Teen Adherence in Kidney Transplant, Improving Tracking to Optimize Outcomes

Project Summary

TAKE-IT TOO builds on the TAKE-IT study, which combined an electronic pillbox with medication adherence feedback to patients via text message, and a trained study coach to help participants identify and address barriers to medication adherence. TAKE-IT TOO will adapt the TAKE-IT intervention into clinical practice and aims to develop a better e-pillbox and companion website for real-world use. Stage 3 of TAKE-IT TOO involves patients' use of the adapted electronic pillbox, text message reminders, adherence-tracking web portal; and coaching on barriers to adherence, or healthy living education, in an adherence- promoting intervention arm and healthy living education intervention arm, respectively. 

The is an interventional, multicenter clinical trial that is coordinated at the McGill University Health Centre/Research Institute. BC Children's Hospital is one of the participating research sites, led by Dr. Tom Blydt-Hansen (site investigator). 

For more information, visit the TAKE-IT TOO website

This study is funded by the National Institutes of Health (NIH).

Project Status

Status: Closed
Study Start Date: October 1, 2021
Study End Date: June 30, 2023

Study Enrollment Status: Closed
Start Date: October 1, 2021
End Date: August 30, 2022

Project Team

Principal Investigators

Dr. Bethany J. Foster, McGill University Health Centre
Dr. Anette DeVito Dabbs, University of Pittsburgh Medical Center


Dr. Catherine Girardin, Central Hospital of the University of Montreal
Dr. Jodi Smith, Seattle Children’s Hospital
Dr. Mina Matsuda-Abedini, University of Toronto Hospital for Sick Children
Dr. Veronique Phan, CHU Sainte-Justine
Dr. Vikas Dharnidharaka, St. Louis Children’s Hospital
Dr. Tom Blydt-Hansen, BC Children's Hospital

Research Team Members

Candice Wiedman, Research Assistant
Monica Ho, Research Coordinator

Enrollment Eligibility Criteria

Stage 3 includes both patients (and their parents/caregivers if patient is <18 years old) and healthcare professional participants.

Inclusion criteria for patient participants: 

  • Prevalent kidney-only transplant recipients -12-24 years old
  • ≥3 months post-transplant 

Inclusion criteria for healthcare professional participants:

  • Representatives from variety of disciplines typically involved in promoting medication adherence as deemed appropriate from each centre
  • Most involved in direct patient care 

For more information, email sotresearch@bcchr.ca.

  1. Vaisbourd, Y., Dahhou, M., De Simone, A., Zhang, X., and Foster, B. J. (2022). Differences in medication adherence between preemptive and post-dialysis young kidney transplant recipients. Pediatric Nephrology. doi.org/10.1007/s00467-022-05797-7
  2. Nguyen, C., Dew, M. A., Irizarry, T., McNulty, M., Rennick, J., Knäuper, B., Descoteaux, A., Grenier, A., Jeannot, L., Foster, B. J., and DeVito Dabbs, A. J. (2020). Promoting medication adherence from the perspective of adolescent and young adult kidney transplant recipients, parents, and Health Care Professionals: A take‐it too study. Pediatric Transplantation, 24(5)
  3. Dharnidharka, V. R., Hebert, D., Zelikovsky, N., Amaral, S., Furth, S. L., and Foster, B. J. (2019). Association between Day of the week and medication adherence among adolescent and young adult kidney transplant recipients. American Journal of Transplantation, 20(1), 274–281. doi.org/10.1111/ajt.15590
  4. Foster, B. J., Pai, A. L. H., Zelikovsky, N., Amaral, S., Bell, L., Dharnidharka, V. R., Hebert, D., Holly, C., Knauper, B., Matsell, D., Phan, V., Rogers, R., Smith, J. M., Zhao, H., and Furth, S. L. (2018). A randomized trial of a multicomponent intervention to promote medication adherence: The teen adherence in kidney transplant effectiveness of intervention trial (take-it). American Journal of Kidney Diseases, 72(1), 30–41. doi.org/10.1053/j.ajkd.2017.12.012
  5. Foster, B. J., Pai, A., Zhao, H., &amp; Furth, S. (2014). The take-it study: Aims, design, and methods. BMC Nephrology, 15(1). doi.org/10.1186/1471-2369-15-139