Utility of urinary biomarkers in characterizing chronic active T cell-mediated rejection in kidney transplant recipients

Project Summary

The purpose of this study is to compare urinary immune biomarker (cytokines and chemokine) levels in pediatric kidney transplant recipients with chronic rejection and controls without chronic rejection. The study seeks to characterize the chemical (proregulatory and proinflammatory) signaling in patients with chronic inflammatory changes (i-IFTA changes on allograft kidney biopsy), to further our understanding of the pathogenesis of chronic rejection and identify potential future targets for therapeutic interventions.

This is a cross-sectional, single center, cohort study of pediatric kidney transplant recipients at BC Children’s Hospital. Dr. Tom Blydt-Hansen is the principal investigator.

Project Status

Study Start Date: October 20, 2021
Study End Date: August 18, 2022

Project Team

Principal Investigator

Dr. Tom Blydt-Hansen


Mei-Lin Bissonnette, UBC Medicine, Department of Pathology & Laboratory Medicine
Vanessa Masson, UBC Faculty of Medicine
Kevin D Vytlingam, UBC Medicine, Department of Pediatrics
Li Wang, UBC Medicine, Department of Pathology & Laboratory Medicine
Maziar Riazy, UBC Medicine, Department of Pathology & Laboratory Medicine

Research Team Members

Candice Wiedman, Research Assistant
Monica Ho, Research Coordinator

Enrollment Eligibility Criteria

Patients who participate in the Biobanking for SOT patients and HOPE SOT registry studies have consented for their samples and clinical information held within these database/registries to be available and used for ongoing research studies. These studies were put in place to avoid the burden of multiple re-consent to low-risk studies that include use of samples and clinical data. By linking this chronic active T-cell medicated inflammation (caTCMR) study to these studies, we can respect the intent of participants who consented to utilize these samples for similar, low-risk projects that require collection of samples.

For more information, please email sotresearch@bcchr.ca.