Validating Injury to the Renal Transplant Using Urinary Signatures in Children (VIRTUUS)
Transplant rejection contributes to irreversible damage to the transplanted organ. Sub-clinical detection of transplant rejection (when no definite or readily observable clinical symptoms are present) and detection of other post-transplantation complications using non-invasive means, such as urinary biomarkers, will allow earlier diagnosis of rejection. This approach will ultimately allow less aggressive and earlier intervention, and thus preserve transplant function. The purpose of the study is to investigate whether the existing urinary mRNA and metabolite profiles used for detection of early kidney transplant injury in adults can also predict rejection and other complications of kidney transplantation in children.
This is a prospective, observational, multicenter, cohort study coordinated at the Children's Hospital of Philadelphia. BC Children's Hospital is one of the participating research sites, led by Dr. Tom Blydt-Hansen (site investigator).
For more information, visit ClinicalTrials.gov.
This study is being funded by the National Institutes of Health (NIH).
- Project Status
Status: Active, data collection ongoing
Study Start Date: September 26, 2018
Study End Date: May 31, 2023
Study Enrollment Status: Closed
Start Date: October 2018
End Date: February 2022
- Project Team
Research Team Members
Candice Wiedman, Research Assistant
- Enrollment Eligibility Criteria
- Males or females between 2 to 18 years at the time of recruitment, receiving the first, or additional, kidney transplants.
- Parental/guardian permission (informed consent) and, if appropriate, child/adolescent assent can be obtained.
For more information, please email firstname.lastname@example.org.
Harry Chae, Worklearn student
David Camarda, Undergraduate student
Kevin Vytlingam, Undergraduate student
Bita Ghordani, Undergraduate student
Kerry Hu, Undergraduate student
Ibarheem Babar, Undergraduate student
Jasmine Malhi, Undergraduate student
Simranpreet Mann, Undergraduate student