Investigating serum immunometabolomic profiles associated with alloimmune outcomes in pediatric kidney and heart transplant recipients

Some people's immune systems adapt better or become more "tolerant" to the transplant, but we don't know all of the reasons why. While medications are an important part, we also know that a person's metabolism can play a role. We will look at samples collected before transplant to see if there are any measurable changes in metabolism that predict who will have a positive (adaptive) or negative (rejection) response to the transplant. We will test for small molecules (called metabolites) that tell us about metabolism and see how patterns of these metabolites might predict development of chronic forms of rejection.

This is a database registry being built by Dr. Tom Blydt-Hansen's research team at BC Children's Hospital Research Institute. Dr. Tom Blydt-Hansen is the Principal Investigator.

Linked Projects

HOPE SOT data registry
EnMo study

Project Status

Status: Closed
Study End Date: September 20, 2020

Study Enrollment Status: Closed

Project Team

Principal Investigator

Tom Blydt-Hansen
 
Co-Investigators

Paul A. Keown, Professor, UBC, Faculty of Medicine, Department of Nephrology
David Wishart, Non-UBC Faculty Member, Other University/Hospital
Suzanne Vercauteren, Clinical Professor, UBC, Faculty of Medicine, Department of Pathology & Laboratory Medicine
Graham Sinclair, Clinical Professor, UBC, Faculty of Medicine, Department of Pathology & Laboratory Medicine

Research Team Members

Amy Thachil, Graduate Student, UBC, Faculty of Medicine, Department of Pediatrics
Or Golan, Medical Student, UBC
Mike Guron, Research Assistant, UBC, Faculty of Medicine, Department of Pediatrics
Julie Matheson, Unspecified, UBC, Faculty of Medicine, Department of Pediatrics
Kathryn Armstrong, Assistant Professor, UBC
Atul Sharma, Assistant Professor, University of Manitoba
Simon Urschel, Associate Professor, University of Alberta
Seema Mital, Professor, University of Toronto

Enrollment Eligibility Criteria

This study requires sample and data analysis. The following samples will be included in the analysis: 

  1. All kidney transplants at BCCH in the time frame eligible (February 1st 2009 - February 28th 2019).
  2. All samples provided by the Genome Canada study, PROBE study, POSITIVE study, and the BC Children's Hospital Biobank.

For more information, please email sotresearch@bcchr.ca.