéro B and Gantt S and Price VE and Rassekh SR and Sung L and McConnell A and Rubin E and Chawla R and Halperin SA
DOI: 10.1093/cid/ciaa163
PubMed: 32067048
02/2020

Performance of the Alethia CMV Assay for Detection of Cytomegalovirus by Use of Neonatal Saliva Swabs
Journal of Clinical Microbiology
Soren Gantt and David M. Goldfarb and Albert Park and William Rawlinson and Suresh B. Boppana and Tiziana Lazzarotto and Lawrence M. Mertz
DOI: 10.1128/JCM.01951-19
01/2020

Valganciclovir prophylaxis delays onset of EBV viremia in high-risk pediatric solid organ transplant recipients
Pediatric Research
Albatati, S. and Sharma, A. and Haubrich, K. and Wright, A. and Gantt, S. and Blydt-Hansen, T.D.
DOI: 10.1038/s41390-019-0523-4
2020

AMMI Canada: Response to FAQs about the management of children with congenital cytomegalovirus infection in Canada
Official Journal of the Association of Medical Microbiology and Infectious Disease Canada
DOI: 10.3138/jammi.2019-08-21
10/2019

Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein
mSphere
DOI: 10.1128/msphere.00393-19
07/2019

Humoral Immune Correlates for Prevention of Postnatal Cytomegalovirus Acquisition.
The Journal of infectious diseases
Saccoccio FM and Jenks JA and Itell HL and Li SH and Berry M and Pollara J and Casper C and Gantt S and Permar SR
DOI: 10.1093/infdis/jiz192
PubMed: 31107951
07/2019

Increased oral Epstein-Barr virus shedding with HIV-1 co-infection is due to a combination of B cell activation and impaired cellular immune control
Byrne CM and Johnston C and Orem J and Okuku F and Huang M and Selke S and Wald A and Corey L and Schiffer JT and Casper C and Coombs D and Gantt S
DOI: 10.1101/587063
03/2019

Anti-factor H antibody reactivity in young adults vaccinated with a meningococcal serogroup B vaccine containing factor H binding protein
mSphere
Sharkey, K. and Beernink, P.T. and Langley, J.M. and Gantt, S. and Quach, C. and Dold, C. and Liu, Q. and Galvan, M. and Granoff, D.M.
DOI: 10.1128/mSphere.00393-19
2019

116. Role of Maternal Antibodies in Protection Against Postnatal Cytomegalovirus Acquisition.
Open Forum Infectious Diseases
Saccoccio F and Itell H and Li S and Jenks J and Xie G and Pollara J and Gantt S and Permar S
DOI: 10.1093/ofid/ofy209.007
11/2018

LB18. An Enveloped Virus-like Particle (eVLP) Cytomegalovirus (CMV) Vaccine Is Immunogenic and Safe: Results of a First-in-Humans Study.
Open forum infectious diseases
Gantt S and Quach C and Anderson DE and Diaz-Mitoma F and Langley J
DOI: 10.1093/ofid/ofy229.2192
11/2018

Natural history of postnatal rhesus cytomegalovirus shedding by dams and acquisition by infant rhesus monkeys
PLOS ONE
Amitinder Kaur and Hannah L. Itell and E. Peek Ehlinger and Valerie Varner and Soren Gantt and Sallie R. Permar
DOI: 10.1371/journal.pone.0206330
10/2018

In reference to should infants who fail their newborn hearing screen undergo cytomegalovirus testing ?
The Laryngoscope
Soren Gantt and David M. Goldfarb and Francois Dionne and Dennis Bulman and Sara Menlove Doutré
DOI: 10.1002/lary.27032
07/2018

Nonprimary Maternal Cytomegalovirus Infection After Viral Shedding in Infants.
The Pediatric infectious disease journal
DOI: 10.1097/INF.0000000000001877
PubMed: 29889809
07/2018

Higher Expectations for a Vaccine To Prevent Congenital Cytomegalovirus Infection
Journal of Virology
Soren Gantt and Arnaud Marchant and Suresh B. Boppana
DOI: 10.1128/jvi.00764-18
07/2018

Recovery of cytomegalovirus DNA from newborn saliva samples by different methods
Journal of Clinical Virology
Oran Goshen and David M. Goldfarb and Laura Book and Peter Tilley and Soren Gantt
DOI: 10.1016/j.jcv.2018.05.001
07/2018

Effects of spatiotemporal HSV-2 lesion dynamics and antiviral treatment on the risk of HIV-1 acquisition
PLOS Computational Biology
Catherine M. Byrne and Soren Gantt and Daniel Coombs
DOI: 10.1371/journal.pcbi.1006129
04/2018

Real-time Detection and Monitoring of Loop Mediated Amplification (LAMP) Reaction Using Self-quenching and De-quenching Fluorogenic Probes.
Scientific reports
DOI: 10.1038/s41598-018-23930-1
PubMed: 29615801
04/2018

Successful treatment of chronic norovirus gastroenteritis with nitazoxanide in a pediatric kidney transplant recipient
Pediatric Transplantation
Kathryn Haubrich and Soren Gantt and Tom Blydt-Hansen
DOI: 10.1111/petr.13186
04/2018

The Potential Harm of Cytomegalovirus Infection in Immunocompetent Critically Ill Children
Frontiers in Pediatrics
Raidan Alyazidi and Srinivas Murthy and Jennifer A. Slyker and Soren Gantt
DOI: 10.3389/fped.2018.00096
04/2018

Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6.
BMC genomics
DOI: 10.1186/s12864-018-4604-2
PubMed: 29554870
03/2018

KSHV oral shedding and plasma viremia result in significant changes in the extracellular tumorigenic miRNA expression profile in individuals infected with the malaria parasite.
PloS one
DOI: 10.1371/journal.pone.0192659
PubMed: 29425228
02/2018

Herpes simplex Virus
Oxford Medicine Online
Raidan Alyazidi and Soren Gantt
DOI: 10.1093/med/9780190604813.003.0007
01/2018

Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants.
AIDS (London, England)
DOI: 10.1097/QAD.0000000000001680
PubMed: 29112074
01/2018

Higher expectations for a vaccine to prevent congenital cytomegalovirus infection
Journal of Virology
Gantt, S. and Marchant, A. and Boppana, S.B.
DOI: 10.1128/JVI.00764-18
2018

Virus and host-specific differences in oral human herpesvirus shedding kinetics among Ugandan women and children.
Scientific reports
DOI: 10.1038/s41598-017-12994-0
PubMed: 29026166
10/2017

Reply to “Early Stochastic Dynamics in Human Cytomegalovirus Infection”
Journal of Virology
Soren Gantt and Bryan T. Mayer and Joshua T. Schiffer
DOI: 10.1128/jvi.01006-17
08/2017

Genomic and proteomic analysis of Human herpesvirus 6 reveals distinct clustering of acute versus inherited forms and reannotation of reference strain
Greninger AL and Knudsen GM and Roychoudhury P and Hanson DJ and Sedlak RH and Xie H and Guan J and Nguyen T and Peddu V and Boeckh M and Huang M and Cook L and Depledge DP and Zerr DM and Jerome KR
DOI: 10.1101/181248
08/2017

Transient Oral Human Cytomegalovirus Infections Indicate Inefficient Viral Spread from Very Few Initially Infected Cells.
Journal of virology
DOI: 10.1128/JVI.00380-17
PubMed: 28381570
05/2017

Diagnosis and management of infants with congenital cytomegalovirus infection
Paediatrics & Child Health
Soren Gantt and Ari Bitnun and Christian Renaud and Fatima Kakkar and Wendy Vaudry
DOI: 10.1093/pch/pxx002
04/2017

Reply to "Early stochastic dynamics in human cytomegalovirus infection"
Journal of Virology
Gantt, S. and Mayer, B.T. and Schiffer, J.T.
DOI: 10.1128/JVI.01006-17
2017

Cost-effectiveness of Universal and Targeted Newborn Screening for Congenital Cytomegalovirus Infection.
JAMA pediatrics
DOI: 10.1001/jamapediatrics.2016.2016
PubMed: 27723885
12/2016

Dynamics of Persistent Oral Cytomegalovirus Shedding During Primary Infection in Ugandan Infants.
The Journal of infectious diseases
DOI: 10.1093/infdis/jiw442
PubMed: 27651417
09/2016

Diagnosis and management of congenital cytomegalovirus infection
This Changed My Practice
06/2016

Bacillus pumilus Septic Arthritis in a Healthy Child.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
DOI: 10.1155/2016/3265037
PubMed: 27366165
04/2016

Prospective Characterization of the Risk Factors for Transmission and Symptoms of Primary Human Herpesvirus Infections Among Ugandan Infants
J Infect Dis.
Soren Gantt and Jackson Orem and Elizabeth M. Krantz and Rhoda Ashley Morrow and Stacy Selke and Meei-Li Huang and Joshua T. Schiffer and Keith R. Jerome and Annet Nakaganda and Anna Wald and Corey Casper and Lawrence Corey
DOI: 10.1093/infdis/jiw076
02/2016

Symptomatic Congenital Cytomegalovirus Infection Is Underdiagnosed in British Columbia
The Journal of Pediatrics
Brendan Sorichetti and Oran Goshen and Julie Pauwels and Frederick K. Kozak and Peter Tilley and Mel Krajden and Soren Gantt
DOI: 10.1016/j.jpeds.2015.10.069
02/2016

Patterns of human herpesvirus-8 oral shedding among diverse cohorts of human herpesvirus-8 seropositive persons
Infect Agents Cancer
Rachel A. Bender Ignacio and Jason D. Goldman and Amalia S. Magaret and Stacy Selke and Meei-Li Huang and Soren Gantt and Christine Johnston and Warren T. Phipps and Joshua T. Schiffer and Richard A. Zuckerman and R. Scott McClelland and Connie Celum and Larry Corey and Anna Wald and Corey Casper
DOI: 10.1186/s13027-016-0052-2
02/2016

Risk of congenital cytomegalovirus infection among HIV-exposed uninfected infants is not decreased by maternal nelfinavir use during pregnancy
Journal of Medical Virology
Gantt, S. and Leister, E. and Jacobsen, D.L. and Boucoiran, I. and Huang, M..-L. and Jerome, K.R. and Jourdain, G. and Ngo-Giang-Huong, N. and Burchett, S. and Frenkel, L.
DOI: 10.1002/jmv.24420
2016

Authors reply
British Columbia Medical Journal
Roberts, A. and Gantt, S. and Ng, K. and Paquette, V. and Kang, K.
2016

Nelfinavir Impairs Glycosylation of Herpes Simplex Virus 1 Envelope Proteins and Blocks Virus Maturation
Advances in Virology
Soren Gantt and Eliora Gachelet and Jacquelyn Carlsson and Serge Barcy and Corey Casper and Michael Lagunoff
DOI: 10.1155/2015/687162
2015

Recommended curriculum for training in pediatric transplant infectious diseases
Journal of the Pediatric Infectious Diseases Society
Danziger-Isakov, L. and Allen, U. and Englund, J. and Herold, B. and Hoffman, J. and Green, M. and Gantt, S. and Kumar, D. and Michaels, M.G.
DOI: 10.1093/jpids/pit079
2015

Management of influenza infection in children and pregnant women in BC, an update
British Columbia Medical Journal
Ng, K. and Paquette, V. and Kang, K.T. and Gantt, S. and Roberts, A.
2015

Development of Online Branched Learning Modules in Pediatric Transplant Infectious Diseases
Open Forum Infectious Diseases
Bernhard Wiedermann and Monica I. Ardura and Lara Danziger-Isakov and Soren Gantt and Blanca E Gonzalez and Tanvi Sharma
DOI: 10.1093/ofid/ofv133.314
2015

Bacillus Pumilus; A Rare Cause of Paediatric Septic Arthritis. A Case Report
JOURNAL OF RHEUMATOLOGY
2015

Management of influenza infection in children and pregnant women in BC, an update
382 the Mobile Medical Unit: A unique program in British columbia
2015

Myeloid Derived Suppressor Cells Are Present at High Frequency in Neonates and Suppress In Vitro T Cell Responses
PLoS ONE
Ana Gervassi and Nicholas Lejarcegui and Sandra Dross and Amanda Jacobson and Grace Itaya and Elvis Kidzeru and Soren Gantt and Heather Jaspan and Helen Horton
DOI: 10.1371/journal.pone.0107816
09/2014

The Role of Myeloid-Derived Suppressor Cells in Immune Ontogeny
Front. Immunol.
Soren Gantt and Ana Gervassi and Heather Jaspan and Helen Horton
DOI: 10.3389/fimmu.2014.00387
08/2014

Reduced human herpesvirus-8 oropharyngeal shedding associated with protease inhibitor-based antiretroviral therapy
Journal of Clinical Virology
Soren Gantt and Ashok Cattamanchi and Elizabeth Krantz and Amalia Magaret and Stacy Selke and Steven R. Kuntz and Meei-Li Huang and Lawrence Corey and Anna Wald and Corey Casper
DOI: 10.1016/j.jcv.2014.03.002
06/2014

Breast milk transmission of nevirapine-resistant HIV-1 to infants after single-dose nevirapine in Beira, Mozambique
Journal of Infectious Diseases
2014

Transmission of nevirapine-resistant HIV type 1 via breast milk to infants after single-dose nevirapine in Beira, Mozambique
Journal of Infectious Diseases
Micek, M.A. and Dross, S. and Blanco, A.J. and Beck, I.A. and Matunha, L. and Seidel, K. and Montoya, P. and Matediana, E. and Gantt, S. and Gloyd, S. and Frenkel, L.
DOI: 10.1093/infdis/jiu130
2014

Acute flaccid paralysis in a child infected with enterovirus D68: A case report
British Columbia Medical Journal
Sherwood, M.D. and Gantt, S. and Connolly, M. and Dobson, S.
2014

Acute flaccid paralysis in a child infected with enterovirus D68: A case report
BC Medical Journal
2014

The Immunologic Basis for Severe Neonatal Herpes Disease and Potential Strategies for Therapeutic Intervention
DOI: 10.1155/2013/369172
2013

Valganciclovir dosing using area under the curve calculations in pediatric solid organ transplant recipients
Pediatric Transplantation
Villeneuve, D. and Brothers, A. and Harvey, E. and Kemna, M. and Law, Y. and Nemeth, T. and Gantt, S.
DOI: 10.1111/petr.12030
2013

Human herpesvirus 6, 7 and 8 in solid organ transplantation
American Journal of Transplantation
Le, J. and Gantt, S.
DOI: 10.1111/ajt.12106
2013

An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremia
Journal of Clinical Virology
Gantt, S. and Huang, M.-L. and Magaret, A. and Bunts, L. and Selke, S. and Wald, A. and Rosenthal, P.J. and Dorsey, G. and Casper, C.
DOI: 10.1016/j.jcv.2013.06.008
2013

Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and prevention
Current Opinion in Oncology
Gantt, S. and Casper, C. and Ambinder, R.F.
DOI: 10.1097/CCO.0b013e328363dfee
2013

Implications of age-dependent immune responses to enterovirus 71 infection for disease pathogenesis and vaccine design
Journal of the Pediatric Infectious Diseases Society
Gantt, S. and Yao, L. and Kollmann, T.R. and Casper, C. and Zhang, J. and Self, S.G.
DOI: 10.1093/jpids/pit017
2013

Insights into the broad cellular effects of nelfinavir and the HIV protease inhibitors supporting their role in cancer treatment and prevention
DOI: 10.1097/cco.0b013e328363dfee
2013

Human herpesvirus 6, 7 and 8 in solid organ transplantation
American Journal of Transplantation
2013

Early Life Immunity and Ability to Respond to Vaccines Hindered by Myeloid Derived Suppressor Cells: Implications for Infant HIV Vaccinology
AIDS RESEARCH AND HUMAN RETROVIRUSES
2013

Central Venous Catheter Repair Is Associated With an Increased Risk of Bacteremia and Central Line-associated Bloodstream Infection in Pediatric Patients
DOI: 10.1097/inf.0b013e31823eeec5
2012

Effects of short-course zidovudine on the selection of nevirapine-resistant HIV-1 in women taking single-dose nevirapine
Journal of Infectious Diseases
Micek, M.A. and Blanco, A.J. and Carlsson, J. and Beck, I.A. and Dross, S. and Matunha, L. and Seidel, K. and Montoya, P. and Gantt, S. and Matediana, E. and Jamisse, L. and Gloyd, S. and Frenkel, L.M.
DOI: 10.1093/infdis/jis282
2012

Nevirapine-resistant HIV-1 DNA in breast milk after single-dose nevirapine with or without zidovudine for prevention of mother-to-child transmission
Journal of the Pediatric Infectious Diseases Society
Gantt, S. and Payant, R. and Carlsson, J. and Micek, M.A. and Blanco, A.J. and Beck, I.A. and Matunha, L. and Montoya, P. and Matediana, E. and Gloyd, S. and Frenkel, L.M.
DOI: 10.1093/jpids/pis065
2012

Central venous catheter repair is associated with an increased risk of bacteremia and central line-associated bloodstream infection in pediatric patients
Pediatric Infectious Disease Journal
Lundgren, I.S. and Zhou, C. and Malone, F.R. and McAfee, N.G. and Gantt, S. and Zerr, D.M.
DOI: 10.1097/INF.0b013e31823eeec5
2012

the roles of viral replication and antiviral treatment
DOI: 10.1097/qco.0b013e3283486d04
2011

Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump
International Journal of Antimicrobial Agents
Qin, X. and Poon, B. and Kwong, J. and Niles, D. and Schmidt, B.Z. and Rajagopal, L. and Gantt, S.
DOI: 10.1016/j.ijantimicag.2011.03.007
2011

Human herpesvirus 8-associated neoplasms: The roles of viral replication and antiviral treatment
Current Opinion in Infectious Diseases
Gantt, S. and Casper, C.
DOI: 10.1097/QCO.0b013e3283486d04
2011

The HIV protease inhibitor nelfinavir inhibits Kaposi's sarcoma-associated herpesvirus replication in vitro
Antimicrobial Agents and Chemotherapy
Gantt, S. and Carlsson, J. and Ikoma, M. and Gachelet, E. and Gray, M. and Geballe, A.P. and Corey, L. and Casper, C. and Lagunoff, M. and Vieira, J.
DOI: 10.1128/AAC.01295-10
2011

Human herpesvirus 8-associated neoplasms: the roles of viral replication and antiviral treatment
Current opinion in infectious diseases
2011

The HIV Protease Inhibitor Nelfinavir Inhibits Kaposi's Sarcoma-Associated Herpesvirus Replication In Vitro
DOI: 10.1128/aac.01295-10
2011

Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants: a multicentre cohort study
DOI: 10.1016/s1473-3099(10)70133-x
2010

Genetic analyses of HIV-1 env sequences demonstrate limited compartmentalization in breast milk and suggest viral replication within the breast that increases with mastitis
Journal of Virology
Gantt, S. and Carlsson, J. and Heath, L. and Bull, M.E. and Shetty, A.K. and Mutsvangwa, J. and Musingwini, G. and Woelk, G. and Zijenah, L.S. and Katzenstein, D.A. and Mullins, J.I. and Frenkel, L.M.
DOI: 10.1128/JVI.00543-10
2010

Clinical presentation and outcome of epidemic Kaposi sarcoma in Ugandan children
Pediatric Blood and Cancer
Gantt, S. and Kakuru, A. and Wald, A. and Walusansa, V. and Corey, L. and Casper, C. and Orem, J.
DOI: 10.1002/pbc.22369
2010

Nevirapine resistance by timing of HIV type 1 infection in infants treated with single-dose nevirapine
Clinical Infectious Diseases
Micek, M.A. and Blanco, A.J. and Beck, I.A. and Dross, S. and Matunha, L. and Montoya, P. and Seidel, K. and Gantt, S. and Matediane, E. and Jamisse, L. and Gloyd, S. and Frenkel, L.M.
DOI: 10.1086/652151
2010

Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants: A multicentre cohort study
The Lancet Infectious Diseases
Kumar, D. and Michaels, M.G. and Morris, M.I. and Green, M. and Avery, R.K. and Liu, C. and Danziger-Isakov, L. and Stosor, V. and Estabrook, M. and Gantt, S. and Marr, K.A. and Martin, S. and Silveira, F.P. and Razonable, R.R. and Allen, U.D. and Levi, M.E. and Lyon, G.M. and Bell, L.E. and Huprikar, S. and Patel, G. and Gregg, K.S. and Pursell, K. and Helmersen, D. and Julian, K.G. and Shiley, K. and Bono, B. and Dharnidharka, V.R. and Alavi, G. and Kalpoe, J.S. and Shoham, S. and Reid, G.E. and Humar, A.
DOI: 10.1016/S1473-3099(10)70133-X
2010

Genetic Analyses of HIV-1 env Sequences Demonstrate Limited Compartmentalization in Breast Milk and Suggest Viral Replication within the Breast That Increases with Mastitis
DOI: 10.1128/jvi.00543-10
2010

Clinical presentation and outcome of epidemic Kaposi sarcoma in Ugandan children
DOI: 10.1186/1750-9378-5-s1-a12
2010

Intermittent preventive treatment using artemisinin-based combination therapy reduces malaria morbidity among school-aged children in Mali
DOI: 10.1111/j.1365-3156.2009.02294.x
2009

Cytomegalovirus and Epstein-Barr virus in breast milk are associated with HIV-1 shedding but not with mastitis
DOI: 10.1097/qad.0b013e32830184f2
2008

Cytomegalovirus and Epstein-Barr virus in breast milk are associated with HIV-1 shedding but not with mastitis
AIDS
Gantt, S. and Carlsson, J. and Shetty, A.K. and Seidel, K.D. and Qin, X. and Mutsvangwa, J. and Musingwini, G. and Woelk, G. and Zijenah, L.S. and Katzenstein, D.A. and Frenkel, L.M.
DOI: 10.1097/QAD.0b013e32830184f2
2008

Laboratory Indicators of Mastitis Are Not Associated with Elevated HIV-1 DNA Loads or Predictive of HIV-1 RNA Loads in Breast Milk
DOI: 10.1086/519843
2007

Use of 16S Ribosomal DNA Polymerase Chain Reaction to Identify Haemophilus influenzae Type b as the Etiology of Pericarditis in an Infant
The Pediatric Infectious Disease Journal
Crystal Benson and Soren Gantt and Danielle M Zerr and Xuan Qin and Patrick Abe
DOI: 10.1097/01.inf.0000154593.22356.e2
03/2005

Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology
The EMBO journal
2002

Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology
EMBO Journal
Thathy, V. and Fujioka, H. and Gantt, S. and Nussenzweig, R. and Nussenzweig, V. and M{\'e}nard, R.
DOI: 10.1093/emboj/21.7.1586
2002

Antibodies against Thrombospondin-Related Anonymous Protein Do Not Inhibit Plasmodium Sporozoite Infectivity In Vivo
DOI: 10.1128/iai.68.6.3667-3673.2000
2000

Antibodies against thrombospondin-related anonymous protein do not inhibit Plasmodium sporozoite infectivity in vivo
Infection and Immunity
Gantt, S. and Persson, C. and Rose, K. and Birkett, A.J. and Abagyan, R. and Nussenzweig, V.
DOI: 10.1128/IAI.68.6.3667-3673.2000
2000

Conservation of a Gliding Motility and Cell Invasion Machinery in Apicomplexan Parasites
J Cell Biol
Stefan Kappe and Thomas Bruderer and Soren Gantt and Hisashi Fujioka and Victor Nussenzweig and Robert Ménard
DOI: 10.1083/jcb.147.5.937
11/1999

Proteasome Inhibitors Block Development ofPlasmodium spp.
Antimicrobial agents and chemotherapy
1998

Proteasome inhibitors block development of Plasmodium spp.
Antimicrobial Agents and Chemotherapy
Gantt, S.M. and Myung, J.M. and Briones, M.R.S. and Li, W.D. and Corey, E.J. and Omura, S. and Nussenzweig, V. and Sinnis, P.
DOI: 10.1128/aac.42.10.2731
1998

Cell Adhesion to a Motif Shared by the Malaria Circumsporozoite Protein and Thrombospondin Is Mediated by Its Glycosaminoglycan-binding Region and Not by CSVTCG
DOI: 10.1074/jbc.272.31.19205
1997

Research

Current Projects
Infections with human herpesviruses (HHVs), such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), and Kaposi's sarcoma-associated herpesvirus (KSHV), cause an enormous amount of morbidity and mortality worldwide. Although nearly everyone becomes infected with one or more of these viruses, most have no significant illness from them. However, in young infants or people immunocompromised by HIV or having a transplant, these viruses frequently cause a range of severe infections and cancers. Vaccines or drugs to prevent these infections or their complications would have profound public health implications, but first additional research is required to better understand the underlying pathogenesis. As such, we carry out translational research studies, utilizing cohorts of children in Africa and North America as well as epidemiologic, clinical, and molecular approaches, to address fundamental questions about how to prevent and treat HHV-related diseases.

We are particularly interested in the role of HHV infections very early in life. For example, CMV infects approximately 1% of all infants in utero, which frequently results in neurologic sequelae like deafness and mental retardation; postnatal infections, however, are normally benign. Similarly, high risk for Burkitt's lymphoma, one of the most common childhood cancers in Africa, appears to be due to EBV infection in early infancy combined with exposure to malaria. We have established a cohort of children in Uganda who were followed every week during the first year of life to study CMV and EBV infection. The precise timing of infection with these viruses was established by weekly PCR testing. Comprehensive data were collected regarding epidemiologic and biologic risks of acquisition, including detailed behavioral questionnaires, determination of the viral exposure by household contacts, and collection of blood for measurement of virus-specific neutralizing maternal antibodies. Symptoms of illness associated with infection were captured using standardized physical exams and clinical histories, and blood was collected to evaluate the humoral and cellular immune responses to these viruses that are associated with control of viral replication.

Another recent focus of our group has been to elucidate the mechanism of action of the HIV protease inhibitor (PI) nelfinavir to inhibit HHV replication, and investigate the drug's potential to prevent and treat HHV-related diseases. We discovered that nelfinavir is able to block in vitro replication of all HHVs tested to date, at concentrations that are achieved in patients taking doses that are FDA-approved for treatment of HIV. This activity is unique to nelfinavir among PIs, and appears to result from effects of nelfinavir on host cell pathways that are required for viral replication, rather than on the virus itself. Interestingly, at least some of these cellular effects also confer nelfinavir's increasingly appreciated antitumor activities. Because nelfinavir is safe for use in humans, we have undertaken a phase 1/2 trial of nelfinavir for the treatment of Kaposi's sarcoma in Africa and the US. In addition, because nelfinavir is also safe during pregnancy, we are testing whether nelfinavir given to HIV-infected women during pregnancy can prevent congenital CMV infection.

Grants

CIHR Operating Grant - Project: "Correlates of acquisition and immune control of primary Epstein-Barr virus infection in Ugandan infants" – 2014-19

P01 Project: “Immune Control of KSHV Infection and Impact of HIV Infection And Therapy”

NIH (Co-PIs: Soren Gantt and Serge Barcy) 03/01/11 – 02/29/16

Honours & Awards

Sigma Xi Society, 1993

Honors for Undergraduate Research, Brown University, 1993

Rosenbluth Foundation Travel Award, 1999

Research Group Members

Jairah Alindogan, Direct study student
Catherine Byrne, PhD Student
Jason Jassal, Research Trainee
Aaron Liu, Doctoral Student
Rory Long, INSPIRE Student
Citlali Marquez, Postdoctoral fellow
Habibur Rahman
Shabnam Raufi, Research Volunteer
Carolyn Smith, Program Assistant
Guadalein Tanunliong, Directed study student
Jessica Tuengel, Graduate Research Asst
Emily Wong, Trainee